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Type 1, Type 2 Diabetes Share Underlying Mechanism
BioscienceTechnology.com ^ | 08/20/14 | University of Manchester

Posted on 08/20/2014 8:42:35 PM PDT by Pining_4_TX

Work by scientists at the Universities of Manchester and Auckland suggest that both major forms of diabetes, type 1 and type 2, are the result of the same mechanism.

The findings, published in the FASEB Journal, provide compelling evidence that juvenile-onset or type 1 diabetes and type 2 diabetes are both caused by the formation of toxic clumps of a hormone called amylin.

The results, based on 20 years’ work in New Zealand, suggest that type 1 and type 2 diabetes could both be slowed down and potentially reversed by medicines that stop amylin forming these toxic clumps.

(Excerpt) Read more at biosciencetechnology.com ...


TOPICS: Health/Medicine
KEYWORDS: diabetes; medicine

1 posted on 08/20/2014 8:42:35 PM PDT by Pining_4_TX
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To: Pining_4_TX

Maybe in 5 years of so they might have a cure.


2 posted on 08/20/2014 8:48:50 PM PDT by Parley Baer
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To: Parley Baer

Wouldn’t that be wonderful? I pray for that.


3 posted on 08/20/2014 8:50:35 PM PDT by Pining_4_TX (All those who were appointed to eternal life believed. Acts 13:48)
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To: neverdem

ping


4 posted on 08/20/2014 8:51:01 PM PDT by Pining_4_TX (All those who were appointed to eternal life believed. Acts 13:48)
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To: Pining_4_TX

Bkmrk


5 posted on 08/20/2014 8:52:12 PM PDT by krunkygirl (force multiplier in effect...)
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To: Pining_4_TX

Type II Diabetes runs rampant in my family. I’m the Last One Standing. Grandparents on both sides had it. Dad has it. Sister has it. Many cousins have it.

My answer is simple. I walk a lot. I do, ‘push-aways’ from the dinner table and I back off the booze and the Twinkies.

If it’s genetic, you do what needs to be done.


6 posted on 08/20/2014 8:52:21 PM PDT by Diana in Wisconsin (I don't have 'Hobbies.' I'm developing a robust Post-Apocalyptic skill set...)
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To: Blue Jays

That is fantastic news about this silent killer.
Many sufferers played absolutely no part getting this malady.
Unfortunate kids who get it as adolescents, for example.


7 posted on 08/20/2014 8:53:58 PM PDT by Blue Jays (Rock Hard, Ride Free)
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To: Pining_4_TX

If it works, it’s a long way off, but it would seem important in understanding the disease.

Thanks for posting this.


8 posted on 08/20/2014 8:56:39 PM PDT by krunkygirl (force multiplier in effect...)
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To: Pining_4_TX

Just like the long and costly scourge of ulcers which were eliminated very simply, diabetes may soon be only a memory.


9 posted on 08/20/2014 8:57:12 PM PDT by X-spurt (CRUZ missile - armed and ready.)
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To: Diana in Wisconsin

True, but I hate to be the bearer of bad news, one can do all that and the disease will probably still progress. Our bodies break down with age, and for people with diabetes, the pancreas deterioriates faster than it does for others. Some people die at a ripe old age of cancer, some of heart disease, and some of diabetes. Nobody dies of nothing.

You might be interested in a blog by David Mendoza. He controls his type 2 with a low carb diet and exercise.

Again, though, diabetes is progressive in nature, and unless researchers come up with a genuine cure, as opposed to all the medications now that treat the symptoms and may or may not forestall the complications, that is probably what will get diabetics before something else does. :-(


10 posted on 08/20/2014 9:01:22 PM PDT by Pining_4_TX (All those who were appointed to eternal life believed. Acts 13:48)
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To: krunkygirl

You’re welcome. :-)


11 posted on 08/20/2014 9:02:25 PM PDT by Pining_4_TX (All those who were appointed to eternal life believed. Acts 13:48)
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To: Blue Jays

I don’t believe that being over weight “causes’’ diabetes. It might make it come on a little sooner, but extra fat doesn’t cause pancreatic failure. I think it’s more the reverse because it’s the job of the pancreas to help with digesting fats. If it’s in failure, it can’t do that very well.

Anyway, it really would be a huge blessing to many if a cure was found.

I was a very young adult when it happened upon me, and I wasn’t over weight. Some docs say I’m type 1, but those who cater to the party line automatically decided it was type 2 simply because I happen to be older now...sheesh.

Other than genetics, I’d still like to know what causes it.

what causes the malfunction in the first place. Being genetically predisposed is one thing, but is there a trigger like a virus or childhood disease or mold or dust or something? Is it a food additive that triggers it. Something has to trigger it.]


12 posted on 08/20/2014 9:03:52 PM PDT by PrairieLady2
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To: Pining_4_TX

Oh, I understand that. It’s just that others in my family prefer to be lazy about it all, take their insulin and not change one single thing about their lives, even after SEEING that when they DO lost the weight, cut out the booze and carbs and white sugar and otherwise behave themselves, their blood sugar is just fine.

*SIGH*


13 posted on 08/20/2014 9:04:26 PM PDT by Diana in Wisconsin (I don't have 'Hobbies.' I'm developing a robust Post-Apocalyptic skill set...)
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To: Diana in Wisconsin

I understand, but it is very hard to do. I think the disease also makes people crave the very thing that makes them sicker - carbs.

I have type 2 in my family as well. It’s a horrible disease.
Stay well, fellow Freeper. :-)


14 posted on 08/20/2014 9:07:39 PM PDT by Pining_4_TX (All those who were appointed to eternal life believed. Acts 13:48)
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To: Pining_4_TX

bump


15 posted on 08/20/2014 9:59:00 PM PDT by blueplum
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To: Diana in Wisconsin

Vitamin d3 plays a big role as well. You are probably outside more than your family due to your job.


