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Machinery Of The 'Marijuana Munchies'
Science Daily ^ | December 26, 2005

Posted on 12/27/2005 7:26:46 AM PST by billorites

Marijuana--or more specifically its active ingredient, tetrahydrocannabinol--has a well-documented tendency to stimulate hunger. And while scientists have traced this property to cannabinoid receptors in the brain, they have had little understanding of the neural circuitry underlying this effect.

Understanding this circuitry has important practical implications because blocking the cannabinoid receptor, CB1, offers a promising approach to treating obesity. One such compound, rimonabant (trade name AcompliaTM) is already undergoing clinical testing.

In an article in the December 22, 2005, issue of Neuron, Young-Hwan Jo and colleagues report how the circuitry of CB1 is integrated with signaling by the appetite-suppressing hormone leptin. The CB1 receptor is normally triggered by natural regulatory molecules, called endocannabinoids.

In their studies, the researchers concentrated on the lateral hypothalamus (LH) of the brain, known to be a center of control of food intake. Their studies involved detailed electrophysiological measurements of the effects of specific neurons that they had identified in previous studies as being important in endocannabinoid signaling.

Their studies revealed that activation of CB1 receptors, as by endocannabinoid molecules, induced these neurons to be rendered more excitable by a mechanism called "depolarization-induced suppression of inhibition" (DSI).

What's more, they found that leptin inhibits DSI. However, they found that leptin did not interfere with the CB1 receptors themselves. Rather, leptin "short-circuits" the endocannabinoid effects by inhibiting pore-like channels in the neurons that regulate the flow of calcium into the neurons. Such calcium is necessary for the synthesis of endocannabinoids.

In further studies of mice genetically altered to be leptin deficient, the researchers found the DSI to be more prolonged than in normal mice. Thus, they said, the findings "implicate this mechanism for leptin receptor/endocannabinoid signaling in contributing to the maintenance of weight balance...." The researchers also included that "upregulation of endocannabinoid signaling in the LH may explain, at least in part, the increased body weight consistent with a prior report of elevated endocannabinoids" in such leptin-deficient mice.

The researchers concluded that their findings "are consistent with the hypothesis that the integration of endocannabinoid and leptin signaling regulates the excitability of neurons on appetite-related circuits."

They also wrote that "the cellular mechanisms of recently developed antiobesity drugs, such as rimonabant, may include decreased endocannabinoid signaling and hence decreased excitability of LH circuits related to appetite, even in the context of leptin insufficiency or resistance."


TOPICS: Heated Discussion
KEYWORDS: marijuana; medicalmarijuana; potheads; wodlist
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To: Protagoras
They made me do it! They made me post like that!

WODdies aren't big on personal responsibility.

101 posted on 12/27/2005 9:05:29 AM PST by Know your rights (The modern enlightened liberal doesn't care what you believe as long as you don't really believe it.)
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To: sandbar

I think his tagline says it all.


102 posted on 12/27/2005 9:05:41 AM PST by Woman on Caroline Street (Go sell crazy somewhere else. We're all stocked up here.)
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To: Clint N. Suhks
Yet more Liberaltarian palaver...the 10th amendment trumps the 9th.

Horsefeathers. No amendment of the Bill of Rights can trump another, they were passed at the same time, as a package.

Now the real question is whether the 9th amendment binds the state governments. Rights reserved to the people verses powers reserved to the states. Oh, and to the people. People have powers and rights, governments only have powers.

Several states have passed laws semi-legalizing the use of marijuana for medical purposes. The Feds have overridden them at every turn. So much for both the 9th and 10th amendments, as far as the drug warriors are concerned.

103 posted on 12/27/2005 9:06:40 AM PST by El Gato
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To: billorites

bump for later


104 posted on 12/27/2005 9:07:22 AM PST by bassmaner (Let's take the word "liberal" back from the commies!!)
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To: albertp; Allosaurs_r_us; Abram; AlexandriaDuke; Americanwolf; Annie03; Baby Bear; bassmaner; ...
Libertarian ping.To be added or removed from my ping list freepmail me or post a message here
105 posted on 12/27/2005 9:07:27 AM PST by freepatriot32 (Holding you head high & voting Libertarian is better then holding your nose and voting republican)
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To: Know your rights
(And if used from a vaporizer rather than smoked it doesn't have the ill effects of smoking.)

