Skip to comments.Soy Sauce Ingredient Found to Fight HIV
Posted on 05/13/2014 2:58:05 PM PDT by nickcarraway
A compound found in soy sauce may be more potent than the current top antiviral therapy in fighting HIV, University of Missouri researchers have found. Seventy times stronger, in fact.
The molecule was accidentally discovered by a Japanese soy sauce company in 2001 while trying to enhance the flavor of its product. The soy sauce molecule they isolated, EFdA, turns out to be part of the family of compounds called nucleoside analogues, which are very similar to existing drugs for the treatment of HIV and other viruses. EFdA samples were sent for further testing, which confirmed EFdA's potential usefulness against HIV and started more than a decade of research.
Resistance to first-line drug therapy regimens is common in HIV patients being treated with anti-AIDS medications such as the anti-viral drug Tenofovir. Many are forced to adopt more potent medications.
"Patients who are treated for HIV infections with Tenofovir eventually develop resistance to the drugs that prevent an effective or successful defense against the virus," said Stefan Sarafianos, associate professor of molecular microbiology and immunology in the University of Missouri School of Medicine and a virologist at the Bond Life Sciences Center at MU.
"EFdA, the molecule we are studying, is less likely to cause resistance in HIV patients because it is more readily activated and is less quickly broken down by the body as similar existing drugs," he said.
EFdA, along with eight existing HIV drugs, is part of the class of compounds called nucleoside reverse transcriptase inhibitors (NRTIs). NRTIs "hijack" the HIV replicating process by "tricking" building blocks inside the virus, according to MU scientists. Since EFdA appears similar to those building blocks, the virus is misled into using the imposter, which prevents HIV replication and halts the spread of the virus.
In their latest study, Sarafianos and his colleagues, including researchers from the University of Pittsburgh and the National Institutes of Health, helped figure out how EFdA works on a molecular level. Compounds developed by Sarafianos and his team currently are being tested for usefulness as potential HIV-halting drugs with pharmaceutical company Merck.
"The structure of this compound is very important because it is a lock-and-key kind of mechanism that can be recognized by the target," Sarafianos said. "Not only does EFdA work on resistant HIV, it works better on HIV that has not become Tenofovir-resistant."
The research was published the in the journals Retrovirology, Antimicrobial Agents and Chemotherapy and The International Journal of Pharmaceutics.
The Chinese use Soy Sauce as a cure for everything. It is sort of a folk medicine. My wife would rub it on burns and bruises
So what are they supposed to do, shove up their . . .
You can buy this by the bucketful...
Is this why there are still people in San Fran Sicko???
Perhaps drench an eggroll with it first?
Chinese Food added to Rams locker room spread.
[ My wife would rub it on burns and bruises ]
Hers or yours, because if it was only yours she may not have liked you.....
Look for EFdA to be sold for pennies in the form of soy sauce and for thousands of dollars in the form of a pill.
I think its true. If you bathe in it or use it as cologne, you won’t be having sex with anyone.
Covered by CommieCare, no doubt.
“for the treatment of HIV AND OTHER VIRUSES.”
That’s the interesting part - which other viruses? There could be some interesting meds here for viruses we have trouble curing, which is most viruses.
Very interesting. Natto is pretty fascinating too, but for its vitamin K.
Yep, but in a straight-up choice between eating Natto and dying, I’d...I’d...I’d have to think about it...
I’ve felt the same. Not even the little packets of mustard they provide with it really helps.
Are they buffet or soy sauce?
Will we see more gays eating at Chinese restaurants?
With sex you get eggroll...
“So what are they supposed to do, shove up their . .”