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Stem cells used to restore vision
BBC News ^ | April 28, 2005

Posted on 05/02/2005 9:45:13 PM PDT by Founding Father

Stem cells used to restore vision

A hospital in West Sussex is pioneering the use of stem cells to restore the eyesight of patients. The trial, being carried out at the Queen Victoria Hospital, East Grinstead, has already helped 40 people see again.

The surgery at the hospital has been developed over the past five years.

Stem cells from the patient or a donor are used to redevelop the cornea, the transparent film at the front of the eye which lets in light.

Opthalmic surgeon Sheraz Daya said: "Many people who've had injuries to their eyes, or even people born with congenital deficiencies of stem cells, land up having a problem with the top layer of their cornea.

Eyesight restored

"Even if we do a corneal transplant, that will not stay clear, it'll cloud over and fail.

"So what we need to do is replace those stem cells that are missing."

Among the 40 people who have already had their eyesight restored is Deborah Catlyn.

She was blind in one eye from the age of seven and then became partially-sighted in the other eye after an acid attack in a nightclub.

The treatment at Queen Victoria Hospital meant Ms Catlyn could see her daughter properly for the first time.

"I thought, 'My God, is that really my baby, look at her she's beautiful'," she said.

Story from BBC NEWS: http://news.bbc.co.uk/go/pr/fr/-/1/hi/england/southern_counties/4495419.stm

Published: 2005/04/28 19:11:10 GMT


TOPICS: Business/Economy; Culture/Society; Foreign Affairs; Front Page News; News/Current Events; Philosophy; United Kingdom
KEYWORDS: abortion; adultstemcells; blind; blindness; cornea; cornealtransplant; eyes; eyesight; fetaltissue; health; ophthalmology; sight; stemcell; stemcellresearch; stemcells; vision
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More exciting stem cell news.
1 posted on 05/02/2005 9:45:19 PM PDT by Founding Father
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To: Founding Father
Stem cells used to restore vision

But wouldn't it a violation of a Democrat's civil rights to change the visual orientation he was born with?

2 posted on 05/02/2005 9:47:20 PM PDT by sourcery (Resistance is futile: We are the Blog)
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To: Founding Father
Stem cells from the patient or a donor are used to redevelop the cornea, the transparent film at the front of the eye which lets in light.

Notice where the stem cells came from?

3 posted on 05/02/2005 9:54:16 PM PDT by FreeperinRATcage (I am free because I know that I alone am morally responsible for every thing I do. - R. A. Heinlein)
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To: sourcery

Notice they're "from the donor" and not a dead baby.


4 posted on 05/02/2005 9:54:58 PM PDT by Grn_Lantern (Let's go to work...)
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To: FreeperinRATcage

beat me to it by 30 seconds...


5 posted on 05/02/2005 9:55:21 PM PDT by Grn_Lantern (Let's go to work...)
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To: Founding Father

BTTT


6 posted on 05/02/2005 9:58:05 PM PDT by kellynla (U.S.M.C. 1st Battalion,5th Marine Regiment, 1st Marine Div. Viet Nam 69&70 Semper Fi)
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To: Founding Father; 2ndMostConservativeBrdMember; afraidfortherepublic; Alas; al_c; ...


7 posted on 05/02/2005 9:59:25 PM PDT by Coleus (I support ethical, effective and safe stem cell research and use: adult, umbilical cord, bone marrow)
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To: Founding Father

As someone who lost their eyesight and was looking at cornea transplants only a year ago, this is very exciting news.


8 posted on 05/02/2005 10:03:04 PM PDT by Hillary's Lovely Legs (We had gay burglars the other night. They broke in and rearranged the furniture.)
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To: Founding Father

I posted this a few days ago.

It is amazing,isn't it?


9 posted on 05/02/2005 10:05:02 PM PDT by Finalapproach29er (America is gradually becoming the Godless,out-of-control golden-calf scene,in "The Ten Commandments")
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To: Grn_Lantern

Or even the patient.


