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UEA researchers discover Achilles’ heel in antibiotic-resistant bacteria
University of East Anglia ^ | June 18, 2014 | Press Release

Posted on 06/18/2014 6:27:26 PM PDT by 2ndDivisionVet

Scientists at the University of East Anglia have made a breakthrough in the race to solve antibiotic resistance.

New research published today in the journal Nature reveals an Achilles’ heel in the defensive barrier which surrounds drug-resistant bacterial cells.

The findings pave the way for a new wave of drugs that kill superbugs by bringing down their defensive walls rather than attacking the bacteria itself. It means that in future, bacteria may not develop drug-resistance at all.

The discovery doesn’t come a moment too soon. The World Health Organization has warned that antibiotic-resistance in bacteria is spreading globally, causing severe consequences. And even common infections which have been treatable for decades can once again kill.

Researchers investigated a class of bacteria called ‘Gram-negative bacteria’ which is particularly resistant to antibiotics because of its cells’ impermeable lipid-based outer membrane.

This outer membrane acts as a defensive barrier against attacks from the human immune system and antibiotic drugs. It allows the pathogenic bacteria to survive, but removing this barrier causes the bacteria to become more vulnerable and die.

Until now little has been known about exactly how the defensive barrier is built. The new findings reveal how bacterial cells transport the barrier building blocks (called lipopolysaccharides) to the outer surface.

Group leader Prof Changjiang Dong, from UEA’s Norwich Medical School, said: “We have identified the path and gate used by the bacteria to transport the barrier building blocks to the outer surface. Importantly, we have demonstrated that the bacteria would die if the gate is locked.”

“This is really important because drug-resistant bacteria is a global health problem. Many current antibiotics are becoming useless, causing hundreds of thousands of deaths each year.

“The number of super-bugs are increasing at an unexpected rate. This research provides the platform for urgently-needed new generation drugs.”

Lead author PhD student Haohao Dong said: “The really exciting thing about this research is that new drugs will specifically target the protective barrier around the bacteria, rather than the bacteria itself.

“Because new drugs will not need to enter the bacteria itself, we hope that the bacteria will not be able to develop drug resistance in future.”

This research was funded by Wellcome Trust. Research collaborators included the University of St Andrews, Dr Neil Paterson of Diamond Light Source (UK), Dr Phillip Stansfield from the University of Oxford, and Prof Wenjan Wang of Sun Yat-sen University (China).

‘Structural basis for outer membrane lipopolysaccharide insertion’ is published in the journal Nature on June 18, 2014.


TOPICS: Education; Health/Medicine; Science
KEYWORDS: antibiotics; britain; illness; medicine

1 posted on 06/18/2014 6:27:26 PM PDT by 2ndDivisionVet
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To: 2ndDivisionVet
When I first read the title, I was ready to call for a G-G-G ping. Wrong again!



America demands Justice for the Fallen of Benghazi!

O stranger, tell the Lacedaemonians that we lie here, obedient to their command.

Listen, O isles, unto me; and hearken, ye people, from far; The LORD hath called me from the womb; from the bowels of my mother hath he made mention of my name. (Isaiah 49:1 KJV)

2 posted on 06/18/2014 6:37:59 PM PDT by ConorMacNessa (HM/2 USN, 3/5 Marines RVN 1969 - St. Michael the Archangel, defend us in Battle!)
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To: 2ndDivisionVet

This is good news.
I hope it passes human trials.


3 posted on 06/18/2014 6:48:33 PM PDT by dadgum (Overjoyed to be the Pariah.)
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To: 2ndDivisionVet

This is stupid. Bacteria reproduce by the billions under constant adaptational stress. There ARE bacteria resistant to this attack. They WILL survive and reproduce.


4 posted on 06/18/2014 7:09:57 PM PDT by Talisker (One who commands, must obey.)
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To: Talisker

Yup.


5 posted on 06/18/2014 7:26:57 PM PDT by piytar (The predator-class is furious that their prey are shooting back.)
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To: 2ndDivisionVet

Great if it’s true, but this is the bunch that has given us the FAKE GLOBAL WARMING data. It’s really hard to trust them at all.


6 posted on 06/18/2014 7:30:17 PM PDT by BobL
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To: BobL

Different departments, I would think.


