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Cholesterol-lowering medication accelerates depletion of plaque in arteries
NYU Langone Medical Center / New York University School of Medicine ^ | December 13, 2011

Posted on 12/13/2011 12:11:01 PM PST by decimon

New study reveals molecular mechanism promoting the breakdown of plaque by statins

In a new study, NYU Langone Medical Center researchers have discovered how cholesterol-lowering drugs called statins promote the breakdown of plaque in the arteries...

The findings support a large clinical study that recently showed patients taking high-doses of the cholesterol-lowering medications not only reduced their cholesterol levels but also reduced the amount of plaque in their arteries. However, until now researchers did not fully understand how statins could reduce atherosclerosis, the accumulation of fat and cholesterol that hardens into plaque in arteries, a major cause of mortality in Western countries. High blood cholesterol is a major culprit in atherosclerosis. As a result of narrowing arteries, blood clots can form or plaque can break off causing blockages in vessels. This can lead to a potentially fatal heart attack or stroke.

"Our new research shows statins actually promote the regression of atherosclerosis by altering the expression of a specific cell surface receptor within plaque cells," said co-author of the study, Edward Fisher, MD, PhD, Leon H. Charney Professor of Cardiovascular Medicine and director of the Marc and Ruti Bell Vascular Biology Program at NYU Langone Medical Center. "This molecular phenomenon helps dissolve plaque by expelling coronary artery disease-causing cells from the plaque lining the arteries."

The NYU Langone study reveals how statins promote the transformation of arterial plaques by activating a protein that sits on the surface of macrophages, immune cells that are prevalent in plaque. The immune system sends macrophages to clean up cholesterol deposits in arteries, but once they fill up with the bad form of cholesterol they get stuck in the arteries, triggering the body's inflammatory response. The bloated macrophages then become major components of plaque lining artery walls.

(Excerpt) Read more at eurekalert.org ...


TOPICS: Health/Medicine; Science
KEYWORDS: anuerysms; arteryplaque; atherosclerosis; cholesterol; coq10; dangerous; kidneydamage; lecithin; myopathy; plaque; statins

1 posted on 12/13/2011 12:11:04 PM PST by decimon
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To: neverdem; DvdMom; grey_whiskers; Ladysmith; Roos_Girl; Silentgypsy; conservative cat; ...

Ping


2 posted on 12/13/2011 12:12:07 PM PST by decimon
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To: neverdem; DvdMom; grey_whiskers; Ladysmith; Roos_Girl; Silentgypsy; conservative cat; ...

Ping


3 posted on 12/13/2011 12:12:31 PM PST by decimon
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To: decimon

Lecithin does the same thing for pennies a dose.
You can buy it without prescription at any health-food
store or online.

Also, no side effects.


4 posted on 12/13/2011 12:22:38 PM PST by aMorePerfectUnion (You know, 99.99999965% of the lawyers give all of them a bad name)
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To: aMorePerfectUnion

Studies. links, proof ?


5 posted on 12/13/2011 12:27:43 PM PST by UB355 (Slower traffic keep right)
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To: UB355

Google is your friend. Unfortunately, I’m at work and they don’t pay me to do research for FR here... :-(


6 posted on 12/13/2011 12:51:30 PM PST by aMorePerfectUnion (You know, 99.99999965% of the lawyers give all of them a bad name)
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To: aMorePerfectUnion
Wiki says just the opposite...

New studies suggest gut bacteria metabolites of choline promote atherosclerosis in mice through TMAO production and "augmented macrophage cholesterol accumulation and foam cell formation". [6] Mice fed with egg-yolk derived lecithin, developed arterial plaque in spite of no increase in cholesterol or triglyceride levels.[7]

7 posted on 12/13/2011 12:54:49 PM PST by blasater1960 (Deut 30, Psalm 111...the Torah and the Law, is attainable past, present and forever.)
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To: aMorePerfectUnion

OK, stick to your day job.


8 posted on 12/13/2011 12:58:06 PM PST by steve86 (Acerbic by nature, not nurture (Could be worst in 40 years))
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To: decimon
I started taking red rice yeast, a natural statin, about 7 years ago. Along with fish oil, and niacin.

My cholesterol dropped from 248 to 195, with a high ratio of HDL (good) to LDL (bad) cholesterol. It has been the same ever since.

