Prayers for Barbara. The natural way is not the way to go for Stage 4. This is . . from experience.
My brother lost his wife to breast cancer through the same mistake. There are "cancer centers" throughout the country where the care provided is not based on any sort of science. One wonders how these "hospitals" get licensed...
Prayers for your sister, your mother and family are on the way. Keep the faith, all will be as it should be.
Gandalf
PS My father died of cancer when he was 53, my Mother died of cancer at 60, my eldest brother died of cancer, my next oldest brother has so far survived cancer as have I. I was 53 when diagnosed and am currently 68. I know what you are going through.