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This picture triggered a memory cell and yes, M100 was the first object used to test the astronaut-repaired Hubble Space Telescope in 1994! The difference between the pre- (June 27, 1990) & post-repair (Jan. 13, 1994) images was quite striking!

Hubble’s view of the M100 galactic nucleus before (left) and after (right) repairs to correct
the telescope’s deformed mirror. Credit: NASA/STScI/JPL

This repair of the Hubble ranks, in my mind, with the Apollo 13 save, as the best of NASA making lemonade!

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Oops, I should have seen that the Hubble fix was already mentioned. Still these images are striking!