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Treating diabetes (metformin + exercise NG?)
University of Alberta ^ | August 18, 2011 | Jane Hurly

Posted on 08/19/2011 11:02:40 AM PDT by decimon

It’s common enough for researchers to look at the impacts of prescribed drugs on the body. And if you’re a diabetes researcher who believes that exercise has great benefits for those with type 2 diabetes, you’re hoping your research will show that. But when Normand Boulé looked at the dual impacts of exercise and metformin – two of the most commonly-prescribed modalities for glucose control – on that very outcome, the hoped-for double whammy wasn’t the result.

“The study had three objectives: we wanted to look at the effect of metformin on exercise in people with type 2 diabetes, examine the effect of exercise on metformin concentrations in the body, and finally to look at the effects of metformin and exercise on glucose control, which is essential for people with diabetes,” says Boulé, whose study – a randomized, double-blind, crossover study - involved a multi-disciplinary team of researchers from five faculties at the U of A.

>

“Metformin reduces glucose in the blood and many believe it does so by activating exercise-like pathways,” explains Boulé. “As expected, in our study metformin lowered the blood glucose concentrations measured during a two-hour period after lunch. But we found that on the non-exercise day metformin led to better glucose control after lunch than on the day our participants took metformin and exercised.”

>

(Excerpt) Read more at physedandrec.ualberta.ca ...


TOPICS: Health/Medicine
KEYWORDS: diabetes; metformin

1 posted on 08/19/2011 11:02:42 AM PDT by decimon
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To: neverdem; DvdMom; grey_whiskers; Ladysmith; Roos_Girl; Silentgypsy; conservative cat; ...

Ping


2 posted on 08/19/2011 11:03:37 AM PDT by decimon
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To: decimon
Good. I'm soooooo there!

I even have the shirt...

3 posted on 08/19/2011 11:07:37 AM PDT by null and void (Day 938. The mob is decisive when the law is not.)
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To: decimon

I wish that were true. Metformin doesn’t lower my blood sugar all that much. Nor does Metformin combined with Januvia.


4 posted on 08/19/2011 11:09:13 AM PDT by LottieDah (If only those who speak so eloquently on behalf of animals would do so on behalf of the unborn.)
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To: LottieDah

Neither does for me. I even exercise everyday (1 hour at the treadmill).


5 posted on 08/19/2011 11:12:30 AM PDT by Justaham
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To: LottieDah

Neither does for me. I even exercise everyday (1 hour at the treadmill).


6 posted on 08/19/2011 11:12:42 AM PDT by Justaham
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To: decimon
I take insulin and Metformin...I can't tell the Metformin does anything!
7 posted on 08/19/2011 11:16:05 AM PDT by ontap
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To: decimon

bttt


8 posted on 08/19/2011 11:17:07 AM PDT by TEXOKIE (Anarchy IS the strategy of the forces of darkness!)
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To: null and void

I love that one!


9 posted on 08/19/2011 11:21:16 AM PDT by SuzyQue
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To: decimon

Exercise + Metabolism, however, does work.


10 posted on 08/19/2011 11:22:13 AM PDT by struggle
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To: struggle

This can help too:
http://www.mylifevantage.com/radio


11 posted on 08/19/2011 11:25:20 AM PDT by Cowgirl
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To: decimon

Instead of messing around with drugs and exercise, a new technique may actually *reverse* type 2 diabetes, reactivating the cells long thought dead or non-functioning to produce normal amounts of insulin.

It’s not easy, but for 2 months the diabetic person must live on a 600 calorie a day diet of liquids and non-starchy vegetables.

http://www.popsci.com/science/article/2011-06/ultra-low-calorie-low-carb-diet-sufficient-reverse-type-2-diabetes-study-finds

Two months to be diabetes free. That result was found in 7 of 11 patients. A lot of hunger, but to be free of the curse...


12 posted on 08/19/2011 11:36:27 AM PDT by yefragetuwrabrumuy
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To: LottieDah

I have been taking Metformin for about four years. My blood suger hung around the 135 area. For the past two years I have been taking a tablespoon (2000mg) of Omega3 every night. About two months ago I began taking 2000mg in the morning, too. Since then my blood sugar has been steady in the 105-110 range. I exercise moderately and can only attribute the lower blood sugar to the additional Omega3.


13 posted on 08/19/2011 11:39:47 AM PDT by Russ (Repeal the 17th amendment)
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To: Russ

Thanks for the tip. I am going to try the Omega3.


