i've been using SuSE since 9.2 Professional. i found it to be more user friendly. It has since been split off into Novell SuSE Enterprise Linux and the OpenSUSE project. Novell Enterprise is less cutting edge and more stable. OpenSUSE is used as more of a beta testing platform for Novell Enterprise, and can be downloaded freely.
I"ve been meaning to try KDE again - I used it years ago under Solaris and liked it, but somebody else mentioned Gnome was superior to KDE so I went with Gnome this time. For the most part I connect to Linux/Unix via putty and never see the graphical interface.
KDE has two available versions, 3.5.x and 4.6.x. Gnome always reminded me of Macintosh OSX. While it was impressive, i always thought it to be somewhat limited in comparison to KDE.
The software I mentioned is Logos Bible software. I have a lot of money tied up with Logos and can't part with it, so I have to keep a Windows box for now just to run Logos. I might try setting up a Windows VM under Ubuntu...
There is a great deal of software available with the OpenSuSE distribution. Among that is an application called BibleTime. i'm certain that others have Linux versions. i don't know about Logos. If it does exist, you may have to download it as an RPM, and install it yourself.