9 posted on 12/13/2011 1:26:52 PM PST by Victor (If an expert says it can't be done, get another expert." -David Ben-Gurion, the first Prime Minister)
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To: decimon
From the end of the article:

"This research study was supported by funding from the National Institutes of Health, Astra Zeneca and Pfizer. "

Feel free to draw your own conclusions. I have.

10 posted on 12/13/2011 1:53:35 PM PST by woodchukwood ("The only thing that saves us from the bureaucracy is its inefficiency." -E. McCarthy)
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To: Victor

Good show! What dietary changes did you make, if any? Am taking RYR now along with niacin and fish oil plus cinnamon and turmeric and some other vitamins.


11 posted on 12/13/2011 2:01:47 PM PST by miele man
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To: decimon

Want your cholesterol numbers to go down?

Walk 20-30 minutes outside with a lot of your skin exposed to decent sunlight.

YOur body will convert cholesterol into vitamin D. Not only do you decrease cholesterol, you increase vitamin D, essential for your immune system to function properly and efficiently.


12 posted on 12/13/2011 2:32:33 PM PST by Secret Agent Man (I'd like to tell you, but then I'd have to kill you.)
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To: decimon
Speaking for myself....and myself only....

YOU GO, STATINS!!

13 posted on 12/13/2011 2:35:21 PM PST by Logic n' Reason (N/A)
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To: decimon; Mother Abigail; EBH; vetvetdoug; Smokin' Joe; Global2010; Battle Axe; null and void; ...
immunology ping

Statins Promote the Regression of Atherosclerosis via Activation of the CCR7-Dependent Emigration Pathway in Macrophages

That's a FReebie.

IIRC, according to one of my pathology teachers, pathologists found fatty streaks in the aortas of our young, otherwise formerly healthy casualties during the Korean War.

14 posted on 12/13/2011 3:10:51 PM PST by neverdem (Xin loi minh oi)
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To: neverdem

bfl


15 posted on 12/13/2011 4:01:13 PM PST by katykelly
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To: Secret Agent Man
Want your cholesterol numbers to go down? Walk 20-30 minutes outside with a lot of your skin exposed to decent sunlight. YOur body will convert cholesterol into vitamin D. Not only do you decrease cholesterol, you increase vitamin D, essential for your immune system to function properly and efficiently.



Everybody is unique. What works for some, might not for others. I did what you said and my results were different. It did lower overall cholesterol, HDL, but had no effect on LDL at all. So I switched to Vit D-3 @1000 iu, same results. Nothing I, or my Dr., has done has had a positive impact on my HDL being too low. It seems I'm stuck at 84x6 months now. I still take Vit D-3, since I have witnessed other improvements in my health that my Dr. attributes to it.

16 posted on 12/13/2011 4:07:24 PM PST by papasmurf (I pledge to vote (R). How 'bout you?)
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To: Victor

Since I have had bad reactions to the 5 Statins I was prescribed, I now take Niacin (Niaspan) and Omega-3 (fish oil). I’ve actually had results that matched my best Statin results, and no side effects.


17 posted on 12/13/2011 4:10:22 PM PST by papasmurf (I pledge to vote (R). How 'bout you?)
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To: papasmurf
I had bad results to the couple of statins. I am now taking a very low dose of something called Livolo and have not had any ill effects. It is working too.
18 posted on 12/13/2011 4:14:22 PM PST by Ditter
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To: Ditter

Livalo is also a statin. I used it for about two months and had anomalies in my blood tests for liver and the kidney. Last test showed them lessening. I’m still aching from muscle pain due to taking Simvastatin. Man, I sure wish this would settle down.


19 posted on 12/13/2011 5:05:26 PM PST by papasmurf (I pledge to vote (R). How 'bout you?)
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To: papasmurf
20% of the population should normally have a bad (painful) reaction to all but one statin.

Several solutions if you've just got to use them are: (1) Lower the dose to where you don't get the pain, (2) Check into the enzymes that will help you metabolize them, (3) Give up grapefruit or any other food or food byproduct that creates an overdose situation.

