Skip to comments.Cancer drug also reverses Alzheimer's disease in mice: Hope for humans?
Posted on 02/17/2012 8:24:49 AM PST by SeekAndFind
A new study of a promising Alzheimer's treatment has doctors buzzing that the drug may reverse the deadly neurodegenerative disease. But the new treatment isn't a new drug at all, rather a skin cancer pill that's been FDA-approved for more than a decade.
The drug, bexarotene, reversed signs of Alzheimer's in mice brains and also improved their memory in as little as 72 hours, according to the study.
"This is an unprecedented finding," study author Paige Cramer, a PhD candidate at Case Western Reserve School of Medicine, said in a university written statement. "Previously, the best existing treatment for Alzheimer's disease in mice required several months to reduce plaque in the brain."
Bexarotene - sold under the brand name Targretin - was approved by the FDA in 1999 for treating cutaneous T-cell lymphoma, a cancer of the white blood cells that primarily affects the skin. But the drug also happens to switch on a gene that makes a naturally occurring protein in the brain called Apolipoprotein E, or ApoE.
Previous research by study co-author Dr. Gary Landreth, a professor of neurosciences at Case Western Reserve, showed that ApoE could help facilitate the removal of amyloid beta proteins, which are a toxic substance in the brain that causes plaque buildup that's a marker for Alzheimer's
Dr. Landreth and his grad student, Cramer, thought if they could use this drug to increase ApoE, then maybe they could reduce some of the plaques in mice that were genetically bred to have Alzheimer's. The researchers found that the drug caused a 50 percent reduction in the amount of amyloid plaques within only three days, and after 14 days, they saw a 75 percent reduction. The drug essentially "reprogrammed" the brain's immune cells to "eat" the amyloid plaques.
(Excerpt) Read more at cbsnews.com ...
Ok, but before we roll this out on humans, let’s wait six months and make sure the mice don’t become super-intelligent and highly aggressive, and lead a rebellion against their captors.
How do I invest?
Interesting on the warnings ... Targretin = (Bexarotene)
Bexarotene may be harmful if it gets on the skin. Do not touch the capsules or powder from the capsules if they are broken or leaking. If the powder from a broken capsule gets on your skin, wash the area with soap and water immediately and call your doctor.
Wow, some nasty crap ...
No, but Soylent Green is...
Is there an interview with any of the mice? Uh. . . I forgot what I was going to say.
In the US, the patent on this drug expires in 2016.
If it really works in humans, it will be cheap as well as a breakthrough. OTOH, without someone standing to make a huge profit, it is hard to envision any company funding the research necessary.
It works for mouse brains? Oh, another drug for the Democrats.
What the heck has a mouse got to remember?
“Oh, what’s my pin number again? Honey, what’s my pin number? I’m trying to get cash for the weekend.”
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