100 Trillion Good Bacterias Are Living In Human Body: Report

iTech Post ^ | June 14, 2012 | Sarah Martinez

[nickcarraway]

Do you think bacteria, fungi and other microbes are harmful for your body? Discard the thought right away as a recent research has mapped and revealed that 100 trillion good bacteria are living in and on human body at every point of time and are contributing to good health.

The report presented on Wednesday was the result of a five-year, $173 million-worth US government initiative called the Human Microbiome Project which attempted to better examine bacteria, fungi and organisms - while all human bodies harbor trillions of bacteria but what they really are, how they differ from one person's body to another, how they coexist in harmony, play a significant role in digestion, synthesizing certain vitamins, forming immunity against disease-causing bacteria and more.

"Most of the time we live in harmony with them," said Eric Green, director of the National Human Genome Research Institute. But sometimes the harmony breaks down and we fall sick, cautioned Green.

The project, which was funded by the National Institutes of Health, involved 200 scientists at 80 institutions and bacteria taken from 242 healthy people and samples were taken from mouth, nose, skin, intestine and vagina. Researchers studied the DNA-sequencing machines used to map DNA in the Human Genome Project.

"This gives us a reference set of genes and microbes from healthy individuals," said James Servalovic, director of the Texas Children's Microbiome Center at Baylor College of Medicine and one of the researchers.

"This is really a new vista in biology," said Phillip Tarr, director of pediatric gastroenterology and nutrition at Washington University School of Medicine, St. Louis and one of the leaders of the Human Microbiome Project.

With the accomplishment, new avenues to research genetic predisposition will be open, believe scientists.

"It's likely this work will lead to new treatments for [the inflammatory bowel disorder] Crohn's disease, new treatments for diabetes and metabolic diseases, new treatments for even other diseases, like eczema," said Michael Fischbach to Wall Street Journal, a biologist at the University of California, San Francisco. Fischbach, however, was not part of the project.

Going ahead, scientists will do similar research sampling microbiomes of children, elderly and also Africans and South Americans. Diseased people will also be studied to discover how microbes play in maintaining health or causing disease.

The findings are published by Nature and the Public Library of Science.

[a fool in paradise]

A professor of chemistry wanted to teach his 5th grade class a lesson about the evils of liquor, so he produced an experiment that involved a glass of water, a glass of whiskey, and two worms.

"Now, class, closely observe the worms," said the professor while putting a worm into the water. The worm in the water writhed about, happy as a worm in water could be.

He then put the second worm into the whiskey. It curled up and writhed about painfully, then quickly sank to the bottom, dead as a doornail.

"Now, what lesson can we learn from this experiment?" the professor asked.

Lil' Johnny, who naturally sits in back, raised his hand and wisely, responded confidently, "Drink whiskey and you won't get worms!"

[yefragetuwrabrumuy]

I gather “coliform” is sometimes used, such as in medicine, as shorthand for coliform concentrations which contain other bacteria. By themselves, the coliform types are generally harmless, yet serve as an indicator of the likely presence of other bacteria, both harmless and pathogenic.

For example, health departments frequently test water for its level of coliform bacteria, beyond a certain concentration the assumption being that sewage or other source of contamination has been introduced.

Granted some forms of coliform bacteria, such as e. coli, can have dangerously pathogenic strains.

[kroll]

stupid regulatory regime at the FDA

It is stupid no doubt and also a bit behind the times. Take the example of the Bacteriophages that I was talking about - these are viruses which normally exist EVERYWHERE in nature and feed on bacteria. Since they are viruses, they evolve faster than the bacteria that they eat. Before penicillin was discovered, Phages were one of the treatments being considered for treatment of bacterial infections but they required a lot more understanding than what we did then (but do now). Unfortunately because they evolve so rapidly naturally, the FDA would treat each new strain of Phages as a new drug requiring an entire set of Phase - I-III trials. The FDA's regulatory regime is not prepared to compete with nature at the moment. Though its not a given that even with less regulation, antibiotics would work. Sometimes you actually need paradigm shifts.