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This Grandfather Allegedly Cured Liver Cancer With Homemade Cannabis Oil
Medical Daily ^ | 7-13-2014 | Lizette Borreli

Posted on 07/23/2014 11:37:23 AM PDT by Citizen Zed

Mike Cutler, a 63-year-old grandfather, allegedly killed his cancer cells with homemade cannabis oil, after receiving his second liver cancer diagnosis in five years.

The cancer survivor was first diagnosed with liver cancer in 2009 after he blacked out at work, after which he then received an organ transplant in November of that year. However, last year, his health took a turn for the worst when he found out new cancerous cells were attacking his new organ.

A liver transplant and a second cancer diagnosis later, Cutler decided to buy marijuana from a dealer and make his tablets from the oil to treat his condition. The grandfather admits that after three days of taking one capsule, his severe pain disappeared and eventually began to cough up blood, which he believes contained the dead cancer cells. “I can’t believe cannabis oil isn’t being used regularly as treatment. It is a miracle cure."

(Excerpt) Read more at m.medicaldaily.com ...


TOPICS: Chit/Chat; Health/Medicine
KEYWORDS: cancer; cannabis; cannabisoil; liver; marijuana; medicalmarijuana; pot; wod
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This just in. Draino cures constipation.
1 posted on 07/23/2014 11:37:23 AM PDT by Citizen Zed
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To: Citizen Zed

We'll be right over.

2 posted on 07/23/2014 11:41:59 AM PDT by 2ndDivisionVet (The most dangerous man to any government is the man who is able to think things out for himself.)
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To: Citizen Zed
The grandfather admits that after three days of taking one capsule, his severe pain disappeared and eventually began to cough up blood, which he believes contained the dead cancer cells.

Is this Medical Daily a trade publication? If so, why is this article in it? This is the type of thing you'd expect to see in Star or National Inquirer. I wouldn't try this at home.

3 posted on 07/23/2014 11:42:33 AM PDT by Opinionated Blowhard ("When the people find they can vote themselves money, that will herald the end of the republic.")
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To: Citizen Zed
CBD oil helps people who suffer from epilepsy seizures.

Part of the push in some states for legalized maryjane is for being able to receive treatment with CBD oil, without having to get the .gov approval.

4 posted on 07/23/2014 11:49:04 AM PDT by Theoria (I should never have surrendered. I should have fought until I was the last man alive)
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To: Citizen Zed

5 posted on 07/23/2014 11:51:12 AM PDT by Vendome (Don't take life so seriously-you won't live through it anyway-Enjoy Yourself ala Louis Prima)
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To: Citizen Zed

THC has been shown to shrink tumors...maybe his just responded incredibly well.


6 posted on 07/23/2014 11:58:38 AM PDT by Wolfie
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To: Citizen Zed

hempseed oil / pot oil/can work against cancer.

i doubt he just knew what to do, but was rather following a guide already out there by a doctor who has instructions on how to do this. the article excerpt just makes it sound like he knew what he was doing all by himself.


7 posted on 07/23/2014 12:00:25 PM PDT by Secret Agent Man ( Gone Galt; Not averse to Going Bronson.)
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To: 2ndDivisionVet

Love that pic.
Can’t wait to visit the Choom Gang Museum opening 2017....


8 posted on 07/23/2014 12:01:02 PM PDT by nascarnation (Toxic Baraq Syndrome: hopefully infecting a Dem candidate near you)
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To: Citizen Zed
This just in. Draino cures constipation.

Allegedly.

9 posted on 07/23/2014 12:01:58 PM PDT by Carl Vehse
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To: Opinionated Blowhard

“...began to cough up blood...”

That’s not a good sign of anything.


