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Sea snail saliva may become new treatment for most severe pain
American Chemical Society ^ | July 28, 2010 | Unknown

Posted on 07/28/2010 11:50:33 AM PDT by decimon

Scientists have developed a new version of a medication, first isolated from the saliva of sea snails, that could be taken in pill form to relieve the most severe forms of pain as effectively as morphine but without risking addiction. An article on the topic appears in the current issue of Chemical & Engineering News (C&EN), ACS' weekly newsmagazine.

C&EN Senior Editor Bethany Halford notes that a sea snails' saliva contains chemicals that help the slow-moving creatures catch prey. They include chemicals that the snails inject into passing prey with hypodermic-needle-like teeth that shoot from their mouths like harpoons. Scientists already have transformed one of these chemicals into a pain-reliever for humans, but it has to be injected directly into the spinal cord, limiting its use.

Now scientists in Australia have developed a form of the painkiller that can be given by mouth. It relieves severe pain, such as that in people with peripheral neuropathy, at a much lower dose than existing medications and without the risk of causing addiction. The article quotes one expert as speculating that such a drug could revolutionize the treatment of the most severe forms of pain.

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ARTICLE FOR IMMEDIATE RELEASE "Pain Relief From Snail Spit"

This story is available at http://pubs.acs.org/cen/science/88/8830sci2.html


TOPICS: Health/Medicine; Science
KEYWORDS:

1 posted on 07/28/2010 11:50:34 AM PDT by decimon
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To: neverdem; DvdMom; grey_whiskers

By the seashore ping.


2 posted on 07/28/2010 11:51:29 AM PDT by decimon
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To: decimon

Stick some of that in my gin and tonic and surely I’ll be feeling no pain.


3 posted on 07/28/2010 11:53:52 AM PDT by brooklyn dave (Support your local Tea Party)
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To: decimon

Potent painkiller and escargo. Sounds like a good recipe for happy hour.


4 posted on 07/28/2010 11:53:58 AM PDT by linear
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To: decimon
All well and good but the people usually in the most severe pain are in a terminal condition and the last thing that should be of concern is “addiction.”
5 posted on 07/28/2010 11:54:19 AM PDT by JPG (Sarah Spitz? No, she swallowed the Obama agenda.)
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To: decimon

If its ever discovered that Mastiff saliva is good for anything...I’m in!


6 posted on 07/28/2010 11:55:56 AM PDT by Deb (Beat him, strip him and bring him to my tent!)
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To: decimon

The magic of sea snails has been unknown to me. But the flesh of the fugu fish makes me tingly all over.


7 posted on 07/28/2010 11:57:04 AM PDT by ClearCase_guy
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To: sauropod

home


8 posted on 07/28/2010 11:59:12 AM PDT by sauropod (The truth shall make you free but first it will make you miserable.)
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To: decimon

Perfect for us whiteys on Obamamedicare.

Do you want the red pill or do you want snail spit?


9 posted on 07/28/2010 11:59:21 AM PDT by dforest
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To: Deb
If its ever discovered that Mastiff saliva is good for anything...I’m in!

It's good for warning you that mastiff breath is coming.

10 posted on 07/28/2010 12:05:22 PM PDT by decimon
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To: decimon
Okay . . . now why did the story call it "saliva" when it's actually venom? Even snake venom is a form of saliva.
11 posted on 07/28/2010 12:11:49 PM PDT by Olog-hai
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To: decimon
Next time my son skins his knee, instead of grabbing a can of Bactine spray, I'll just reach into our Reef Aquarium and pull out a Sea Snail, or better a Sea Slug and rub its slime all over the wound. I like it!
12 posted on 07/28/2010 12:15:09 PM PDT by NavyCanDo
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To: Olog-hai

because Venom sounds so violent. We don’t want to upset the poor snails so we just call it snail spit.

/s/s/s/s


13 posted on 07/28/2010 12:16:02 PM PDT by halfright (My presidents picture is in the dictionary, next to the word, "rectum".)
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To: NavyCanDo
Next time my son skins his knee, instead of grabbing a can of Bactine spray, I'll just reach into our Reef Aquarium and pull out a Sea Snail, or better a Sea Slug and rub its slime all over the wound. I like it!

Could be the last time he skins his knee. Or the last time he lets you know he did.

14 posted on 07/28/2010 12:23:40 PM PDT by decimon
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To: decimon

Conotoxin. We had some of that in our lab, along with bungarotoxin, epibatidine, and a few others.


15 posted on 07/28/2010 12:24:05 PM PDT by aruanan
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To: aruanan

bungarotoxin

I don’t even want to know where that one comes from.


16 posted on 07/28/2010 12:35:03 PM PDT by loungitude ( The truth hurts.)
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To: decimon
“Could be the last time he skins his knee. Or the last time he lets you know he did.”

My thinking as well....
Seriously, my wife and I both have scars on our arms from things we came in contact with when reaching into our tank. A few of those things have been known to send some aquariumist to the emergency ward.

17 posted on 07/28/2010 12:38:54 PM PDT by NavyCanDo
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To: loungitude
bungarotoxin

I don’t even want to know where that one comes from.

Or how it's administered.

