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One pill a day could keep food and nicotine cravings away (Rimonabant)
USA Today ^ | March 9, 2004 | Steve Sternberg

Posted on 03/09/2004 8:58:30 PM PST by FairOpinion

Edited on 04/13/2004 1:42:06 AM PDT by Jim Robinson. [history]

NEW ORLEANS Researchers took aim Tuesday at two of the world's leading killers by unveiling a single pill that suppresses the powerful cravings that drive people to overeat and smoke. Doctors don't view the drug, called rimonabant, as a Viagra-like lifestyle enhancer. Instead, they see it as a potential lifesaver that can reduce a constellation of risk factors for diabetes and heart disease.


(Excerpt) Read more at usatoday.com ...


TOPICS: Heated Discussion
KEYWORDS: classicflamewar
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"He found that the drug lowered levels of the dangerous blood fats called triglycerides and small dense LDL, the so-called "bad cholesterol," and C-reactive protein, a dangerous sign of artery inflammation. Rimonabant also improved the metabolic syndrome that signals imminent diabetes and heart disease and raised levels of HDL, which protect the heart."

Sounds like a miracle drug!

1 posted on 03/09/2004 8:58:31 PM PST by FairOpinion
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To: FairOpinion
For those interested reading the report -- here is the press release by Sanofi-Sythelabo:



Two pivotal studies indicate ACOMPLIA™ (rimonabant) offers a novel approach to cardiovascular risk management in overweight/obese people and smokers

RIO-LIPIDS AND STRATUS-US Study Results Announced Today at American College of Cardiology Annual Meeting

http://en.sanofi-synthelabo.com/press/ppc_23804.asp?ComponentID=23804&SourcePageID=22494#4
2 posted on 03/09/2004 9:04:15 PM PST by FairOpinion ("America will never seek a permission slip to defend the security of our country." --- G. W. Bush)
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To: FairOpinion
I'm there dude!

I need to quit smoking, the food thing isn't a problem...
3 posted on 03/09/2004 9:16:06 PM PST by TheSpottedOwl (Until Kofi Annan rides the Jerusalem RTD....nothing will change.)
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To: TheSpottedOwl
Once they showed it's amazingly effective, which they did, and that it has basically no side effects, which they also showed -- WHY does it take them two more years to bring it to market?

I am sure it's not the company's fault, it's probably more regulations. They really should do something about that.

On one hand, they are talking about how many people smoking and obesity kills, then they don't hurry and get something to market, which may save thousands of lives in the next couple of years -- or conversely, people will keep dying from diseases related to obesity, heart disease, and smoking, who could have been saved, if they allowed this pill to be sold.
4 posted on 03/09/2004 9:20:13 PM PST by FairOpinion ("America will never seek a permission slip to defend the security of our country." --- G. W. Bush)
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To: FairOpinion
bookmark bump
5 posted on 03/09/2004 9:33:43 PM PST by Bernard Marx (In theory there's no difference between theory and practice. But in practice there is.)
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To: FairOpinion
Trying to save people who are "killing themselves" is about as smart as trying to throw away a ball to discourage a Labrador Retriever from dropping it at your feet.
6 posted on 03/09/2004 9:42:10 PM PST by Old Professer
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To: FairOpinion
Once they showed it's amazingly effective, which they did, and that it has basically no side effects, which they also showed -- WHY does it take them two more years to bring it to market? I am sure it's not the company's fault, it's probably more regulations. They really should do something about that. On one hand, they are talking about how many people smoking and obesity kills, then they don't hurry and get something to market, which may save thousands of lives in the next couple of years -- or conversely, people will keep dying from diseases related to obesity, heart disease, and smoking, who could have been saved, if they allowed this pill to be sold.

Because next they will test it on several thousand people and look for unexpected side effects......like sudden death, complete failure of your bone marrow and other such stuff that may not be common but very dangerous.
Sometimes the cure is worse than the disease.

7 posted on 03/09/2004 9:47:07 PM PST by Politically Correct
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To: FairOpinion
They can't rush these things. Remember Phen-Phen? If it works to loose weight, people WILL take it. A lot of people. The FDA and the drug makers have to be sure it's safe or they'll be in for a very large lawsuit.

I wish these things would be available faster, too; but I'm glad they're cautious.

In the meantime...

http://ultrashape.com/

8 posted on 03/09/2004 10:05:25 PM PST by Marie (My coffee cup is waaaaay too small to deal with this day.)
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To: TheSpottedOwl
I'm there dude!

