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Chili's Heat Kills Prostate Cancer Cells
HealthDay via Yahoo! ^ | 03/16/2006 | Steven Reinberg

Posted on 03/16/2006 10:10:11 AM PST by BJClinton

THURSDAY, March 16 (HealthDay News) -- Capsaicin, the component that gives jalapeno peppers their heat, may also kill prostate cancer cells, a new study suggests.

Initial experiments in cancer cells and mice show that capsaicin causes prostate cancer cells to undergo a kind of suicide. Researchers speculate that, in the future, pills containing capsaicin might be used as therapy to prevent prostate cancer's return.

According to their report, capsaicin caused almost 80 percent of prostate cancer cells in the mice to die. In addition, prostate cancer tumors treated with capsaicin were about one-fifth the size of tumors in untreated mice.

"Capsaicin inhibits the growth of human prostate cancer cell in Petri dishes and mice," said lead researcher Dr. H. Phillip Koeffler, director of hematology and oncology at Cedars-Sinai Medical Center and a professor of medicine at the University of California, Los Angeles. Based on the findings, Koeffler believe the next step is a trial to see if it works in patients with prostate cancer.

The report appears in the March 15 issue of Cancer Research.

Capsaicin probably has several effects, Koeffler said. Most noticeable is its effect in blocking NF-kappa Beta, a molecular mechanism that promotes cancer cell growth, he noted.

In addition, capsaicin also was effective against leukemia, and might be effective in slowing or preventing the growth of other cancers as well, he added.

But it's still too early to reach for the chili sauce, Koeffler said.

"I am not recommending that people increase their consumption of peppers," he said. "Our calculation is that you would have to eat 10 habanera peppers three times a week, which would be equivalent to the amount of capsaicin we gave to the mice."

The researcher believes capsaicin could someday gain a place in adjuvant prostate cancer therapy. For example, it might be used after prostate surgery to kill cancer cells in patients whose blood PSA levels start to rise, indicating the presence of tumors too small to be seen, he said.

The study does highlight the crossover that can occur between conventional and alternative therapies. "We should take note of herbal medicines and then use modern-day techniques to find what the active compounds are and bring them into clinical trials," Koeffler said.

One expert thinks it's too early to know if capsaicin will ever be an effective prostate cancer treatment, however.

"Since large amounts of capsaicin have never been given to people, we don't know what the side effects might be," cautioned Dr. Len Lichtenfeld, deputy chief medical officer at the American Cancer Society. "We don't know about the right dose or anything."

Lichtenfeld believes that any trial should be done in patients who are not responsive to other standard therapies. "We are ways away from a clinical trial," he said. "We need more basic research before we start treating patients."

Another expert concurred.

"This study does not prove that capsaicin will prove effective in the treatment of prostate cancer in humans," said Dr. David L. Katz, an associate professor of public health and director of the Prevention Research Center at Yale University School of Medicine. "Nor does it tell us that eating peppers rich in the substance will help prevent such cancer, or forestall its growth. But it provides a compelling argument for clinical study of capsaicin in human prostate cancer to put these questions to the test."

"This paper should serve to remind us that herbal remedies and pharmacotherapy are often of common origins, differing only in our capacity to identify, purify and package the active ingredients," Katz said. "This work suggests that the conventional medical community should turn a discriminating eye, rather than a jaded eye, toward time-honored herbal treatments. Many will doubtless prove ineffective when put to the test of high-quality research. But some will pass that test, and we must meticulously distinguish between them."


TOPICS: Food; Health/Medicine
KEYWORDS: cancer; capcaisin; chili; peppers; prostate; prostatecancer
causes prostate cancer cells to undergo a kind of suicide

I can relate. I had the Habenero Chili at the Texas Chili Parlor a few weeks ago, it made me want to commit suicide as well. Thankfully it was $3 pitcher night...
1 posted on 03/16/2006 10:10:14 AM PST by BJClinton
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To: BJClinton
"Since large amounts of capsaicin have never been given to people, we don't know what the side effects might be," cautioned Dr. Len Lichtenfeld


Oh, I can think of a couple...

2 posted on 03/16/2006 10:15:02 AM PST by LongElegantLegs (Going armed to the terror of the public.)
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To: BJClinton

You could always have the doctor use the capsaicin-impregnated gloves, the next time you get your prostate checked!!


3 posted on 03/16/2006 10:17:49 AM PST by stuartcr (Everything happens as God wants it to.....otherwise, things would be different.)
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To: BJClinton

You could always have the doctor use the capsaicin-impregnated gloves, the next time you get your prostate checked!!


4 posted on 03/16/2006 10:17:51 AM PST by stuartcr (Everything happens as God wants it to.....otherwise, things would be different.)
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To: BJClinton

You could always have the doctor use the capsaicin-impregnated gloves, the next time you get your prostate checked!!


5 posted on 03/16/2006 10:17:54 AM PST by stuartcr (Everything happens as God wants it to.....otherwise, things would be different.)
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To: BJClinton
"Bend over. Spread 'em."

