Drug prohibition is at its core a utopian social-engineering agenda that contradicts a fundamental reality of human nature. We've had 30+ years of the so-called "War on Drugs" and "illegal" drugs are more plentiful than ever, despite the fact that there are 500,000+ prisoners in the U.S. in jail for drug "crimes".
Memo to Drug War-supporting conservatives: utopian social-engineering agendas are the stock-in-trade of the socialist left, and are eternally doomed to failure. Even ex-Drug Czar Barry McCaffery once admitted that we would never be able to "jail our way out of the drug problem". It's time to admit that the best solution is the market solution: legalize, tax, and regulate, get the federal government out of the drug prohibition enforcement business, and leave regulation up to the states like it is for alcohol and tobacco.
Fine. Pass an amendment similar in wording to the 21st which, in Section 2, turned the alcohol legalization decision over to the states.