To conquer interstellar space, first you must conquer time............
Is patience a way of conquering time? A large asteroid ark with an Oriion or nuclear salt-water drive could transport people to another star. Of course the people who arrive would be the great great grandchildren of the people who departed. However when you consider that by the time we would attempt such an adventure humanity would have been living in big orbital space colonies like the O'Neill cylinder and Bernal sphere. So for them the idea of living their lives in an artificial environment would not seem at all strange.