Free Republic
Browse · Search
General/Chat
Topics · Post Article

Skip to comments.

Researchers link herpes to Alzheimer's disease (cold sore virus)
Brown University ^ | April 4, 2011 | Unknown

Posted on 04/04/2011 11:56:33 AM PDT by decimon

'Cold sores' connected to cognitive decline

ALBUQUERQUE, NM – Laboratories at the University of New Mexico (UNM), Brown University, and House Ear Institute (HEI) have developed a new technique to observe herpes simplex virus type 1 (HSV1) infections growing inside cells. HSV1, the cause of the common cold sore, persists in a latent form inside nerve cells. Re-activation and growth of HSV1 infections contribute to cognitive decline associated with Alzheimer's disease. Details are published in the March 31 issue of PLoS ONE magazine from the Public Library of Science.

"Herpes infects mucous membranes, such as the lip or eye, and generates viral particles," submits study Principal Investigator Elaine Bearer, M.D., Ph.D., Harvey Family Professor and Vice Chair for Research, Department of Pathology, UNM School of Medicine. "These viral particles burst out of the cells of the mucous membrane and enter sensory nerve cells where they travel inside the nerve toward the brain. We now can see this cellular transportation system and watch how the newly formed virus engages cellular APP on its journey out of the cell."

Tagging herpes virus inside cells with green fluorescent protein, scientists used live confocal imaging to watch HSV1 particles emerge from infected cells. Newly produced viral particles exit the cell nucleus and then bud into cellular membranes containing amyloid precursor protein (APP). Electron microscopy at HEI detailed the ultrastructural relationship between HSV1 particles and APP.

This dance between viral particles and cellular APP results in changes in cellular architecture and the distribution of APP, the major component of senile plaques found in the brains of Alzheimer's disease patients. Results from this study indicate that most intracellular HSV1 particles undergo frequent, dynamic interplay with APP, which facilitates viral transport while interfering with normal APP transport and distribution. This dynamic interaction reveals a mechanism by which HSV1 infection leads to Alzheimer's disease.

In developed countries such as the U.S., approximately 20 percent of children are infected with HSV1 prior to the age of five. By the second and third decades of life, as much as 60 percent of the population is infected, and late-in-life infection rate reaches 85 percent.

Symptoms of primary HSV1 infection include painful blisters of the mouth, lips or eyes. After infection, HSV1 persists in nerve cells by becoming latent. Upon re-awakening, new viral particles are made in the neuron and then travel back out its pathways to re-infect the mucous membrane. Many infected people experience sporadic episodes of viral outbreaks as the well-known recurrent cold sore.

"Clinicians have seen a link between HSV1 infection and Alzheimer's disease in patients, so we wanted to investigate what might be going on in the body that would account for this," adds Dr. Shi-Bin Cheng, post-doctoral associate, Department of Pathology and Laboratory Medicine, Alpert Medical School, Brown University. "What we were able to see in the lab strongly suggests a causal link between HSV1 and Alzheimer's Disease."

"It's no longer a matter of determining whether HSV1 is involved in cognitive decline, but rather how significant this involvement is," Bearer asserts. "We'll need to investigate anti-viral drugs used for acute herpes treatment to determine their ability to slow or prevent cognitive decline."

Researchers recommend people treat a cold sore as quickly as possible to minimize the amount of time the virus is actively traveling through a person's nervous system. The faster a cold sore is treated, the faster the HSV1 returns to a dormant stage.

###

Additional Authors include: Paulette Ferland, senior research assistant, UNM; Paul Webster, House Ear Institute, Los Angeles, CA; participation of Kathleen Kilpatrck, UNM; and many undergraduate students at Brown who contributed to this project are acknowledged.


TOPICS: Health/Medicine; Science
KEYWORDS: alzheimers; coldsores; herpes

1 posted on 04/04/2011 11:56:35 AM PDT by decimon
[ Post Reply | Private Reply | View Replies]

To: neverdem; DvdMom; grey_whiskers; Ladysmith; Roos_Girl; Silentgypsy; conservative cat; ...

Ping


2 posted on 04/04/2011 11:57:27 AM PDT by decimon
[ Post Reply | Private Reply | To 1 | View Replies]

To: decimon

Oh swell. Looks like we’re (almost) all DOOOOOOOOMED!