10 posted on 07/23/2014 12:03:29 PM PDT by carriage_hill (Some days you're the windshield, and some days you're the bug.)
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To: Citizen Zed
Cannabis Chemicals Stop Prostate Cancer Growth

Inhibition of human tumour prostate PC-3 cell growth by cannabinoids R(+)-Methanandamide and JWH-015: Involvement of CB2

'Cannabis' brain tumour drug hope

Marijuana Fights Cancer and Helps Manage Side Effects, Researchers Find

11 posted on 07/23/2014 12:04:52 PM PDT by TigersEye ("No man left behind" means something different to 0bama.)
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To: Citizen Zed

allegedly


12 posted on 07/23/2014 12:06:35 PM PDT by Moonman62 (The US has become a government with a country, rather than a country with a government.)
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To: Citizen Zed

Why do people think it’s so outlandish that Marijuana could be of benefit for certain diseases and conditions? Most of our current drugs come from terrestrial or aquatic plant / animal life.


13 posted on 07/23/2014 12:07:14 PM PDT by Usagi_yo
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To: Usagi_yo
This is why:


14 posted on 07/23/2014 12:09:37 PM PDT by ConservingFreedom (A goverrnment strong enough to impose your standards is strong enough to ban them.)
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To: Usagi_yo

Who was the guy in Germany that ate the willow tree bark and it made his headache go away?
I think his name was Mr. Bayer......


15 posted on 07/23/2014 12:13:59 PM PDT by woodbutcher1963
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To: Citizen Zed

Comet cleanser clears nasal passages.. Permanently.

Although, in fairness , mother nature has many healing substances in its flora and fauna and such. Not to mention tiny colorful frogs are hopping chemical factories.

The WoD goes on..


16 posted on 07/23/2014 12:14:07 PM PDT by NormsRevenge (Semper Fi - Revolution is a'brewin!!!)
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To: Citizen Zed

while I think this story is more than farfetched, as there is no such thing as an overnight miracle-cure, there is much foundation to support the cannabis component CBD as noninvasive cancer therapy, especially pertaining to breast cancer:

“An in vitro study of the effect of CBD on programmed cell death in breast cancer cell lines found that CBD induced programmed cell death, independent of the CB1, CB2, or vanilloid receptors. CBD inhibited the survival of both estrogen receptor–positive and estrogen receptor–negative breast cancer cell lines, inducing apoptosis in a concentration-dependent manner while having little effect on nontumorigenic, mammary cells.[19]”

THC, on the other hand, should be the subject of more study to resolve the conflict in angiogenic effects noted at footnotes 23/24:

“In an in vivo model using severe combined immunodeficient mice, subcutaneous tumors were generated by inoculating the animals with cells from human non-small cell lung carcinoma cell lines.[22] Tumor growth was inhibited by 60% in THC-treated mice compared with vehicle-treated control mice. Tumor specimens revealed that THC had antiangiogenic and antiproliferative effects. Tumor growth was inhibited by 60% in THC-treated mice compared with vehicle-treated control mice. Tumor specimens revealed that THC had antiangiogenic and antiproliferative effects.

However, research with immunocompetent murine tumor models has demonstrated immunosuppression and enhanced tumor growth in mice treated with THC.[23,24]

http://www.cancer.gov/cancertopics/pdq/cam/cannabis/healthprofessional/page4


17 posted on 07/23/2014 12:14:13 PM PDT by blueplum
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To: Citizen Zed
Why would you post crap like this?

The grandfather admits that after three days of taking one capsule, his severe pain disappeared and eventually began to cough up blood, which he believes contained the dead cancer cells. “I can’t believe cannabis oil isn’t being used regularly as treatment. It is a miracle cure. The NHS should use it — it would save money,” Cutler said.

Obviously this man has a very strong knowledge of biology and medicine and is not a crackpot attempting a quack home remedy.

18 posted on 07/23/2014 12:16:00 PM PDT by DiogenesLamp (Partus Sequitur Patrem)
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To: Usagi_yo

People tend to believe what they want to believe. What most people don’t know is it’s very easy to get National Institute on Drug Abuse approval for studies on the harmful effects of pot, and very difficult to get FDA approval for any studies on medical benefits. As a result, much of that research is being done in places like Israel.


19 posted on 07/23/2014 12:16:27 PM PDT by Hugin ("Do yourself a favor--first thing, get a firearm!")
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To: Usagi_yo

According to the INTERNET:

“Hippocrates, the Greek physician who lived from about 460 to 377 B.C., wrote that willow leaves and bark relieved pain and fevers.

