Skip to comments.Memory and learning deficits restored in Alzheimer's mouse models (brain cell transplantation)
Posted on 07/17/2014 3:56:32 AM PDT by Innovative
Now, researchers from the Gladstone Institutes in San Francisco, CA, and the University of California-San Francisco reveal they have successfully reversed learning and memory deficits in mouse models of Alzheimer's through transplantation of healthy brain cells.
The team transplanted inhibitory neuron progenitors - early-stage brain cells that can change into mature inhibitory regulator cells - into the hippocampus of two mouse models of Alzheimer's disease. One mouse model possessed the apoE4 gene, while the other had the apoE4 gene alongside a build-up of amyloid-beta - a protein also believed to play a role in Alzheimer's development.
The researchers found that the transplanted healthy inhibitory regulator cells not only survived in the hippocampus of both mouse models, but also successfully boosted inhibitory signaling and restored learning and memory function.
Furthermore, the team found that when they transplanted healthy inhibitory regulator cells into mice with both the apoE4 gene and an amyloid-beta build-up, the new cells also restored learning and memory deficits caused by amyloid-beta accumulation.
But the team notes that the new healthy cells did not influence amyloid-beta levels, indicating that cognitive restoration was not due to a reduction in amyloid-beta, nor did the protein interfere with the function of the transplanted cells.
(Excerpt) Read more at medicalnewstoday.com ...
Was the mouse named Algernon?
Dementia Reversal with Coconut oil - in an 85yr old at 35 days.
I wonder how many younger Americans recognize the name Algernon. Required reading in my day.
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