14 posted on 08/19/2011 11:42:39 AM PDT by LottieDah (If only those who speak so eloquently on behalf of animals would do so on behalf of the unborn.)
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To: Russ

Sounds good !


15 posted on 08/19/2011 11:43:42 AM PDT by Eric in the Ozarks (Eh ?)
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To: LottieDah

Let me know how it works out...


16 posted on 08/19/2011 11:45:12 AM PDT by Russ (Repeal the 17th amendment)
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To: decimon

My wife took Metformin ONCE...never again.


17 posted on 08/19/2011 11:48:24 AM PDT by who knows what evil? (G-d saved more animals than people on the ark...www.siameserescue.org.)
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To: sauropod

read


18 posted on 08/19/2011 11:51:05 AM PDT by sauropod (ObaMao: Let them eat peas!)
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To: who knows what evil?

Why is that? Did it have an adverse effect on her?


19 posted on 08/19/2011 12:05:09 PM PDT by 353FMG (Liberalism is Satan's handiwork.)
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To: Russ

What kind of Omega 3? Pills, powder, brand name - what?

Inquiring minds want to know!

CA....


20 posted on 08/19/2011 12:16:02 PM PDT by Chances Are (Seems I've found that silly grin again....)
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To: 353FMG

Sure did...disorientation. She manages her blood sugar with supplements, exercise, and low-carb diet. NO medication whatsoever.


21 posted on 08/19/2011 12:22:44 PM PDT by who knows what evil? (G-d saved more animals than people on the ark...www.siameserescue.org.)
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To: decimon

It’s a shame the FDA classified Pyridoxamine (vitamin b6) as a drug and removed it from the US market. But that’s what the FDA does. Taking care of big pharma.


22 posted on 08/19/2011 12:26:30 PM PDT by Post5203 (Our political class have sullied a good man's name...Washington)
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To: who knows what evil?

Wow, thanks for the info. I’ve to talk to my doctor about this.

I don’t like to take medicine if I don’t need to. With proper diet and exercise I can get my blood sugar in the 80s. I sometimes wonder why I take metformin.


23 posted on 08/19/2011 12:45:39 PM PDT by 353FMG (Liberalism is Satan's handiwork.)
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To: 353FMG
Metformin gave me gas and occasionally the runs. It actually irritated my bowel the point that my doctor thought I had internal bleeding. Had to take the “scope” early as a result - nothing showed up, except the irritated colon. It did keep my sugar down though. He put me on Januvia and sugar levels have gone back up.
24 posted on 08/19/2011 1:07:34 PM PDT by jettester (I got paid to break 'em - not fly 'em)
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To: decimon; austinmark; FreedomCalls; IslandJeff; JRochelle; MarMema; Txsleuth; Newtoidaho; ...
Boulé says despite these findings, “exercise has hundreds of benefits” and should still be an important part of a healthy approach to glucose control for those with diabetes, including those taking metformin.

The abstract is linked at the end of the presser.

FReepmail me if you want on or off the diabetes ping list.

25 posted on 08/19/2011 8:05:33 PM PDT by neverdem (Xin loi minh oi)
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To: Russ
“I have been taking Metformin for about four years. My blood sugar hung around the 135 area. For the past two years I have been taking a tablespoon (2000mg) of Omega3 every night. About two months ago I began taking 2000mg in the morning, too. Since then my blood sugar has been steady in the 105-110 range. I exercise moderately and can only attribute the lower blood sugar to the additional Omega3.”

I just started taking Omega 3.
Are you still taking the metformin with the Omega 3?

For me exercise is the only way I can tolerate the metformin.

Generally, just working 10-12 hours a day on my feet controls my sugar pretty good. (I am a mechanic.)

If I just lounge around on the weekend It really makes me feel really poor.

26 posted on 08/19/2011 8:56:12 PM PDT by right way right (What's it gonna take?)
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To: LottieDah
Nor does Metformin combined with Januvia.

We have a friend just like that. The combination is not nearly as effective as hoped. However, for my wife, just metformin alone lowered A1C to 6.5.

27 posted on 08/19/2011 9:04:37 PM PDT by steve86 (Acerbic by nature, not nurture (Could be worst in 40 years))
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To: yefragetuwrabrumuy

That sounds a lot like what I did. And it works. My BS is steady at 80-100. 5.5 A1C.

