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Scientists remove amyloid plaques from brains of live animals with Alzheimer's disease
Federation of American Societies for Experimental Biology ^ | Oct 15, 2009 | Unknown

Posted on 10/15/2009 7:52:05 AM PDT by decimon

New research in the FASEB Journal suggests that manipulation of the brain's own immune cells with IL-6 could lead to reversal of Alzheimer's disease pathology

A breakthrough discovery by scientists from the Mayo Clinic in Jacksonville, FL, may lead to a new treatment for Alzheimer's Disease that actually removes amyloid plaques—considered a hallmark of the disease—from patients' brains. This discovery, published online in The FASEB Journal (http://www.fasebj.org), is based on the unexpected finding that when the brain's immune cells (microglia) are activated by the interleukin-6 protein (IL-6), they actually remove plaques instead of causing them or making them worse. The research was performed in a model of Alzheimer's disease established in mice.

"Our study highlights the notion that manipulating the brain's immune response could be translated into clinically tolerated regimens for the treatment of neurodegenerative diseases," said Pritam Das, co-author of the study, from the Mayo Clinic in Jacksonville, FL.

Das and colleagues made this unexpected discovery when they initially set out to prove that the activation of microgila trigger inflammation, making the disease worse. Their hypothesis was that microglia would attempt to remove the plaques, but would be unable to do so, and in the process cause excessive inflammation. To the surprise of the researchers, when microglia were activated by IL-6, they cleared the plaques from the brains.

To do this, the researchers over-expressed IL-6 in the brains of newborn mice that had yet to develop any amyloid plaques, as well in mice with pre-existing plaques. Using somatic brain transgenesis technology, scientists analyzed the effect of IL-6 on brain neuro-inflammation and plaque deposition. In both groups of mice, the presence of IL-6 lead to the clearance of amyloid plaques from the brain. Researchers then set out to determine exactly how IL-6 worked to clear the plaques and discovered that the inflammation induced by IL-6 directed the microglia to express proteins that removed the plaques. This research suggests that manipulating the brain's own immune cells through inflammatory mediators could lead to new therapeutic approaches for the treatment of neurodegenerative diseases, particularly Alzheimer's disease.

"This model is as close to human pathology as animal models get. These results give us an exciting lead to newer, more effective treatments of Alzheimer's disease," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "This study demonstrates that investment in experimental biology is the best way to approach the challenge posed by an aging population to the cost of health care."

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Receive monthly highlights from The FASEB Journal by e-mail. Sign up at http://www.faseb.org/fasebjournalreaders.htm. The FASEB Journal (http://www.fasebj.org) is published by the Federation of the American Societies for Experimental Biology (FASEB). The journal has been recognized by the Special Libraries Association as one of the top 100 most influential biomedical journals of the past century and is the most cited biology journal worldwide according to the Institute for Scientific Information. FASEB comprises 22 nonprofit societies with more than 80,000 members, making it the largest coalition of biomedical research associations in the United States. FASEB advances health and welfare by promoting progress and education in biological and biomedical sciences through service to its member societies and collaborative advocacy.

Details: Paramita Chakrabarty, Karen Jansen-West, Amanda Beccard, Carolina Ceballos-Diaz, Yona Levites, Christophe Verbeeck, Abba C. Zubair, Dennis Dickson, Todd E. Golde, and Pritam Das. Massive gliosis induced by interleukin-6 suppresses A deposition in vivo: evidence against inflammation as a driving force for amyloid deposition. FASEB J. doi:10.1096/fj.09-141754 ; http://www.fasebj.org/cgi/content/abstract/fj.09-141754v2


TOPICS: Health/Medicine; Science
KEYWORDS: alzheimer; alzheimersdisease; caffeine; coffee; nodoz

1 posted on 10/15/2009 7:52:05 AM PDT by decimon
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To: decimon

Too bad Obamacare will make all that a moot point. Just withhold fluids and nutrients and the “problem” will be “solved.” Never waste a good crisis.


2 posted on 10/15/2009 7:55:12 AM PDT by hometoroost (Time to bust the nut - stamp out ACORN)
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To: hometoroost

The new procedure will be too expensive for 0bamaCare.


