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Alzheimer brain damage 'reversed'
BBC News ^ | Saturday, 22 January, 2005, 00:26 GMT | BBC News

Posted on 01/22/2005 12:05:15 PM PST by Middle-O-Road

Scientists have reversed the damage caused to the brain by Alzheimer's disease during tests on mice. The US team used an antibody to remove the build up of potentially damaging deposits from the area of the brain responsible for memory and cognition.

The treatment reversed the nerve cell damage in days, Washington University School of Medicine researchers said.

UK experts described the findings, published in the Journal of Clinical Investigation, as "exciting".

Prior to the study, it was thought that once the damage had been caused to the brain there was no way of repairing it.

This new work is particularly interesting since it seems the nerve cells that were damaged in Alzheimer's disease were able to partly recover after the plaques cleared

Harriet Millward

Lead author Robert Brendza said: "We thought that clearing the plaques (deposits) would halt the progression of the damage.

"But what we saw was much more striking - in just three days there were 20 to 25% reductions in the number or six of the existing swellings."

He said more research was needed to see if the effects could be repeated in humans with the degenerative brain disorder for which there is no cure.

It is estimated that 2% to 5% of people over 65 years of age and up to 20% of those over 85 years of age have Alzheimer's.

The cause of the disease is not known although people with Alzheimer's do have a build up of abeta, a glycoprotein, which could be responsible for the nerve cell damage.

Mice with a build up of abeta were injected with the antibody and then using a dye to give detailed images of the nerve cell branches, the team were able to monitor the improvement over a few days.

'Interesting'

"From the details that I've seen, these could be very interesting results.

Alzheimer's Research Trust deputy chief executive Harriet Millward said: "This new work is particularly interesting since it seems the nerve cells that were damaged in Alzheimer's disease were able to partly recover after the plaques cleared."

But she added: "We are still a long way from finding an answer to Alzheimer's, but by learning more about the disease process, we will be able to accelerate progress towards ways to treat and prevent this devastating condition."

Dr Susanne Sorensen, head of research at the Alzheimer's Society, said several researchers across the world were also looking into the use of antibodies.

But she added: "The research in animal models reported here is exciting because it provides additional, important information about how abeta antibodies may reverse the signs of disease in neurons.

"However, there is still a lot to learn about what happens to the brain cells during Alzheimer's, and what these antibodies do to reverse the situation."


TOPICS: Culture/Society; News/Current Events
KEYWORDS: alzheimer
This is one disease I'd like to see bite the dust.
1 posted on 01/22/2005 12:05:16 PM PST by Middle-O-Road
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To: Middle-O-Road

WOW! Wonderful!


2 posted on 01/22/2005 12:07:15 PM PST by RoseofTexas
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To: Middle-O-Road

I agree, and this is encouraging. I am very hopeful that gene therapy is going to provide a number of much needed fixes to ailments that have gone untreatable before this. Very cool.


3 posted on 01/22/2005 12:09:40 PM PST by DoughtyOne (US socialist liberalism would be dead without the help of politicians who claim to be conservative.)
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To: RoseofTexas

I agree! It's an awful disease.


4 posted on 01/22/2005 12:10:54 PM PST by Mears
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To: Middle-O-Road

Hmmm...no stem cells from aborted babies needed after all? Great news!


5 posted on 01/22/2005 12:12:25 PM PST by arasina (So there.)
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To: Middle-O-Road

Too bad there isn't a cure for the brain disease that causes people to become liberals...


6 posted on 01/22/2005 12:14:16 PM PST by WestVirginiaRebel ("Senator, we can have this discussion in any way that you would like.")
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To: Middle-O-Road
Scientists have reversed the damage caused to the brain by Alzheimer's disease during tests on mice.

Good news for Liberals.

7 posted on 01/22/2005 12:17:11 PM PST by pabianice
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To: Middle-O-Road

Great news - thanks.


8 posted on 01/22/2005 12:18:32 PM PST by lodwick (Integrity has no need of rules. Albert Camus)
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To: Middle-O-Road

"In families descended from Volga Germans--a group of German families that settled in the Volga River valley in Russia in the 1800s--dozens of descendants have developed Alzheimer's disease in middle age."

I'm in the above at risk group.