And, you still get stoned. :)

106 posted on 12/27/2005 9:08:51 AM PST by ppaul
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Everybody must get stoned...
107 posted on 12/27/2005 9:09:54 AM PST by ppaul
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To: ppaul
And, you still get stoned. :)

There are worse side effects for a medicine to have.

108 posted on 12/27/2005 9:11:56 AM PST by Know your rights (The modern enlightened liberal doesn't care what you believe as long as you don't really believe it.)
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To: Know your rights

If the morbidly obese had willpower to do anything besides overeat, they wouldn't be morbidly obese.


109 posted on 12/27/2005 9:12:48 AM PST by 308MBR (Not only older, but bolder. Merry Christmas and a Happy New Year.)
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To: PJ-Comix
Um...I think something in the OTHER direction is needed. Suppression of the appetite.

Administer as needed.


110 posted on 12/27/2005 9:13:14 AM PST by M203M4 ( MERRY BOXING DAY)
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To: Know your rights
"If you can show that the numerical increase in drug users is not substantially larger than the number of persons released by the Community Mental Health Centers Act,

That's a silly question to attempt to answer 40 years later. Nevertheless, the drug problems in the USA and its creation of a world wide market in drugs is the result of both the USA, Canada and Western Europe attempting to treat the mentally ill on a community based, out-patient basis. From Sarah Jane Moore to Mark Chapman, to David Hinkley and Patrick Purdy, of the Stockton School yard Massacre, all were mental patients being treated at a community clinic.

111 posted on 12/27/2005 9:16:04 AM PST by elbucko
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To: sandbar
Mostly because if a person is drug tested and there is presence of marijuana they are considered DWI. Even if that intoxication occured last week sometime, it still shows in your system.

Fortunately, like with alcohol, there would be a level test. Heck a large fraction the population could probably get a positive indication for MJ, just by second hand smoke in the halls and public areas of businesses and residences such as apartment buildings.

112 posted on 12/27/2005 9:18:33 AM PST by El Gato
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To: elbucko
If you can show that the numerical increase in drug users is not substantially larger than the number of persons released by the Community Mental Health Centers Act,

That's a silly question to attempt to answer 40 years later. Nevertheless, the drug problems in the USA and its creation of a world wide market in drugs is the result of both the USA, Canada and Western Europe attempting to treat the mentally ill on a community based, out-patient basis.

So you have no evidence but you'll make the claim anyway. Typical Drug War 'logic.'

From Sarah Jane Moore to Mark Chapman, to David Hinkley and Patrick Purdy, of the Stockton School yard Massacre, all were mental patients being treated at a community clinic.

And they were all pot smokers? Or are you dragging in red herrings?

113 posted on 12/27/2005 9:18:50 AM PST by Know your rights (The modern enlightened liberal doesn't care what you believe as long as you don't really believe it.)
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To: elbucko
Moron is as good as any for hose who propose the legalization of drugs before the national problem of the homeless and mentally ill on the street is addressed.

Keep hitting that one piano key, my friend.

114 posted on 12/27/2005 9:19:16 AM PST by Hemingway's Ghost (Spirit of '75)
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To: 308MBR
Could be ... but I'd rather have a medicine be available than have lack of willpower be a death sentence.
115 posted on 12/27/2005 9:19:47 AM PST by Know your rights (The modern enlightened liberal doesn't care what you believe as long as you don't really believe it.)
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To: elbucko

>>>So shove your, "Why are you here?" where it belongs, you friggin ignorant moron!>>>

I have reported you for abuse.

Questioning your reason for being on a conservative website when you obviously have a thing for limiting freedoms of private citizens is not quite the same as calling you an ignorant moron.


116 posted on 12/27/2005 9:22:23 AM PST by sandbar
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To: Know your rights
WODdies aren't big on personal responsibility.

Actually, I think the War on Drugs is a bad policy. Money spent and wasted on a futile effort. Better the money had been spent on mental facilities.