3 posted on 04/04/2011 11:58:30 AM PDT by sinanju
[ Post Reply | Private Reply | To 1 | View Replies]

To: decimon

This is bad news for a lot of people.


4 posted on 04/04/2011 12:00:12 PM PDT by Pearls Before Swine
[ Post Reply | Private Reply | To 1 | View Replies]

To: sinanju

I’m one of those 40 year old virgins, that you hear about, but question their existence.

I’ll save you all.


5 posted on 04/04/2011 12:03:57 PM PDT by Jonty30
[ Post Reply | Private Reply | To 3 | View Replies]

To: Jonty30

I started getting cold sores when I was a child. I presume I got it from my parents.

About 80 percent of American adults have oral herpes (cold sores).

http://www.globalherbalsupplies.com/herpes/stats.html


6 posted on 04/04/2011 12:09:11 PM PDT by DManA
[ Post Reply | Private Reply | To 5 | View Replies]

To: Jonty30
I don't think you read the article. This is HSV1, not what most people refer to as herpes.

In developed countries such as the U.S., approximately 20 percent of children are infected with HSV1 prior to the age of five. By the second and third decades of life, as much as 60 percent of the population is infected, and late-in-life infection rate reaches 85 percent.

Your virginity has very little to do with whether or not you have HSV1... unless you think 20% of children are having sex prior to the age of 5...
7 posted on 04/04/2011 12:10:12 PM PDT by Domalais
[ Post Reply | Private Reply | To 5 | View Replies]

To: decimon

Looks like those of us who have had chicken pox are in trouble ;-)


8 posted on 04/04/2011 12:10:12 PM PDT by achilles2000 ("I'll agree to save the whales as long as we can deport the liberals")
[ Post Reply | Private Reply | To 2 | View Replies]

To: decimon

My Father lived to be almost 90... his Father lived to be 92... both suffered cold sores... one smoked himself to death (and was an MD) and my Dad... an Engineer... died of kidney disease. No signs of Alzheimers in my family anywhere.

LLS


9 posted on 04/04/2011 12:11:16 PM PDT by LibLieSlayer (WOLVERINES!!!)
[ Post Reply | Private Reply | To 1 | View Replies]

To: achilles2000
Looks like those of us who have had chicken pox are in trouble ;-)

And those who haven't should they get it as adults. You just can't win.

10 posted on 04/04/2011 12:15:21 PM PDT by decimon
[ Post Reply | Private Reply | To 8 | View Replies]

To: decimon
http://cache.gawker.com/assets/images/2009/08/custom_1249356214076_bill-clinton.jpg
11 posted on 04/04/2011 12:16:27 PM PDT by max americana ( NF)
[ Post Reply | Private Reply | To 1 | View Replies]

To: decimon

20 years ago, aluminum was tagged as the culprit. I wounder what the cause will be 20 years from now when I’m getting to be that age?


12 posted on 04/04/2011 12:19:39 PM PDT by The_Victor (If all I want is a warm feeling, I should just wet my pants.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: achilles2000

I haven’t looked it up but I think HSV1 is the oral type of herpes, and isn’t associated with chicken pox. Chicken pox is Herpes Zoster, and can cause Shingles in someone who’s had chicken pox.


13 posted on 04/04/2011 12:30:39 PM PDT by dawn53
[ Post Reply | Private Reply | To 8 | View Replies]

To: DManA
My grandmother use to get cold sores and she suffered from Alzheimers the last ten years of her life. I worry about my father now that he's getting older. I don't want to see him suffer that way. Alzheimers is a horrible disease that hurts the victim and the family.
14 posted on 04/04/2011 1:35:25 PM PDT by peeps36 (America is being destroyed by filthy traitors in the political establishment)
[ Post Reply | Private Reply | To 6 | View Replies]

To: peeps36

“I don’t want to see him suffer that way.”

So sorry to hear about your grandparents but Alzheimer’s is the only disease where the patient does not suffer but those around them are often terribly affected.


15 posted on 04/04/2011 2:00:46 PM PDT by Cyman
[ Post Reply | Private Reply | To 14 | View Replies]

To: decimon

On the other hand, my dad has never had a cold sore, but has Alzheimer’s.


