[Vn_survivor_67-68]

Discovery of Unexpected Ibuprofen-Aspirin Interaction will Force a Change in Ibuprofen Prescribing
New England Journal of Medicine

A new study published in the December 20, 2001 issue of the New England Journal of Medicine has found that ibuprofen blocks the heart-protecting effects of aspirin.

The study entitled Cyclooxygenase Inhibitors and the Antiplatelet Effects of Aspirin by Francesca Catella-Lawson, M.D and her colleagues concludes: "The concomitant administration of ibuprofen but not rofecoxib, acetaminophen, or diclofenac antagonizes the irreversible platelet inhibition induced by aspirin. Treatment with ibuprofen in patients with increased cardiovascular risk may limit the cardioprotective effects of aspirin."

The study found that when patients took a single dose of ibuprofen beforehand, aspirin lost 98 percent of its blood-thinning power. If aspirin was taken first, three daily doses of ibuprofen eliminated 90 per cent of aspirin's benefit.

The study found show no conflict between aspirin and three other arthritis drugs: rofecoxib, diclofenac, and acetaminophen.

[neverdem]

Thanks for the citation. Folks taking daily aspirin should take it at least one hour before taking any NSAIDs.

Cyclooxygenase Inhibitors and the Antiplatelet Effects of Aspirin

FReepmail me if you want on or off my health and science ping list. IIRC, rofecoxib was Vioxx.

[Veto!]

Over here. Read post #8