117 posted on 12/27/2005 9:23:40 AM PST by elbucko
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To: Xenalyte

why even bother with some of nutty responses, Like spitting into a tornado.......stay safe


118 posted on 12/27/2005 9:24:19 AM PST by vin-one (REMEMBER the WTC !!!!!!!!)
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To: Hemingway's Ghost
Keep hitting that one piano key, my friend.

I will. It's the only one in tune.

119 posted on 12/27/2005 9:28:11 AM PST by elbucko
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To: elbucko
The mentally ill are the reason that the 2nd Amendment is being infringed. Or is that too high a concept to wrap your drug addled brain around?

Again, horsefeathers. The second amendment is being infringed because the notion of an armed populace scares many politicians, and for good reason I might add. Now, they use the rise in crime and drug abuse as an excuse, but it's not the real reason. In fact, as we know, crime drops when the law abiding are armed.

The attacks on the second amendment started well before the '63 law that you cite. The first major attack at the federal level came in the 1930s, with the passage of the ('34) National Firearms Act, and the ('38) Federal Firearms Act. For those, especially the former, they used the crime caused by the prohibition of alcohol as the excuse, even though by then, prohibition had been repealed, although the crime syndicates remained. Then there was the 1968 Gun Control Act, which was passed using as the excuse events that happened after your '63 law, but not so much after that the societal effects had yet had enough time to grow enough to be really be noticeable.

120 posted on 12/27/2005 9:29:34 AM PST by El Gato
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To: elbucko
I think the War on Drugs is a bad policy. Money spent and wasted on a futile effort. Better the money had been spent on mental facilities.

I'm surprised but pleased to hear it. Now if you could just rid yourself of the factually unsupported notion that ending the WOD must wait until after reinstitutionalization, we'd be 100% in agreement.

121 posted on 12/27/2005 9:32:20 AM PST by Know your rights (The modern enlightened liberal doesn't care what you believe as long as you don't really believe it.)
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To: Know your rights
And they were all pot smokers? Or are you dragging in red herrings?

Possibly and probably, but to be honest, I don't know for sure. Pot is your issue, the mentally ill on the street is mine. Once the mental and homeless are institutionalized, I really don't care what you smoke.

122 posted on 12/27/2005 9:32:45 AM PST by elbucko
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To: varyouga
Except, of course, for the fact that it would be difficult to tax

No more so than 'shine, bathtub gin, and so forth. If it were legal to grown, sell and buy, most users wouldn't bother growing it, any more than most drinkers run their own stills. After all, all that takes is some sugar and some tubing, a bit more if you are trying to make beer or drinkable wine.

123 posted on 12/27/2005 9:32:58 AM PST by El Gato
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To: elbucko
I will. It's the only one in tune.

More like a simple tune for a simpleton.

124 posted on 12/27/2005 9:36:54 AM PST by Hemingway's Ghost (Spirit of '75)
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To: elbucko
to be honest, I don't know for sure. Pot is your issue, the mentally ill on the street is mine.

Then post to (or start) a mental-illness thread; discussion of non-drug-using criminals is irrelevant to WOD threads.

125 posted on 12/27/2005 9:37:40 AM PST by Know your rights (The modern enlightened liberal doesn't care what you believe as long as you don't really believe it.)
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To: elbucko

What in the world do the "homeless and mentally ill" have to do with legalizing reefer?

Absolutely nothing.

Regardless of what is legal or illegal, the homeless still won't give a crap about themselves and the mentally ill will still be crazy. A significant portion of both groups should be in jail for vagrancy, non payment of child support or violent acts, but we don't have the room because the jails are full of pot growers and smokers.

The war on drugs IS a personal attack on every individual American's liberty. The gummint is just honing its skill and developing its resources for when they come for your guns and Bibles. If you can't see that, you either haven't looked at the big picture or a blinded by self righteousness.


126 posted on 12/27/2005 9:38:28 AM PST by 308MBR (Not only older, but bolder. Merry Christmas and a Happy New Year.)
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To: El Gato
all that takes is some sugar and some tubing

If anything, it appears to be considerably more difficult to grow high-potency marijuana than to distill alcohol.

