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Relapse of 'cured' HIV patients spurs AIDS science on
reuters.com ^ | Jan 2, 20114 | Kate Kelland

Posted on 01/04/2014 2:06:58 PM PST by ransomnote

(Reuters) - Scientists seeking a cure for AIDS say they have been inspired, not crushed, by a major setback in which two HIV positive patients believed to have been cured found the virus re-invading their bodies once more.

True, the news hit hard last month that the so-called "Boston patients" - two men who received bone marrow transplants that appeared to rid them completely of the AIDS-causing virus - had relapsed and gone back onto antiretroviral treatment.

But experts say the disappointment could lay the basis for important leaps forward in the search for a cure.

"It's a setback for the patients, of course, but an advance for the field because the field has now gained a lot more knowledge," said Steven Deeks, a professor and HIV expert at the University of California, San Francisco.

He and other experts say the primary practical message is that current tests designed to detect even very low levels of HIV present in the body are simply not sensitive enough.

As well as having the human immunodeficiency virus (HIV), the Boston patients both also had a type of blood cancer called lymphoma, for which they were treated using bone marrow transplants - one man in 2008 and the other in 2010.

They continued taking the antiretroviral AIDS drugs, but eight months after each patient's transplant, doctors found they could not detect any sign of HIV in their blood.

In the early part of 2013, both patients decided to stop taking their AIDS drugs and both appeared to remain HIV-free - prompting their doctors, Timothy Henrich and Daniel Kuritzkes from Boston's Brigham and Women's Hospital, to announce at a conference in July that they may have been cured.

(Excerpt) Read more at reuters.com ...


TOPICS: Miscellaneous
KEYWORDS: aids; cure; medicalresearch
So might this indicate that the AIDS tests commonly in use are not sensitive enough to accurately report whether bone marrow donation or blood has the aids virus? Is it that they couldn't test in a system as complex as the human body? If so, wouldn't the tested population in the US actually have higher levels of aids than currently reported?
1 posted on 01/04/2014 2:06:58 PM PST by ransomnote
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To: ransomnote

Research grants are inspiring, not crushing.


2 posted on 01/04/2014 2:12:19 PM PST by Berlin_Freeper (Mia San Mia)
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To: ransomnote

Just a further reminder that its a diseased world out there.


3 posted on 01/04/2014 2:12:52 PM PST by Viennacon
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To: Viennacon

Wonder if behavior modification was part of the curative regimen...


4 posted on 01/04/2014 2:14:05 PM PST by awelliott (What one generation tolerates, the next embraces....)
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To: ransomnote

Maybe the tests are sensitive enough...or maybe their behavior that got them infected in the first place didn’t change and they reinfected themselves.


5 posted on 01/04/2014 2:15:09 PM PST by DannyTN (A>)
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To: ransomnote

It may be the virus hid out deep in the fat or nervous tissue and emerged after some time.


6 posted on 01/04/2014 2:17:12 PM PST by LukeL
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To: DannyTN

both patients decided to stop taking their AIDS drugs


I wonder why..................................


7 posted on 01/04/2014 2:18:37 PM PST by PeterPrinciple
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To: ransomnote

maybe they should stop doing what got them AIDS in the first place...


8 posted on 01/04/2014 2:18:49 PM PST by Mr. K (If you like your constitution, you can keep it...Period.)
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To: ransomnote

fortunately 100% of any health care treatments they want will be covered by Obamacare

(and then some!)


9 posted on 01/04/2014 2:20:17 PM PST by Mr. K (If you like your constitution, you can keep it...Period.)
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To: ransomnote

Good example why homosexual men should never be allowed to donate blood no matter what tests show.


10 posted on 01/04/2014 2:20:23 PM PST by icwhatudo (Low taxes and less spending in Sodom and Gomorrah is not my idea of a conservative victory)
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To: ransomnote

Relapse or reinfection?


11 posted on 01/04/2014 2:22:36 PM PST by dangerdoc (I don't think you should be forced to make the same decision I did even if I know I'm right.)
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To: ransomnote

Which the wanted to stop doing even though it is flawed... because it offended the homosexuals to ask them about their lifestyles and “discriminate” against them.