I was warned that my metabolism would slow down and that I’d gain weight after I stopped the diet, but the opposite held true for me. When I stopped, I could eat a LOT more than I ever could before and hardly gained weight. (and I was *seriously* bad. I have not been eating well at all! I’ve never been so hungry.) After about two months, things have finally settled down and I’m back on the diet.


28 posted on 08/19/2011 10:06:28 PM PDT by Marie (I agree with everything that Rick Perry is saying. I just wish that *he* did. (NO to Bush II))
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To: Marie

I would suggest taking a few other common supplements to help insure things continue to be good.

1) Vitamin E shows promise for treating fatty liver disease.

http://www.usatoday.com/news/health/2010-04-29-vitamin-e-liver_N.htm

Figure that if your pancreas had some fatty blockages, you likely also have some degree of fatty liver, which Vitamin E might be beneficial for.

2) The chemical silymarin, found in milk thistle, and available OTC under its own name, is known to be the very best liver therapeutic ever found. It has three major actions in the liver: protecting it from uptaking toxins too quickly, protecting liver cells from damage, and stimulating damage repair 30% faster than normal. As such, it is recommended for liver conditions such as cirrhosis, hepatitis damage, poisoning from mushrooms and carbon tetrachloride, and other weakening conditions, such as diabetes. It also has secondary healing effects for the kidneys.

3) Diabetes damage linked to vitamin B1 shortage.

http://www.telegraph.co.uk/news/uknews/1559766/Diabetes-damage-linked-to-vitamin-B1-shortage.html

Diabetics have three-quarters less vitamin B1 in their blood than healthy people, research has shown. A study by the University of Warwick has linked this shortfall, which occurs in sufferers with both type one and two of the disease, to damage to the kidneys, retina and nerves in the arms and legs that are all common symptoms of the disease.

4) R-Alpha Lipoic Acid. It is an OTC form of ALA which is now a standard anti-diabetic peripheral neuropathy and diabetic nephropathy treatment in much of Europe. It also improves circulation in the extremities.


29 posted on 08/20/2011 7:30:44 AM PDT by yefragetuwrabrumuy
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To: steve86; decimon; austinmark; FreedomCalls; IslandJeff; JRochelle; MarMema; Txsleuth; Newtoidaho

Just lowering the numbers does not mean that one is doing anything to arrest the course of the disease! All the hypoglycemic drugs do is treat the symptom, not the disease.

If There’s No Benefit, Why Tolerate Any Risk?

http://abcnews.go.com/Health/story?id=3232247&page=1

Also, check out the book, Overdiagnosed. http://www.amazon.com/Overdiagnosed-Making-People-Pursuit-Health/dp/0807022004


30 posted on 08/22/2011 4:02:01 PM PDT by Pining_4_TX ( The state is the great fiction by which everybody seeks to live at the expense of everybody else. ~)
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To: Pining_4_TX
Just lowering the numbers does not mean that one is doing anything to arrest the course of the disease!

My wife actually felt quite sickly in the 4 or 5 years preceding going on Glucophage. It was remarkable to watch the change in her with treatment (I know this is not typical) and she still marvels about it. I will check your link, but we would never want her to go off it!

31 posted on 08/22/2011 7:59:48 PM PDT by steve86 (Acerbic by nature, not nurture (Could be worst in 40 years))
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To: Pining_4_TX
I liked this comment from your article:

8:37 AM EDT Jun 03, 2007 Hm; so Dr. Hadler doesn't bother treating diabetes, hypertension or hyperlipidemia. I'm sure his nephrology colleagues adore him for augmenting their dialysis practices with patients whose kidneys fail years earlier than they otherwise would. Likewise, his cardiologist friends are probably toasting his continued health, as are the vascular surgeons. I don't disagree in principle with being a "late adopter" of new therapies, but to say that "high blood sugar" does no harm marks him as foolishly antiquated.

Don't think we'll follow that doc.

32 posted on 08/22/2011 8:21:56 PM PDT by steve86 (Acerbic by nature, not nurture (Could be worst in 40 years))
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To: steve86

People are lulling themselves into a false sense of security when they use the hypoglycemic drugs to lower their numbers. That is treating the symptom, not the disease. Dr. Hadler did not say that very high blood sugar is OK; he said that the drugs don’t do anything to stop the disease progress. He also had an article published in a clinical journal for nephrologists detailing how these drugs do not save an eye, a limb, or a kidney.


33 posted on 08/23/2011 10:14:57 PM PDT by Pining_4_TX ( The state is the great fiction by which everybody seeks to live at the expense of everybody else. ~)
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