They all lost.
I don't think there's ever been a Republican win the Presidency with just 22% of the base behind him at the end of the primary campaigns.
Ronald Reagan had about 80% of the Republican base behind him, but NOT the GOP-e ~ and HE WON! Nixon had fantastic Republican support for his two big wins, as did George Bush when he ran and won (both of them).
You will do everything you can to create that damage and I will do what I can to stop you.