Here is the link with a discussion.
http://www.medhelp.org/NIHlib/GF-62.html


9 posted on 01/22/2005 12:18:58 PM PST by Prost1 (I get my news at Free Republic!)
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To: Middle-O-Road

Prior post this subject
http://freerepublic.com/focus/f-news/1324947/posts
Antibody treatment partially reverses nerve damage in Alzheimer disease


10 posted on 01/22/2005 12:19:19 PM PST by HangnJudge
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To: WestVirginiaRebel

Too bad there isn't a cure for the brain disease that causes people to become liberals...
======
I think such a finding would be a miracle for the world...along with curing Alzheimers (sp?) -- I watched a relative die over 5 years from it, and it was a very ugly death. A merciful quick death would have been a blessing.

Liberalism is just as bad because it kills the living -- and they continue to live with the mental disorder...


11 posted on 01/22/2005 12:19:22 PM PST by EagleUSA
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To: Middle-O-Road

Most interesting. Thanks for posting. My dad has dementia.


12 posted on 01/22/2005 12:20:09 PM PST by Starboard
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To: pabianice
Scientists have reversed the damage caused to the brain by Alzheimer's disease during tests on mice.

Yes, but bad news for PETA. Now if they'd said "during tests on 'rats," then PETA wouldn't care since they prefer all humans die, including Democrats.

Given that, I wonder why Democrats like PETA?

13 posted on 01/22/2005 12:23:17 PM PST by Middle-O-Road (In favor of blowing all terrorists to China, via other hotter places where they'll linger a while.)
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To: Middle-O-Road

A dreadful disease..heartbreaking for the victim and the families...I do hope help is on the way soon.


14 posted on 01/22/2005 12:24:12 PM PST by MEG33 (GOD BLESS OUR ARMED FORCES)
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To: Middle-O-Road
How many decade will pass before the FDA gets around to thinking about approving this treatment?
15 posted on 01/22/2005 12:24:36 PM PST by fella
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To: fella
They tried an earlier version of this vaccine in humans ~2yrs ago,
12 people developed encephalitis before halting trials.
They will be a little more cautious this time
16 posted on 01/22/2005 12:33:51 PM PST by HangnJudge
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To: Middle-O-Road

Thank you for posting this. My mom died from Alzheimers and dementia, so I'm very interested in any developments in this field. This looks very promising.


17 posted on 01/22/2005 12:34:58 PM PST by TheSpottedOwl
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To: Middle-O-Road

Absolutely! My father was a brilliant man, and watching Alzheimers destroy him was like seeing the lights in a great city blink out -- one by one -- until total darkness claimed everything...


18 posted on 01/22/2005 12:43:03 PM PST by TXnMA (Attention, ACLU: There is no constitutionally protected right to NOT be offended -- Shove It!)
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To: TheSpottedOwl

My mother developed dementia..It broke my heart the night I finally moved a bed against the door to keep her from going outside again in total darkness to turn off a faucet that was not running...I think I went a bit demented facing it.


19 posted on 01/22/2005 12:44:39 PM PST by MEG33 (GOD BLESS OUR ARMED FORCES)
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To: Middle-O-Road

"This is one disease I'd like to see bite the dust."

You got that right. Imagine the implications if we could count on additional millions of our people being lucid, mentally alert, memory sharp, routinely into their 80's and 90's.


Plus the benefits to longevity and lifespan, since most Alzheimers patients die from complications rather than some other concurrent illness.

If this were to pan out it would radically alter every policy equation in our society today.

The only comparable innovation would be an affordable effective medicine to reverse severe arthritis.

Solve these two and you automatically shut down the entire nursing home industry and the major expense of medicare and medicaid as well. Health care "crisis" would be over, that simply.


20 posted on 01/22/2005 12:48:15 PM PST by hinckley buzzard
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To: Middle-O-Road

What??? And no babies had to die for their stem cells???


STUNING!


21 posted on 01/22/2005 12:50:56 PM PST by melbell (There are 10 types of people in the world...those who understand binary, and those who don't.)
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To: Prost1
Wow, thank you for that link. I am also a direct descendant of the Germans in Russia group. My grandmother died of it as well as 7 of the 9 members in my mother's family (1 heart attack. 1 war casualty). Really interesting information.