127 posted on 12/27/2005 9:39:23 AM PST by Know your rights (The modern enlightened liberal doesn't care what you believe as long as you don't really believe it.)
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To: Know your rights
Now if you could just rid yourself of the factually unsupported notion that ending the WOD must wait until after reinstitutionalization, we'd be 100% in agreement.

No, absolutely not! If the former is done without the latter, it will only result in increased drug abuse and its attendant street and international violence. As long as you pot heads have an interest in seeing the mentally ill hospitalized, you'll be on the side of a return to sanity in the nations mental health policies. But once it's legalized, you will care less.

128 posted on 12/27/2005 9:41:20 AM PST by elbucko
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To: 308MBR
. If you can't see that, you either haven't looked at the big picture or a blinded by self righteousness.

One could say the same about your own opinion.

129 posted on 12/27/2005 9:46:31 AM PST by elbucko
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To: elbucko
Moron is as good as any

I'll bet you can think of many other names to call people.

What seems to be lacking is you understanding that name calling in general is the problem, not the names.

What name would you call someone who couldn't make that connection?

130 posted on 12/27/2005 9:47:46 AM PST by Protagoras (If jumping to conclusions was an Olympic event, FR would be the training facility.)
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To: Hemingway's Ghost
More like a simple tune for a simpleton.

You must like it. You are paying a lot of attention to it.

131 posted on 12/27/2005 9:49:40 AM PST by elbucko
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To: elbucko
it [drug legalization] will only result in increased drug abuse and its attendant street and international violence.

It's drug criminalization that results in increased violence, as it did during Prohibition.

132 posted on 12/27/2005 9:51:15 AM PST by Know your rights (The modern enlightened liberal doesn't care what you believe as long as you don't really believe it.)
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To: elbucko
Once the mental and homeless are institutionalized, I really don't care what you smoke.

You want to institutionalize the non mentally ill homeless?

Why?

Now it's true that many of the homeless are mentally ill, but far from all. Many are addicts, addicted to the legal drug ethanol, others are addicted to other illegal drugs. Very few of them exclusively to MJ. Most people can function sufficiently well to hold a job and provide for themselves, even though addicted to ethanol or MJ. As much as anyone can be said to be addicted to MJ, the medical jury is still out on that one, but even if the addiction is not direct, there does seem to be an addiction to the "buzz" one gets from MJ.. I wouldn't know though, I've only even smelled the stuff once, over 30 years ago, and it smelled like an alfalfa drying plant to me.

133 posted on 12/27/2005 9:55:19 AM PST by El Gato
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To: Know your rights
Then post to (or start) a mental-illness thread; discussion of non-drug-using criminals is irrelevant to WOD threads.

This is a WOD thread? I thought it was about some medical resource into appetite regulation, either increasing or decreasing.

I believe it was hijacked into a WOD/Pot Legalization thread.

134 posted on 12/27/2005 9:58:35 AM PST by El Gato
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To: Protagoras
..name calling in general is the problem, not the names.

No, the subject of this thread was about the chemicals in pot that stimulated the appetite, then the pro-pot crowd jumped in with medicinal pot anecdotes, then I jumped in with the opinion that legalizing pot would be premature before the mentally ill were institutionalized, then someone jumped in accusing me of wanting to "infringe" on pot the way the 2nd. Amendment is infringed now. Anyone who would accuse me of being an enemy of the 2nd. Amendment, is, well, a moron because I believe that the beginning of drug abuse and gun violence, in this country, began with Kennedy signing the CMHC Act of 1963.

Now if you want to go back to your irrelevant tangents, be my guest.

135 posted on 12/27/2005 10:00:18 AM PST by elbucko
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To: Know your rights
If anything, it appears to be considerably more difficult to grow high-potency marijuana than to distill alcohol.

Quite probably, but I suspect growing "good stuff" is no more difficult than growing good tomatoes, or good wine grapes for that matter. Or making good drinkable beer. (Wouldn't know about that either, almost all beer tastes like something that should be put back into the horse or bull it came from, but that's just me, others have differing opinions, and are welcome to them)

136 posted on 12/27/2005 10:02:52 AM PST by El Gato
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To: elbucko
Your post admits you were the first to use name calling as a debating technique. Thank you for admitting that.