16 posted on 04/04/2011 5:03:41 PM PDT by beaversmom
[ Post Reply | Private Reply | To 1 | View Replies]

To: beaversmom
On the other hand, my dad has never had a cold sore, but has Alzheimer’s.

Sorry to hear about your dad.

I think you can carry the virus without ever displaying symptoms.

17 posted on 04/04/2011 5:15:33 PM PDT by decimon
[ Post Reply | Private Reply | To 16 | View Replies]

To: decimon; texas booster; Mother Abigail; EBH; vetvetdoug; Smokin' Joe; Global2010; Battle Axe; ...
bump & a micro ping

Herpes Simplex Virus Dances with Amyloid Precursor Protein while Exiting the Cell

18 posted on 04/05/2011 12:56:56 PM PDT by neverdem (Xin loi minh oi)
[ Post Reply | Private Reply | To 17 | View Replies]

To: decimon
Researchers recommend people treat a cold sore as quickly as possible to minimize the amount of time the virus is actively traveling through a person's nervous system. The faster a cold sore is treated, the faster the HSV1 returns to a dormant stage.

What's the treatment? Acyclovir at $5 a pop?

How does one treat a cold sore? I get them and nothing seems to help.

19 posted on 04/05/2011 7:22:38 PM PDT by raybbr (People who still support Obama are either a Marxist or a moron.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: raybbr
How does one treat a cold sore?

I don't know.

20 posted on 04/05/2011 8:16:55 PM PDT by decimon
[ Post Reply | Private Reply | To 19 | View Replies]

To: raybbr

sfl


21 posted on 04/05/2011 8:28:16 PM PDT by bitt ( ..Congress - either investigate Obama ...or yourselves, for complicity)
[ Post Reply | Private Reply | To 19 | View Replies]

To: decimon
Lysine Works great!
22 posted on 04/05/2011 8:32:55 PM PDT by Randy Larsen (Wise To The Lies!)
[ Post Reply | Private Reply | To 20 | View Replies]

To: decimon
Used to get cold sores on my lips, especially during the winter. Around 40 I grew a beard and mustache, hardly had a cold sore since. When I do, I dab a little Chapstick on it and it's gone the next day.
Really think shaving has something to do with it......Irritation triggered maybe.
23 posted on 04/05/2011 8:38:12 PM PDT by The Cajun (Palin, Bachmann, Free Republic, Mark Levin, Rush, Hannity......Nuff said.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: Randy Larsen
Lysine Works great!

I'll second that! Fought cold sores/fever blisters for most of my life. Someone suggested L-Lysine and I thought what the heck; can't hurt. I took two at the onset(you know, when you get those little "tingly" spots on the lips) and one a day for another few days. After several years of this, the cold sores became fewer and farther between bouts. And now, I can't remember the last time I had a cold sore; it's been that long -- or maybe I just can't remember... ;^)

24 posted on 04/05/2011 9:57:23 PM PDT by ForGod'sSake (You have only two choices: SUBMIT or RESIST with everything you've got!!!)
[ Post Reply | Private Reply | To 22 | View Replies]

To: decimon
How does one treat a cold sore?

I don't know.

You'd think an article this alarming would say, wouldn't you?

25 posted on 04/06/2011 3:01:21 AM PDT by raybbr (People who still support Obama are either a Marxist or a moron.)
[ Post Reply | Private Reply | To 20 | View Replies]

To: raybbr
You'd think an article this alarming would say, wouldn't you?

No.

26 posted on 04/06/2011 3:59:23 AM PDT by decimon
[ Post Reply | Private Reply | To 25 | View Replies]

To: raybbr
I've had good luck with Abreva if I manage to apply it to the site at the first tingling feeling. Once the sore has 'erupted' it's much too late for Abreva.
27 posted on 04/06/2011 4:31:37 AM PDT by whd23 (Every time a link is de-blogged an angel gets its wings.)
[ Post Reply | Private Reply | To 19 | View Replies]

Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.

Free Republic
Browse · Search
General/Chat
Topics · Post Article

FreeRepublic, LLC, PO BOX 9771, FRESNO, CA 93794
FreeRepublic.com is powered by software copyright 2000-2008 John Robinson