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Dopamine controls formation of new brain cells
Karolinska Institutet ^ | April 8, 2011 | Unknown

Posted on 04/08/2011 1:05:08 PM PDT by decimon

A study of the salamander brain has led researchers at Karolinska Institutet to discover a hitherto unknown function of the neurotransmitter dopamine. In an article published in the prestigious scientific journal Cell Stem Cell they show how in acting as a kind of switch for stem cells, dopamine controls the formation of new neurons in the adult brain. Their findings may one day contribute to new treatments for neurodegenerative diseases, such as Parkinson's.

The study was conducted using salamanders which unlike mammals recover fully from a Parkinson's-like condition within a four week period. Parkinson's disease is a neurodegenerative disease characterised by the death of dopamine-producing cells in the mid-brain. As the salamander re-builds all lost dopamine-producing neurons, the researchers examined how the salamnder brain detects the absence of these cells. This question is a fundamental one since it has not been known what causes the new formation of nerve cells and why the process ceases when the correct number have been made.

What they found out was that the salamander's stem cells are automatically activated when the dopamine concentration drops as a result of the death of dopamine-producing neurons, meaning that the neurotransmitter acts as a constant handbrake on stem cell activity.

"The medicine often given to Parkinson's patients is L-dopa, which is converted into dopamine in the brain," says Dr Andras Simon, who led the study at the Department of Cell and Molecular Biology. "When the salamanders were treated with L-dopa, the production of new dopamine-producing neurons was almost completely inhibited and the animals were unable to recover. However, the converse also applies. If dopamine signalling is blocked, new neurons are born unnecessarily."

(Excerpt) Read more at ki.se ...


TOPICS: Health/Medicine; Science
KEYWORDS: adultstemcells; dopamine; progenitorcells; stemcells

1 posted on 04/08/2011 1:05:13 PM PDT by decimon
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To: neverdem; DvdMom; grey_whiskers; Ladysmith; Roos_Girl; Silentgypsy; conservative cat; ...

Ping


2 posted on 04/08/2011 1:05:44 PM PDT by decimon
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To: Salamander

Salamander ping.


3 posted on 04/08/2011 1:09:32 PM PDT by jessduntno ("Money...can't exist unless there are goods produced and men able to produce them." - Rand)
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To: jessduntno; Salamander
Heh, you beat me to it.

The Salamander Supremacy - ping

4 posted on 04/08/2011 1:37:18 PM PDT by TigersEye (Who crashed the markets on 9/15/08 and why?)
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To: jessduntno; TigersEye

Y’all probably have heard this already but in 1981, a horse I was leading got spooked by a door slamming and flattened me on a blacktop driveway.

I was in a coma for 11 days and was expected to die because the _entire frontal lobe_ of my brain was reduced to Slurpee.

Their “best case scenario” was me living as a vegetable for the rest of my days.
[my dad bought me a box and a plot, that’s how hopeless the neuros were]

Obviously, I lived.

I had to go for MRIs every year [and technically, I still should be] but every one still showed a fist-sized “hole” in my brain where my thought-bits used to be.

Several years ago I had one just out of curiosity, after ignoring them for over a decade.

Now, the neuros not only can’t explain how or why am I not only ‘cognizant and functioning’ [to the point where I actually started learning to read Greek, got into quantum physics, holographic universe theory and a bunch of other “egg head” stuff I never cared about before], they can’t explain *why* the “hole” is gone and has apparently regrown brain tissue.

Right after the injury, they kept giving me evals to see “what was left of my intellect”.

The test dude said I did better than 99% of people who’d never had head injuries to begin with.

IMO, God spared my life and my brain “rewired” itself while I was “out”.

To really creep y’all out, I grew up a “tom boy” and got a zillion cuts, gashes, punctures and whatnot in my ridge-running days.
I have also accidentally cut off the tips of two fingers to where the bone ends.
The horse wreck sheared off the entire top of my right hand and my right ankle [including the ankle bone] yet with a magnifying glass, none of you could find one single scar on me *anywhere*.
[even the finger tips and ankle bone “grew back”]

I just regenerate.....:)

[and you thought my user name was just some cute little thing]....LOL


5 posted on 04/08/2011 4:36:48 PM PDT by Salamander (I made friends with a lot of people in the Danger Zone.)
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To: Salamander

I did read a bit of that story before. I just want to know; do you like the water? lol


6 posted on 04/08/2011 4:43:24 PM PDT by TigersEye (Who crashed the markets on 9/15/08 and why?)
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To: Salamander


7 posted on 04/08/2011 4:43:30 PM PDT by JoeProBono (A closed mouth gathers no feet - Visualize)
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To: Salamander

“[and you thought my user name was just some cute little thing]....LOL”

Nope. It’s why I pinged you...seemed to me that Salamanders are pretty special.