3 posted on 10/15/2009 7:57:04 AM PDT by reg45 (Be calm everyone. The idiot children are in charge!)
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To: decimon

There is also research showing that L-carnitine prevents the accumulation of amyloid plaque. The best dietary source of it is beef.


4 posted on 10/15/2009 7:59:19 AM PDT by La Lydia
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To: decimon

Who pays for this type of research under ObamaCare???

(Answer: no one)


5 posted on 10/15/2009 8:00:45 AM PDT by Mr. K (THIS ADMINISTRATION IS WEARING OUT MY CAPSLOCK KEY DAMMIT DAMMIT DAMMIT!!!!!)
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To: reg45

That’s precisely my point. Not to mention that researchers won’t be looking into developing these types of treatments if no one can make any money from them. But, thank goodness we’ll still have politically-driven, government-funded research - and we all know how effective that is.


6 posted on 10/15/2009 8:04:29 AM PDT by hometoroost (Time to bust the nut - stamp out ACORN)
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To: decimon
Caffeine treatment removed the beta amyloid plaques from the brains of Alzheimer's mice.
7 posted on 10/15/2009 8:32:44 AM PDT by E. Pluribus Unum (Ask not what the Kennedys can do for you, but what you can do for the Kennedys.)
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To: E. Pluribus Unum

Thanks for the link. Alzheimers is in my family, yet hope it is not in my future. I drink lots of coffee in a day, so it is good to know it may help.


8 posted on 10/15/2009 9:34:39 AM PDT by annieokie (i)
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To: annieokie
I like coffee, but I don't drink it consistently, so I started taking 600 mg of caffeine a day.

I bought it at VitaCost.com.

It was the cheapest I found.

9 posted on 10/15/2009 9:42:50 AM PDT by E. Pluribus Unum (Ask not what the Kennedys can do for you, but what you can do for the Kennedys.)
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To: E. Pluribus Unum

If caffeine will do it then I should be protected for the next few hundred years.


10 posted on 10/15/2009 9:46:04 AM PDT by decimon
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To: E. Pluribus Unum
interesting, I did not know caffine came in pill form. Maybe something I will do later, for not its good til the last drop for me. lol

Thanks for the info.

11 posted on 10/15/2009 10:54:49 AM PDT by annieokie (i)
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To: annieokie
I did not know caffine came in pill form.

Remember No-Doz? I think it was 100% caffeine.

12 posted on 10/15/2009 10:59:40 AM PDT by bankwalker (In the land of the blind, the one-eyed man is king.)
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To: annieokie; bankwalker; E. Pluribus Unum; decimon; La Lydia; nw_arizona_granny
Sorry to ping you to such an old thread, but I can't find this topic being discussed in any newer messagethread.

I am curious how many freepers are supplementing with No-Doz, or with generic tablets of caffeine -- have any of you seen any newer discussions about this?

I was surprised to learn on another website, one dealing with side effects from drugs, that overuse of No-Doz is associated with diarrhea, which surprised me, because even though I've read lots about caffeine, I'd never come across that as a normal side effect of too much caffeine.

I haven't been able to get past 2 tablets of either the generic variety or of the brand name No-Doz. Two pills is my current tolerance. Each pill contains 200 mg. of caffeine, and I also drink several cups of coffee each day.

Although I'm a long term coffee drinker, the very first time I took a No-Doz, shortly after the research with mice & caffeine & Alzheimer's Disease came out, I was UP ALL NIGHT LONG, wide wide awake & alert.

So, for a while I started breaking up the hard tablets, so that they'd have a better chance of dissolving and entering my system long before 3 am.

Are any of you now using pill-form caffeine as a result of this research?


Thank you.

13 posted on 10/28/2009 8:37:21 AM PDT by hennie pennie
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To: decimon

BUMP for later reference


14 posted on 10/28/2009 8:57:13 AM PDT by paul51 (11 September 2001 - Never forget)
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To: hennie pennie
Caffeine May Prevent and Help Reverse Alzheimer's Disease

http://www.freerepublic.com/focus/f-news/2306792/posts

Posting to this thread for quick cross reference of another thread on this same topic.

15 posted on 10/28/2009 9:14:45 AM PDT by hennie pennie
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To: hennie pennie
Caffeine May Prevent and Help Reverse Alzheimer's Disease

I should be safe for the next few lifetimes.

