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Total darkness at night key to success of breast cancer therapy, study shows
Science Daily ^ | July 25, 2014 | Arthur Nead

Posted on 07/29/2014 11:24:43 AM PDT by Tired of Taxes

Exposure to light at night, which shuts off nighttime production of the hormone melatonin, renders breast cancer completely resistant to tamoxifen, a widely used breast cancer drug, says a new study by Tulane University School of Medicine cancer researchers. The study, "Circadian and Melatonin Disruption by Exposure to Light at Night Drives Intrinsic Resistance to Tamoxifen Therapy in Breast Cancer," published in the journal Cancer Research, is the first to show that melatonin is vital to the success of tamoxifen in treating breast cancer.

Principal investigators and co-leaders of Tulane's Circadian Cancer Biology Group, Steven Hill and David Blask, along with team members Robert Dauchy and Shulin Xiang, investigated the role of melatonin on the effectiveness of tamoxifen in combating human breast cancer cells implanted in rats.

"In the first phase of the study, we kept animals in a daily light/dark cycle of 12 hours of light followed by 12 hours of total darkness (melatonin is elevated during the dark phase) for several weeks," says Hill. "In the second study, we exposed them to the same daily light/dark cycle; however, during the 12 hour dark phase, animals were exposed to extremely dim light at night (melatonin levels are suppressed), roughly equivalent to faint light coming under a door."

Melatonin by itself delayed the formation of tumors and significantly slowed their growth but tamoxifen caused a dramatic regression of tumors in animals with either high nighttime levels of melatonin during complete darkness or those receiving melatonin supplementation during dim light at night exposure.

These findings have potentially enormous implications for women being treated with tamoxifen and also regularly exposed to light at night due to sleep problems, working night shifts or exposed to light from computer and TV screens.

"High melatonin levels at night put breast cancer cells to 'sleep'

(Excerpt) Read more at sciencedaily.com ...


TOPICS: Health/Medicine
KEYWORDS: cancer; health
I'm posting this in "Chat" under "Health/Medicine."

Sending out a ping in the next post...

1 posted on 07/29/2014 11:24:43 AM PDT by Tired of Taxes
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To: AllAmericanGirl44; Armen Hareyan; B4Ranch; Ban Draoi Marbh Draoi; bayareablues; BykrBayb; ...
Thank you again, PastorBooks, for this information.

CANCER WARRIORS PING

This is a ping list for cancer survivors and caregivers to share information. If you would like your name added to or removed from this ping list, please tell us in the comments section at this link (click here). (For the most updated list of names, click on the same link and go to the last comment.)

2 posted on 07/29/2014 11:26:35 AM PDT by Tired of Taxes
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To: JoyjoyfromNJ

ping to self to read later. May make a big difference for lots of women battling this disease.


3 posted on 07/29/2014 11:28:11 AM PDT by JoyjoyfromNJ (everything written by me on FR is my personal opinion & does not represent my employer)
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To: Tired of Taxes

aren’t breasts normally kept in dark places (underneath bras, for example)?


4 posted on 07/29/2014 11:28:59 AM PDT by camle (keep an open mind and someone will fill it full of something for you)
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To: Tired of Taxes

Why would they not just take supplemental melatonin? Body doesn’t know the difference.


5 posted on 07/29/2014 11:30:52 AM PDT by steve86 ( Acerbic by nature, not nurture)
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To: Tired of Taxes

If true, couldn’t they just add a melatonin supplement to the chemo protocol?


6 posted on 07/29/2014 11:31:40 AM PDT by Semper911 (When you want to rob Peter to pay Paul, you'll always have the support of Paul.)
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To: steve86; Semper911

Sorry, I had to excerpt the article for FR. At the end, the article does go on to say that melatonin could be prescribed as a supplement.


7 posted on 07/29/2014 11:34:31 AM PDT by Tired of Taxes
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To: steve86
Why would they not just take supplemental melatonin? Body doesn’t know the difference.

Sounds like the next thing to investigate. Just because we think the body doesn't know the difference doesn't make it so. It would have to be investigated and verified. In the meantime, I don't see any harm in women battling breast cancer trying this out.

8 posted on 07/29/2014 11:37:02 AM PDT by scouter
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To: scouter

I think there are other studies showing the benefit to total darkness (getting better sleep, Circadian rhythms, etc.).

This is advisable even if you are not a woman or don’t have breast cancer.


9 posted on 07/29/2014 11:48:26 AM PDT by a fool in paradise (Elian Gonzalez sought asylum and was sent back to Cuba, send these kids back to THEIR parents.)
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To: Tired of Taxes

incredible and amazing. wonderful news.