18 posted on 07/28/2010 12:46:22 PM PDT by decimon
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To: decimon

If only Squidward had known this when Gary slimed him.


19 posted on 07/28/2010 12:53:34 PM PDT by Minn (Here is a realistic picture of the prophet: ----> ([: {()
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To: JPG

All well and good but the people usually in the most severe pain are in a terminal condition and the last thing that should be of concern is “addiction.”

Not true. I know most terminal patients are in pain, but not all. Both of my parents died from cancer, but the morphine kept their pain under control. I have spinal pain, and other pain, that without pain meds, would be totally unbearable. It’s not addiction, but dependence. I depend on pain medication the same way my husband depends on his diabetes and high blood pressure medication.


20 posted on 07/28/2010 12:54:56 PM PDT by doesnt suffer fools gladly (Liberals lie.)
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To: loungitude

That is very funny.


21 posted on 07/28/2010 1:27:48 PM PDT by 1raider1
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To: decimon

Well, dang. What’s the point then?


22 posted on 07/28/2010 1:29:14 PM PDT by vpintheak (Love of God, Family and Country has made me an extremist.)
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To: loungitude
bungarotoxin

I don’t even want to know where that one comes from.


It comes from a the Taiwanese banded krait (Bungarus multicinctus):



Its bite can cause death in two hours if not treated. The venom is a neurotoxin that binds competitively and irreversibly to the acetylcholine receptor. I used I-125-labeled bungarotoxin in binding assays of acetylcholine receptor alpha subunits.
23 posted on 07/28/2010 1:40:05 PM PDT by aruanan
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To: aruanan
My wife is deathly afraid of water.On a vacation in Corpus Christie,she found the nerve to venture out about up to her ankles.
She stepped on a sea shell that was huge.She picked it up and rinsed it out.
Before we left the beach,she was offered a large sum of money for it,which she declined.When I explained to her what had lived in it and what might happen if she had been stung,she was horrified.
It is on display along with other various sea things in our bathroom.
It has been awhile since we have owned it,but I still check it out every once in a while.Just in case!PS,It is huge!
24 posted on 07/28/2010 2:22:39 PM PDT by xarmydog
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To: xarmydog
On a vacation in Corpus Christie,she found the nerve to venture out about up to her ankles.
She stepped on a sea shell that was huge.She picked it up and rinsed it out. Before we left the beach,she was offered a large sum of money for it,which she declined.When I explained to her what had lived in it and what might happen if she had been stung,she was horrified.


Conus shells rarely get up to about 9 cm in length or about 3.5 inches. Is that what you mean by huge? I think they're the only venomous molluscs in the Gulf of Mexico (except for the octopus). Did it look anything like this? Conus spurius



Or like this? Conus ermineus



I don't want to swim anywhere I can be bitten, stung, shocked, swallowed, or urethrally-invaded.
25 posted on 07/28/2010 3:40:08 PM PDT by aruanan
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To: aruanan
I don't want to swim anywhere I can be bitten, stung, shocked, swallowed, or urethrally-invaded.

Dude!


26 posted on 07/28/2010 4:11:29 PM PDT by agere_contra
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To: aruanan

I used I-125-labeled bungarotoxin in binding assays of acetylcholine receptor alpha subunits.

+++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++
Of course!
Me, I’m more of a beta subunits type. All joking aside, thank you for the interesting science.


27 posted on 07/28/2010 4:35:13 PM PDT by loungitude ( The truth hurts.)
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To: JPG
All well and good but the people usually in the most severe pain are in a terminal condition and the last thing that should be of concern is “addiction.”

Actually no. There are a lot of people who are healing who are in severe pain. They generally have two options, lots of pain which hinders healing, or enough pain medicines to stop the pain with the possibility of dealing with addiction after they are well again.

Not a happy choice to have to make.

28 posted on 07/28/2010 4:45:15 PM PDT by Harmless Teddy Bear (there are huge chunks of time...at night...where I'm just asleep...for hours...it's ridiculous....)
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To: loungitude
Me, I’m more of a beta subunits type. All joking aside, thank you for the interesting science.

This is why this snake venom kills you. When it binds irreversibly and competitively to your body's acetylcholine receptors, it prevents the transmission of nerve impulses from brain to muscles and you suffocate.
29 posted on 07/28/2010 6:54:38 PM PDT by aruanan
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To: aruanan

Sorry for not replying sooner.It looks a little similar to the shell picture in the bottom,but with different coloration.
It measures 9 and 3/4 inches long and about the same when measured from the’foot’as I call it to the top of the ‘wing ‘as I call it!
The wife collects them and there is another one beside it that is six inches long that has multiple ‘horns’around it.
Both are very pretty especially the large one that has a mother of pearl look to it.
As you may have well known by now I am no Marine Biologist!
The colors do not look like the ones you posted.She has one that I have never seen and it is strange looking.
The small 6 incher is a dark tan/light brown,and the other is dark tan.
If I knew how,I would send a picture.Hope it helps and if you have an inkling as to what lived in it,i would be curious to know.
We used to hide messages to each other in the big one!Later,xarmydog.


30 posted on 08/08/2010 8:13:59 AM PDT by xarmydog
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