It wasn’t until thousands of years later that people began to isolate the key ingredients of aspirin. An 18th-century clergyman, Edward Stone, rediscovered aspirin, in effect, when he wrote a report about how a preparation of powdered willow bark seemed to benefit 50 patients with ague and other maladies, Roueché wrote.

In the 1800s, researchers across Europe explored salicylic acid. French pharmacist Henri Leroux isolated it in 1829, Roueché writes. Hermann Kolbe discovered synthetic salicylic acid in 1874, but when administered often in large doses, patients experienced nausea and vomiting, and some even went into a coma. A buffer was needed to ease the effects of this acid on the stomach.

The aspirin we know came into being in the late 1890s in the form of acetylsalicylic acid when chemist Felix Hoffmann at Bayer in Germany used it to alleviate his father’s rheumatism, a timeline from Bayer says. Beginning in 1899, Bayer distributed a powder with this ingredient to physicians to give to patients. The drug became a hit and, in 1915, it was sold as over-the-counter tablets”


20 posted on 07/23/2014 12:17:30 PM PDT by woodbutcher1963
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To: Usagi_yo

I don’t know. I don’t understand the attitude. There is sufficient data to support the claims that cannabis oil works as a cancer treatment.


21 posted on 07/23/2014 12:18:00 PM PDT by BuckeyeTexan (There are those that break and bend. I'm the other kind. ~Steve Earle)
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To: DiogenesLamp

Couldn’t resist posting. I’m thinking of flagging my own post as objectionable abuse now.


22 posted on 07/23/2014 12:18:54 PM PDT by Citizen Zed ("Freedom costs a buck o five" - Gary Johnston, TAWP)
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To: ConservingFreedom
I'm sure you are entirely motivated by a desire to see good medicines developed. You obviously have no childish or selfish reasons for wanting Marijuana legalized.

I have no problems with scientists researching the efficacy of Marijuana and it's derivative chemicals for various illnesses, but I am not interested in reading crap from people who start their research with that as their central premise.

Which appears to be most, if not all of them.

23 posted on 07/23/2014 12:22:47 PM PDT by DiogenesLamp (Partus Sequitur Patrem)
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To: woodbutcher1963
French pharmacist Henri Leroux isolated it in 1829, Roueché writes. Hermann Kolbe discovered synthetic salicylic acid in 1874, but when administered often in large doses, patients experienced nausea and vomiting, and some even went into a coma. A buffer was needed to ease the effects of this acid on the stomach.

Ironically the salicylic acid in willow bark is already buffered by other phytochemicals in the willow bark.

24 posted on 07/23/2014 12:23:00 PM PDT by TigersEye ("No man left behind" means something different to 0bama.)
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To: BuckeyeTexan
I don’t know. I don’t understand the attitude. There is sufficient data to support the claims that cannabis oil works as a cancer treatment.

From what i've seen, most of that "research" comes from people with agendas. They start out trying to prove the stuff is beneficial, and by golly all of their tests and experiments reveal that they were right!

Not buying it. It's like the Palestinians reporting on Israel. You already know what they are going to say, and it isn't likely to be the truth.

25 posted on 07/23/2014 12:28:44 PM PDT by DiogenesLamp (Partus Sequitur Patrem)
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To: DiogenesLamp

Yes, the British Journal of Cancer, the NIH, the biology dept. of Complutense University, the British Journal of Pharmacology and Cancer Research UK all have agendas. lol


26 posted on 07/23/2014 12:36:27 PM PDT by TigersEye ("No man left behind" means something different to 0bama.)
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To: DiogenesLamp
From what i've seen, most of that "research" comes from people with agendas. They start out trying to prove the stuff is beneficial

What have you seen that leads you to this conclusion?

27 posted on 07/23/2014 12:38:40 PM PDT by ConservingFreedom (A goverrnment strong enough to impose your standards is strong enough to ban them.)
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To: 2ndDivisionVet

Pic saved to faves. You are GOOD!