10 posted on 07/29/2014 11:57:05 AM PDT by wiggen (The teacher card. When the racism card just won't work.)
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To: Tired of Taxes

The author would benefit from improved writing skills.

Tamoxifen needs Melatonin to be effective, and light inhibits the production of Melatonin, which in turn renders the Tamoxifen less effective.


11 posted on 07/29/2014 12:01:31 PM PDT by G Larry (Which of Obama's policies do you think I'd support if he were white?)
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To: camle

Gee, are we getting the opinion of a 12-year-old here?


12 posted on 07/29/2014 12:01:47 PM PDT by Bigg Red (31 May 2014: Obamugabe officially declares the USA a vanquished subject of the Global Caliphate.)
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To: a fool in paradise

Breast cancer is a disease of the developed world, they don’t have it in undeveloped places without electric lighting.

Folks exposed to light at night, such as night shift workers, have higher rates of breast and colon cancer.

This study shows that a common cancer treatment may be rendered ineffective by even a small amount of light.

Melatonin was a cancer treatment in the past, had been overtaken by newer treatments. This doesn’t mean that melatonin or darkness can beat any cancer, but it would be wise to sleep in a totally dark room to protect the immune system.


13 posted on 07/29/2014 12:32:23 PM PDT by Williams
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To: Tired of Taxes

I like to sleep in total darkness but MrD needs a tiny bit of light to get to the bathroom several times. So I wear a black sleep mask. Are they talking about light on your skin or in your eyes? My skin is under the sheets and my eyes are covered, just wondering if this would be enough. I do not have breast cancer BTW.


14 posted on 07/29/2014 12:38:51 PM PDT by Ditter
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To: wiggen

In a way, it is good news to know. OTOH, I just spent 2-1/2 years up late at night while on tamoxifen. *facepalm*


15 posted on 07/29/2014 12:39:22 PM PDT by Tired of Taxes
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To: Tired of Taxes

I sometimes take 10mg of Melatonin before bed to help me fall asleep. It works well, not habit forming.

Some of you may be wondering, “Gee, upchuck, what causes you to need a sleep aid?”

Answer: Depends on how evil nobama has been that day.


16 posted on 07/29/2014 12:48:13 PM PDT by upchuck (It's a shame nobama truly doesn't care about any of this. Our country, our future, he doesn't care.)
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To: Ditter

I haven’t read an explanation of whether it is the skin or eyes or both, however I think skin exposure to light is a factor in the production (or non production) of melatonin, and the safest bet is to be in darkness.


17 posted on 07/29/2014 1:06:58 PM PDT by Williams
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To: Ditter

This study http://www.health.harvard.edu/newsletters/Harvard_Health_Letter/2012/May/blue-light-has-a-dark-side implicates blue light.

Another found that blue light behind the knee had the same effect as daylight but it was found untrue by a later study http://www.genomenewsnetwork.org/articles/08_02/bright_knees.shtml


18 posted on 07/29/2014 1:41:14 PM PDT by pa_dweller (Extremist tea-party-driven hostage-taking legislative arsonist without a life)
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To: camle
aren’t breasts normally kept in dark places

Yes they are until teenage boys get their hands on them.........

19 posted on 07/29/2014 1:44:40 PM PDT by Hot Tabasco (Is there such a thing as a vegan zombie?)
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To: Tired of Taxes

Thought I would share this experience re: Cancer patients.

Waiting for calls from my physician’s office, when the phone rings the caller identifies herself as ??????Cancer???and immediately launches into a solicitation with “How this charity helps cancer patients”. When I asked a question related to transportation difficulties - she made no effort to refer me to a source.

It made me wonder just how much do these “Cancer Support” entities spend on the patients and how much on their organization expenses.


20 posted on 07/29/2014 1:47:15 PM PDT by sodpoodle (Life is prickly - carry tweezers.)
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To: sodpoodle

I receive many calls from “cancer charities,” too. Every time, I tell whoever calls that I wish I could help the charity (which is true), but I’m currently unemployed and financially broke and still paying off medical bills for cancer myself.

Every single time, without fail, their response is: “Well, what can you afford? How about $20? $15? Even if you have just $5 to donate, it would go a long way.”

LOL. It just makes you wonder...


21 posted on 07/29/2014 2:06:13 PM PDT by Tired of Taxes
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To: Tired of Taxes

Bfl


22 posted on 07/31/2014 7:00:07 AM PDT by katykelly
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