Skip to comments.Longevinex exhibits L-shaped safety curve for first time in resveratrol biology
Posted on 12/29/2010 2:09:24 PM PST by decimon
While protecting animal hearts from a mortal event
Las Vegas, Nevada (Dec. 30, 2010) It was Paracelsus, the Renaissance physician (1493-1541 A.D.) who first said "the dose makes the poison." So, you can drink too much wine, or ingest too much resveratrol, but in an unprecedented study, heart researchers report they couldn't find a toxic dose for Longevinex®, a resveratrol-based dietary supplement.
Investigators previously reported that six or more glasses of red wine per day actually increase the risk, whereas 3-5 glasses per day optimally reduce risk for cardiac death. This is the well-known J-shaped risk curve (risk goes down, then up with excessive dose) that has been documented for both red wine and resveratrol.
North Americans who abstain from drinking wine have higher mortality rates for coronary heart disease (~240 per 100,000), making red wine and resveratrol pills tantalizing for those individuals who wish to reduce their risk for a mortal heart attack (~90 per 100,000 for wine drinkers).
The drawback here is that consumption of 3-5 glasses of red wine a day approaches the point of inebriation. Health seekers who wish to avoid the undesirable effects of alcohol may be led to try resveratrol pills, which if taken in mega-doses, could be potentially toxic to the heart.
In an animal experiment that surprised researchers, circulation was blocked to excised animal hearts and it was unexpectedly found that Longevinex® exhibited cardio-protection (minimized damage to heart muscle) over a wide dosage range 100 to 7000 milligrams human equivalent dosage --- whereas 1750 mg of plain resveratrol increases damage to the heart and 3500 milligrams stops ("kills") an excised mouse heart in the laboratory every time. The study is published in a recent issue of Experimental & Clinical Cardiology and is available for viewing online. ( http://www.pulsus.com/journals/toc.jsp?sCurrPg=journal&jnlKy=8&fold=Current%20Issue )
Incredulous researchers, at first puzzled by the results of their animal experiment with mice, continued to increase the human equivalent dosage up to 7000 mg, prolonged the duration of the study up to six months, and even administered Longevinex® to another animal species, rabbits, with the same results.
Resveratrol antioxidant or pro-oxidant?
In prior animal studies it has been shown that as dosage increases resveratrol shifts from being an antioxidant to a pro-oxidant (promotes oxidation) it binds to copper at low doses and releases copper at high doses. Longevinex® exhibited no such toxicity. This remarkable range of safety for any resveratrol-based product has never been demonstrated before.
Animal studies show plain resveratrol is optimally cardio-protective at human-equivalent dose of 100-175 mg and begins to lose its protective effects in a dose as low as 350 mg. Published studies confirm that low-dose resveratrol, particularly when combined with other synergistic small molecules from nature as provided in Longevinex®, works better in animal hearts than mega doses.
While this is the first time a resveratrol pill has been demonstrated to exhibit an L-shaped risk curve (risk goes down and stays down at all tested doses), this does not imply that mega-dose Longevinex® is totally without side effect at all doses, says Bill Sardi, spokesperson for Longevinex®. Consumers should refer to the product label which describes recommended dosage range and potential side effects with resveratrol pills, Sardi says.
Researchers indicate low-dose resveratrol protects the heart from damage should a heart attack occur, while "plain resveratrol should only be used at lower doses as opposite effects can occur higher doses, resulting in adverse effects on health."
Longevinex® is the first branded resveratrol product to show true evidence for cardio-protection (i.e. laboratory animals survive an otherwise mortal heart attack) In another recently published paper Longevinex® was also shown to restore a near-normal gene activation profile to excised animal hearts subjected to an intentional heart attack.
Red wine drinkers in France have a very low rate of cardiovascular mortality. There are more centenarians per capita in France than any other country. The idea of creating a red wine pill that mimics the beneficial effects of red wine without side effects has advanced one step closer with Longevinex®.
For more information about Longevinex® go to www.longevinex.com
“North Americans who abstain from drinking wine have higher mortality rates for coronary heart disease”
Yeah but why? It might not be that the wine alone is any good, but rather that it partially digests fat in a helpful way during a meal.
Resvertol itself inhibits fat cells from growing.
By cells growing - do you mean it stops globules of fat from acreting? Fat comes in molecules rather than cells, so globules of fat acrete rather than grow. If so, then it basically has the same effect as paint thinner does to paint?
“By cells growing - do you mean it stops globules of fat from acreting? Fat comes in molecules rather than cells, so globules of fat acrete rather than grow. If so, then it basically has the same effect as paint thinner does to paint?”
Resveratrol downregulates the secretion and gene expression of adipokines (IL6, IL8 and monocyte chemoattractant protein 1) and thereby decreases fat storage.
Fischer-Posovszky P, Kukulus V, Tews D, Unterkircher T, Debatin KM, Fulda S, Wabitsch M.
Resveratrol regulates human adipocyte number and function in a Sirt1-dependent manner. Am J Clin Nutr. 2010 Jul;92(1):5-15. Epub 2010 May 12
To summarize, fat cells do not take in the fat molecules and don’t grow independantly from carbohydrates. The fat molecules are used for something else (energy) or removed from your body (poop).
The take away is reservtol makes it much harder to GET FAT.
A glass of wine should be taken with meals and after sex, or both, if it is a Roman orgy.
Toga! Toga! Toga!
The idea is the idea of creating a red-wine pill THAT CAN BE PATENTED so we get to watch INCESSANT COMMERCIALS ON THE TUBE about side effect lists as long as your arm and see your doctor for a prescription...
Few people know that all the statins are analogs of a natural compound found in red-yeast rice...
Ask your doctor if Resveratrol is right for you!
And be sure to stop by our state of the art vomitorium between courses.
Your explanation was very helpful - my last response didn’t do it justice.
Jewbacca, thanks for getting the title of the citation. If you enclose a title within quotation marks, you can get the abstract, if there is one, and sometimes the original article, if it's open access, i.e. a FReebie.
The last link goes to the abstract. The abstract links a PDF FReebie. Happy New Year!
FReepmail me if you want on or off the diabetes or immunology ping lists.
P.S. It's helpful to remember what's happening intracellularly as opposed to extracellularly. When your doc does a lipid profile, the last time that I checked, the lab measures total cholesterol, HDL-cholesterol and serum triglycerides. (The "bad" LDL-cholesterol was calculated from from those fractions.) The serum triglycerides are in equilibrium between the blood level and the amount in adipocytes. In the blood, serum triglycerides are in equilibrium between the three free fatty acids and the glycerol spine of a triglyceride molecule. In human hearts, and probably most mammals, the mitochondria can use free fatty acids, as well as carbohydrates, to generate Adenosine TriPhosphate, ATP, the currency of energy at the cellular level from aerobic or anaerobic respiration.
P.P.S. Any corrections or updates are always appreciated.
The human body has fat cells which grow, multiply or shrink. The fat in your body is mostly made up of fat cells, and it is metabolically active.