28 posted on 07/23/2014 12:44:44 PM PDT by redhead (NO GROUND TO THE DEVIL! Remember BENGHAZI!! Use Weaponized Prayer)
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To: ConservingFreedom

“From what i’ve seen, most of that “research” comes from people with agendas. They start out trying to prove the stuff is beneficial
“What have you seen that leads you to this conclusion?

Hmmmmm... What is the big drug makers, Alex?


29 posted on 07/23/2014 12:50:28 PM PDT by aMorePerfectUnion ( "I didn't leave the Central Oligarchy Party. It left me." - Ronaldus Maximus)
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To: aMorePerfectUnion
Exactly wrong - Big Pharma can't patent cannabis so they have no interest in its medical benefits.
30 posted on 07/23/2014 12:52:35 PM PDT by ConservingFreedom (A goverrnment strong enough to impose your standards is strong enough to ban them.)
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To: aMorePerfectUnion
Fox News Alert! Medical Researchers Try To Prove Stuff Is Beneficial!
Here is Shemp with more on this breaking controversy.

31 posted on 07/23/2014 12:55:12 PM PDT by TigersEye ("No man left behind" means something different to 0bama.)
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To: 2ndDivisionVet

It isn’t just for killing brain cells anymore.


32 posted on 07/23/2014 1:04:43 PM PDT by Buckeye McFrog
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To: woodbutcher1963

Some wonder kid out of high school has received a huge grant to work with the cannabis oil as a cancer cure. Supposedly it does work.


33 posted on 07/23/2014 1:17:35 PM PDT by Georgia Girl 2 (The only purpose o f a pistol is to fight your way back to the rifle you should never have dropped.)
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To: DiogenesLamp

You don’t have to buy it. It either works or it doesn’t. The cancer is gone or it isn’t. The alleged agenda is largely irrelevant.


34 posted on 07/23/2014 1:20:59 PM PDT by BuckeyeTexan (There are those that break and bend. I'm the other kind. ~Steve Earle)
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To: TigersEye
Yes, the British Journal of Cancer, the NIH, the biology dept. of Complutense University, the British Journal of Pharmacology and Cancer Research UK all have agendas. lol

And this is what I mean about pot causing brain damage, the researchers aren't "the British Journal of Cancer", the researchers are N Olea-Herrero, D Vara, S Malagarie-Cazenave, and I Díaz-Laviada.

Lot of Spanish sounding names for a British Journal, don't you think? Where do these people work, and what do they do? Well they would appear to constantly write papers about Marijuana being good for you. They appear to be out of Spain. You know, where smoking that crap is legal, and a lot of people make money off of selling it. Not without problems, of course.

So Cancer cells stop growing when you hit them with pot? I'm suspecting brain cells stop growing too, when you hit them with pot.

But YAH! That drug we like to smoke kills cancer! Far out man! We should totes legalize that sh*t or somethin.

35 posted on 07/23/2014 1:23:11 PM PDT by DiogenesLamp (Partus Sequitur Patrem)
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To: DiogenesLamp
You're really going to split hairs about which ones are researchers and which are medical review boards? LOL

Nice display of some real brain damage there, skippy.

36 posted on 07/23/2014 1:25:40 PM PDT by TigersEye ("No man left behind" means something different to 0bama.)
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To: DiogenesLamp
I'm suspecting brain cells stop growing too, when you hit them with pot.

And that's based on research from DiogenesLamp's Suspicions. Never heard of that outfit.

But YAH! That drug we like to smoke kills cancer! Far out man! We should totes legalize that sh*t or somethin.

Straw men arguments are so Alinsky.

37 posted on 07/23/2014 1:29:17 PM PDT by TigersEye ("No man left behind" means something different to 0bama.)
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To: ConservingFreedom
What have you seen that leads you to this conclusion?

Six years of people posting similar articles. At first I thought of them as credible, but the more digging I did, the more it became apparent that this stuff comes from an echo chamber of interconnected people who are looking for beneficial results of pot because they want to use them to justify legalizing pot.

They aren't "researchers" per se, they are specifically POT researchers, which are just like "Gay" researchers or "Global Warming" researchers in their methods and results.

