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Powerful antioxidant resveratrol prevents metabolic syndrome in lab tests: U of A study (diabetes?)
University of Alberta Faculty of Medicine & Dentistry ^ | September 2, 2011 | Unknown

Posted on 09/04/2011 5:33:09 PM PDT by decimon

(Edmonton) Researchers in the Faculty of Medicine & Dentistry at the University of Alberta have discovered that resveratrol, a powerful antioxidant found in common foods, prevents a syndrome in some offspring that could lead to later health issues such as diabetes.

Resveratrol is found in fruits, nuts and red wine, and has been shown to extend the lifespan of many species.

Human offspring that have trouble growing in the womb have an increased risk of developing metabolic problems later in life. But U of A medical researchers Jason Dyck and Sandra Davidge and their teams found that administering resveratrol to the young offspring of lab rats after weaning actually prevented the development of a metabolic syndrome, which is characterized by glucose intolerance, insulin resistance and higher deposits of abdominal fat.

Dyck and Davidge published their findings in a recent edition of the peer-reviewed journal Diabetes. Dyck is a researcher in the departments of Pediatrics and Pharmacology, while Davidge is a researcher in the departments of Obstetrics & Gynecology and Physiology. Both are also members of the Mazankowski Alberta Heart Institute, as well as the Women and Children’s Health Research Institute. Dyck and Davidge were co-senior authors of the study.

The study took advantage of the fact that "infancy is a potential window of opportunity to intervene and prevent the future development of metabolic diseases." The researchers noted this is the first potential pharmacological treatment that may help babies that developed in a growth-restricted environment in the womb.

"There is a concept that in utero, there are genetic shifts that are occurring – reprogramming is occurring because of this strenuous environment babies are in, that allows them to recover very quickly after birth," says Dyck.

"When babies are growth-restricted, they usually have a catch-up period after they are born where they catch up to non-growth-restricted groups. It might be that reprogramming that creates this kind of 'thrifty' phenotype, where they want to consume and store and get caught up.

"That reprogramming appears to make them more vulnerable to developing a host of metabolic problems."

Earlier this year, Dyck and Davidge published another paper in Diabetes demonstrating that rat offspring not growing well in the womb had noticeable side effects from high-fat diets after birth – the rats deposited more fat in the abdominal area, developed glucose intolerance, more dramatic cases of insulin resistance and insulin resistance at earlier stages of life.

Dyck and Davidge are continuing their research in this area, examining whether treating the mother during pregnancy can prevent metabolic problems in rat offspring affected by intrauterine growth restriction.

Davidge is an Alberta Innovates-Health Solutions (AIHS) Scientist and a Canada Research Chair in Women’s Cardiovascular Health. Dyck is an AIHS Senior Scholar and the Director of the Cardiovascular Research Centre at the U of A.

###

Their research was funded by: the Canadian Institutes of Health Research, the Heart & Stroke Foundation of Canada, and the Women and Children’s Health Research Institute.


TOPICS: Health/Medicine; Science
KEYWORDS: diabetes; health; medicine; resveratrol

1 posted on 09/04/2011 5:33:13 PM PDT by decimon
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To: neverdem; DvdMom; grey_whiskers; Ladysmith; Roos_Girl; Silentgypsy; conservative cat; ...

Ping


2 posted on 09/04/2011 5:33:50 PM PDT by decimon
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To: decimon

Two drawbacks. First of all, it takes a LOT of Resveratrol, I’m talking buckets full, to get the best of its health benefits.

Second, like other antioxidants, while a little is good, more than that tends to create its own problems.


3 posted on 09/04/2011 5:37:59 PM PDT by yefragetuwrabrumuy
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To: decimon

I have metabolic syndrome and I would welcome any good news that could help me manage this problem. While this antioxidant may or may not help, I would love to find something to help me.


4 posted on 09/04/2011 5:52:05 PM PDT by ducttape45
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To: yefragetuwrabrumuy

Where do you get it? It’s a bit pricey at GNC.


5 posted on 09/04/2011 5:55:12 PM PDT by RussP
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To: ducttape45
I have metabolic syndrome and I would welcome any good news that could help me manage this problem. While this antioxidant may or may not help, I would love to find something to help me.

The supplements aren't too costly. I look for the drugstore two-fer sales that come up every week or so.

6 posted on 09/04/2011 5:59:16 PM PDT by decimon
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To: decimon

bttt


7 posted on 09/04/2011 6:00:58 PM PDT by TEXOKIE (Anarchy IS the strategy of the forces of darkness!)
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To: decimon

is this also in grape juice? or only after it is made into wine?