20 posted on 12/13/2011 5:14:02 PM PST by muawiyah
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To: papasmurf

My dose of Livolo is so small. I get 8 1mg tabs, cut them in half and take one half every other day. that last me one month. My cholestrol dropped 100 points in 2 months. I have a lot of trouble with reactions to prescription drugs, I feel really lucky that I can take this one....... so far so good! :D


21 posted on 12/13/2011 5:18:27 PM PST by Ditter
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To: muawiyah

We did try dosing adjustments, and even different brands. I was aware of the grapefruit issue before I started taking them, so that wasn’t an issue. BUT...# 2 is something new to me, I’ll look into it. Thanks.


22 posted on 12/13/2011 5:39:34 PM PST by papasmurf (I pledge to vote (R). How 'bout you?)
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To: papasmurf

hdl should read 34, not 84. duh!


23 posted on 12/13/2011 5:40:45 PM PST by papasmurf (I pledge to vote (R). How 'bout you?)
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To: papasmurf

I believe if you take a very good absorbable calcium supplement along with your D, you can increase the amount of D and calcium (both) you can absorb.

In general most people are way, way low on vitamin D. I know doctors who take 10-20,000 IU of D a day. And then bump it up more in the winter.

Considering your body can make 50,000 IU with decent skin exposure for a half hour at peak sun, almost everyone is deficient.


24 posted on 12/13/2011 5:43:18 PM PST by Secret Agent Man (I'd like to tell you, but then I'd have to kill you.)
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To: papasmurf

If you want to lower LDL, I thought eating oatmeal was good for that.


25 posted on 12/13/2011 5:44:52 PM PST by Secret Agent Man (I'd like to tell you, but then I'd have to kill you.)
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To: papasmurf; Kellis91789
There are other Freepers who knew about the enzymes and suggested we use them. I named one above ( kellis91789 ).

Since I don't use the enzyme he names ( Co Enzyme Q10 ) he might have more information to pass along to you.

My doctor didn't think that would be of much interest to me since my cholesterol levels were already LOW ~ although she thinks I should stick to a low dose for the plaque effects.

26 posted on 12/13/2011 5:50:32 PM PST by muawiyah
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To: miele man
"....Good show! What dietary changes did you make, if any? Am taking RYR now along with niacin and fish oil plus cinnamon and turmeric and some other vitamins....."

No other dietary changes. In fact, I eat eggs almost every day, red meat about once a week, ice cream when I get the urge, and of course pasta every Sunday ( I am Italian, after all).

I don't know about cinnamon and tumeric. How do they help...?

27 posted on 12/13/2011 6:03:39 PM PST by Victor (If an expert says it can't be done, get another expert." -David Ben-Gurion, the first Prime Minister)
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To: decimon

Studies show that higher cholesterol could slash your stroke risk by nearly 300%!
William Campbell Douglass, M.D.
Keeping cholesterol levels HIGHER can...
• Revive your sex drive...
• Lower your likelihood of cancer...
• Improve your brain function...
• And make you far less likely to die!
That’s because of one simple truth: Cholesterol is not your enemy!
1. HIGHER cholesterol makes you far less likely to die...
FACT: Lowering cholesterol can make heart disease worse. A review of medical studies on cholesterol and mortality in heart patients found that lower cholesterol levels led to death––not survival, like the drug companies want you to think.
FACT: Low cholesterol can trigger the deadliest kind of stroke. It’s called a massive stroke and it happens when blood vessels in your brain are so weak, they burst open. Any cholesterol count below 200 is a red flag for this kind of stroke.
FACT: Low cholesterol may raise your cancer risk. Yes, a new study actually links low LDL levels with an increased risk of developing cancer. And it’s not the first one. In fact, more than 20 studies have been done on cholesterol and cancer. And the overall majority linked cancer with low cholesterol!
How could all this be so? For the same reason that your body makes its own cholesterol. It’s a vital nutrient! Cholesterol is a necessary building block for your immune system and especially your brain cells. In fact...
2. HIGHER cholesterol may improve your memory, stave off depression and even protect you from Alzheimer’s...
Believe it or not, healthy brain cells are chock full of cholesterol. Yup, 25% of your body’s cholesterol is in your brain. It fuels the electrical impulses that make thinking possible. Plus, studies show...
FACT: Low cholesterol impairs brain function. It’s been linked to depression. And cholesterol-lowering drugs have been shown to trigger memory loss. (Drug companies want us to forget this — and we may – if we keep taking statin drugs!)
FACT: Low cholesterol is linked to Alzheimer’s. The eminent researcher Iwo J. Bohr recently published a peer-reviewed paper on the subject. He points out that Alzheimer’s patients typically have lower cholesterol and suggests that a great way to prevent the disease may be to eat a high cholesterol diet.
FACT: Low cholesterol is even linked to suicide ––and it’s not just because folks are fed up with celery and tofu! The real reason is probably that low cholesterol literally makes you crazy!
And now for some upbeat news...
3. HIGHER cholesterol could super-charge anyone’s sex life...
Why? Because cholesterol is the “raw material” for your sex hormones. Without it, you can’t manufacture testosterone, women can’t make estrogen––and none of us would have any more sex drive than an earthworm!
Now aren’t you ecstatic
that your cholesterol is over 200?
If it isn’t, think of all the fun you’ll have getting it back up to healthy levels!


