Don't be exclusive:
Howard the Duck,
(current) Day by Day...
Cartoons can come closer to reality than most of the news.
PS: I omitted Malard Filmore because it is overtly political,
And I omitted Junkwaffle and Cheech Wizard because they fall totally outside polite society, talented and funny, but weird.
And "Day by Day" isn't.
Calvin and Hobbes, however, was in a class of its own. And this is a very sweet tribute. 26 years. I'm feeling kind of old.