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New synthetic molecules treat autoimmune disease in mice
Weizmann Institute of Science ^ | December 25, 2011

Posted on 12/25/2011 11:25:41 AM PST by decimon

A team of Weizmann Institute scientists has turned the tables on an autoimmune disease. In such diseases, including Crohn's and rheumatoid arthritis, the immune system mistakenly attacks the body's tissues. But the scientists managed to trick the immune systems of mice into targeting one of the body's players in autoimmune processes, an enzyme known as MMP9. The results of their research appear today in Nature Medicine.

Prof. Irit Sagi of the Biological Regulation Department and her research group have spent years looking for ways to home in on and block members of the matrix metalloproteinase (MMP) enzyme family. These proteins cut through such support materials in our bodies as collagen, which makes them crucial for cellular mobilization, proliferation and wound healing, among other things. But when some members of the family, especially MMP9, get out of control, they can aid and abet autoimmune disease and cancer metastasis. Blocking these proteins might lead to effective treatments for a number of diseases.

Originally, Sagi and others had designed synthetic drug molecules to directly target MMPs. But these drugs proved to be fairly crude tools that had extremely severe side effects. The body normally produces its own MMP inhibitors, known as TIMPs, as part of the tight regulation program that keeps these enzymes in line. As opposed to the synthetic drugs, these work in a highly selective manner. An arm on each TIMP is precisely constructed to reach into a cleft in the enzyme that shelters the active bit – a metal zinc ion surrounded by three histidine peptides – closing it off like a snug cork. 'Unfortunately,' says Sagi, 'it is quite difficult to reproduce this precision synthetically.'

(Excerpt) Read more at eurekalert.org ...


TOPICS: Health/Medicine; Science
KEYWORDS: autoimmunedisease; biotechnology; enzymes; mice; mouse

1 posted on 12/25/2011 11:25:43 AM PST by decimon
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To: neverdem; DvdMom; grey_whiskers; Ladysmith; Roos_Girl; Silentgypsy; conservative cat; ...

Ping


2 posted on 12/25/2011 11:26:06 AM PST by decimon
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To: decimon

My family has gotten out of control with their mp9s. Shot up the neighborhood.


3 posted on 12/25/2011 11:44:47 AM PST by blueunicorn6 ("A crack shot and a good dancer")
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To: blueunicorn6

I asked the Oracle, “What is the matrix metalloproteinase?”.


4 posted on 12/25/2011 1:54:47 PM PST by BipolarBob (Of all the taglines in all the posts in all the world and she read mine.)
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To: decimon

Thank God. It’s heartbreaking to watch a mouse suffer with autoimmune disease.


5 posted on 12/25/2011 1:54:47 PM PST by the invisib1e hand (omg - obama must go!)
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To: the invisib1e hand

A Christmas story where you really feel good inside, don’t you know?


6 posted on 12/25/2011 1:55:46 PM PST by BipolarBob (Of all the taglines in all the posts in all the world and she read mine.)
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To: the invisib1e hand

Oops, I thought you said heart warming, not heart breaking. My bad.


7 posted on 12/25/2011 1:56:45 PM PST by BipolarBob (Of all the taglines in all the posts in all the world and she read mine.)
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To: decimon

“Pinky, are you pondering what I’m pondering?”
“I dunno, Bwain...but I feel as fit as a fiddle!”


8 posted on 12/25/2011 2:03:53 PM PST by RichInOC (No! BAD Rich! (What'd I say?))
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To: RichInOC
Keep it up, Rich, you're on a roll!

...oh, and Merry Christmas!

9 posted on 12/25/2011 2:09:58 PM PST by grey_whiskers (The opinions are solely those of the author and are subject to change without notice.)
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To: decimon
I really hope this pans out. It's been nearly 2 years since my last serious Crohns disease flare up (I spent all of Feb & March, 2010 in the hospital, the first month on IV antibiotics), I've had 9 surgeries in less than 2 years, and I still haven't gotten "back to normal," though I've been back at work - But that's about all I do now.

A cure for Crohns or Rheumatoid Arthritis would be a really wonderful step forward for medicine, improving the lives of many millions of people.

Mark

10 posted on 12/25/2011 2:35:05 PM PST by MarkL (Do I really look like a guy with a plan?)
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To: MarkL

You had to go and mess up this thread with a serious comment?


11 posted on 12/25/2011 2:49:31 PM PST by Misterioso
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To: MarkL

Bless you. I hope they find something soon. And I agree.


