Free Republic
Browse · Search
Smoky Backroom
Topics · Post Article

Skip to comments.

One pill a day could keep food and nicotine cravings away (Rimonabant)
USA Today ^ | March 9, 2004 | Steve Sternberg

Posted on 03/09/2004 8:58:30 PM PST by FairOpinion

Edited on 04/13/2004 1:42:06 AM PDT by Jim Robinson. [history]

NEW ORLEANS Researchers took aim Tuesday at two of the world's leading killers by unveiling a single pill that suppresses the powerful cravings that drive people to overeat and smoke. Doctors don't view the drug, called rimonabant, as a Viagra-like lifestyle enhancer. Instead, they see it as a potential lifesaver that can reduce a constellation of risk factors for diabetes and heart disease.


(Excerpt) Read more at usatoday.com ...


TOPICS: Heated Discussion
KEYWORDS: classicflamewar
Navigation: use the links below to view more comments.
first 1-2021-4041-6061-80 ... 141-158 next last
"He found that the drug lowered levels of the dangerous blood fats called triglycerides and small dense LDL, the so-called "bad cholesterol," and C-reactive protein, a dangerous sign of artery inflammation. Rimonabant also improved the metabolic syndrome that signals imminent diabetes and heart disease and raised levels of HDL, which protect the heart."

Sounds like a miracle drug!

1 posted on 03/09/2004 8:58:31 PM PST by FairOpinion
[ Post Reply | Private Reply | View Replies]

To: FairOpinion
For those interested reading the report -- here is the press release by Sanofi-Sythelabo:



Two pivotal studies indicate ACOMPLIA™ (rimonabant) offers a novel approach to cardiovascular risk management in overweight/obese people and smokers

RIO-LIPIDS AND STRATUS-US Study Results Announced Today at American College of Cardiology Annual Meeting

http://en.sanofi-synthelabo.com/press/ppc_23804.asp?ComponentID=23804&SourcePageID=22494#4
2 posted on 03/09/2004 9:04:15 PM PST by FairOpinion ("America will never seek a permission slip to defend the security of our country." --- G. W. Bush)
[ Post Reply | Private Reply | To 1 | View Replies]

To: FairOpinion
I'm there dude!

I need to quit smoking, the food thing isn't a problem...
3 posted on 03/09/2004 9:16:06 PM PST by TheSpottedOwl (Until Kofi Annan rides the Jerusalem RTD....nothing will change.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: TheSpottedOwl
Once they showed it's amazingly effective, which they did, and that it has basically no side effects, which they also showed -- WHY does it take them two more years to bring it to market?

I am sure it's not the company's fault, it's probably more regulations. They really should do something about that.

On one hand, they are talking about how many people smoking and obesity kills, then they don't hurry and get something to market, which may save thousands of lives in the next couple of years -- or conversely, people will keep dying from diseases related to obesity, heart disease, and smoking, who could have been saved, if they allowed this pill to be sold.
4 posted on 03/09/2004 9:20:13 PM PST by FairOpinion ("America will never seek a permission slip to defend the security of our country." --- G. W. Bush)
[ Post Reply | Private Reply | To 3 | View Replies]

To: FairOpinion
bookmark bump
5 posted on 03/09/2004 9:33:43 PM PST by Bernard Marx (In theory there's no difference between theory and practice. But in practice there is.)
[ Post Reply | Private Reply | To 1 | View Replies]

To: FairOpinion
Trying to save people who are "killing themselves" is about as smart as trying to throw away a ball to discourage a Labrador Retriever from dropping it at your feet.
6 posted on 03/09/2004 9:42:10 PM PST by Old Professer
[ Post Reply | Private Reply | To 4 | View Replies]

To: FairOpinion
Once they showed it's amazingly effective, which they did, and that it has basically no side effects, which they also showed -- WHY does it take them two more years to bring it to market? I am sure it's not the company's fault, it's probably more regulations. They really should do something about that. On one hand, they are talking about how many people smoking and obesity kills, then they don't hurry and get something to market, which may save thousands of lives in the next couple of years -- or conversely, people will keep dying from diseases related to obesity, heart disease, and smoking, who could have been saved, if they allowed this pill to be sold.