TC

22 posted on 01/22/2005 12:51:28 PM PST by I_be_tc
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To: neverdem

ping


23 posted on 01/22/2005 12:52:07 PM PST by farmfriend ( Congratulations. You are everything we've come to expect from years of government training.)
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To: Middle-O-Road

Oh my God. What a hopeful story.
Thy will be done.


24 posted on 01/22/2005 12:55:42 PM PST by Finalapproach29er (I can no longer discern reality from satire on this site. America is losing her common sense.)
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To: HangnJudge

Did the encephalitis kill them? How was their brain function after the encephalitis cleared? Did every-one in the study get encephalitis? Of the ones who didn't, was there any improvement in Alzheimer's symptoms?
Just curious...that's all!


25 posted on 01/22/2005 12:56:11 PM PST by mdmathis6
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To: EagleUSA

"Liberalism is just as bad because it kills the living---and they continue to live with the mental disorder".



BUT WE CAN HOPE THEY HAVE AN EPIPHANY DURING OR BEFORE MIDLIFE! :)

A NEW POSTER AND A "RECOVERED" DEMOCRAT



26 posted on 01/22/2005 1:00:28 PM PST by KATIE-O
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To: Middle-O-Road

Thanks for the post and welcome aboard!


27 posted on 01/22/2005 1:02:19 PM PST by PGalt
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To: mdmathis6
http://alzheimers.about.com/od/research/a/vaccine_alz.htm
...attempts at developing a protein-based vaccine have met with limited success
http://www.mercola.com/2002/mar/16/alzheimers_vaccine.htm
Alzheimer's Vaccine is Halted Due to Brain Inflammation
28 posted on 01/22/2005 1:04:50 PM PST by HangnJudge
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To: KATIE-O

Welcome to FR!


29 posted on 01/22/2005 1:05:03 PM PST by MEG33 (GOD BLESS OUR ARMED FORCES)
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To: Middle-O-Road
I hear a powerful rustling sound. Must be my mom, dancing in Heaven at this promising news.

Either that or she's redecorating the place.

30 posted on 01/22/2005 1:05:44 PM PST by Graymatter
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To: Middle-O-Road
Wow. Even if they could've arrested it's progression as a first step, that would have been fantastic. But to actually get the damage to start reversing itself, that is outstanding.It's a vile disease that slowly eats away at a person's mind, their memories, their lucidity. Wiping Alzheimer's out would be one of the great medical miracles of the last 200 years.


31 posted on 01/22/2005 1:08:43 PM PST by Viking2002 (Taglines? Vikings don't need no steenkin' taglines..............)
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To: MEG33

By the time I was able to move down there, she had been placed in a facility. She kept calling the cops saying there were people in her attic(actually a crawl space), and living in the garage. She turned on everyone, either from the dementia or the Alzheimers, or both. I had her moved eventually from the first facility, to a 6 person facility in a single family home a couple of miles from where we lived. It was a good move for her, but it was hard on us to see her steadily decline. After a visit, I needed a drink.

I felt bad for Nancy Reagan, especially seeing her at RR's funeral. Going through it is bad enough, without being in the public eye.


32 posted on 01/22/2005 1:58:44 PM PST by TheSpottedOwl
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To: hinckley buzzard
You got that right. Imagine the implications if we could count on additional millions of our people being lucid, mentally alert, memory sharp, routinely into their 80's and 90's.

I have to disagree with your post. Some families must take care of their afflicted relatives at home, because of lack of money or insurance. Alzheimers can turn your beloved parent or grandparent into a raving, paranoid lunatic. They can become violent. After my mom had hip replacement surgery, she tried to punch out a nurse. They had to tie her to the bed. After the anasthesia was out of her system, they were able to resume her meds.

Try dealing with that at home. With children in the home. They wander off, forget who you are, and can possibly turn violent. I'm all for a vaccine, cure, or anything that can alleviate this condition.

33 posted on 01/22/2005 2:11:53 PM PST by TheSpottedOwl
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To: WestVirginiaRebel

there is.
it's called death.


34 posted on 01/22/2005 2:19:08 PM PST by eccl1212
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.


35 posted on 01/22/2005 7:53:23 PM PST by firewalk
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