12 posted on 12/25/2011 3:03:02 PM PST by brytlea (An ounce of chocolate is worth a pound of cure)
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To: decimon

Bookmark


13 posted on 12/25/2011 3:13:17 PM PST by GOP Poet (Time for Bambi and his commie crew to go.)
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To: MarkL

Yes. I agree and bless you Mark. Glad to hear it has been awhile.


14 posted on 12/25/2011 3:25:20 PM PST by GOP Poet (Time for Bambi and his commie crew to go.)
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To: Misterioso

Take a hike. Idiot.


15 posted on 12/25/2011 3:27:04 PM PST by GOP Poet (Time for Bambi and his commie crew to go.)
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To: MarkL

I also suffer from this. This is good news.


16 posted on 12/25/2011 4:15:46 PM PST by freepertoo
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To: freepertoo

bump for chrone’s cure.


17 posted on 12/25/2011 5:47:10 PM PST by AdvisorB (Dilma is "hope and change" Brazilian style.)
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To: AdvisorB
bump for chrone’s cure.

Crohns?
18 posted on 12/25/2011 5:49:03 PM PST by aruanan
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To: MarkL; freepertoo; afnamvet; decimon; Mother Abigail; EBH; vetvetdoug; Smokin' Joe; Global2010; ...
immunology ping

I really hope this pans out. It's been nearly 2 years since my last serious Crohns disease flare up (I spent all of Feb & March, 2010 in the hospital, the first month on IV antibiotics), I've had 9 surgeries in less than 2 years, and I still haven't gotten "back to normal," though I've been back at work - But that's about all I do now.

A cure for Crohns or Rheumatoid Arthritis would be a really wonderful step forward for medicine, improving the lives of many millions of people.

Antibodies targeting the catalytic zinc complex of activated matrix metalloproteinases show therapeutic potential

This was brilliant, IMHO.

FReepmail me if you want on or off my combined microbiology/immunology ping list.

19 posted on 12/26/2011 11:59:27 PM PST by neverdem (Xin loi minh oi)
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To: 2ndreconmarine; Fitzcarraldo; Covenantor; Mother Abigail; EBH; Dog Gone; ...

Ping! (Thanks, decimon!)


20 posted on 12/27/2011 12:05:42 AM PST by Smokin' Joe (How often God must weep at humans' folly. Stand fast. God knows what He is doing)
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To: 2ndreconmarine; Fitzcarraldo; Covenantor; Mother Abigail; EBH; Dog Gone; ...

Ping! (Thanks, decimon!)


21 posted on 12/27/2011 12:05:55 AM PST by Smokin' Joe (How often God must weep at humans' folly. Stand fast. God knows what He is doing)
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To: 2ndreconmarine; Fitzcarraldo; Covenantor; Mother Abigail; EBH; Dog Gone; ...

Ping! (Thanks, decimon!)


22 posted on 12/27/2011 12:06:29 AM PST by Smokin' Joe (How often God must weep at humans' folly. Stand fast. God knows what He is doing)
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To: MarkL

I was diagnosed with Crohn’s Disease back in ‘04 and like you I was suffering until Remicade literally cured me. Also, I’ve heard others use Humira and that drug works great too. However, I know both drugs are not for everyone but have you tried one of them?


23 posted on 12/27/2011 12:09:46 AM PST by MinorityRepublican
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To: neverdem

Thank you for the ping, neverdem!


24 posted on 12/27/2011 12:12:38 AM PST by Smokin' Joe (How often God must weep at humans' folly. Stand fast. God knows what He is doing)
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To: MarkL

Just some FYI articles you might find interesting.

http://www.eurekalert.org/pub_releases/2011-01/nu-npc012611.php

http://www.webmd.com/ibd-crohns-disease/crohns-disease/news/20040519/wormy-cocktail-fights-crohns-disease


25 posted on 12/27/2011 7:09:19 AM PST by yefragetuwrabrumuy
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To: neverdem

Thanks for the ping neverdem. I jusy passed the 38 year mark with Crohn’s. Nine major surgeries and now doing OK on Remecade.


26 posted on 12/27/2011 8:35:15 AM PST by afnamvet (Patriots Rising.....Donate to Free Republic....... It's the right thing to do.)
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To: Smokin' Joe

Awesome news.

I became familiar with this complicated topic years ago, fortunately for unrelated reasons. It’s a scary enmeshed state for the immune system to be in.


27 posted on 12/27/2011 7:27:40 PM PST by Gene Eric (C'mon, Virginia -- are you with us or against us?!)
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