[PA Engineer]

"The correlation between low plaque age, higher insulin levels and instability is also consistent with our findings of gene activity where younger plaques were characterized with higher activity of genes related to immune responses and oxidative phosphorylation"

Correlates also with Metabolic Syndrome and insulin resistance.

[neverdem]

Correlates also with Metabolic Syndrome and insulin resistance.

PA Engineer, this presser links the complete article. I just read the abstract so far. According to my pathology teacher in med school, they found "fatty streaks" in in various major arteries while performing autopsies of fairly young American killed in action during the Korean War. These "fatty streaks" were thought to be precursors of atherosclerotic arterial disease, in particular, coronary artery disease. Maybe we'll live long enough to find out.

IIRC, they eventually found crystals of cholesterol in atherosclerotic plaque as well as macrophages, cells of the innate immune system.

Carotid Plaque Age Is a Feature of Plaque Stability Inversely Related to Levels of Plasma Insulin

This is a combined ping of the diabetes and immunology lists. FReepmail if you want on or off either list.