Skip to comments.Small peptide found to stop lung cancer tumor growth in mice
Posted on 08/26/2009 5:13:21 PM PDT by decimon
WINSTON-SALEM, N.C. In new animal research done by investigators at Wake Forest University School of Medicine, scientists have discovered a treatment effective in mice at blocking the growth and shrinking the size of lung cancer tumors, one of the leading causes of cancer death in the world.
The study, recently published in Molecular Cancer Therapeutics, a journal of the American Association for Cancer Research, is the first to show that treatment with a specific peptide, angiotensin-(1-7), reduces lung tumor growth by inhibiting blood vessel formation.
"If you're diagnosed with lung cancer today, you've got a 15 percent chance of surviving five years and that's just devastating," said co-lead investigator Patricia E. Gallagher, Ph.D., director of the Molecular Biology Core Laboratory in the Hypertension and Vascular Research Center at the School of Medicine. "Those other 85 people 85 percent they're not going to see their kids graduate. They're not going to see their children get married."
The lung cancer survival rate has changed little in the past 30 years, said Gallagher's co-lead investigator, E. Ann Tallant, Ph.D., a professor in the Hypertension and Vascular Research Center a fact that motivates them in their research.
Peptides, found in all animals, are compounds formed by linking one or more amino acids together through the sharing of electrons. They are among the building blocks of life. Peptides can perform a wide range of functions in the body, depending on which amino acids are involved. Some can regulate hormones, for example, while others can have an antibiotic function.
Angiotensin-(1-7) is a small peptide that binds to proteins on the surface of cells and prevents cell growth but only if the cell is actively growing when the binding occurs. That property is what led Tallant and Gallagher to explore the peptide's uses for treating cancer by blocking tumor growth.
Angiotensin-(1-7) works by inhibiting the production of signals sent out by a cancer tumor for food. For tumors to grow, they need nutrients delivered by blood vessels. The signals they send prompt blood vessels to grow and invade the tumor to feed it.
Every day during the six-week study, researchers injected either saline or the angiotensin (1-7) peptide into mice growing human lung cancer tumors. Over the course of the study, the tumors treated with angiotensin-(1-7) shrunk, while the saline-treated tumors grew and, at the end of the study, the tumors treated with angiotensin-(1-7) weighed about 60 percent less than the tumors treated with saline. Analysis also showed that the tumors from mice treated with the peptide had significantly fewer blood vessels compared to the tumors from the saline-treated animals.
The researchers further tested angiotensin (1-7)'s affect on blood vessel formation, or angiogenesis, by treating chick embryos with the peptide a procedure considered the gold standard for determining anti-angiogenic ability. They found that blood vessels continued to grow in a saline-injected control group, while blood vessel formation decreased by more than 50 percent in the embryos treated with angiotensin-(1-7).
Tallant and Gallagher said the treatment likely has applications beyond lung cancer they have collected data showing it is effective on breast, colon and brain tumors, as well.
The treatment also presents an attractive possibility for future human cancer therapy from a cost perspective, they said.
"Because it's a peptide, it's very small and can be made very easily," Gallagher said. "We sometimes like to say we're the aspirin of cancer therapy."
Co-investigators on the study were graduate students David R. Soto-Pantoja and Jyotsana Menon of the School of Medicine. The study was funded by the Susan G. Komen Breast Cancer Research Foundation, Department of Defense, National Institutes of Health, Unifi, Farley-Hudson Foundation, and Golfers Against Cancer of the Triad.
The first clinical trial of angiotensin-(1-7) has been completed at the School of Medicine and the results are currently being reviewed.
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Wake Forest University Baptist Medical Center (www.wfubmc.edu) is an academic health system comprised of North Carolina Baptist Hospital, Brenner Children's Hospital, Wake Forest University Physicians, and Wake Forest University Health Sciences, which operates the university's School of Medicine and Piedmont Triad Research Park. The system comprises 1,056 acute care, rehabilitation and long-term care beds and has been ranked as one of "America's Best Hospitals" by U.S. News & World Report since 1993. Wake Forest Baptist is ranked 32nd in the nation by America's Top Doctors for the number of its doctors considered best by their peers. The institution ranks in the top third in funding by the National Institutes of Health and fourth in the Southeast in revenues from its licensed intellectual property.
Great idea but Obama’s death panel might not like it. Don’t want to take a chance with the governments money don’t you know.
You’ve got a great point. Prob. 80-90% of R & D related medical discoveries are made in the US. Wonder what that percent will be after 10 years of Obamacare
I think that it is ironic that a possible cure for lung cancer originated at Wake Forest University. Back in tghe 1950’s when the Reynolds family (of R. J. Reynolds Tobacco fame) decided they needed a big time college in Winston-Salem, they shopped around. They found that Wake Forest College of Wake Forest, North Carolina could be bought and moved the entire school except for the seminary to Winston-Salem. So profits from tobacco have possibly set the stage for a cancer cure.
“If you’re diagnosed with lung cancer today, you’ve got a 15 percent chance of surviving five years and that’s just devastating,” said co-lead investigator Patricia E. Gallagher, Ph.D., director of the Molecular Biology Core Laboratory in the Hypertension and Vascular Research Center at the School of Medicine. “Those other 85 people 85 percent they’re not going to see their kids graduate. They’re not going to see their children get married.”
What a bizarrre statement-—she is assuming the everyone who is diagnosed with lung cancer is young.
It’s comments like hers that makes me ignore all studies.
Obama “death panels” are like treating a horse with a broken leg.
BANG!!! ..... NEXT !!!
Entering angiotensin (1-7), adverse effects into PubMed's query box gets 152 hits.
There were over 1800 citations for angiotensin (1-7).
There are two classes of drugs that would probably be affected by using angiotensin (1-7), angiotensin-converting enzyme inhibitors and angiotensin II receptor blockers. They have been looking at angiogenesis inhibitors for cancer therapy for over a decade, IIRC.
Does that mean that people Angiotensin-Converting Enzyme Inhibitors such as Altace or Lotensin are at a higher risk of cancer?
That's above my posting grade.
That question is not above my posting grade and the answer is "No" if they are non-smokers.
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