I need to quit eating, the tobacco thing isn't a problem...
9 posted on 03/09/2004 10:11:02 PM PST by null and void
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To: FairOpinion
But I like smoking and eating..................
10 posted on 03/09/2004 10:12:52 PM PST by WhiteGuy (Congress shall make no law... abridging the freedom of speech, or of the press...)
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To: FairOpinion
WHY does it take them two more years to bring it to market? I am sure it's not the company's fault, it's probably more regulations.

When I was in grad school, I was involved in research using Sanofi's latest cannabinoid antagonist (the early version of Rimonabant) and that was ten years ago. Using SR141716, we found early evidence for the cannabinoid CNS receptor subtypes and their actions. Fascinating stuff.

Again, that was 10 years ago. It usually takes that long to get a drug to the clinical trials and then with great results, another 2-3 years to work through the FDA regulation requirements. Unfortunately, very few people realize how long and how expensive it is to get a drug to market.

What's really sad is that this new class of drugs has been developed from cannabinoid research (that means evil POT) which was strongly "discouraged" by the federal government. This research showed medical potential to an evil drug during the Drug War. The Clinton Administration and the anti-drug groups were very unhappy that such research was going on and the funding dried up. Sanofi was one of the few pharmaceutical companies that kept going.

11 posted on 03/10/2004 2:53:02 AM PST by Ophiucus
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To: TheSpottedOwl
I'm there dude! I need to quit smoking, the food thing isn't a problem...

I'm there dude! I need to invest in this company's stock...

12 posted on 03/10/2004 2:58:49 AM PST by Ichneumon
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To: Ophiucus
Thanks for the insight. Very interesting.

I think people should never discourage research -- you never know, what you will find, as this pill is an example.
13 posted on 03/10/2004 8:37:52 AM PST by FairOpinion ("America will never seek a permission slip to defend the security of our country." --- G. W. Bush)
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To: Ophiucus
Research has shown that smoked marijuana will never be a medicine.
14 posted on 03/10/2004 8:41:09 AM PST by cinFLA
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To: FairOpinion
I think people should never discourage research -- you never know, what you will find, as this pill is an example.

Precisely/I have a friend who did his dissertation on a waste product from a Pacific Ocean sea sponge that slows tumor growth. Helpful drugs can come the most unusual sources.

15 posted on 03/10/2004 6:12:24 PM PST by Ophiucus
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To: cinFLA
Research has shown that smoked marijuana will never be a medicine.

First, reread the article and the post. This is not about smoked marijuana; it is about cannabinoids, the active agents in marijuana that bind with the cannabinoid receptors in the central and peripheral nervous systems. These receptors have many important roles in pain perception, anxiety and anger pathways, hormonal stress response, hormonal reproduction modulation, and others. The research is important for new treatments such as the one described for cardiac benefits of weight and smoking control.

Second - be careful with the word "never" in medicine and physiology. Marijuana has a long history as a medicine. For instance, the cannibis plant has been used in antiquity in many cultures for pain control. Chinese Emperor Shen Nung's Digest of Herbal Medicine, 2737 BC, lists cannabis as a treatment for digestive disfunctions and maladies now thought to be related to tumor growths. The Greeks and Romans listed it as a medicine for pain and seizures. Serious research began in the 1800's. In 1830's, there were published papers regarding the use of cannibus as an analgesic, anti-spasmodic, and muscle relaxant. Medical papers of the late 1800's and early 1900's listed cannabis as an effective treatment for tetanus, neuralgia, analgesia for persistent pain, uterine hemmorhage, and to relieve withdrawal symptoms of alcoholics. The banning of marijuana in the US stopped research into cannabis derivatives.

Then in the late 1960's, delta-9THC was found to be a powerful anti-epileptic. The FDA was pressured into considering the merits of cannabinoid research. In 1985, dronabinol was approved for the use of allieving the side-effects of chemotherapy and later, the use as an appetite stimulant for anorexia and AIDS therapy. Nabilone was then approved for similar uses. Research into cannabinoids was grudgingly allowed to continue. That lasted until the the end of the G.H.W. Bush administration and the beginning of the Clinton administration when cannabinoid research was again suppressed by the new War on Drugs efforts. Further research was left to less capable and less funded facilities in France, Germany, and Israel. Luckily, it looks like they have been able to produce some good results.

Smoked marijuana difficulties lay in dosage control and lack of purity of the active substances - not basic effectiveness. This is why the research on synthesized agents is necessary.

