Alzheimer's breakthrough: Discovered the disease's 'ground zero' - paving the way to a cure

Daily Mail ^ | 12/20/17 | Staff

[x1stcav]

Alzheimer's disease is caused by immune cells in the brain triggered by inflammation, according to a breakthrough discovery.

The new research could lead to the development of a drug that treats or even prevents the condition within five years, say scientists.

Experiments found destroying specific cells - known as microglia - reduced the formation of clumps of amyloid beta that form in Alzheimer's and destroy memory.

These are the rogue proteins believed to lie at the root of the devastating neurological illness.

Human trials of all therapies have failed in the past. Most have targeted the amyloid plaques that build up in the brains of patients.

[Paladin2]

Does aspirin help to avoid the mechanism?

[zek157]

What causes inflammation? Most likely glucose.

[marktwain]

Looks promising.

[editor-surveyor]

.
More BS!
.

[DannyTN]

From Wikipedia...
"Microglia are a type of neuroglia (glial cell) located throughout the brain and spinal cord.[1] Microglia account for 10–15% of all cells found within the brain.[2] As the resident macrophage cells, they act as the first and main form of active immune defence in the central nervous system (CNS).[3] Microglia (and other neuroglia including astrocytes) are distributed in large non-overlapping regions throughout the CNS.[4][5] Microglia are key cells in overall brain maintenance—they are constantly scavenging the CNS for plaques, damaged or unnecessary neurons and synapses, and infectious agents.[6] Since these processes must be efficient to prevent potentially fatal damage, microglia are extremely sensitive to even small pathological changes in the CNS.[7] This sensitivity is achieved in part by the presence of unique potassium channels that respond to even small changes in extracellular potassium.[6]"

10 to 15% of the brian?

What the heck! Let's kill them!!! Let's get the bastards!!!

[RushIsMyTeddyBear]

Hope so. Runs in my family.

[humblegunner]

These are the rogue proteins believed to lie at the root of the devastating neurological illness.

So it's crazy diseased people that post excerpts of their blogs?

[plain talk]

I hope it really is a breakthrough as I have had the disease in my family. We shall see if this amounts to something.

[dayglored]

> 10 to 15% of the brian?

And ANOTHER 10 to 15% of the BRAIN...

[erlayman]

That has already been shown in the early stages. Sugar damage reduces functions and completely inhibits other enzymes that allows Alzheimer’s to develop. The reality of what’s possible and maybe not that far off is really exciting and really important! At least for me since I have cut off sugar and artificial flavorings almost entirely.

[lonevoice]

ping!

[kiryandil]

That has already been shown in the early stages. Sugar damage reduces functions and completely inhibits other enzymes that allows Alzheimer’s to develop. The reality of what’s possible and maybe not that far off is really exciting and really important! At least for me since I have cut off sugar and artificial flavorings almost entirely.

I've seen some talk that it's kind of like Type 3 diabetes - of the brain.

As usual, the carbohydrates & and funny oils which cause inflammation appear to be responsible.

[semaj]

"What causes inflammation? Most likely glucose."

Glycation.

Glycation (sometimes called non-enzymatic glycosylation) is the result of the covalent bonding of a sugar molecule, such as glucose or fructose, to a protein or lipid molecule, without the controlling action of an enzyme. Glycation - Wikipedia https://en.wikipedia.org/wiki/Glycation

[Karoo]

have u cut out complex carbs as well?

[Bigg Red]

Wonderful news!

[GnuThere]

I agree - but the drug companies can’t make any money if they tell everybody to eat right.

[KC Burke]

Asparagus. You can have Asparagus, we’ll get back to you on the other stuff.

[Bigg Red]

I read an article a while back that cited the harm to the brain of excessive sugar. It referred to dementia as “diabetes type III”.

[Does so]

When I was prescribed a statin drug for moderately-high cholesterol readings, I was told that plaque accumulation in the brain was similarly reduced. I’ve read nothing to doubt that assertion.