8 posted on 04/08/2011 4:59:17 PM PDT by jessduntno ("Money...can't exist unless there are goods produced and men able to produce them." - Rand)
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To: Salamander

Sorry you suffered that injury, but...it’s good to see that your remarkable regeneration has apparently made you stronger.


9 posted on 04/08/2011 5:02:08 PM PDT by decimon
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To: TigersEye

Only shallow vernal pools during the mating season.
[I’m not a newt, ya nut!]...LOL

I much prefer relaxing under a damp log, on soft, rich, loamy moss....:)


10 posted on 04/08/2011 5:05:13 PM PDT by Salamander (I made friends with a lot of people in the Danger Zone.)
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To: JoeProBono

Right back atcha, buddy....:)


11 posted on 04/08/2011 5:06:03 PM PDT by Salamander (I made friends with a lot of people in the Danger Zone.)
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To: Salamander

Well, of course! I newt that. LOL


12 posted on 04/08/2011 5:06:58 PM PDT by TigersEye (Who crashed the markets on 9/15/08 and why?)
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To: jessduntno

Actually, the Frankenstein-ian stuff they pull is kinda creepy, if ya think abut it....:))

I mean, my God...who loses an arm or leg and just says “Eh, whatever. I’ll just grow a new one.”.

That’s just *weird*...LOL


13 posted on 04/08/2011 5:09:32 PM PDT by Salamander (I made friends with a lot of people in the Danger Zone.)
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To: TigersEye

Ouch!

That was a painfully funny pun...:)


14 posted on 04/08/2011 5:10:32 PM PDT by Salamander (I made friends with a lot of people in the Danger Zone.)
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To: decimon

The glory is God’s, not mine.

In fact, in Christian symbolism, the salamander represents the soul that has endured the fires of tribulation and emerged unscathed.

Even in heathen alchemy, the salamander is the indestructible element.

How cool is that?...:)

[and even better, Muslims fear and hate them...it’s like hitting the symbolic trifecta]

;D


15 posted on 04/08/2011 5:15:13 PM PDT by Salamander (I made friends with a lot of people in the Danger Zone.)
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To: Salamander

That’s just *weird*...LOL

Oh, I dunno ... my nephew grew another foot since I saw him last.


16 posted on 04/08/2011 5:15:57 PM PDT by jessduntno ("Money...can't exist unless there are goods produced and men able to produce them." - Rand)
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To: jessduntno

*rim-shot!*


17 posted on 04/08/2011 5:27:44 PM PDT by Salamander (I made friends with a lot of people in the Danger Zone.)
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To: Salamander
I had a Tiger Salamander for a pet once. He looked a lot like this one.

I named him Badass.

(ref. "The Last Detail" w/Jack Nicholson and Dennis Quaid) The first 2:30 explains it all.

18 posted on 04/08/2011 5:57:21 PM PDT by TigersEye (Who crashed the markets on 9/15/08 and why?)
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To: TigersEye

How beautiful!

I had several road rescue Eastern Spotteds as pets for a long time.

One was a huge female and the other two were smaller males who lived in terror of her ginormous uppity self.

She was so cool.

She’d see me coming with her worm supper and run up and down the terrarium, standing up against the glass and “barking” for her food.
[seriously]

The males would hide in their cave for fear she’d mistake them for chow...LOL

I had them for about 3 years and one day when I went to get their special worms at the bait store, they were all out so I had to get some “hand dug” ones from a liquor store.

I don’t know where they’d been dug up but obviously it was someplace contaminated by something toxic to them.
Two days later, they all died.

That’s been 15 years ago and I haven’t had any since.


19 posted on 04/08/2011 8:28:30 PM PDT by Salamander (I made friends with a lot of people in the Danger Zone.)
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To: Salamander
Oh, that's too bad. I had two actually. I suppose the big one, Badass, was a female and the little one (I don't recall what I named it) was a male. Badass got its name for the way it jumped on grasshoppers I fed it. The little one would let the grasshoppers crawl all over it. Wimpy wimpy wimpy!

They are so soft and smooth and funny looking you wouldn't think of them as ferocious predators at first glance. Wrong!

Never underestimate a Salamander ... that's my motto! LOL

20 posted on 04/08/2011 9:03:23 PM PDT by TigersEye (Who crashed the markets on 9/15/08 and why?)
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To: TigersEye

I was pretty upset about it but considering I saved them from being carelessly crushed by drivers who just can’t seem to notice *hundreds* of them plodding across the road on the mountain top, en mass, during mating season [as if they ‘dart out so fast you can’t avoid them’] they had long, happy lives here.

They’re savage little beasts and contrary to popular belief, they do have teeth...LOL

http://wiki.answers.com/Q/Will_a_spotted_salamander_bite_your_child

“salamanders do bite but they wont if you dont make them mad”

Words to the wise.

;D


21 posted on 04/08/2011 9:35:00 PM PDT by Salamander (I made friends with a lot of people in the Danger Zone.)
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To: Salamander

LOL I guess I never made Badass mad. Drop a grasshopper in front of her and she would leap her whole body length in the blink of an eye.