38 posted on 07/23/2014 1:31:29 PM PDT by DiogenesLamp (Partus Sequitur Patrem)
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To: TigersEye
Fox News Alert! Medical Researchers Try To Prove Stuff Is Beneficial!

How about "POT researchers try to prove POT is Beneficial."

That is probably closer to the truth.

While we're at it.

"Gay researchers try to prove that "Gay" is Normal!"

"Global Warming Researchers try to Prove Global Warming is true!"

39 posted on 07/23/2014 1:38:43 PM PDT by DiogenesLamp (Partus Sequitur Patrem)
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To: DiogenesLamp

How about, it doesn’t take much to make a drug warrior go bananas! ROTFLOL


40 posted on 07/23/2014 1:41:10 PM PDT by TigersEye ("No man left behind" means something different to 0bama.)
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To: DiogenesLamp; BuckeyeTexan
BuckeyeTexan: I don’t know. I don’t understand the attitude. There is sufficient data to support the claims that cannabis oil works as a cancer treatment.

From what i've seen, most of that "research" comes from people with agendas. They start out trying to prove the stuff is beneficial

What have you seen that leads you to this conclusion?

Six years of people posting similar articles. [...] They aren't "researchers" per se, they are specifically POT researchers

So by "researchers" you mean people posting articles, not scientists. I think the latter are what BuckeyeTexan was talking about.

41 posted on 07/23/2014 1:43:56 PM PDT by ConservingFreedom (A goverrnment strong enough to impose your standards is strong enough to ban them.)
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To: BuckeyeTexan
You don’t have to buy it. It either works or it doesn’t. The cancer is gone or it isn’t. The alleged agenda is largely irrelevant.

And how do you know if the cancer is gone or not? How do you know if it was killed by THC? That one paper was written in 2009. If it's so effective, where are the clinical trials? I would think Spain would get right on this. They could become the cancer treatment center of the world.

Meanwhile, if it turns out all the claims are Bullshit, but we've legalized the stuff based on bullshit like this, what do we do? Say "oooooopppppssss!" ?

A lot of stuff works on Cancer in a petri dish. Not so much in the human body.

The real truth about articles such as this is that most of the promoters do not give a rats behind about curing cancer, they are just trying to build a case for legalizing/decriminalizing the stuff so they can smoke it.

If i'm wrong, i'll be happy to look at OTHER posts from this same group of people on the topic of cancer. I'm betting all these people promoting the cancer treating properties of Pot, probably have no other treatments for cancer on their radar.

They post about THIS form of treatment, because it isn't really about cancer, it's about fooling people. "Cancer treatment" is just a tool they use to do this.

42 posted on 07/23/2014 1:48:05 PM PDT by DiogenesLamp (Partus Sequitur Patrem)
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To: TigersEye
You're really going to split hairs about which ones are researchers and which are medical review boards? LOL

If you aren't using any intellectual honesty, I don't see why I should either.

43 posted on 07/23/2014 1:50:37 PM PDT by DiogenesLamp (Partus Sequitur Patrem)
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To: TigersEye
I'm suspecting brain cells stop growing too, when you hit them with pot.

And that's based on research from DiogenesLamp's Suspicions. Never heard of that outfit.

You are here providing evidence in support of the claim.

Straw men arguments are so Alinsky.

So is argumentum ad vericundiam and argumentum ad populum, which is what you have so far provided.

44 posted on 07/23/2014 1:54:20 PM PDT by DiogenesLamp (Partus Sequitur Patrem)
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To: TigersEye
How about, it doesn’t take much to make a drug warrior go bananas! ROTFLOL

It just looks like bananas to you because you're stoned.

45 posted on 07/23/2014 1:55:49 PM PDT by DiogenesLamp (Partus Sequitur Patrem)
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To: Wolfie

When you have liver cancer start coughing up blood it means that you have lost the ability to clot blood which was one of the functions of the liver (to provide the factors for clotting).