Also, until cannabinoids were researched with modern understandings of physiology. We were not aware that there is an endogenous cannabinoid pathway system and naturally occurring cannabinoid receptors in the body. Opium research resulted in our understanding the opioid systems in the brain and the mechanism of pain reception in the periphery. Without that, analgesics above the level of aspirin would not be possible. The cannabinoid receptors will have an even wider impact.

16 posted on 03/10/2004 7:07:32 PM PST by Ophiucus
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To: Ophiucus
I repeat: Research has shown that smoked marijuana will never be a medicine.
17 posted on 03/10/2004 7:36:23 PM PST by cinFLA
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To: cinFLA
I repeat: Research has shown that smoked marijuana will never be a medicine.

What research is this?

If you check again, you will find that the problems are of delivery and purity. Meaning, it can be used as a medicine, has been used as a medicine, but that better ways can be found and now are being found. As the receptors are characterized, localized, and the second messenger systems are elucidated (so far, extensive g-protein use, K+ channels, and glutamate modulation), then more specific substances can be created.

Your blind insistence is like saying opium would never be used as a medicine when it was and it led to morphine, opioid gate-controlled pain perception, then a range of specific agents of better use.

If you ever made a post that had a contribution outside of being merely disruptive, I would be stunned.

18 posted on 03/10/2004 11:52:28 PM PST by Ophiucus
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To: Ophiucus
You have made several replies but none have refuted my statement:

I repeat: Research has shown that smoked marijuana will never be a medicine.
19 posted on 03/11/2004 7:34:13 AM PST by cinFLA
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To: cinFLA
I repeat: Research has shown that smoked marijuana will never be a medicine.

I think the burden is on you to show this research.

Cough it up, so to speak :-)

20 posted on 03/11/2004 7:42:03 AM PST by krb (the statement on the other side of this tagline is false)
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To: krb
I think the burden is on you to show this research. Cough it up, so to speak :-)

That was MrLeroy's rule. He was banned and now onmyfeet has set the new rule. The one that challenges the post is required to show evidence that it is false.

21 posted on 03/11/2004 7:49:40 AM PST by cinFLA
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To: cinFLA
That's an illogical rule. You asserted that research has proved your thesis, so share your research.
22 posted on 03/11/2004 7:58:04 AM PST by krb (the statement on the other side of this tagline is false)
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To: krb
That's an illogical rule.

Then address your concern to MrLeroy onmyfeet. He is the master controller of these pro-drug propanda threads.

23 posted on 03/11/2004 8:00:43 AM PST by cinFLA
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To: FairOpinion
One pill a day could keep food and nicotine cravings away (Rimonabant)

Now if it could only enlarge a penis, spam would be almost defeated with a free market solution.

24 posted on 03/11/2004 8:02:39 AM PST by jwalsh07 (We're bringing it on John but you can't handle the truth!)
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To: FairOpinion
May I have ten-thousand Accomplia please?
25 posted on 03/11/2004 8:04:47 AM PST by Petronski (the co-ordination however falsification to subordinate joins easy the left democracy understanding)
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To: Ophiucus
Smoked marijuana difficulties lay in dosage control and lack of purity of the active substances - not basic effectiveness. This is why the research on synthesized agents is necessary.

That's funny. The potheads on FR always say the opposite: that dosage control is better when smoked, and that there are all sorts of magical properties from what normal people call impurities.

26 posted on 03/11/2004 8:12:35 AM PST by Moonman62
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To: cinFLA
Ok, we'll deal with the rule later. For now though, stop hiding behind it and post a link to your research that has shown that smoked marijuana will never be a medicine.

This appears to be a scientific thread, not a propaganda thread, BTW.
27 posted on 03/11/2004 8:19:12 AM PST by krb (the statement on the other side of this tagline is false)
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To: krb
Perhaps reality would be a better guide. Smoked marijuana is already medicine in several States, with more being proposed every year.
28 posted on 03/11/2004 8:23:45 AM PST by Wolfie
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To: krb
That's an illogical rule. You asserted that research has proved your thesis, so share your research.

Easy. Find me a doctor that recommends smoking for your health.

29 posted on 03/11/2004 8:26:52 AM PST by AppyPappy (If You're Not A Part Of The Solution, There's Good Money To Be Made In Prolonging The Problem.)
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To: AppyPappy
Easy. Find me a doctor that recommends smoking for your health.

Not so easy I am afraid. By your standard of "research," abortion is good medicine; I can probably find you docs all over the place to perform that "service" for you.