Also, I'll go back and look, but it seems that early on you used the childish phrase, "put down the bong". I'll check it out.

137 posted on 12/27/2005 10:04:06 AM PST by Protagoras (If jumping to conclusions was an Olympic event, FR would be the training facility.)
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To: El Gato
You want to institutionalize the non mentally ill homeless?

No! Only the mentally ill homeless.

138 posted on 12/27/2005 10:05:11 AM PST by elbucko
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To: elbucko
I believe that the beginning of drug abuse and gun violence, in this country, began with Kennedy signing the CMHC Act of 1963

How to explain the likes of "Machine Gun Kelly", "Pretty Boy" Floyd, and of course "Bonnie and Clyde". Big "gun violence" types, who lived and died before 1963.

139 posted on 12/27/2005 10:06:59 AM PST by El Gato
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To: elbucko
Ah yes, post #61. Your SECOND post.
140 posted on 12/27/2005 10:07:49 AM PST by Protagoras (If jumping to conclusions was an Olympic event, FR would be the training facility.)
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To: Protagoras
Your post admits you were the first to use name calling as a debating technique.

I repudiate that. Overt name calling, yes, but in response to the covert name calling directed at me below:

"This sounds like the liberal attitude toward guns. Is this your take on guns as well? Why are you at Free Republic?"

I don't feel any contrition to having called him a "moron" in response to such innuendo.

141 posted on 12/27/2005 10:13:13 AM PST by elbucko
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To: elbucko

post #61. Your SECOND post.


142 posted on 12/27/2005 10:17:25 AM PST by Protagoras (If jumping to conclusions was an Olympic event, FR would be the training facility.)
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To: Clint N. Suhks
Just can't wait for the Liberaltarians to chime in with justifications for pot use.

No, you ______, pot decriminalization and/or legalization. And I don't use it.

How about your justification for pot's prohibition?

143 posted on 12/27/2005 10:18:39 AM PST by Eagle Eye (There ought to be a law against excess legislation.)
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To: El Gato
I believe it was hijacked into a WOD/Pot Legalization thread.

The first mention of legalization was by an opponent, in post #10.

144 posted on 12/27/2005 10:31:18 AM PST by Know your rights (The modern enlightened liberal doesn't care what you believe as long as you don't really believe it.)
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To: El Gato
I suspect growing "good stuff" is no more difficult than growing good tomatoes

I'm not aware that one has to prevent fertilization to get good tomatoes.

145 posted on 12/27/2005 10:32:36 AM PST by Know your rights (The modern enlightened liberal doesn't care what you believe as long as you don't really believe it.)
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To: Know your rights
I'm not aware that one has to prevent fertilization to get good tomatoes.

You don't, instead you must encourage it, something that can be difficult in pesticide ridden cities with few bees. However the details might differ, I still suspect the level of difficulty is about the same. One must not only prevent the wrong fertilization, but provide the correct fertilization in order to grow hybrid seed corn. Legions of "Jutes", are used in this endeavor in many areas.

146 posted on 12/27/2005 10:38:44 AM PST by El Gato
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To: El Gato
I still suspect the level of difficulty is about the same.

I grew very nice tomatoes this summer, and all I did was plant and fertilize (once).

147 posted on 12/27/2005 10:40:56 AM PST by Know your rights (The modern enlightened liberal doesn't care what you believe as long as you don't really believe it.)
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To: El Gato
fertilize

By which I mean "put down Miracle Gro soil."

148 posted on 12/27/2005 10:42:13 AM PST by Know your rights (The modern enlightened liberal doesn't care what you believe as long as you don't really believe it.)
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To: Protagoras
post #61. Your SECOND post.

What about it?

149 posted on 12/27/2005 10:53:24 AM PST by elbucko
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To: elbucko
You must like it. You are paying a lot of attention to it.

Your argument is so ridiculous it's tough to ignore.

150 posted on 12/27/2005 11:00:59 AM PST by Hemingway's Ghost (Spirit of '75)
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