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This Is Your Brain on Meth: A 'Forest Fire' of Damage
NY Times ^ | July 20, 2004 | SANDRA BLAKESLEE

Posted on 07/19/2004 8:22:02 PM PDT by neverdem

People who do not want to wait for old age to shrink their brains and bring on memory loss now have a quicker alternative - abuse methamphetamine for a decade or so and watch the brain cells vanish into the night.

The first high-resolution M.R.I. study of methamphetamine addicts shows "a forest fire of brain damage," said Dr. Paul Thompson, an expert on brain mapping at the University of California, Los Angeles. "We expected some brain changes but didn't expect so much tissue to be destroyed."

The image, published in the June 30 issue of The Journal of Neuroscience, shows the brain's surface and deeper limbic system. Red areas show the greatest tissue loss.

The limbic region, involved in drug craving, reward, mood and emotion, lost 11 percent of its tissue. "The cells are dead and gone," Dr. Thompson said. Addicts were depressed, anxious and unable to concentrate.

The brain's center for making new memories, the hippocampus, lost 8 percent of its tissue, comparable to the brain deficits in early Alzheimer's. The methamphetamine addicts fared significantly worse on memory tests than healthy people the same age.

The study examined 22 people in their 30's who had used methamphetamine for 10 years, mostly by smoking it, and 21 controls matched for age. On average, the addicts used an average of four grams a week and said they had been high on 19 of the 30 days before the study began.

Methamphetamine is an addictive stimulant made in clandestine laboratories nationwide. When taken by mouth, snorted, injected or smoked, it produces intense pleasure by releasing the brain's reward chemical, dopamine. With chronic use, the brains that overstimulate dopamine and another brain chemical, serotonin, are permanently compromised.

The study held one other surprise, Dr. Thompson said: white matter, composed of nerve fibers that connect different areas, was severely inflamed, making the addicts' brains 10 percent larger than normal. "This was shocking," he said. But there was one piece of good news: the white matter was not dead. With abstinence, it might recover.



TOPICS: Culture/Society; Extended News; News/Current Events
KEYWORDS: brain; mentalhealth; meth; methamphetamine; mri; neuroscience; speedkills; wod
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To: TheErnFormerlyKnownAsBig
"... buddy of mine in the Navy went from normal to meth user to booted out of the Navy to selling his ass on the street to men to pay for Heroin/meth/crack all in 8 months."

Oh, come on... How do you know it was the methamphetamines and not the Navy that did it to him?

21 posted on 07/19/2004 8:49:23 PM PDT by The KG9 Kid (Semper Fi)
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To: Oztrich Boy
Drug use is against the Law, should that not be the sufficient and the only reason for any behavioural decision?

Let's say, just for the sake of discussion, there was a law that said it was OK for one man to own another as property. (pretty silly, eh?)

Let's further suppose that the law said that if said property were to "run off" and was subsequently recaptured, it should be returned to its "rightful owner".

Isn't it nice that you've got The Law to guide your behavioral decision there?

22 posted on 07/19/2004 8:50:29 PM PDT by DuncanWaring (...and Freedom tastes of Reality)
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To: neverdem

http://news.google.com/news?q=This%20Is%20Your%20Brain%20on%20Meth%3A%20A%20Forest%20Fire%20of%20Damage&hl=en&lr=&ie=UTF-8&safe=off&sa=N&tab=wn

Click on the google link above, then click on the top link with this text:

This Is Your Brain on Meth: A 'Forest Fire' of Damage
New York Times, NY
... The first high-resolution MRI study of methamphetamine addicts shows "a forest fire of brain damage," said Dr. Paul Thompson, an expert on brain mapping at the ...


This will avoid NYT registration.


23 posted on 07/19/2004 8:53:40 PM PDT by counterpunch (The CouNTeRPuNcH Collection - www.counterpunch.us)
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To: martin_fierro

Slammin' the Libertarian argument tonight, eh? Good on ya.


24 posted on 07/19/2004 8:54:58 PM PDT by ErnBatavia ("Dork"; a 60's term for a 60's kinda guy: JFK)
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To: Pikachu_Dad
You asked:
"I wonder if the same effects are seen with Adderall and Ritalin."

Well, I wouldn't be surprised if the effects are EXACTLY the same, but,,, reread the article, it says:

"On average, the addicts used an average of four grams a week and said they had been high on 19 of the 30 days before the study began."

A normal dose of Adderall (for an adult with ADHD) is 20 to a maximum of 60 mG per day. This is 0.02 to 0.06 G per day.

4 G/week = 0.57 G/day, from the usage indicated in the article.

So, this means if you take 10 to 30 times the NORMAL PRESCRIBED DOSE, you would quite likely see some damage.

This of it this way:

So you had a couple drinks last night?