And on top of that, there are docs in the states that have tried to legitimize "medical mj" who will prescribe it for you.

30 posted on 03/11/2004 8:30:44 AM PST by krb (the statement on the other side of this tagline is false)
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To: krb
So those doctors do recommend smoking. Alert the tobacco companies.
31 posted on 03/11/2004 8:31:22 AM PST by AppyPappy (If You're Not A Part Of The Solution, There's Good Money To Be Made In Prolonging The Problem.)
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To: cinFLA
You have made several replies but none have refuted my statement: I repeat: Research has shown that smoked marijuana will never be a medicine.

You're being an ignorant, lying ass as usual. You fail to present any of your 'research' because it doesn't exist. Are you a physician, physician's assistant, any health professional at all? Have you gone through a graduate program in human physiology, pharmacology, microbiology, or neurology? You're completely unable to discern that the research debate was never about efficacy as a medicine but efficiency of delivery and complications of other substances endogenous to the cannabis plant.

Try to get this into your puny brain - Your statement of "will never be a medicine" is blatantly false as smoked marijuana has been used as a medicine in the past and in some quarters is still being used as a medicine. There have been programs in the US with smoked marijuana as a medicine in treatment regimens and there are ongoing ones in Canada. Thus smoked marijuana already is a medicine.

Thus, once again, you are simply repeating a lie to make yourself feel you can be the big argue man in a discussion.

Here's some examples of the research of smoked marijuana as a medicine: An Executive Summary from the National Institute of Medicine, Division of Neuroscience, 1999, recommended the short-term use of smoked marijuana until synthetic cannabinoids were approved or a controlled inhaler was developed. It as approved and served as the basis for a pilot study using smoked marijuana as a medicine - and even attempted to develop an inhaler.

UCSF performed a clinical trial using smoked marijuana in a treatment regimen for AIDS patients, 1997-1998.

The New York Journal of Medicine published a state clinical study in 1988 - "Inhalation Marijuana as an Antiemetic for Cancer Chemotherapy" by Vincent Vinciguerra, MD; Terry Moore, MSW; Eileen Brennan, RN - That would be smoked marijuana as a medicine.

August, 2003, Health Canada approved smoked marijuana for medical use for AIDS patients - again, as a medicine.

March, 2001, the International Association of Physicians in AIDS Care published in their journal a summary of the uses of smoked and derivative marijuana as medicines.

The Annals of Internal Medicine in January 2001 reviewed the uses of smoked marijuana as a medicine.

In April, 2001, Nature published a review of the medical uses of smoked marijuana.

The point studies have made is that a pill with one purified or synthetic cannabinoid is easier to control for dosage, purity, and action. This does not negate smoked marijuana as a medicine. A pill form or solution for injection will replace uses for smoked marijuana. Before morphine was developed, opium was dissolved in ethanol and taken in liquid form as a medicine - then purified and synthesized agents like morphine and codeine were later used for pills and injections as medicines. But the raw opium in ethanol is still considered a medicine.

Do you see how that works? Can you understand such a complex and difficult idea?

Or will you continue your mentality of a spoiled three year old like in other threads and yell, "Is not, is not, is not?"

32 posted on 03/11/2004 8:39:16 AM PST by Ophiucus
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To: Ophiucus
"The point studies have made is that a pill with one purified or synthetic cannabinoid is easier to control for dosage, purity, and action. This does not negate smoked marijuana as a medicine. A pill form or solution for injection will replace uses for smoked marijuana. "

You proved my point. Smoked marijuana is not going to be a medicine.
33 posted on 03/11/2004 8:41:54 AM PST by cinFLA
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To: Moonman62
That's funny. The potheads on FR always say the opposite: that dosage control is better when smoked, and that there are all sorts of magical properties from what normal people call impurities.

If someone says they can control the dosage better by smoking, they're either stoned or ignorant. If you had to take a 5 mg dose of widgetol and your choices were to smoke a 'rolled cigarette' of widget leaf containing 3-10 mg of widgetol depending on where it grew, how wet the growing season was, and how long ago it was harvested or 2.5 mg tablets of measured and processed widgetol, which would you use?

As far as impurities, smoked marijuana not only delivers a couple carcinogens but has many other physiologically active substances. That's why early studies had difficulties. It was hard to determine which cannabinoid was the one causing the desired effect and which were causing the side effects - like pain relief versus mental disorientation. With an isolated cannabinoid or a synthetic, the action becomes specific and side effects can be minimized.