12 posted on 01/04/2014 2:22:46 PM PST by dhs12345
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To: awelliott

We know what “re-invaded” their bodies.


13 posted on 01/04/2014 2:28:58 PM PST by lulu16 (May the Good Lord take a liking to you!)
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To: ransomnote

so Obama forces homosexual perverts on military while allowing these scum to attack good religious people they hate...the new label is homo skeptic


14 posted on 01/04/2014 3:06:13 PM PST by Understand the stimulus
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To: awelliott

Eradicating mosquitos keept Yellow Fever under control.


15 posted on 01/04/2014 3:11:06 PM PST by BenLurkin (This is not a statement of fact. It is either opinion or satire; or both.)
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To: ransomnote

Reinfection, most likely.


16 posted on 01/04/2014 3:13:29 PM PST by Darksheare (Try my coffee, first one's free..... Even robots will kill for it!)
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To: ransomnote

it was previously announced in another recent study that this kind of result was likely; that after heavy bombardment by the cocktails of anti-HIV drugs, HIV was discovered to be hibernating so inconspicously, and at such minute levels, in the body’s cells as to be hard to detect; where, if and when the cocktail of anti-HIV drugs is reduced or ended, it - the HIV - detects a change in the blood stream that indicates that fact, comes out of hibernation and starts attacking the immune cells all over again


17 posted on 01/04/2014 3:16:23 PM PST by Wuli
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To: ransomnote
There is a window of time after a person has been exposed to HIV during which the person will test negative because the amount of antibody is too low to be detected by our current tests. That is always a problem when blood donors are screened prior to the donation. If they answer the screening questions honestly, any male donor who is currently a practicing homosexual or a female donor who admits to even one sexual contact with a bisexual male would automatically be rejected. The ARC gives the donor every opportunity to be honest because the questions are asked via computer in a cubicle in which only the donor is present.
18 posted on 01/04/2014 3:42:31 PM PST by srmorton (Deut. 30 19: "..I have set before you life and death,....therefore, choose life..")
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To: ransomnote

HIV is a retrovirus. There will never be a cure.


19 posted on 01/04/2014 3:55:16 PM PST by 43north (BHO: 50% black, 50% white, 100% RED)
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To: ransomnote

i’ll get flamed for this statement but here goes: No one ever died from HIV or Aids. They die or contract other deadly diseases. What is the difference between a lymphoma patient with or without HIV. Isn’t the lymphoma the problem. Does HIV cause the lymphoma? ( i think this is what the science says it does) Then what causes the lymphoma in a person without HIV? and where did the HIV apocalyptic epidemic go? Isn’t Magic Johnson still floating around 20 years after an HIV discovery?


20 posted on 01/04/2014 5:12:52 PM PST by kvanbrunt2 (i don't believe any court in this country is operating lawfully anyway)
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To: ransomnote
So might this indicate that the AIDS tests commonly in use are not sensitive enough to accurately report whether bone marrow donation or blood has the aids virus? Is it that they couldn't test in a system as complex as the human body? If so, wouldn't the tested population in the US actually have higher levels of aids than currently reported?

It might also mean that it doesn't take as high a concentration of the virus to infect someone - they thought there was a cure because they couldn't detect it and the undetectable amount was sufficient to reinfect. I wonder if there are other factors that occur with having been infected that make it easier for a smaller amount of the virus to propagate.

21 posted on 01/05/2014 5:04:31 AM PST by trebb (Where in the the hell has my country gone?)
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To: ransomnote

I don’t think that either Steve Deeks or Dan Kuritzkes ever said anything other than “maybe” about these two.

And, yes, it’s quite significant, but not at all surprising, that a test cutoff of 20 copies per mL of blood is not sensitive enough to detect a very significant total body viral burden.


22 posted on 01/05/2014 5:14:05 AM PST by Jim Noble (When strong, avoid them. Attack their weaknesses. Emerge to their surprise.)
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