8 posted on 09/04/2011 6:07:16 PM PDT by Mr. K (Physically unable to proofread....)
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To: decimon

Are you talking about the Resveratrol?


9 posted on 09/04/2011 6:11:54 PM PDT by ducttape45
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To: ducttape45
Are you talking about the Resveratrol?

Along with other supplements, yes. I just saw that CVS has a two-fer sale on Nature's Bounty supplements. That should include resveratrol as either Red Wine or Grape Seed extract. Could be worth a look if there's a CVS near you. If there's not a CVS near you then some other drugstore chain may have a similar sale. Those sales come so often that it's hardly worth buying at any other time.

10 posted on 09/04/2011 6:21:23 PM PDT by decimon
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To: decimon

I think muscadine grapes have a crapload of resveratrol in them.


11 posted on 09/04/2011 6:26:28 PM PDT by aruanan
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To: ducttape45
Resveratrol is one of the few supplements that seem to actually have good science behind them (the others being Fish Oil and Vit D).

The only problem now is that you really dont know what you are getting when you buy it, there is no standardization or regulation. Look for a reputable supplement manufacturer.

12 posted on 09/04/2011 6:34:05 PM PDT by Paradox (Obnoxious, Bumbling, Absurd, Maladroit, Assinine)
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To: RussP

Consumerlab (needs subscription) says a good quality, inexpensive (~ 20 cents per 100 mg) is from Biotivia.
You can get 500 mg tablets — others only have 100 mg tablets, so you have to take a lot and some cost as much as 45 cents per 100 mg.

http://www.biotivia.com/transmaxresveratrol.html

If you want to check out consumerlabs, it’s

http://www.consumerlab.com

It’s $20+ for a 1 year subscription and they publish research about supplements, whether they have what they say they have,quality, price, etc. I find it’s worth the subscription price, you can save money on the supplements.

also — some list larger amounts but the “trans-resveratrol” amount is what counts.


13 posted on 09/04/2011 6:40:57 PM PDT by Clairity ("The United States needs to be not so much loved as it needs to be respected." -- VP Dick Cheney)
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To: decimon
thanks, for the information.
i take Omega 3 & this supp.

14 posted on 09/04/2011 6:46:06 PM PDT by skinkinthegrass (Who can take tomorrow, Spend it all today? Who can take your income And tax it all away? Obama Man :)
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To: RussP

Another place where you can order pure and reasonably priced resvratrol:

http://www.revgenetics.com/


15 posted on 09/04/2011 6:46:26 PM PDT by Clairity ("The United States needs to be not so much loved as it needs to be respected." -- VP Dick Cheney)
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To: Paradox; skinkinthegrass
Resveratrol is one of the few supplements that seem to actually have good science behind them (the others being Fish Oil and Vit D).

That may be so. Maybe green tea or other teas are as proven.

16 posted on 09/04/2011 7:12:52 PM PDT by decimon
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To: ducttape45

This product reduces antioxidants to a twenty year old level. It is all natural and the professor that is
being shown on the video is for real, not an actor.
He has been working on this product for decades and it
is a wonderful discovery. I’ve been taking it four months and have lower blood pressure. There a lot of good
testimonies that it helps many types of illnesses. Take a look.
http://www.mylifevantage.com/radio/default.aspx


17 posted on 09/04/2011 8:22:06 PM PDT by Cowgirl
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To: ducttape45

This suggestion may help. Systemic enzymes of
Plant and animal sources have shown benefits in
numerous studies, including human case analysis.
Plant sources stay active for about 8 hours and
Animal sources for about 36. Should be enteric
coated. As for antioxidants, they work best in
A synergistic environment(formula) void of iron
And copper. Good luck! Dose depends on severity
Of symptoms.


18 posted on 09/04/2011 8:28:08 PM PDT by mazz44
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To: yefragetuwrabrumuy

First of all, it takes a LOT of Resveratrol, I’m talking buckets full, to get the best of its health benefits.

++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++

It’s in wine, right?


19 posted on 09/04/2011 8:39:47 PM PDT by loungitude ( The truth hurts.)
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To: decimon

bump.


20 posted on 09/04/2011 8:49:48 PM PDT by ken21 (ruling class dem + rino progressives -- destroying america for 150 years.)
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To: Cowgirl

You obviously have more than a casual interest in that product.