46 posted on 07/23/2014 1:55:52 PM PDT by Chickensoup (Leftist totalitarian fascism is on the move.)
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To: ConservingFreedom

“In the General/Chat forum, on a thread titled This Grandfather Allegedly Cured Liver Cancer With Homemade Cannabis Oil, ConservingFreedom wrote:...

“Exactly wrong - Big Pharma can’t patent cannabis so they have no interest in its medical benefits.”

If they could make money selling pot in any form, they would in a heartbeat. Typically, this requires changing one molecule I order to patent it. Just consider “medical” fish oil.


47 posted on 07/23/2014 2:02:26 PM PDT by aMorePerfectUnion ( "I didn't leave the Central Oligarchy Party. It left me." - Ronaldus Maximus)
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To: ConservingFreedom
So by "researchers" you mean people posting articles, not scientists. I think the latter are what BuckeyeTexan was talking about.

You cannot hardly tell the differences anymore. There are plenty of scientists that will "research" anything they are paid to research. The tobacco companies used to have scads of them proving tobacco was harmless.

It is a pain in the @ss trying to figure out if a report is from a legitimate researcher, or someone specifically researching to prove pot is good for you.

Take this lot in Spain. I've already spent more time on it than I liked, and I've found out d@mn little about them. I don't know who is funding them, where they did their research, and whether they were researching cancer specifically, or pot's application to cancer. Judging by the article it sounds as if they started out with Pot in mind.

I found one reference that they also tested capsaicin, and that lends them a bit of credibility in my mind, but most of what I found is Canabanoids and THC.

The internet is stuffed full of references to these (Spanish) people and Canabanoids, and virtually every pro-drug source on the internet links their work. Valid work (if any) is drowned in a sea of references from Pro-Drug sources. Negative or detrimental results are not so widely propagandized, though I have seen such studies.

48 posted on 07/23/2014 2:08:33 PM PDT by DiogenesLamp (Partus Sequitur Patrem)
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To: DiogenesLamp
Speaking of the Negative effects of Pot...

Friend Says Hillary Clinton Was ‘an Enthusiastic Pot User’ in Her Youth

Asked last month for her opinion of marijuana, Hillary Clinton told CNN’s Christiane Amanpour, “I didn’t do it when I was young, I’m not going to start now.”

Not so fast, says Daniel Halper. In his new book Clinton, Inc., which hits bookshelves today, Halper quotes a friend and law-school classmate of the former first lady and New York senator who says: “I think she’s acknowledged it, and if she hasn’t acknowledged it everybody else will tell you: She was an enthusiastic pot user.”

http://www.nationalreview.com/corner/383372/friend-says-hillary-clinton-was-enthusiastic-pot-user-her-youth-ian-tuttle

49 posted on 07/23/2014 2:14:33 PM PDT by DiogenesLamp (Partus Sequitur Patrem)
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To: blueplum
More:

http://www.cancer.gov/cancertopics/pdq/cam/cannabis/healthprofessional/page5#Section_73:

Cancer Treatment

No clinical trials of Cannabis as a treatment for cancer in humans were identified in a PubMed search; however, a single, small study of intratumoral injection of delta-9-THC in patients with recurrent glioblastoma multiforme reported potential antitumoral activity.[14,15]

http://www.cancer.gov/cancertopics/pdq/cam/cannabis/healthprofessional/page4#Section_26:

Antitumor Effects

One study in mice and rats suggested that cannabinoids may have a protective effect against the development of certain types of tumors.[3] During this 2-year study, groups of mice and rats were given various doses of THC by gavage. A dose-related decrease in the incidence of hepatic adenoma tumors and hepatocellular carcinoma (HCC) was observed in the mice. Decreased incidences of benign tumors ( polyps and adenomas) in other organs ( mammary gland, uterus, pituitary, testis, and pancreas) were also noted in the rats. In another study, delta-9-THC, delta-8-THC, and cannabinol were found to inhibit the growth of Lewis lung adenocarcinoma cells in vitro and in vivo .[4] In addition, other tumors have been shown to be sensitive to cannabinoid-induced growth inhibition.[5-8]

