Skip to comments.Dopamine controls formation of new brain cells
Posted on 04/08/2011 1:05:08 PM PDT by decimon
A study of the salamander brain has led researchers at Karolinska Institutet to discover a hitherto unknown function of the neurotransmitter dopamine. In an article published in the prestigious scientific journal Cell Stem Cell they show how in acting as a kind of switch for stem cells, dopamine controls the formation of new neurons in the adult brain. Their findings may one day contribute to new treatments for neurodegenerative diseases, such as Parkinson's.
The study was conducted using salamanders which unlike mammals recover fully from a Parkinson's-like condition within a four week period. Parkinson's disease is a neurodegenerative disease characterised by the death of dopamine-producing cells in the mid-brain. As the salamander re-builds all lost dopamine-producing neurons, the researchers examined how the salamnder brain detects the absence of these cells. This question is a fundamental one since it has not been known what causes the new formation of nerve cells and why the process ceases when the correct number have been made.
What they found out was that the salamander's stem cells are automatically activated when the dopamine concentration drops as a result of the death of dopamine-producing neurons, meaning that the neurotransmitter acts as a constant handbrake on stem cell activity.
"The medicine often given to Parkinson's patients is L-dopa, which is converted into dopamine in the brain," says Dr Andras Simon, who led the study at the Department of Cell and Molecular Biology. "When the salamanders were treated with L-dopa, the production of new dopamine-producing neurons was almost completely inhibited and the animals were unable to recover. However, the converse also applies. If dopamine signalling is blocked, new neurons are born unnecessarily."
(Excerpt) Read more at ki.se ...
The Salamander Supremacy - ping
Y’all probably have heard this already but in 1981, a horse I was leading got spooked by a door slamming and flattened me on a blacktop driveway.
I was in a coma for 11 days and was expected to die because the _entire frontal lobe_ of my brain was reduced to Slurpee.
Their “best case scenario” was me living as a vegetable for the rest of my days.
[my dad bought me a box and a plot, that’s how hopeless the neuros were]
Obviously, I lived.
I had to go for MRIs every year [and technically, I still should be] but every one still showed a fist-sized “hole” in my brain where my thought-bits used to be.
Several years ago I had one just out of curiosity, after ignoring them for over a decade.
Now, the neuros not only can’t explain how or why am I not only ‘cognizant and functioning’ [to the point where I actually started learning to read Greek, got into quantum physics, holographic universe theory and a bunch of other “egg head” stuff I never cared about before], they can’t explain *why* the “hole” is gone and has apparently regrown brain tissue.
Right after the injury, they kept giving me evals to see “what was left of my intellect”.
The test dude said I did better than 99% of people who’d never had head injuries to begin with.
IMO, God spared my life and my brain “rewired” itself while I was “out”.
To really creep y’all out, I grew up a “tom boy” and got a zillion cuts, gashes, punctures and whatnot in my ridge-running days.
I have also accidentally cut off the tips of two fingers to where the bone ends.
The horse wreck sheared off the entire top of my right hand and my right ankle [including the ankle bone] yet with a magnifying glass, none of you could find one single scar on me *anywhere*.
[even the finger tips and ankle bone “grew back”]
I just regenerate.....:)
[and you thought my user name was just some cute little thing]....LOL
I did read a bit of that story before. I just want to know; do you like the water? lol
“[and you thought my user name was just some cute little thing]....LOL”
Nope. It’s why I pinged you...seemed to me that Salamanders are pretty special.
Sorry you suffered that injury, but...it’s good to see that your remarkable regeneration has apparently made you stronger.
Only shallow vernal pools during the mating season.
[I’m not a newt, ya nut!]...LOL
I much prefer relaxing under a damp log, on soft, rich, loamy moss....:)
Right back atcha, buddy....:)
Well, of course! I newt that. LOL
Actually, the Frankenstein-ian stuff they pull is kinda creepy, if ya think abut it....:))
I mean, my God...who loses an arm or leg and just says “Eh, whatever. I’ll just grow a new one.”.
That’s just *weird*...LOL
That was a painfully funny pun...:)
The glory is God’s, not mine.
In fact, in Christian symbolism, the salamander represents the soul that has endured the fires of tribulation and emerged unscathed.
Even in heathen alchemy, the salamander is the indestructible element.
How cool is that?...:)
[and even better, Muslims fear and hate them...it’s like hitting the symbolic trifecta]
Thats just *weird*...LOL
Oh, I dunno ... my nephew grew another foot since I saw him last.
I named him Badass.
(ref. "The Last Detail" w/Jack Nicholson and Dennis Quaid) The first 2:30 explains it all.
I had several road rescue Eastern Spotteds as pets for a long time.
One was a huge female and the other two were smaller males who lived in terror of her ginormous uppity self.
She was so cool.
She’d see me coming with her worm supper and run up and down the terrarium, standing up against the glass and “barking” for her food.
The males would hide in their cave for fear she’d mistake them for chow...LOL
I had them for about 3 years and one day when I went to get their special worms at the bait store, they were all out so I had to get some “hand dug” ones from a liquor store.
I don’t know where they’d been dug up but obviously it was someplace contaminated by something toxic to them.
Two days later, they all died.
That’s been 15 years ago and I haven’t had any since.
They are so soft and smooth and funny looking you wouldn't think of them as ferocious predators at first glance. Wrong!
Never underestimate a Salamander ... that's my motto! LOL
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