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New "Splinter Cell" Super-Immune Cells Created; Ready to Fight Cancer, AIDS
Daily Tech ^ | April 27, 2010 7:45 PM | Jason Mick (Blog)

Posted on 04/29/2010 1:46:20 PM PDT by Ernest_at_the_Beach

Why use drugs, when you can improve the body's own designs?

Evolution has bestowed mammals with amazingly complex and robust immune systems capable of fighting off a variety of foreign invaders including fungi, bacteria, and viruses.  The immune system is also capable of detecting cancerous cells -- cells in which mutations have led to uncontrolled growth which threatens to engulf normal healthy tissues.

The problem is that even nature sometimes falls short.  The immune system's T Cells, special cells used to fight extreme abnormalities such as AIDS and cancer (note, a special type of T cell fights HIV-infected T cells in AIDS), often times lack the supporting cells or can't stop the abnormality's growth fast enough.

A solution is adoptive immunotherapy, an approach in which certain T cells are harvested from the body and then cultured and exposed to the abnormality.  Kept in a tightly controlled environment they reprogram to fight the abnormality faster than in the complex human body.  The final step is to insert the cells back into the human body, now ready to fight the threat.

Unfortunately, the lack of supporting cells has hindered the promising approach.  So

Stanford University bioengineering researchers developed T cells that produce their own cytokines, the special chemical that the T cells typically obtain from other immune cells.  In essence this transforms immune cells into an "army of one", which can fight the threat even if other immune cells have been killed, compromised, or are otherwise unavailable.

To prevent these cells from growing and proliferating out of control (the whole reason for the cytokine system), the researchers encoded a cellular RNA switch that confers a new sensitivity to a specific drug (different riboswitches were used, including ones sensitive to the drugs tetracycline and theophylline).  The T cells only produce their own cytokines when exposed to this drug.

The super-cells featured 24 percent more live cells, when cultured, than normal T cells.  They also had a 50 percent reduced death rate.


TOPICS: Health/Medicine
KEYWORDS: godsgravesglyphs; immunology; immunotherapy; medicine
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1 posted on 04/29/2010 1:46:20 PM PDT by Ernest_at_the_Beach
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To: neverdem; NormsRevenge; Grampa Dave; SierraWasp; Marine_Uncle; BOBTHENAILER; blam; SunkenCiv; ...
Related thread:

Dendreon gets prostate cancer drug approved by FDA

2 posted on 04/29/2010 1:49:25 PM PDT by Ernest_at_the_Beach ( Support Geert Wilders)
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To: Ernest_at_the_Beach

killing cancer bump


3 posted on 04/29/2010 2:20:14 PM PDT by Taffini ( Mr. Pippen and Mr. Waffles do not approve and neither do I)
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To: Ernest_at_the_Beach
You forgot to indicate it was an excerpt.


T cells protect our bodies against attackers like bacteria, cancer, and the AIDS virus. Scientists at Stanford have found a way to not only target them to threats more effectively (past work), but to allow them to act independent of other immune cells (new work). (Source: Laplacian Files)

Genetic control of mammalian T-cell proliferation with synthetic RNA regulatory systems

Forgive the Wikipedia link, Ribozyme.

4 posted on 04/29/2010 2:43:34 PM PDT by neverdem (Xin loi minh oi)
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To: Ernest_at_the_Beach

Great articles. Thanks for the ping.


5 posted on 04/29/2010 2:44:03 PM PDT by Marine_Uncle (Honor must be earned....)
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To: neverdem

I did state it ....just didn’t use the FR mechanism...


6 posted on 04/29/2010 3:23:07 PM PDT by Ernest_at_the_Beach ( Support Geert Wilders)
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To: Ernest_at_the_Beach; StayAt HomeMother; 1ofmanyfree; 21twelve; 240B; 24Karet; 2ndDivisionVet; ...

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Gods
Graves
Glyphs
Thanks Ernest_at_the_Beach.

Why use drugs, when you can improve the body's own designs? Evolution has bestowed mammals with amazingly complex and robust immune systems...
Yes, I do enjoy stickin' my hand into a beehive, why do you ask?
The Doctor Fun Page
To all -- please ping me to other topics which are appropriate for the GGG list.
GGG managers are SunkenCiv, StayAt HomeMother, and Ernest_at_the_Beach
 

·Dogpile · Archaeologica · LiveScience · Archaeology · Biblical Archaeology Society ·
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· The Archaeology Channel · Excerpt, or Link only? · cgk's list of ping lists ·


7 posted on 04/29/2010 5:22:04 PM PDT by SunkenCiv ("Fools learn from experience. I prefer to learn from the experience of others." -- Otto von Bismarck)
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To: SunkenCiv; Ernest_at_the_Beach
Why use drugs

Say WHAT?


8 posted on 04/29/2010 7:20:47 PM PDT by colorado tanker
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To: Ernest_at_the_Beach

Thank you Ernest. I’ve been an investor in Dendreon for over 7 years. Today was the culmination of 15 years of research, trials and yes, unnecessary patient deaths caused by an FDA delay the first time it came up for approval. Today is the begining of a new way to treat cancer. Prosate cancer is only the first. Dendreon has a pipeline; this is no one-trick pony. And yes, i’d recommend buying some stock. This will be Amgn or Celgene within a few years.


9 posted on 04/29/2010 8:41:15 PM PDT by SueRae
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To: Ernest_at_the_Beach

BTTT


10 posted on 04/30/2010 2:21:33 PM PDT by diamond6 (Pray the Rosary to defeat communism and Obamacare!!)
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