Because next they will test it on several thousand people and look for unexpected side effects......like sudden death, complete failure of your bone marrow and other such stuff that may not be common but very dangerous.
Sometimes the cure is worse than the disease.

7 posted on 03/09/2004 9:47:07 PM PST by Politically Correct
[ Post Reply | Private Reply | To 4 | View Replies]

To: FairOpinion
They can't rush these things. Remember Phen-Phen? If it works to loose weight, people WILL take it. A lot of people. The FDA and the drug makers have to be sure it's safe or they'll be in for a very large lawsuit.

I wish these things would be available faster, too; but I'm glad they're cautious.

In the meantime...

http://ultrashape.com/

8 posted on 03/09/2004 10:05:25 PM PST by Marie (My coffee cup is waaaaay too small to deal with this day.)
[ Post Reply | Private Reply | To 4 | View Replies]

To: TheSpottedOwl
I'm there dude!

I need to quit eating, the tobacco thing isn't a problem...
9 posted on 03/09/2004 10:11:02 PM PST by null and void
[ Post Reply | Private Reply | To 3 | View Replies]

To: FairOpinion
But I like smoking and eating..................
10 posted on 03/09/2004 10:12:52 PM PST by WhiteGuy (Congress shall make no law... abridging the freedom of speech, or of the press...)
[ Post Reply | Private Reply | To 1 | View Replies]

To: FairOpinion
WHY does it take them two more years to bring it to market? I am sure it's not the company's fault, it's probably more regulations.

When I was in grad school, I was involved in research using Sanofi's latest cannabinoid antagonist (the early version of Rimonabant) and that was ten years ago. Using SR141716, we found early evidence for the cannabinoid CNS receptor subtypes and their actions. Fascinating stuff.

Again, that was 10 years ago. It usually takes that long to get a drug to the clinical trials and then with great results, another 2-3 years to work through the FDA regulation requirements. Unfortunately, very few people realize how long and how expensive it is to get a drug to market.

What's really sad is that this new class of drugs has been developed from cannabinoid research (that means evil POT) which was strongly "discouraged" by the federal government. This research showed medical potential to an evil drug during the Drug War. The Clinton Administration and the anti-drug groups were very unhappy that such research was going on and the funding dried up. Sanofi was one of the few pharmaceutical companies that kept going.

11 posted on 03/10/2004 2:53:02 AM PST by Ophiucus
[ Post Reply | Private Reply | To 4 | View Replies]

To: TheSpottedOwl
I'm there dude! I need to quit smoking, the food thing isn't a problem...

I'm there dude! I need to invest in this company's stock...

12 posted on 03/10/2004 2:58:49 AM PST by Ichneumon
[ Post Reply | Private Reply | To 3 | View Replies]

To: Ophiucus
Thanks for the insight. Very interesting.

I think people should never discourage research -- you never know, what you will find, as this pill is an example.
13 posted on 03/10/2004 8:37:52 AM PST by FairOpinion ("America will never seek a permission slip to defend the security of our country." --- G. W. Bush)
[ Post Reply | Private Reply | To 11 | View Replies]

To: Ophiucus
Research has shown that smoked marijuana will never be a medicine.
14 posted on 03/10/2004 8:41:09 AM PST by cinFLA
[ Post Reply | Private Reply | To 11 | View Replies]

To: FairOpinion
I think people should never discourage research -- you never know, what you will find, as this pill is an example.

Precisely/I have a friend who did his dissertation on a waste product from a Pacific Ocean sea sponge that slows tumor growth. Helpful drugs can come the most unusual sources.

15 posted on 03/10/2004 6:12:24 PM PST by Ophiucus
[ Post Reply | Private Reply | To 13 | View Replies]

To: cinFLA
Research has shown that smoked marijuana will never be a medicine.

First, reread the article and the post. This is not about smoked marijuana; it is about cannabinoids, the active agents in marijuana that bind with the cannabinoid receptors in the central and peripheral nervous systems. These receptors have many important roles in pain perception, anxiety and anger pathways, hormonal stress response, hormonal reproduction modulation, and others. The research is important for new treatments such as the one described for cardiac benefits of weight and smoking control.