7 posted on 06/18/2014 7:31:41 PM PDT by 2ndDivisionVet (I will raise $2Million for ANY 2016 pro-2nd Amendment candidate.)
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To: 2ndDivisionVet

“Different departments, I would think.”

Agree...but still too close for me.


8 posted on 06/18/2014 7:44:47 PM PDT by BobL
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To: 2ndDivisionVet; BobL; Talisker

Personally wouldn’t trust East Anglia on anything no matter the department. BobL is right on in his post. I was about to post the same when I saw his, and I believe Talisker is right on the mark as well.


9 posted on 06/18/2014 7:45:35 PM PDT by rockinqsranch (Dems, Libs, Socialists, call 'em what you will. They ALL have fairies livin' in their trees.)
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To: Talisker
This is stupid.

The study and new methods are not stupid. What would be stupid would be if we killed the 'good' bacteria.

Bacteria reproduce by the billions under constant adaptational stress.

High speed micro-evolution.

There ARE bacteria resistant to this attack. They WILL survive and reproduce.

Pretty smart little buggers, aren't they?

Whatever we do to interfere with their ability to survive, they will adapt to. Although we must (and fairly well do) control them to an extent, without bacteria and viruses, we could not live.

All life on Earth is dependent on death and destruction.

This new 'discovery' may give us a temporary ability to control certain bacteria. Which is a very good thing.

That it will not work perfectly on every type of bacterial cell, or forever, is expected.

10 posted on 06/18/2014 7:47:13 PM PDT by UCANSEE2 (Lost my tagline on Flight MH370. Sorry for the inconvenience.)
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To: UCANSEE2
That it will not work perfectly on every type of bacterial cell, or forever, is expected.

But that is exactly the claim I'm seeing them try to make. That's why I call it stupid.

11 posted on 06/18/2014 8:08:51 PM PDT by Talisker (One who commands, must obey.)
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To: Smokin' Joe

Possible list interest ping.


12 posted on 06/19/2014 12:41:02 AM PDT by Gene Eric (Don't be a statist!)
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To: 2ndreconmarine; Fitzcarraldo; Covenantor; Mother Abigail; EBH; Dog Gone; ...

Ping...(Thanks, Gene Eric!)


13 posted on 06/19/2014 1:54:24 AM PDT by Smokin' Joe (How often God must weep at humans' folly. Stand fast. God knows what He is doing.)
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To: BobL
“Different departments, I would think.”

Agree...but still too close for me.

I can assure you that, as a PhD educated life scientist, I have never even taken an atmospheric science course, nor have any of the other PhD level scientists that I work with. Equating life scientists like those described in the article with climatologists is like equating a bridge engineer with a train engineer--they are completely different.

Even within the life sciences, there are major differences. I would take much of the research published by medical doctors with a huge grain of salt, for instance.

14 posted on 06/19/2014 3:36:21 AM PDT by exDemMom (Current visual of the hole the US continues to dig itself into: http://www.usdebtclock.org/)
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To: 2ndDivisionVet
Researchers investigated a class of bacteria called ‘Gram-negative bacteria’ which is particularly resistant to antibiotics because of its cells’ impermeable lipid-based outer membrane.

Oy. Once again, we have a reporter with no understanding of science trying to describe a physical concept and getting it utterly wrong. Gram-negative bacteria actually have very thin cell walls as compared to Gram-positive bacteria, although both classes of bacteria have structural similarities. Both have an outer membrane covering the cell wall, and an inner membrane inside the cell wall. Antibiotic resistance takes many forms. From reading this article, I do not know which form of resistance is being negated; I guess I will have to look up the original research to find out.

15 posted on 06/19/2014 3:42:41 AM PDT by exDemMom (Current visual of the hole the US continues to dig itself into: http://www.usdebtclock.org/)
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To: Talisker

Yup. They can adapt to any single stress.

The key is an antibiotic cocktail. If one in a million is resistant to “A”, one in a million is resistant to “B” and one in a million is resistant to “C”, how many are resistant to A+B+C?

1/1,000,000,000,000,000,000, a number so large it exceeds the National Debt, a fraction so small that most people have never even heard of a quintillionth by name.