21 posted on 09/04/2011 8:53:31 PM PDT by decimon
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To: loungitude

Resveratrol is a very good antioxidant, among other things. It is derived from either Japanese Knotweed or from Mascadine GrapesThe type derived from grapes has better activity, especially when combined with the skins of the grape. Dosages should be 400-600 mg. Of trans-resveratrol, which is standardized from resveratrol. NutraBio.com has the best product for the price and does not contain fillers. You can get bulk pricing. For all who need help, metabolic syndrome is most likely caused from glycation, which is caused by too many carbohydrates coupled with a toxicity to environmental toxins of other chemicals put into refined, packaged food. Systemic Enzymes help to limit glycation. Also, cinnamon is another good spice to use on a daily basis. Hope everyone finds this useful.


22 posted on 09/04/2011 9:08:28 PM PDT by mazz44
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To: loungitude

Just tiny amounts are in wine.


23 posted on 09/04/2011 9:11:05 PM PDT by yefragetuwrabrumuy
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To: RussP

It’s pretty pricey about anywhere.


24 posted on 09/04/2011 9:11:59 PM PDT by yefragetuwrabrumuy
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To: ducttape45

What do you do now?


25 posted on 09/04/2011 9:14:06 PM PDT by mlo
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To: yefragetuwrabrumuy

That can only mean one thing.....


26 posted on 09/04/2011 9:35:00 PM PDT by loungitude ( The truth hurts.)
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To: mlo; mazz44; Cowgirl; Paradox
Nothing.

A local doctor had me try Byetta a couple of years ago. The meds made me sick and tired, but the doctor said it would pass in about 3 weeks and start working. But after 4-5 weeks of being sick and tired, I got sick and tired of being sick and tired so I stopped using it.

So I haven't done anything for about 2 years. It's interesting; I've been going over some medical records from about 3-4 years ago, and the results of a scan came back showing the possibility of a growth on my thyroid gland. If memory serves, the thyroid gland is what regulates the body's metabolism. I wonder if there is a connection. I saw this article online one day and I wonder if I have the same thing Nolin has:

Gena Lee Nolin - Thyroid Illness

I'd like to have that checked out again, but in the meantime I'll check out what was posted here in this thread and see what happens. Thanks all for your suggestions.

27 posted on 09/05/2011 7:13:08 AM PDT by ducttape45
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To: RussP
Where do you get it? It’s a bit pricey at GNC.

Try Resveratrol at Nutrition Express

28 posted on 09/05/2011 8:23:28 AM PDT by Uri’el-2012 (Psalm 119:174 I long for Your salvation, YHvH, Your law is my delight.)
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To: ducttape45

You should completely eliminate sugar from your diet as the first basic step.


29 posted on 09/05/2011 8:24:57 AM PDT by mlo
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To: ducttape45

Another suggestion with regards to your thyroid issue. An overgrowth of Candida Albicans can cause thyroid disorders. However, typical thyroid tests will not indicate this. You must have a Candida antibody test. The pitfall is only 1 out of 6 physicians have the necessary knowledge about Candida and how it effects our entire body and organ systems. Many people who have metabolic syndrome will show a high antibody level and high, whats called RT3(reverse T3) numbers. Candida is silent and does not always present itself as skin erruptions or nail fungus. Lastly, bromide toxicity plays a large role in thyroid disfunction as it competes for Iodine, for the lone receptor site. Many baked goods use brominated flour. It is in plastics, fire retardents,computer keyboards and screens, clothing, soda and other textiles. Unfortunately, some people have a lower tolerance to this. The good news is that diet and proper supplementation can reverse anything, if it is implemented soon enough and there is a willingness to follow through. Good luck!


30 posted on 09/05/2011 3:34:04 PM PDT by mazz44
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To: ducttape45
See the following links about Candida.
31 posted on 09/05/2011 3:45:19 PM PDT by aruanan
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To: ducttape45
As far as bromine inhibiting thyroid function, note the following:

"Bromine can replace [iodine] on position 5 of both T(3) and T(4) with no loss of thyroid hormone activity."

From,
Exp Biol Med (Maywood). 2004 Jun;229(6):473-8.
Iodine toxicity and its amelioration.
Baker DH.
Department of Animal Sciences and Division of Nutritional Sciences,
290 Animal Sciences Laboratory,
University of Illinois

32 posted on 09/05/2011 3:53:58 PM PDT by aruanan
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To: aruanan; mazz44; mlo; decimon
You've all given me many things to ponder.

I think I'm gonna change doctors and see what happens. I need to have everything all checked out, again, and see what the docs say. Resveratrol is an interesting item to check out and I will next time I'm near a CVS (thanks decimon).

In the meantime, we'll see what happens. Thanks again for everything.