Second - be careful with the word "never" in medicine and physiology. Marijuana has a long history as a medicine. For instance, the cannibis plant has been used in antiquity in many cultures for pain control. Chinese Emperor Shen Nung's Digest of Herbal Medicine, 2737 BC, lists cannabis as a treatment for digestive disfunctions and maladies now thought to be related to tumor growths. The Greeks and Romans listed it as a medicine for pain and seizures. Serious research began in the 1800's. In 1830's, there were published papers regarding the use of cannibus as an analgesic, anti-spasmodic, and muscle relaxant. Medical papers of the late 1800's and early 1900's listed cannabis as an effective treatment for tetanus, neuralgia, analgesia for persistent pain, uterine hemmorhage, and to relieve withdrawal symptoms of alcoholics. The banning of marijuana in the US stopped research into cannabis derivatives.

Then in the late 1960's, delta-9THC was found to be a powerful anti-epileptic. The FDA was pressured into considering the merits of cannabinoid research. In 1985, dronabinol was approved for the use of allieving the side-effects of chemotherapy and later, the use as an appetite stimulant for anorexia and AIDS therapy. Nabilone was then approved for similar uses. Research into cannabinoids was grudgingly allowed to continue. That lasted until the the end of the G.H.W. Bush administration and the beginning of the Clinton administration when cannabinoid research was again suppressed by the new War on Drugs efforts. Further research was left to less capable and less funded facilities in France, Germany, and Israel. Luckily, it looks like they have been able to produce some good results.

Smoked marijuana difficulties lay in dosage control and lack of purity of the active substances - not basic effectiveness. This is why the research on synthesized agents is necessary.

Also, until cannabinoids were researched with modern understandings of physiology. We were not aware that there is an endogenous cannabinoid pathway system and naturally occurring cannabinoid receptors in the body. Opium research resulted in our understanding the opioid systems in the brain and the mechanism of pain reception in the periphery. Without that, analgesics above the level of aspirin would not be possible. The cannabinoid receptors will have an even wider impact.

16 posted on 03/10/2004 7:07:32 PM PST by Ophiucus
[ Post Reply | Private Reply | To 14 | View Replies]

To: Ophiucus
I repeat: Research has shown that smoked marijuana will never be a medicine.
17 posted on 03/10/2004 7:36:23 PM PST by cinFLA
[ Post Reply | Private Reply | To 16 | View Replies]

To: cinFLA
I repeat: Research has shown that smoked marijuana will never be a medicine.

What research is this?

If you check again, you will find that the problems are of delivery and purity. Meaning, it can be used as a medicine, has been used as a medicine, but that better ways can be found and now are being found. As the receptors are characterized, localized, and the second messenger systems are elucidated (so far, extensive g-protein use, K+ channels, and glutamate modulation), then more specific substances can be created.

Your blind insistence is like saying opium would never be used as a medicine when it was and it led to morphine, opioid gate-controlled pain perception, then a range of specific agents of better use.

If you ever made a post that had a contribution outside of being merely disruptive, I would be stunned.

18 posted on 03/10/2004 11:52:28 PM PST by Ophiucus
[ Post Reply | Private Reply | To 17 | View Replies]

To: Ophiucus
You have made several replies but none have refuted my statement:

I repeat: Research has shown that smoked marijuana will never be a medicine.
19 posted on 03/11/2004 7:34:13 AM PST by cinFLA
[ Post Reply | Private Reply | To 18 | View Replies]

To: cinFLA
I repeat: Research has shown that smoked marijuana will never be a medicine.

I think the burden is on you to show this research.

Cough it up, so to speak :-)

20 posted on 03/11/2004 7:42:03 AM PST by krb (the statement on the other side of this tagline is false)
[ Post Reply | Private Reply | To 19 | View Replies]


Navigation: use the links below to view more comments.
first 1-2021-4041-6061-80 ... 141-158 next last

Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.

Free Republic
Browse · Search
Smoky Backroom
Topics · Post Article

FreeRepublic, LLC, PO BOX 9771, FRESNO, CA 93794
FreeRepublic.com is powered by software copyright 2000-2008 John Robinson