16 posted on 06/19/2014 6:22:40 AM PDT by null and void (In this war, the front line is at your front door...)
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To: Talisker

And no one factors in the good bacteria from the bad, they just kill it all.

As a female, every time I was put on antibiotics I developed yeast infections. Finally found that taking 50 billion Probiotics multi strain, stopped it. Yogurt is a waste of money.

I listen to the ads on TV, and they pick and chose what they disclose. Nexium just went OTC at the 20 mg dose, what the ad leaves out is that long term use can lead to Bone Density issues, and Barrett’s Esophagus Nexium
Bone density side effects, and Barret’s Esophagus
http://www.valleyhealthcancercenter.com/Cancer-Services/Barretts-Esophagus - GERD treatment Upper GI every 2 yrs biopsy.

Lyrica actually mimics the Fibromyalgia it is being touted for; and sex life good bye if you react to it along with the high weight gain like you get from being on Predisone to long. Besides it is highly addictive.
Lyrica anti-epileptic http://www.rxlist.com/lyrica-side-effects-drug-center.htm

Often used beside Lyrica.

Gabapentin Side Effects http://www.rxlist.com/neurontin-side-effects-drug-center.htm

To the regret of many patients put on them. OP drugs are dangerous. They have a FDA warning doctors are ignoring. How many have to die of kidney failure, jaw degeneration and develop A FIB before they are removed from the market?

My PCP and ENDO are pushing for this crap. Foreto which reverses itself at the end of the treatment period. Already had a bad reaction to Fosamax sample. Made 5 days with terrible bone pain. Went in the trash. I chose to do Holistic s with Vitamins and minerals bones are made out of. Never heard of one of them killing patients. And with Bone Density test now MANDATED at every 2 yrs, same as PSA’s for men I won’t know how well it works until 2015.

OP DRUGS

FDA ALERT RECLAST higher risk of Kidney Failure and A Fib.
http://www.natap.org/2011/newsUpdates/090911_03.htm

Reclast UPS kidney failure, A FIB risk.
http://www.webmd.com/osteoporosis/news/20110901/fda-osteoporsis-drug_ups-kidney-failure-risk

Safety update for osteoporosis drugs, bisphosphonates, and atypical fractures
http://www.fda.gov/drugs/drugsafety/drugsafetypodcasts/ucm229800.htm

Black box warning Foreto
http://www.inspire.com/groups/national-osteoporosis-foundation/discussion/forteo-black-box-warning-and-fda-testimony/

Damaged Care
http://www.washingtonpost.com/wp-srv/liveonline/02/health/health052102.htm

First do No HARM
http://www.psychologytoday.com/blog/the-superhuman-mind/201212/first-do-no-harm

Lorenzo’s oil
http://www.sciencebasedmedicine.org/lorenzos-oil/

The Ketogenic Diet Works; A Mom Reflects on the Success
http://epilepsymoms.com/blog/complimentary-alternative-therapies/ketogenic-diet-works-mom-reflects.html

http://www.myelin.org/lorenzosoil/lorenzosoiltheoil.html


17 posted on 06/19/2014 6:45:52 AM PDT by GailA (IF you fail to keep your promises to the Military, you won't keep them to Citizens!)
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To: Smokin' Joe

Thanks for the ping!


18 posted on 06/19/2014 6:56:57 AM PDT by Alamo-Girl
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To: null and void
Yup. They can adapt to any single stress. The key is an antibiotic cocktail. If one in a million is resistant to “A”, one in a million is resistant to “B” and one in a million is resistant to “C”, how many are resistant to A+B+C? 1/1,000,000,000,000,000,000, a number so large it exceeds the National Debt, a fraction so small that most people have never even heard of a quintillionth by name.

Fale analogy, there is no such thing as a single stress in the real world, it's all multiples. And in addition (no pun intended) your numbers are illustrative, otherwise there woul dnever be any successful bactrerial adaptation ever. Finally, how many successful adaptations are necessary? Answer - only one that lives to reproduce. Your same mathematics grows that survivor into trillions because it can defeat what is attacking it.

I'm not saying this isn't probably a success. I just get cheesed off when it totuts itself as perfect. And that's coming from the actual science foundation, not even the press, so it's a million times more offensive.