What would have happened to you if you had TWENTY or THIRTY drinks last night?
25 posted on 07/19/2004 8:55:19 PM PDT by RonHolzwarth
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To: Mr. Mojo

LOL!!


26 posted on 07/19/2004 8:58:35 PM PDT by randog
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To: RonHolzwarth

PS: Maybe should have ended that posting with: What would happen to you if you had TWENTY or THIRTY drinks EVERY night, for the last TEN YEARS?


27 posted on 07/19/2004 9:02:34 PM PDT by RonHolzwarth
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To: neverdem
I wonder if similar differences are seen with chronic cocaine abuse.

From what I've seen, methamphetamine makes cocaine and crack look like baby food by comparison. That stuff is incredibly dangerous, and when it fries you, you stay fried.

28 posted on 07/19/2004 9:02:49 PM PDT by lafroste
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To: RonHolzwarth

I imagine if you abused orange juice for ten years, a scan of your kidneys would be horrible, too. Good thing OJ isn't addictive.


29 posted on 07/19/2004 9:03:12 PM PDT by gcruse (http://gcruse.typepad.com/)
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To: martin_fierro

Good Grief! Talk about a downward spiral, post# 18, hey Martin Is there a time line for those photos?


30 posted on 07/19/2004 9:07:35 PM PDT by DirtyHarryY2K (G W B 2004!)
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To: DuncanWaring
Isn't it nice that you've got The Law to guide your behavioral decision there?

1. Just that once I thought I'd try a hit of WOD to see if the rush was all the users claimed it was.

2. I don't do sarcasm tags

31 posted on 07/19/2004 9:07:42 PM PDT by Oztrich Boy (/"Despise not the jester. Often he is the only one speaking the truth")
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To: lafroste

its the smoking, i think. some people use it as a cheap strong speed, orally or nasally, but many unfortunates start smoking the stuff and apparently thats when it spirals. the effect is different when smoked, too.


32 posted on 07/19/2004 9:17:32 PM PDT by sweneop
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To: lafroste
From what I've seen, methamphetamine makes cocaine and crack look like baby food by comparison.

That's what I've seen too. The crackheads you can sometimes pull back. The tweakers are gone. They are broken people with broken brains, and no one knows how to fix them. I have met too many 20- and 22-year old tweakers who will never have "lives." They will have "existences" as paranoid vegetables, living in flophouse hotels and stealing and lying their way to the next hit.

The drug has been around as long as I have. But you never meet an old tweaker. You don't even meet any middle-aged tweakers. I've met 40-year-old crackheads. I've never seen a 40-year-old tweaker.


33 posted on 07/19/2004 9:24:44 PM PDT by Nick Danger (Be shuh two zee da nuuuu Ahnold Schwohza-naygah moooovie)
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To: Larry381
Here's hoping they don't do a study of former heroin users.

Why not?

34 posted on 07/19/2004 9:25:47 PM PDT by neverdem (Xin loi min oi)
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To: The KG9 Kid

It was a double blind study and I didn't suffer the same effect. The control group was your local chapter.


35 posted on 07/19/2004 9:27:02 PM PDT by TheErnFormerlyKnownAsBig (You can turn your head away from the Berg video and still hear Al Queda's calls to prayer.)
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To: gcruse

Oh NO! You commented:

"I imagine if you abused orange juice for ten years, a scan of your kidneys would be horrible, too. Good thing OJ isn't addictive."

I joke quite often that I have a drinking problem with OJ, no matter how much I buy, I drink it ALL within 24 hours! I just can't stop!

Are you SURE it is NOT addictive? But, I must admit, I only buy it when it is on sale! And I NEVER put anything like vodka in it. But I gotta admit, once every couple or three years I do have a bit of tequila and have a "sunrise". But that makes my head hurt really bad.


36 posted on 07/19/2004 9:27:10 PM PDT by RonHolzwarth
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To: RonHolzwarth

Uh, oh. My advice is that you keep an inventory of the number of navels you have. When it gets to be more than one, watch for resemblance to Anita Bryant, the terminal stage. :)


37 posted on 07/19/2004 9:41:37 PM PDT by gcruse (http://gcruse.typepad.com/)
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To: TheErnFormerlyKnownAsBig

As they say, if you're not crazy when you start Meth, you will be after...


38 posted on 07/19/2004 9:45:27 PM PDT by null and void (Middle East n. former name for the region commonly known as Oil Under Glass)
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To: Nick Danger

I assume a speedfreak is a tweaker. Let me know if I'm wrong. It's the first time that I've heard or read it. Do you have any idea how it was derived?


39 posted on 07/19/2004 9:46:52 PM PDT by neverdem (Xin loi min oi)
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To: neverdem

High 19 out of 30 days, it was under any of the users were still coherent.


40 posted on 07/19/2004 9:48:15 PM PDT by .cnI redruM (Knight of The Mind - On Crusade Vs. Liberal Stupidity!!)
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