Skip to comments.New approach makes cancer cells explode (and die)
Posted on 03/23/2014 11:25:02 AM PDT by RoosterRedux
Researchers at Karolinska Institutet in Sweden have discovered that a substance called Vacquinol-1 makes cells from glioblastoma, the most aggressive type of brain tumour, literally explode. When mice were given the substance, which can be given in tablet form, tumour growth was reversed and survival was prolonged. The findings are published in the journal Cell .
The established treatments that are available for glioblastoma include surgery, radiation and chemotherapy. But even if this treatment is given the average survival is just 15 months. It is therefore critical to find better treatments for malignant brain tumours.
Researchers at Karolinska Institutet and colleagues atUppsalaUniversityhave discovered an entirely new mechanism to kill tumour cells in glioblastoma. Researchers in an initial stage have exposed tumour cells to a wide range of molecules. If the cancer cells died, the molecule was considered of interest for further studies, which initially applied to over 200 kinds of molecules. Following extensive studies, a single molecule has been identified as being of particular interest. The researchers wanted to find out why it caused cancer cell death.
It was found that the molecule gave the cancer cells an uncontrolled vacuolization, a process in which the cell carries substances from outside the cell into its interior. This carrying process is made via the vacuoles, which can roughly be described as blisters or bags consisting of cell membranes. The process is similar to what was behind last year's Nobel Prize in physiology or medicine, the discovery that describes how cellular vesicles move things from the interior of the cell to its surface.
When cancer cells were filled with a large amount of vacuoles, the cell membranes (the outer wall of the cell) collapsed and the cell simply exploded and necrotized.
(Excerpt) Read more at news.cision.com ...
Making cancer cells explode while leaving nearby healthy cells in the un-exploded state is much harder.
Hah...any suicide bomber knows that.;-)
Cytolysis. A word not invented in Africa or by followers of islam.
It sounds as if this Vacquinol-1 is specifically attracted to glioblastoma cells, from the way the article was written at least.
Gee, they cured cancer in mice AGAIN.
Too bad that typically doesn’t translate to humans.
Great news for mice with cancer.
And lucky for them, they are exempt from Obamascare.
Killing cancer cells in mice is apparently pretty easy. I’ve seen a dozen different substances that killed cancer like gangbusters in mice but have moderate to poor usefulness in humans.
I wish them success.
Conversely, there are probably many things that will kill human cancer cells, which we won't find out about because they are ineffective against mouse cancers.
Exploding brain tumors? Imagine the side effects that will be named in the commercial's legal disclaimer:
And this is the sad truth about the current state of cancer therapy. Despite a War on Cancer being fought since Nixon, life expectancy for most forms of cancer is increased by perhaps mere weeks, misery from treatment is off scale, and expenses are astronomical.
Prevailing cancer dogma is somatic (gene) theory, which is drilling in what increasingly looks like a dry hole. The genetic chaos of cancer is likely a consequence, and not the cause. All we have to show for the billions invested is advanced gene sequencing tools (which are useful) and what may turn out to be a surplus of gene scientists.
Some (Seyfried, D'Agostino) have kicked somatic to the curb, and are following up on Warburg's (metabolic/mitochondrial) theory from the early 20th. This shows some promise.
If I had a diagnosis of this particular cancer, I would go for:
... for example:
Nature: The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth
Oncologists are apt to be largely unaware of the above. Anyone who plans to turn down chemo or rad anyway needs keep an eye on what dissenting researchers are up to, and make their own decisions. Fortunately, much of the dietary approach can be done independently by individuals.
In the meantime, a low-carb, high-fat, grain-free diet, with attention to a long list of other adverse junk sold as "food" is apt to be highly prophylactic against getting cancer in the first place. My bet is placed there at the moment.
I have had great success killing cancer cells with plain old bleach in the lab. Bleach is effective, but would never be a good chemotherapy agent due to its high toxicity against just about everything.
Do a search for the video.
Will A multi billion dollar industry allow a cure?
FTA: “Researchers made mice that had human glioblastoma cells transplanted ingest the substance for five days.”
I don't know if you caught it but that wasn't a reference to the new Vacquinol-1 molecule they found.
Is that from Scanners?
> I don’t know if you caught it but that wasn’t
> a reference to the new Vacquinol-1 molecule they found.
Nor was my reply, which was more about the state of current consensus (Standard of Care) therapies.
This new molecule may have some use in treating human GB, but it’s going to take years for trials and approvals.
In the meantime, anyone with a diagnosis will be dead before that happens. There are non-toxic alternatives that people can look into, particularly if they’re planning to decline “surgery, radiation and chemotherapy” anyway, as many do.