16 posted on 10/28/2009 9:44:52 AM PDT by decimon
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To: hennie pennie
I know nothing about the use of No-Doz or caffeine related to amyloid plaque with caffeine. I've never even heard of it. Sound like it could have serious, undesirable side effects. Read this:

http://www.the-natural-path.com/alpha-lipoic-acid.html

17 posted on 10/28/2009 9:55:20 AM PDT by La Lydia
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To: La Lydia
Would you care to give a small synopsis of why that website says that caffeine is dangerous???

There's no results at google for the word 'caffeine' nor the phrase 'alpha lipoic' at "The Natural Path dot COM.

Google Search http://www.google.com/search?hl=en&num=50&ie=ISO-8859-1&q=site%3Awww.the-natural-path.com%2F+++%22alpha+lipoic%22++caffeine+

I pinged you to the other messagethread where research is in that scientists have recently reversed Alzheimer's Disease in lab animals by using on them what is the equivalent in human terms of 5 or 6 cups of coffee per day, depending upon the brew & roast.

18 posted on 10/28/2009 10:41:11 AM PDT by hennie pennie
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To: decimon
>>>> "I should be safe for the next few lifetimes." <<<<

That's hard to say -- different coffee beans, different coffee roasts, different methods of preparing the coffee can result in significantly different amounts of caffeine.

I was absolutely shocked, as a life long coffee drinker, to stay WIDE awake ALL NIGHT hyper-ALERT and unable to sleep the first day that I took one little No-Doz tablet, which simply contains 200 mg. caffeine... supposedly the amount in 1 or 2 cups of coffee, depending upon the brew.

19 posted on 10/28/2009 10:46:16 AM PDT by hennie pennie
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To: hennie pennie

That website doesn’t say caffeine is dangerous. I pay fairly close attention to that kind of research and have seen nothing on caffeine. Good luck in your quest.


20 posted on 10/28/2009 11:24:39 AM PDT by La Lydia
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To: La Lydia
>>>> quote: "I know nothing about the use of No-Doz or caffeine related to amyloid plaque with caffeine. I've never even heard of it. Sound like it could have serious, undesirable side effects. Read this: http://www.the-natural-path.com/alpha-lipoic-acid.html <<<< Sorry about that -- I presumed that you directed me to that website because it immediately followed your statement that caffeine sounded dangerous. SORRY.
21 posted on 10/28/2009 11:31:08 AM PDT by hennie pennie
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To: hennie pennie
I have been taking 600 mg of this every morning.

1000 mg gives me heartburn, but 600 mg works fine.

Whether it is helping with my memory or not...

...I can't remember.

22 posted on 10/28/2009 6:22:11 PM PDT by E. Pluribus Unum (Ask not what the Kennedys can do for you, but what you can do for the Kennedys.)
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To: Mr. K

Medical research would be devastated by Ubamacare.


23 posted on 10/28/2009 6:26:16 PM PDT by rdl6989 (January 20, 2013 The end of an error.)
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To: decimon

lol, me too. I don’t take NO DOZ, I do want to sleep a little bit.


24 posted on 10/28/2009 8:28:38 PM PDT by annieokie (i)
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To: E. Pluribus Unum
>>>> "I have been taking 600 mg of this every morning. 1000 mg gives me heartburn, but 600 mg works fine. Whether it is helping with my memory or not... ...I can't remember." <<<<

Thank you for sharing, and I'm sorry about the late reply, after I read your posting, I had a difficult time re-locating it in My Comments, in order to reply.

I do fine with 200, and not so bad with 300 -- but two mornings ago I swallowed two No-Doz for 400 mgs. total, and obviously they didn't dissolve in my stomach -- but later on around 2:30 am when they apparently did dissolve, I was WIDE awake, and hypervigilent for HOURS, unfortunately too physically tired to get up and do something useful, but mentally really 'wired.' On occassion, I also get the diarrhea, and once or twice had minor heart palpitations - speeding racing, thump-thump, while going up a flight of stairs, I know its a typical side effect of "too" much caffeine.

25 posted on 10/29/2009 4:52:07 PM PDT by hennie pennie
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