Cannabinoids may cause antitumor effects by various mechanisms, including induction of cell death, inhibition of cell growth, and inhibition of tumor angiogenesis invasion and metastasis.[9-12] Two reviews summarize the molecular mechanisms of action of cannabinoids as antitumor agents.[13,14] Cannabinoids appear to kill tumor cells but do not affect their nontransformed counterparts and may even protect them from cell death. These compounds have been shown to induce apoptosis in glioma cells in culture and induce regression of glioma tumors in mice and rats. Cannabinoids protect normal glial cells of astroglial and oligodendroglial lineages from apoptosis mediated by the CB1 receptor.[15]

The effects of delta-9-THC and a synthetic agonist of the CB2 receptor were investigated in HCC.[16] Both agents reduced the viability of HCC cells in vitro and demonstrated antitumor effects in HCC subcutaneous xenografts in nude mice. The investigations documented that the anti-HCC effects are mediated by way of the CB2 receptor. Similar to findings in glioma cells, the cannabinoids were shown to trigger cell death through stimulation of an endoplasmic reticulum stress pathway that activates autophagy and promotes apoptosis. Other investigations have confirmed that CB1 and CB2 receptors may be potential targets in non-small cell lung carcinoma [17] and breast cancer.[18]

An in vitro study of the effect of CBD on programmed cell death in breast cancer cell lines found that CBD induced programmed cell death, independent of the CB1, CB2, or vanilloid receptors. CBD inhibited the survival of both estrogen receptor–positive and estrogen receptor–negative breast cancer cell lines, inducing apoptosis in a concentration-dependent manner while having little effect on nontumorigenic, mammary cells.[19]

CBD has also been demonstrated to exert a chemopreventive effect in a mouse model of colon cancer.[20] In the experimental system, azoxymethane increased premalignant and malignant lesions in the mouse colon. Animals treated with azoxymethane and CBD concurrently were protected from developing premalignant and malignant lesions. In in vitro experiments involving colorectal cancer cell lines, the investigators found that CBD protected DNA from oxidative damage, increased endocannabinoid levels, and reduced cell proliferation. In a subsequent study, the investigators found that the antiproliferative effect of CBD was counteracted by selective CB1 but not CB2 receptor antagonists, suggesting an involvement of CB1 receptors.[21]

Another investigation into the antitumor effects of CBD examined the role of intercellular adhesion molecule-1 (ICAM-1).[12] ICAM-1 expression has been reported to be negatively correlated with cancer metastasis. In lung cancer cell lines, CBD upregulated ICAM-1, leading to decreased cancer cell invasiveness.

In an in vivo model using severe combined immunodeficient mice, subcutaneous tumors were generated by inoculating the animals with cells from human non-small cell lung carcinoma cell lines.[22] Tumor growth was inhibited by 60% in THC-treated mice compared with vehicle-treated control mice. Tumor specimens revealed that THC had antiangiogenic and antiproliferative effects. However, research with immunocompetent murine tumor models has demonstrated immunosuppression and enhanced tumor growth in mice treated with THC.[23,24]

In addition, both plant-derived and endogenous cannabinoids have been studied for anti- inflammatory effects. A mouse study demonstrated that endogenous cannabinoid system signaling is likely to provide intrinsic protection against colonic inflammation.[25] As a result, a hypothesis that phytocannabinoids and endocannabinoids may be useful in the risk reduction and treatment of colorectal cancer has been developed.[26-29]

CBD may also enhance uptake of cytotoxic drugs into malignant cells. Activation of the transient receptor potential vanilloid type 2 (TRPV2) has been shown to inhibit proliferation of human glioblastoma multiforme cells and overcome resistance to the chemotherapy agent carmustine.[30] In an in vitro model, CBD increased TRPV2 activation and increased uptake of cytotoxic drugs, leading to apoptosis of glioma cells without affecting normal human astrocytes. This suggests that coadministration of CBD with cytotoxic agents may increase drug uptake and potentiate cell death in human glioma cells.

50 posted on 07/23/2014 2:24:01 PM PDT by ConservingFreedom (A goverrnment strong enough to impose your standards is strong enough to ban them.)
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