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Vitamin D and Cancer Mortality: Not to be Taken Lightly
Medscape Today ^ | 1/30/11 | Craig A. Elmets, MD

Posted on 05/12/2011 10:41:03 AM PDT by dangerdoc

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To: dangerdoc
Like almost everything else (food, water, sleep, nutrients, etc), not enough is not good and too much is also not good. The study showed that <25 was not good, and mortality decreased with an increase in V-D. But with high levels (>80) mortality increased again.
21 posted on 05/12/2011 11:52:53 AM PDT by palmer (Cooperating with Obama = helping him extend the depression and implement socialism.)
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To: decimon

The study does not make me concerned that elevated Vitamin D level causes cancer. That is probably just a fluke of doing too many subanalysis tests. If you do 10 tests with a p=.05 you will have a 50% false positive rate even higher if you are looking for both a positive and negative change.

The interesting thing is that in the whole test and looking at all sub groups, it does not look like low Vitamin D levels is a statistically significant risk factor for cancer, even considering the seasonal factor in measurement.


22 posted on 05/12/2011 11:54:25 AM PDT by dangerdoc (see post #6)
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To: chris_bdba

Interesting. Thanks.


23 posted on 05/12/2011 11:57:06 AM PDT by presently no screen name
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To: palmer

How is this for a confounder. Since the effect of high Vitamin D was seen in men, as a population which men would have the highest Vitamin D levels?

Out of all the common trades, I’m thinking construction. Construction worker’s have much higher smoking rates that the general population. Smoking is related to both lung and non-colon GI cancer. This is a significant confounder.

As I mention to Decimon, I don’t think this study shows that elevated Vitamin D levels are a cancer risk. If they were, you would expect to see it across race and gender. The interesting thing is that low Vitamin D levels was not found to be a significant cancer risk in any subgroup or in the study as a whole.


24 posted on 05/12/2011 12:05:25 PM PDT by dangerdoc (see post #6)
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To: bert

Not sure, it would have been my wife that signed it.


25 posted on 05/12/2011 12:07:45 PM PDT by wolfman23601
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To: dangerdoc

Can’t find any more info on this study. They have a lock on it though it’s not a new publish.


26 posted on 05/12/2011 12:51:32 PM PDT by decimon
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To: decimon
Okay folks, this I HAVE TO POST ON !!

The reason is this. We had all been using Sun Block (until that past 3 years) which blocked the UV rays that produce Vitamin D but were letting through the UV rays that would cause cancer in various forms. Not Sunblocks block UAV/UVB, ie, both kinds, I still go out and get full sunshine.

Much of this problem was caused by the idiots now giving us this bogus study information by failing to take in the above obvious important factors.
27 posted on 05/12/2011 12:59:28 PM PDT by Scythian
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To: decimon
Okay folks, this I HAVE TO POST ON !!

The reason is this. We had all been using Sun Block (until the past 3 years) which blocked the UV rays that produce Vitamin D yet were letting through the UV rays that would cause cancer in various forms. Now Sunblocks block both UAV/UVB, ie, both kinds, I still go out and get full sunshine.

Much of this problem was caused by the idiots who are now giving us this bogus study information by failing to take in the above obvious important factors.
28 posted on 05/12/2011 1:00:59 PM PDT by Scythian
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To: chris_bdba

I have the same problem. Seems like I take a lot and struggle to keep my D level above 50. One of my docs says that he thinks the level should be around 100-110. That’s what a life guards level would be. Can you get in the sun at all? 10-15 minutes a day without sun tan lotion. As long as you get no burn or tan. The darker your skin, the longer it takes in the sun to get vit. D. Also weight can have an affect too. The heavier you are the longer it takes to get vit. D from the sun. Also the farther north you are the less D you get from the sun. Where I live you could stay out in the sun all day long in the winter and get none.


29 posted on 05/12/2011 1:16:46 PM PDT by MsLady (Be the kind of woman that when you get up in the morning, the devil says, "Oh crap, she's UP !!")
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To: presently no screen name

Your welcome!!! Just don’t stay in the sun 30 mintues :) You’ll get a tan or burn. The usually recommendation is 10-15 minutes a day without sun tan lotion, in mid-day sun. Avoid any kind of burn or tan, both will inhibit your absorption of vitamin D.