34 posted on 03/11/2004 8:58:02 AM PST by Ophiucus
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To: krb
That's an illogical rule.

No, that's his game. Make a bogus claim, repeat it often as possible instead of responding, attack, lie, and obfuscate. He'd make a good DemoRat.

35 posted on 03/11/2004 9:01:03 AM PST by Ophiucus
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To: cinFLA
You proved my point. Smoked marijuana is not going to be a medicine.

Again you ignore facts that get in your way. Smoked marijuana already has been and already is a medicine.

Your insistence is like saying George Bush will never be President because he already is President.

Can you grasp that at all? It is too late to say smoked marijuana will never be a medicine after it already has been used as one.

36 posted on 03/11/2004 9:08:02 AM PST by Ophiucus
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To: krb; cinFLA
Summary of the cinFLA argument:

C: Charlton Heston will never be a movie star.
O: What do you mean? Charlton Heston is a great movie star.
C: Charlton Heston will never be a movie star.
O: Heston starred in big films like the Ten Commandments, Ben Hur, Planet of the Apes, Midway, Soylent Green, and Touch of Evil.
C: Charlton Heston will never be a movie star.
O: He may not appear in any more movies now that he's ill but he's one of the all time great movie stars.
C: You made my point. Charlton Heston will never be a movie star.
O: You're an idiot.
C: Charlton Heston will never be a movie star.

That's how all his 'contributions' go.

37 posted on 03/11/2004 9:35:48 AM PST by Ophiucus
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To: Ophiucus
Summary of the Ophiucus argument. >>>> Legalize crack and all our problems will go up in smoke.
38 posted on 03/11/2004 9:43:01 AM PST by cinFLA
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To: cinFLA
Summary of the Ophiucus argument. >>>> Legalize crack and all our problems will go up in smoke.

And there is yet another lie.

Was legalization mentioned anywhere? Did I even hint at legalizing crack?

No - you lied. Again.

Using the body's endogenous cannabinoid receptors to develop and use better cannabinoid medicines for treatment of medical conditions from addiction and obesity to control of chronic pain and epileptic seizures. That was mentioned but you failed to comprehend the subject - again - and had to lie - again.

39 posted on 03/11/2004 9:55:55 AM PST by Ophiucus
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To: Ophiucus
Did I even hint at legalizing crack?

Do you deny you are for legalization of crack?

40 posted on 03/11/2004 9:57:13 AM PST by cinFLA
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To: FairOpinion
"On one hand, they are talking about how many people smoking and obesity kills, then they don't hurry and get something to market, which may save thousands of lives in the next couple of years."

I see where you are coming from on this. On the other hand, we do want to make sure that the potential side affects are fully understood. Side affects don't always show up right away.

41 posted on 03/11/2004 10:00:43 AM PST by MEGoody (Kerry - isn't that a girl's name? (Conan O'Brian))
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To: Ophiucus
LOL!!!
42 posted on 03/11/2004 10:22:43 AM PST by krb (the statement on the other side of this tagline is false)
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To: cinFLA
You always answer questions with questions. That is weird and unproductive.
43 posted on 03/11/2004 10:25:32 AM PST by krb (the statement on the other side of this tagline is false)
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To: krb
Are you also one of those pro-crack legalizers?
44 posted on 03/11/2004 10:26:46 AM PST by cinFLA
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To: Ophiucus
"That's how all his 'contributions' go."


That's not fair. He also makes lots of posts accusing onmyfeet of being MrLeRoy, and implying that at least some of the people making anti-WOD statements are paid shills for George Soros. Of course, he can't provide any proof for those claims, either.
45 posted on 03/11/2004 10:32:34 AM PST by -YYZ-
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To: cinFLA
"Do you deny you are for legalization of crack?"

Have you stopped beating your wife yet?
46 posted on 03/11/2004 10:34:04 AM PST by -YYZ-
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To: -YYZ-
Are you also one of those pro-crack legalizers?
47 posted on 03/11/2004 10:36:38 AM PST by cinFLA
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To: Ophiucus; krb; -YYZ-
Ophiucus;krb;-YYZ-


People that won't answer the question: Do you favor legalization of crack?
48 posted on 03/11/2004 10:44:41 AM PST by cinFLA
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To: cinFLA
Are you gay?
49 posted on 03/11/2004 10:44:59 AM PST by krb (the statement on the other side of this tagline is false)
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To: -YYZ-
Have you stopped beating your wife yet?

Have you found help for your cocaine habit?

50 posted on 03/11/2004 10:45:20 AM PST by cinFLA
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