22 posted on 04/08/2011 9:57:45 PM PDT by TigersEye (Who crashed the markets on 9/15/08 and why?)
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To: TigersEye

Most folks would never guess just how personable something with no eyebrows can be, do they?

“Sal” was a trip.

She was very interactive and loved it when I dipped a soft Kolinsky sable watercolor brush into warm water and gently stroked her back and head with it.
[for potential salamander keepers, it’s not good to handle them too much because their skin is fragile and its slime coat is easily damaged, plus, they secrete a mild toxin that is not much fun if you get it in your eyes]

The little boys never came out much.

I never pushed the issue...I assumed if they were scared of her they probably knew more than I did.

Gosh.

I haven’t thought of them in a long time.


23 posted on 04/08/2011 10:51:21 PM PDT by Salamander (I made friends with a lot of people in the Danger Zone.)
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To: TigersEye

I have looked everywhere for that infamous photo of some guy with a Tiger Salamander hanging off of his thumb.

Apparently, he made it very angry as it had about a half inch of thumb stuffed in its mouth....:))


24 posted on 04/08/2011 10:53:33 PM PDT by Salamander (I made friends with a lot of people in the Danger Zone.)
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To: Salamander
Yep, they do have their own personalities. Badass had no fear of me but no aggression either. The little one was afraid of the grasshoppers. I only had them a couple of weeks and decided I didn't want them to end up like so many of my childhood pets. I wasn't sure I could keep them alive.

I don't think their teeth could break the skin. Not on mine but even Tiger Salamanders get bigger. Badass must have been about 7"-8"s long. He/she was about 2"s bigger around the belly when I let them go. :-)

Really cool critters. I'd love to see some of the bigger species that live in the mid-west and southern states. AFAIK Tigers are the only species in CO. When I lived in VT I got out of my truck in the woods, walked about fifty feet down a trail and there were two red efts walking away from each other. I left them alone but it was great to see them. I had seen them in books since I was a kid and always thought they were interesting and mysterious. And so they were!

That's cool about stroking them with a sable brush. I never got poisoned by their toxin. My great aunt lived on a farm in Iowa and had a toad in the root cellar that she brought flies regularly. There was a shelf or something it would get up on to be fed by her. It's hard not to like amphibians.

25 posted on 04/08/2011 11:24:11 PM PDT by TigersEye (Who crashed the markets on 9/15/08 and why?)
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To: decimon; Coleus; Peach; airborne; Asphalt; Dr. Scarpetta; I'm ALL Right!; StAnDeliver; ovrtaxt; ...
stem cell ping

Dopamine Controls Neurogenesis in the Adult Salamander Midbrain in Homeostasis and during Regeneration of Dopamine Neurons

26 posted on 04/09/2011 10:39:30 AM PDT by neverdem (Xin loi minh oi)
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To: TigersEye

Possibly because grasshoppers aren’t their usual diet.

They prefer soft-bodied prey and the chitin in the exoskeletons of “hard” bugs can amass in their intestines and kill them.

I used blood worms which were small, very nutritious and not so cute that guilt overwhelmed me for feeding them to the ‘phibs.

Tigers are actually part of the “Mole” salamander family and spend most of their time under cover.

We have Eastern Spotteds here but you hardly ever see them.

Late Feb/early march is their breeding season and they cross roads following ancestral breeding paths, usually to their detriment because drivers just disregard them and run them down.
[hence my many years of standing alone on the cold, rainy mountain top with a flashlight and a bucket, trying to save as many as possible]

Later in the summer, if I’m really lucky, I’ll see the ‘toddlers’ who emerge from the ponds after spending the last 2 years in an aquatic form.

Red backs are really common and often I see them running _across the snow_ in the middle of winter.

Crazy, huh?

These are the ones we have here:

http://www.fish.state.pa.us/salamander.htm
[I know it’s PA but they’re all in MD, too]

The Jeffersons tend to cross the road when the Spotteds do but I gave up trying to save them.

The Spotteds are slow and lumbering but the Jeffersons are little turbo-manders.
I sure can’t out-run ‘em and they had a much better time dodging cars....:)

I’d love to see one of these but they’re west coast/Pacific critters.

http://www.californiaherps.com/salamanders/images/dtenebrosusneomemr083.jpg

*Huge*!

The only thing we have really big here is Hellbenders and finding them in a stream or crick is nearly impossible.

Little Bronze Frogs and Spring Peepers hang out near the motorcycle shop door waiting for the bugs who fry themselves on the security light to hit the ground.

[work smarter, not harder]....;D

We had a “Guard toad” who challenged anybody who came to our gate.
The stupid UPS driver [who knew the toad was always there and to stay at least 5 feet from the gate] pulled in too far and ran over it one day.


27 posted on 04/09/2011 12:11:14 PM PDT by Salamander (I made friends with a lot of people in the Danger Zone.teds herer)
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