Image hosting by TinyPic

6 posted on 03/16/2006 10:18:29 AM PST by Sax
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To: BJClinton

Sorry...sticky mouse.


7 posted on 03/16/2006 10:18:41 AM PST by stuartcr (Everything happens as God wants it to.....otherwise, things would be different.)
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To: Sax

8 posted on 03/16/2006 10:22:12 AM PST by skeeter
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I'd rather get my capsaicin the natural way... eating a lot of hot spicy chili.
9 posted on 03/16/2006 10:23:21 AM PST by Outland (Proud right-wing conspirator.)
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To: BJClinton; Owl_Eagle; Sam's Army; Lazamataz; Darksheare; pissant; Dashing Dasher; najida; ...
Preparation Habanero kills prostate cancer cells dead!

PING!

10 posted on 03/16/2006 10:26:22 AM PST by Jersey Republican Biker Chick (Cleverly disguised as a responsible adult.)
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To: BJClinton

So all this time all you had to do was stick a pepper up........


11 posted on 03/16/2006 10:26:25 AM PST by marsh_of_mists
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To: BJClinton
Reminds me of the Texas Chili Cook Off.
12 posted on 03/16/2006 10:28:39 AM PST by Constitution Day
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To: Jersey Republican Biker Chick

Doctor: (snaps on glove)...this is a new cancer cure...you'll feel a little pressure...

Patient: Why is there a bottle of Tobasco sauce on the counter...what? F$#K!! THAT S**T HURTS!!!!! WHAT ARE YOU DOING?? THAT BURNS!


13 posted on 03/16/2006 10:28:55 AM PST by RockinRight (Attention RNC...we're the party of Reagan, not FDR)
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To: Jersey Republican Biker Chick

3 habaneras each week?

Someone's got to be kidding.

Can't wait to tell hubby this good news.


14 posted on 03/16/2006 10:30:03 AM PST by peacebaby ("What? Me worry?" Alfred E Newman)
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To: marsh_of_mists; Sax

You guys are killing me here... .


15 posted on 03/16/2006 10:30:48 AM PST by peacebaby ("What? Me worry?" Alfred E Newman)
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To: stuartcr

Meh, one can get the same result the next day after a bowl of chili.


16 posted on 03/16/2006 10:31:02 AM PST by BJClinton (Cubicles are the Fidel Castro of office furniture.)
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To: RockinRight

Hot salsa enema therapy......


17 posted on 03/16/2006 10:31:08 AM PST by Jersey Republican Biker Chick (Cleverly disguised as a responsible adult.)
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To: Outland

Nothing beats chili on a Nathans hotdog.
I heard that really helps with prostate and rectal cancer cells.
Also kills any germs in the turlet!


18 posted on 03/16/2006 10:31:11 AM PST by Holicheese (Does that hat come with a bowl of soup?)
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To: peacebaby

LOL!


19 posted on 03/16/2006 10:31:55 AM PST by Jersey Republican Biker Chick (Cleverly disguised as a responsible adult.)
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To: BJClinton

I guess it depends on which one is considered more fun....I'd opt for the chili myself.


20 posted on 03/16/2006 10:35:22 AM PST by stuartcr (Everything happens as God wants it to.....otherwise, things would be different.)
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To: peacebaby

I love hot peppers! Once in a while, when you get a dose of the really hot stuff, you almost get a euphoric feeling while your eating 'em.

Never seem to get anything remotely resembling a euphoric feeling the next morning however. More like "WOWWWWW-OW! gotta stay seated...gotta stay seated...gotta stay seated..."


21 posted on 03/16/2006 10:41:38 AM PST by Sax
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To: Sax

Just take some shaved ice with you to the restroom. Also, applying some topical numbing product, like those meant for teeth, will get you though those first uncomfortable seconds.


22 posted on 03/16/2006 10:45:42 AM PST by BJClinton
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To: stuartcr
Hmmm ... creates a gentle warming sensation ... where have I heard that before?
23 posted on 03/16/2006 10:47:36 AM PST by NonValueAdded ("If I were a Cuban, I'd certainly be on a raft," Isane Aparicio Busto)
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To: BJClinton

"Hey Dad, where ya going with that sno-cone?"


24 posted on 03/16/2006 10:48:46 AM PST by Sax
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To: BJClinton
BtD: "Mornin', Doc!"

Dr: "Morning, Mr. Drill. Now, drop 'em and bend over." (Snaps on the gloves and holds up an object resembling a translucent nightstick)

BtD: "Whatinellizzat?"

Dr: "Habanero suppository. It's for your prostate. Enjoy! Oh - here's some tortilla chips..."

25 posted on 03/16/2006 10:51:13 AM PST by Billthedrill
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To: BJClinton

ROFL!


26 posted on 03/16/2006 10:51:26 AM PST by Millee (Don't make me get out my voodoo doll out!)
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To: Sax

I had the unfortunate experience of eating a pepper in an oriental dish that actually burned the skin on my tongue. That's no fun.

Euphoria? I think think of other ways...death by chocolate maybe.