28 posted on 12/13/2011 6:05:40 PM PST by GGpaX4DumpedTea (I am a tea party descendant - steeped in the Constitutional legacy handed down by the Founders)
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To: papasmurf
"...Since I have had bad reactions to the 5 Statins I was prescribed, I now take Niacin (Niaspan) and Omega-3 (fish oil). I’ve actually had results that matched my best Statin results, and no side effects....."

Try adding red rice yeast to your diet; a natural statin....it seems that the trio of niacin, red rice yeast, and fish oil is what really works over the long term.

29 posted on 12/13/2011 6:10:37 PM PST by Victor (If an expert says it can't be done, get another expert." -David Ben-Gurion, the first Prime Minister)
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To: muawiyah

CoQ10 in addition to being a powerful antioxidant is also part of the Krebs cycle in the mitochondria of the cells that make the energy “stuff” of the cells, adenosine triphosphate.

ATP is the actually fuuel of the cells that provides energy by donating phosphate groups, then it gets turned into Adenosine di-phosphate, goes back and gets recycled and once again becomes ATP.

The body “burns” sugars and fats for one and one reason: to manufacture ATP.
(the liver does alot of stuff with fats, but it’s not part of the respiratory cycle).

I have read estimates that a healthy young adult man or woman manufactures/recycles THEIR BODY WEIGHT of ATP in a day!

CoQ10 levels in the cells start to drop significantly in the mid-forties and decline faster after that.


30 posted on 12/13/2011 6:20:15 PM PST by djf (http://www.freerepublic.com/focus/f-chat/2801220/posts)
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To: djf

About 4 AM your liver gives you a shot of sugar. The liver does things with fats, and it does things with sugars ~ just like honeybees. Check http://biology.about.com/library/organs/bldigestliver5.htm


31 posted on 12/13/2011 6:27:49 PM PST by muawiyah
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To: GGpaX4DumpedTea

http://jcem.endojournals.org/content/early/2011/11/10/jc.2011-1846.abstract suggests parts of what you cite are wrong, or you are giving them the wrong slant. Low cholesterol, per se, doesn’t hurt anyone.


32 posted on 12/13/2011 6:33:04 PM PST by muawiyah
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To: muawiyah

Not surprising at all. Figure by 4 am the average person has probably not eaten anything for 6 hours or more.

Something I have come to realize over the years is that sleep itself is NOT a period of inactivity like suspended animation or something! Sleep is probably the time when the actual biochemistry of the body is in highest gear, synthesizing proteins, cell division and repair, all the good stuff!

Lots of times I sweat like crazy when I sleep. Way more than if I’m out doing physical activity like gardening or even on my stair-stepper.


33 posted on 12/13/2011 6:39:46 PM PST by djf (http://www.freerepublic.com/focus/f-chat/2801220/posts)
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To: muawiyah; papasmurf

Supposedly, statins reduce the body’s production of cholesterol which is good if you have too much, but they also decrease the production of CoQ10 in the body. Low levels of CoQ10 can mean muscle and nerve pain, so a CoQ10 supplement can help. For me, it reduced the frequent muscle aches I got after starting on Simvastatin.

http://www.ehow.com/facts_5792113_coq10-statin-drugs.html


34 posted on 12/14/2011 3:53:55 AM PST by Kellis91789 (The ultimate result of shielding men from the effects of folly is to fill the world with fools.)
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