30 posted on 05/12/2011 1:19:21 PM PDT by MsLady (Be the kind of woman that when you get up in the morning, the devil says, "Oh crap, she's UP !!")
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To: MsLady

I am about as white as a person could be and do burn easily.I’m fairy far north,SE Ohio, too so the sun does little most of the year. I don’t think they have ever got my level higher than 60.Most likely I have alway been deficient thus the problem with type 1 diabetes at 9yo?


31 posted on 05/12/2011 1:37:33 PM PDT by chris_bdba
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To: dangerdoc

Correlation is not causation. Repeat over and over in your mind every time you read a medical study. Researchers and journalists are always forgetting this.


32 posted on 05/12/2011 1:42:18 PM PDT by mlo
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To: chris_bdba
Could very well be why you have diabetes. They are finding out more and more about a lack of vit. D and how many diseases are caused by low D. Even some autism is caused by low levels of D. Lots of cancers also. It's cheap, the D3 form is the best form to take it. At the very least most people need 2000IU a day. IMHO, unless you live in the sun belt that number should probably be more like 4-5000IU a day.

You can get to much D and if you do, that's not a good thing. But, it takes a lot and is pretty hard to do. The other thing I found out is don't take your D with vitamin A. The D won't get absorbed as well.

33 posted on 05/12/2011 1:48:00 PM PDT by MsLady (Be the kind of woman that when you get up in the morning, the devil says, "Oh crap, she's UP !!")
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To: Scythian

“by the idiots who are now giving us this bogus study information”

They looked at Vitamin D levels and then followed the group for years to see what happened, then published the results. What exactly do you think is bogus?


34 posted on 05/12/2011 1:49:06 PM PDT by dangerdoc (see post #6)
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To: mlo

This is what the author had to say about the paper.

“The large NHANES III database provides a unique opportunity to evaluate in detail the relation between vitamin D and diseases in the U.S. Study limitations include the measurement of vitamin D levels only at baseline. The findings suggest that we don’t yet have the final word on the relationship between vitamin D and human health and that claims that vitamin D protects against specific cancers are not necessarily supported by the facts. Dermatologists can use this information to counter people’s presumption that sun exposure or tanning bed use will protect against cancer mortality; in fact, such exposure may actually increase deaths from some cancers.”


35 posted on 05/12/2011 1:54:58 PM PDT by dangerdoc (see post #6)
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To: dangerdoc

This is what is bogus:

Suppose a guy was in the sun all the time, yet he was using Sun block. Now, he never really got burned but was in the sun a hell of lot and the sun block he was using (and we were all using it) was blocking the production of Vitamin D yet allowing the UV types through that caused cancer. Imagine how long he would have to be in the sun to have high levels of Vitamin D, and then imagine all those cancer causing UV rays that were unblocked until a few years ago by sunblocks.

In essence, Sun block was a terrible thing, it was blocking Vitamin D production while letting through the truly harmful rays.

So, in reality, we won’t know anything about this until 20 years from now. The truth is, cancer rates are in large part really bad because we were told to use sun block, if we had no sunblock we would have truly protected ourselves, gotten a color slowly until we could stay in the sun all day without burning, which is what I do.

And, in central america and so on where they are in the intense sunlight all day long without any sunblock the forms of cancer we get are nearly unheard of. And don’t claim it’s thier skin color, unless you mean getting a good tan on your skin is really healthy.


36 posted on 05/12/2011 1:56:46 PM PDT by Scythian
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To: Scythian

I honestly can’t follow what you are saying. Do you think that UV light is causing increased lung and GI cancer?

If you look a few posts up, you can see my theory on the association.


37 posted on 05/12/2011 2:04:19 PM PDT by dangerdoc (see post #6)
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To: dangerdoc
Dermatologists can use this information to counter people’s presumption that sun exposure or tanning bed use will protect against cancer mortality; in fact, such exposure may actually increase deaths from some cancers.”

That goes to UV exposure and not vitamin D oral supplement. Can't tell if the study made any distinction.

38 posted on 05/12/2011 3:46:46 PM PDT by decimon
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To: decimon

I think the point is that there was some thought that the higher risk of skin cancer was balanced by a lower risk of other cancers but if there is no trade off then the dermatologists win the argument.

Personally I don’t care if I have wrinkles or a few skin cancers.


39 posted on 05/12/2011 5:06:36 PM PDT by dangerdoc (see post #6)
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