Skip to comments.No Ethics? No Problem: The Story of SUPPORT
Posted on 06/13/2014 9:19:36 AM PDT by Oldpuppymax
The National Institute of Child Health and Human Development was established by President John F. Kennedy, with the support of Congress, in 1962 to study the complex process of human development from conception to old age. In 2007, the NICHD was re-christened to include the name of Eunice Kennedy Shriver. Among NICHDs many large projects was the so-called SUPPORT study (Surfactant, Positive Pressure, and Oxygenation Randomized Trial).
The results of this study were published in May, 2010 in the New England Journal of Medicine, in an article entitled Target Ranges of Oxygen Saturation in Extremely Preterm Infants. According to the final protocol for the clinical trial, its primary purpose was to examine the efficacy of two experimental strategies for managing oxygen and two strategies of ventilation therapy in extremely premature babies.
To this end, 1,316 infantsborn between 24 weeks 0 days, and 27 weeks 6 days of gestationwere studied, within institutions belonging to NICHD Neonatal Research Network, from February 2005 to February 2009. The NEJM article set the stage:
Previous studies have suggested that the incidence of retinopathy [often leading the blindness in preemies] is lower in preterm infants with exposure to reduced levels of oxygenation than in those exposed to higher levels of oxygenation. However, it is unclear what range of oxygen saturation is appropriate to minimize retinopathy without increasing adverse outcomes.
As such, the trial compared...
(Excerpt) Read more at coachisright.com ...