33 posted on 09/05/2011 4:45:28 PM PDT by ducttape45
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To: aruanan

As for Thyroid activity not being changed, it is not the immediate concern. The study states it “can”. That is not definitive.

The function of the Thymus gland is what gets affected first, along with adrenal function and metabolism of fats. Also, Bromine makes Iodine become like water to the body, and it just flushes it out. It also can cause “False” Thyroid tests that show normal limits. Long term toxicity, will then begin to cause disruption in function. Thyroid function is dependent on the Thymus gland. Lastly, Thyroid blood tests are one of the most inaccurate of medical tests.

It could be one of the reasons Thyroid disfunction is on the rise, due to the replacement of Iodine with Bromine in the flour industry over the last 50-60 years.

You can research more at drmercola.com and google search dr.brownstein and bromide toxicity. You can come to your own truthful conclusions. In my practice, this is what I see on a weekly basis.


34 posted on 09/05/2011 6:21:28 PM PDT by mazz44
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To: ducttape45

Almost forgot! You can check out “The Bromide Dominance Theory.” Just google it.


35 posted on 09/05/2011 6:21:31 PM PDT by mazz44
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To: ducttape45

You are WELCOME! NutraBio.com best for Resveratrol. Take care!


36 posted on 09/05/2011 6:21:37 PM PDT by mazz44
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To: ducttape45

As for Thyroid activity not being changed, it is not the immediate concern. The study states it “can”. That is not definitive.

The function of the Thymus gland is what gets affected first, along with adrenal function and metabolism of fats. Also, Bromine makes Iodine become like water to the body, and it just flushes it out. It also can cause “False” Thyroid tests that show normal limits. Long term toxicity, will then begin to cause disruption in function. Thyroid function is dependent on the Thymus gland. Lastly, Thyroid blood tests are one of the most inaccurate of medical tests.

It could be one of the reasons Thyroid disfunction is on the rise, due to the replacement of Iodine with Bromine in the flour industry over the last 50-60 years.

You can research more at drmercola.com and google search dr.brownstein and bromide toxicity. You can come to your own truthful conclusions. In my practice, this is what I see on a weekly basis.


37 posted on 09/05/2011 9:40:12 PM PDT by mazz44
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To: mazz44
In my practice...

You are a medical doctor?

38 posted on 09/06/2011 4:56:38 AM PDT by decimon
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To: decimon

I am a Certified Personal Trainer, Nutritional Specialist and will be getting my Doctor of Naturopathy license this year. I am also a product formulator. I have been engaged in the science and art of healing for the last 20 years. Most important, I am driven by helping people get fit, healthy and live longer and more productive lives.


39 posted on 09/06/2011 12:32:12 PM PDT by mazz44
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To: mazz44

You’re singin’ my song! I am just now getting around to reading the resveratrol thread and see that you’re proficient in iodine :)

I posted this thread the other night

http://www.freerepublic.com/focus/f-chat/2775065/posts?page=1

I’m working on getting my thyroid under control. I’m on 50mg iodoral, salt, mag, Vit C, B complex. All in all feeling really well. I am having difficulty getting my sugar under control and was reading up on taking higher doses of chromium picolonate.


40 posted on 09/09/2011 4:50:30 PM PDT by spacejunkie01
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To: mazz44
I don't use normal salt, at least, salt I can apply to my foods myself. I use Sea Salt, free of iodine. I've been told this is better for me. Granted, yes, there is plenty of salt in the foods we buy in the store so it's almost impossible to stay away from, but if I can I use the Sea Salt.

The metabolism of fats is my primary concern. That's what I've been told my body ISN'T doing. Metabolic syndrome is the condition I've been diagnosed with and honestly, no matter how much I exercise the weight just doesn't come off. Yes, I'll lose the initial 10-15 lbs, but after that my weight either levels off or I start gaining again. Most frustrating.

I tried using Byetta, but I got so sick and tired of being "sick and tired" that I stopped using it. I've read many articles about what could help, but frankly there is so much out there it's hard to know what is fact and fiction. Doc says I'll be diabetic within 5 years but I don't know what to do.

Any suggestions?

41 posted on 09/25/2011 11:45:59 AM PDT by ducttape45
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To: ducttape45

Hello, sorry to hear about your health challenges.

I do have some solutions for you. I am extremely busy the next couple of days. I will get back to you by Sunday.

Stay Srong!


42 posted on 09/28/2011 11:37:43 PM PDT by mazz44
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To: mazz44

No problem. You can Private Reply if you want. Thanks.


43 posted on 09/29/2011 6:56:35 AM PDT by ducttape45
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