Skip to comments.Powerful antioxidant resveratrol prevents metabolic syndrome in lab tests: U of A study (diabetes?)
Posted on 09/04/2011 5:33:09 PM PDT by decimon
(Edmonton) Researchers in the Faculty of Medicine & Dentistry at the University of Alberta have discovered that resveratrol, a powerful antioxidant found in common foods, prevents a syndrome in some offspring that could lead to later health issues such as diabetes.
Resveratrol is found in fruits, nuts and red wine, and has been shown to extend the lifespan of many species.
Human offspring that have trouble growing in the womb have an increased risk of developing metabolic problems later in life. But U of A medical researchers Jason Dyck and Sandra Davidge and their teams found that administering resveratrol to the young offspring of lab rats after weaning actually prevented the development of a metabolic syndrome, which is characterized by glucose intolerance, insulin resistance and higher deposits of abdominal fat.
Dyck and Davidge published their findings in a recent edition of the peer-reviewed journal Diabetes. Dyck is a researcher in the departments of Pediatrics and Pharmacology, while Davidge is a researcher in the departments of Obstetrics & Gynecology and Physiology. Both are also members of the Mazankowski Alberta Heart Institute, as well as the Women and Childrens Health Research Institute. Dyck and Davidge were co-senior authors of the study.
The study took advantage of the fact that "infancy is a potential window of opportunity to intervene and prevent the future development of metabolic diseases." The researchers noted this is the first potential pharmacological treatment that may help babies that developed in a growth-restricted environment in the womb.
"There is a concept that in utero, there are genetic shifts that are occurring reprogramming is occurring because of this strenuous environment babies are in, that allows them to recover very quickly after birth," says Dyck.
"When babies are growth-restricted, they usually have a catch-up period after they are born where they catch up to non-growth-restricted groups. It might be that reprogramming that creates this kind of 'thrifty' phenotype, where they want to consume and store and get caught up.
"That reprogramming appears to make them more vulnerable to developing a host of metabolic problems."
Earlier this year, Dyck and Davidge published another paper in Diabetes demonstrating that rat offspring not growing well in the womb had noticeable side effects from high-fat diets after birth the rats deposited more fat in the abdominal area, developed glucose intolerance, more dramatic cases of insulin resistance and insulin resistance at earlier stages of life.
Dyck and Davidge are continuing their research in this area, examining whether treating the mother during pregnancy can prevent metabolic problems in rat offspring affected by intrauterine growth restriction.
Davidge is an Alberta Innovates-Health Solutions (AIHS) Scientist and a Canada Research Chair in Womens Cardiovascular Health. Dyck is an AIHS Senior Scholar and the Director of the Cardiovascular Research Centre at the U of A.
Their research was funded by: the Canadian Institutes of Health Research, the Heart & Stroke Foundation of Canada, and the Women and Childrens Health Research Institute.
Two drawbacks. First of all, it takes a LOT of Resveratrol, I’m talking buckets full, to get the best of its health benefits.
Second, like other antioxidants, while a little is good, more than that tends to create its own problems.
I have metabolic syndrome and I would welcome any good news that could help me manage this problem. While this antioxidant may or may not help, I would love to find something to help me.
Where do you get it? It’s a bit pricey at GNC.
The supplements aren't too costly. I look for the drugstore two-fer sales that come up every week or so.
is this also in grape juice? or only after it is made into wine?
Are you talking about the Resveratrol?
Along with other supplements, yes. I just saw that CVS has a two-fer sale on Nature's Bounty supplements. That should include resveratrol as either Red Wine or Grape Seed extract. Could be worth a look if there's a CVS near you. If there's not a CVS near you then some other drugstore chain may have a similar sale. Those sales come so often that it's hardly worth buying at any other time.
I think muscadine grapes have a crapload of resveratrol in them.
The only problem now is that you really dont know what you are getting when you buy it, there is no standardization or regulation. Look for a reputable supplement manufacturer.
Consumerlab (needs subscription) says a good quality, inexpensive (~ 20 cents per 100 mg) is from Biotivia.
You can get 500 mg tablets — others only have 100 mg tablets, so you have to take a lot and some cost as much as 45 cents per 100 mg.
If you want to check out consumerlabs, it’s
It’s $20+ for a 1 year subscription and they publish research about supplements, whether they have what they say they have,quality, price, etc. I find it’s worth the subscription price, you can save money on the supplements.
also — some list larger amounts but the “trans-resveratrol” amount is what counts.
Another place where you can order pure and reasonably priced resvratrol:
That may be so. Maybe green tea or other teas are as proven.
This product reduces antioxidants to a twenty year old level. It is all natural and the professor that is
being shown on the video is for real, not an actor.
He has been working on this product for decades and it
is a wonderful discovery. I’ve been taking it four months and have lower blood pressure. There a lot of good
testimonies that it helps many types of illnesses. Take a look.
This suggestion may help. Systemic enzymes of
Plant and animal sources have shown benefits in
numerous studies, including human case analysis.
Plant sources stay active for about 8 hours and
Animal sources for about 36. Should be enteric
coated. As for antioxidants, they work best in
A synergistic environment(formula) void of iron
And copper. Good luck! Dose depends on severity
First of all, it takes a LOT of Resveratrol, Im talking buckets full, to get the best of its health benefits.
It’s in wine, right?
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