27 posted on 03/16/2006 10:57:38 AM PST by peacebaby ("What? Me worry?" Alfred E Newman)
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To: peacebaby

I know the ones - about an inch to an inch and a half long, and thin papery red skin.

When I was 20, I once chopped habaneros and then answered nature's call. About :30 seconds later I was a half a block away, because I had a tremendous urge to try to outrun the pain.


28 posted on 03/16/2006 11:00:59 AM PST by Sax
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To: Jersey Republican Biker Chick

Anyone got a good Chili Recipe for me?


29 posted on 03/16/2006 11:01:59 AM PST by MNJohnnie (Are you not entertained? Are you NOT entertained? Is this not what you came here for?)
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To: Billthedrill
Habanero suppository

Wow. Just saying that out loud made me pucker. And I'm eating stuffed jalapenos right now.
30 posted on 03/16/2006 11:11:06 AM PST by BJClinton
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To: MNJohnnie
Anyone got a good Chili Recipe for me?

2 Cans Wolf Brand Chili
1 Can Ranch Style Beans
6 pack of beer

Open first beer, begin consuming. Open cans of Chili and beans, pour into pot.
Open and begin consuming second beer. Turn heat on low under pot, stirring contents together. Cover, leave heat on low.
Open and begin consuming third beer. Take remaining beer with you to couch or reclining chair. Turn on TV.
Open and begin consuming fourth beer. Turn the game on. You'll probably need to visit the restroom about now. Be sure to wash hands.
On the way back from restroom stir chili. Open and begin consuming 5th and 6th beers. Watch game.
Chili should be done now.
31 posted on 03/16/2006 11:16:56 AM PST by BJClinton
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To: MNJohnnie

I have an entire chili cookbook somewhere.


32 posted on 03/16/2006 11:38:50 AM PST by Jersey Republican Biker Chick (Cleverly disguised as a responsible adult.)
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To: Jersey Republican Biker Chick

Wow, I saw this and just went "ouch!". And I'm not a guy.


33 posted on 03/16/2006 12:10:33 PM PST by confederacy of dunces (Workin' & lurkin')
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To: Jersey Republican Biker Chick; BJClinton

Here's my chili sauce recipe:

Sorta Hot Salsa


10 whole Habaneros
12 whole Tomatillos, husked and rinsed
8 whole Jalapeños
6 whole Serranos
2 whole Anaheims
1 whole Vidalia onions, skinned
1 whole sweet red peppers, seeded
1 whole Lime
2 ounces Balsamic vinegar

Dice ingredients put in a blender (I use a food processor) individually and process. Put the mixture in the bowl. Drizzle balsamic vinegar over the top. Let marinate overnight.


34 posted on 03/16/2006 1:00:02 PM PST by blackie (Be Well~Be Armed~Be Safe~Molon Labe!)
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To: peacebaby
Don't be in too much of a hurry. These chaps sound like amateurs, no matter what degrees they may hold.

"I am not recommending that people increase their consumption of peppers," he said. "Our calculation is that you would have to eat 10 habanera peppers three times a week, which would be equivalent to the amount of capsaicin we gave to the mice."

Sorry, fella, the active ''heat'' principle in habanero peppers is not capsaicin, it's oleoresin capsicum, a related but more complex molecule.

35 posted on 03/16/2006 1:55:36 PM PST by SAJ
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To: SAJ

thanks for telling me...hubby enjoys growing these habaneros and using them when he can.


36 posted on 03/16/2006 1:58:49 PM PST by peacebaby ("What? Me worry?" Alfred E Newman)
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To: peacebaby
BTW, if you or hubby ever bite into a pepper that's just too hot, the best remedy in the world is neither water nor beer, but buttermilk. Or just a pat of butter right on the tongue.

Capsaicin and its chemical cousins are not soluble in water and only slightly soluble in ethyl alcohol -- but readily dissolve in fat. They're related to the B vitamins, which if you've ever wondered are classed together because they are fat-soluble.

(entry #9064 in the book of ''More Than You Wanted To Know About ...'').

;^)

37 posted on 03/16/2006 2:06:16 PM PST by SAJ
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To: SAJ

I was wondering how you knew this information, trader. And thanks for the info on the pat of butter, I needed it when I bit down on an asian pepper once.


38 posted on 03/16/2006 2:09:06 PM PST by peacebaby ("What? Me worry?" Alfred E Newman)
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To: peacebaby

Long time ago, Chem 26b, Chemistry of Food. The only chem class I **really** enjoyed.


39 posted on 03/16/2006 2:12:00 PM PST by SAJ
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To: SAJ

hmmm, a trader and a genius.


40 posted on 03/16/2006 2:14:08 PM PST by peacebaby ("What? Me worry?" Alfred E Newman)
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To: peacebaby
Er, thanks...I think. As to the former, certainly. As to the latter, uh, not likely!

;^)

41 posted on 03/16/2006 2:18:12 PM PST by SAJ
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To: Jersey Republican Biker Chick

Ouch...


42 posted on 03/16/2006 5:07:55 PM PST by RockinRight (Attention RNC...we're the party of Reagan, not FDR)
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