16 posted on 08/20/2014 10:06:18 PM PDT by Black Agnes
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To: Diana in Wisconsin
When I was diagnosed with Type 2, every medical professional asked whether there was anyone else in my family who had diabetes and my response was always “not as far as I know.” My parents were carb junkies who both had a history of heart disease, but while Mom and her side of the family had high blood pressure and cholesterol, my father and his family didn't. I don't think Dad was ever tested for diabetes, possibly because doctors at that time didn't consider diabetes as a possible factor in his heart disease. Dad also wasn't overweight or showed any signs of the disease.
17 posted on 08/20/2014 10:20:01 PM PDT by fatnotlazy
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To: Pining_4_TX

This whole article seems like nonsense to me. It’s well established that Type 1 diabetes is an autoimmune disease that destroys the pancreatic islets of langerhan, and that Type 2 diabetes is caused by cellular desensitization to insulin due to massive overproduction of insulin due to massive and continuous ingestion of sugary and carby foods that repeatedly spike blood sugar, with said desensitization causing the pancreatic islets of langerhan to make enormous amounts of insulin to compensate, with eventual exhaustion of the islets of langerhan.


18 posted on 08/20/2014 10:38:35 PM PDT by catnipman (Cat Nipman: Vote Republican in 2012 and only be called racist one more time!)
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To: PrairieLady2; All

No one in my immediate family had diabetes II, except me.
No one in my spouse’s immediate family, mother,father, siblings, grandparents, had the disease, but he contracted it.I would like to know the answer as to why, hopefully in my lifetime.


19 posted on 08/20/2014 10:40:06 PM PDT by itssme
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To: itssme

I understood that generally type II diabetes ran more in families who were short, especially short legged, as if maybe the legs being one of our largest body types had something to do with the digestion or lack of digestion of carbs.

No one in my family has it, being a bit tall, but my very tall son who has played some college sports said that he was told by various nutritional counselors that if one eats enough sugar it will coat the red blood cells and eventually cause type II.

Maybe that is true, as I have several friends from short families and they tell me it runs in the family. They try to watch their carbs. I have a tall friend who has eaten a lot of carbs, sugar junky, and has type II.

It is a terrible disease and it would be great for so many if some cure were found.


20 posted on 08/20/2014 10:55:11 PM PDT by angry elephant (Endangered species in Seattle)
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To: angry elephant
No, my family is of average height. My Scandinavian spouse's family were of average to tall stature. The eventual answer to this question will be a very interesting one, indeed.
21 posted on 08/20/2014 11:05:48 PM PDT by itssme
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To: catnipman
This whole article seems like nonsense to me.

It doesn't seem to square with the “epidemic” of type 2 diabetes in this country that seems to correspond closely with the “epidemic” of obesity. Of course our “epidemic” of obesity seems to correspond with the increased popularity of super-sized fast food, candy and corn syrup based soft drinks.

Around the time that I turned 50 I realized that my gastric system was starting to rebel against the staples in my diet such as 64oz Double Big Gulps, jumbo sized Big Bite Hot-dogs, potato chips and large quantities of candy bars. When I was younger I could gorge on these types of culinary delights day after day with no apparent ill effects. But around the time I turned 50 all those great highly refined food products, the pinnacle of modern industrial food preparation began giving me abdominal pain and diarrhea.

I was forced to change my dietary habits, even give up my normal half gallon of milk every day which had been used to wash down all those candy bars and cookies. My gastric system forced me to start eating less candy, grease filled hot-dogs, hamburgers and sandwiches. I had to stop drinking half gallon sized big gulps filled with caffeinated corn syrup based soft drinks.

It is crazy, but I find that I have lost weight, am sleeping better, feeling better and have more energy. Who da thunk it?

22 posted on 08/20/2014 11:42:37 PM PDT by fireman15 (Check your facts before making ignorant statements.)
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To: Pining_4_TX

There was a company called Amylin Pharmaceuticals that was bought out a couple of years ago. They produced drugs for diabetes.


23 posted on 08/21/2014 12:06:04 AM PDT by Moonman62 (The US has become a government with a country, rather than a country with a government.)
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To: Pining_4_TX

bump


24 posted on 08/21/2014 12:56:32 AM PDT by Robert357 (D.Rather "Hoist with his own petard!" www.freerepublic.com/focus/f-news/1223916/posts)
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To: Pining_4_TX

Bm


25 posted on 08/21/2014 1:06:53 AM PDT by Popman (Jesus Christ Alone: The Cornerstone...)
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To: itssme

I am the only one in my extended family that has it. A nurse told me that an 87 yr. old can get Type I. I think it was the Cherry Coke that did me in.


26 posted on 08/21/2014 3:50:26 AM PDT by bjorn14 (Woe to those who call good evil and evil good. Isaiah 5:20)
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To: itssme

“No one in my immediate family had diabetes II, except me.
No one in my spouse’s immediate family, mother,father, siblings, grandparents, had the disease, but he contracted it.I would like to know the answer as to why, hopefully in my lifetime.”

Either one of you take statins for an extended period...I know someone with the same lack-of-family background that blames statins for the condition.


27 posted on 08/21/2014 3:47:47 PM PDT by BobL
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To: catnipman

I think it is possible that type 2 could be an autoimmune disease, too. Time will tell.


28 posted on 08/21/2014 8:31:51 PM PDT by Pining_4_TX (All those who were appointed to eternal life believed. Acts 13:48)
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