It won't get real legs. The feds will allow the discontent to be expressed, as venting of discontent is an essential part of maintaining control, while giving the illusion of freedom.
There are plenty of microcosms as examples of failure of a state to have its own way, where states try to assert superiority over the feds, for example, drug policy. The feds always win, they have superior firepower.
The ultimate "Catch 22".
Not true. England lost to Scotland when my Scottish ancestors defied the odds back in the 1300's. And our countries founders beat the odds back in the late 1700's. Besides, the feds right now have worked themselves into one of the biggest binds in world history. The largest debt ever. The largest deficits ever. And they have installed throughout their territory very vulnerable nuclear reactors with design flaws. Humpty Dumpty on steroids.