But look WHERE it's from - East Anglia, the hockey-stick climate change liars. So what IS it with that place?

19 posted on 06/19/2014 12:02:58 PM PDT by Talisker (One who commands, must obey.)
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To: exDemMom

I understand that, but that University does seem to have a BIG PROBLEM dealing with people that put out phony information. That’s why ANYTHING out of there is considered suspect.


20 posted on 06/19/2014 3:46:03 PM PDT by BobL
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To: Talisker

Oh. I see. In your world no one ever takes most of a course of a single antibiotic. Interesting. Good to know. Thanks.


21 posted on 06/19/2014 7:54:48 PM PDT by null and void (In this war, the front line is at your front door...)
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To: GailA
Nexium just went OTC at the 20 mg dose, what the ad leaves out is that long term use can lead to Bone Density issues,

Wow! You mean people will actually have to read the warning labels?

What a burden!

How unreasonable!

Of course, untreated reflux leads to erosion of the esophagus and the vomiting that comes with the reflux is not only bad for your teeth but leads to unbalanced electrolytes which can lead to death.

22 posted on 06/19/2014 8:06:26 PM PDT by Harmless Teddy Bear (Proud Infidel, Gun Nut, Religious Fanatic and Freedom Fiend)
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To: null and void
Oh. I see. In your world no one ever takes most of a course of a single antibiotic. Interesting. Good to know. Thanks.

Well now again, is that really fair? A single antibiotic does indeed supply a single threat. And it does (often) have a a beneficial effect. But it is precisely because of the singleness of the effect that bacteria can evolve outside of the effects of a single antibiotic, and the resulting "conditioning" of the bacterial populations is the big fat problem with regular (and even statistically predictable ) antibiotic failures. OUTSIDE of single antibiotics, however, bacteria naturally deal with multiple simultaneous attacks all the time, and so develop - naturally - a simultaneous multi-phasic defense system to deal with it.

Geez Louise, this is the entire problem of the antibiotic approach in a nutshell! That's why it's presumable - IMO - that continuing the same strategy on a different front will inevitably result in the same kinds of conditioning responses from the bacteria. I don't know, maybe this particular approach will last longer or be more effective. But to claim it's the be-all, end-all, game-over for bacterial infections, given that it IS the same general strategy, seems absurd for a scientific declaration. Media, advertising, yeah. But scientists should know better.

23 posted on 06/19/2014 8:24:58 PM PDT by Talisker (One who commands, must obey.)
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To: Talisker

Yes, but might peg them back for a while.


24 posted on 06/20/2014 5:11:18 PM PDT by Vanders9
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To: Vanders9
Yes, but might peg them back for a while.

And that WOULD be a valid scientific claim, IMO.

25 posted on 06/22/2014 6:31:04 PM PDT by Talisker (One who commands, must obey.)
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To: Talisker

Well, I guess scientists have to sell ideas like everyone else these days. I don’t suppose “peg the bacteria back for a couple of decades, tops” has as much appeal as “end bacterial immunity for all time completely.”


26 posted on 06/23/2014 12:19:16 AM PDT by Vanders9
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To: Vanders9
Well, I guess scientists have to sell ideas like everyone else these days. I don’t suppose “peg the bacteria back for a couple of decades, tops” has as much appeal as “end bacterial immunity for all time completely.”

No, it doesn't. But while they were at it, why not add "viagra replacement allows you to walk on water and burn fat at the same time" as well?

There is (nominally) something called scientific ethics. And when that fails there's at least scientific believeability.

Or there was, before global warming.

Oh look, this announcement is coming out of East Anglia, ground zero of the global warming hoax. What a coincidence.

27 posted on 06/23/2014 11:27:37 AM PDT by Talisker (One who commands, must obey.)
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To: Talisker
Its depressing I know, but when I worked in research (and that was far more years ago now than I care to dwell upon) applications for grants from charitable foundations were already more an exercise in creative writing than scientific reality. It was also very commmon to "fix" experiments when they were teaching, and I dont just mean Bachelor's degree students either. Their peers in high powered conferences "discovered" quite a lot of things that had been pre-planted.

And I didnt even go to UEA!

28 posted on 06/24/2014 12:19:59 AM PDT by Vanders9
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