10 posted on 05/02/2005 10:08:10 PM PDT by weegee (WE FOUGHT ZOGBYISM November 2, 2004 - 60 Million Voters versus 60 Minutes - BUSH WINS!!!)
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To: Grn_Lantern

Ya, but I misformatted the HTML and hadda play with it..I aint gud wit dat teknkal stuf.

So I beat ya by more than 30 sec :)


11 posted on 05/02/2005 10:14:03 PM PDT by FreeperinRATcage (I am free because I know that I alone am morally responsible for every thing I do. - R. A. Heinlein)
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To: Hillary's Lovely Legs

Great tagline!

And bless you!


12 posted on 05/02/2005 11:20:36 PM PDT by Yehuda (America: Land of the free, THANKS TO THE BRAVE! [" Choke on it, pinkos!"])
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To: Founding Father
More exciting stem cell news.

More good reasons to kill babies -- is not babies made for growing new eyes is adults?

Of course, I always thought that God had other uses for itty bitty babies...

13 posted on 05/03/2005 12:20:07 AM PDT by topher (John 5:58 + Exodus 21:22 +Jer 1:5 + Gen 9:6 +John 14:6 + Rev 12:1-17)
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To: Finalapproach29er
It is amazing,isn't it?

Nazi Germany was also a very amazing place -- jet plane developed, the V2 rocket -- all sorts of wonderful achievements.

But I seem to forget -- what was the cost of these wonderful developments in Nazi Germany -- was it the loss of millions of lives?

I guess itty bitty babies can now be bottled as a wonder potion -- thanks to the Anti-Christ, excuse me, modern medicine...

14 posted on 05/03/2005 12:22:57 AM PDT by topher (John 5:58 + Exodus 21:22 +Jer 1:5 + Gen 9:6 +John 14:6 + Rev 12:1-17)
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To: topher

These are ADULT stem cells. Are you against that, too?


15 posted on 05/03/2005 2:11:29 AM PDT by Finalapproach29er (America is gradually becoming the Godless,out-of-control golden-calf scene,in "The Ten Commandments")
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To: Grn_Lantern
"Notice they're "from the donor" and not a dead baby."

Because babies are not the only source of stem cells, they are now able to be produced through synthesis and can be extracted from a donor. The type of cell is important the article is not a scientific paper, so it does not mention if the cell is multipotent, pluripotent or totopotent (in the latter case this would mean non-ethical sources but be advised there ARE synthesis techniques pioneered that do not rely on harvesting embryonic stem cells). Just because stem cells are mentioned in this article it is not a given that these are embryonic or non-ethical methodologies.

16 posted on 05/03/2005 2:30:36 AM PDT by Kelly_2000
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To: topher

This has NOTHING to due with babies. These are ADULT stem cells which can be donated by the patient.

Read carefully, there are STEM cells and FETAL Stem cells.


17 posted on 05/03/2005 3:36:45 AM PDT by Hillary's Lovely Legs (We had gay burglars the other night. They broke in and rearranged the furniture.)
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To: neverdem
Please ping your list. This is more good news from the non fetal stem cell front.
18 posted on 05/03/2005 3:46:53 AM PDT by airborne (Dear Lord, please be with my family in Iraq. Keep them close to You and safely in Your arms.)
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To: airborne

agreed :-)


19 posted on 05/03/2005 3:53:29 AM PDT by Kelly_2000
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To: Hillary's Lovely Legs
From the article:

Stem cells from the patient or a donor...

Hillary's Lovely Legs wrote:

This has NOTHING to due with babies. These are ADULT stem cells which can be donated by the patient.

Read carefully, there are STEM cells and FETAL Stem cells.

Okay. At 3 AM I misread it. But they did not say who the donor was -- embryonic stem cell or fetal or someone who willing donates his stem cells.

I admit I am wrong, but article is not clear on what the term donor means. My belief was that this meant an abortion clinic could donate the aborted.

Adult and Ambilical Stem Cells have proven to be better for medicine. Both are morally acceptable. Embryonic Stell Cells have been known to generate tumors (rapid growth).

I apologize for being wrong, but one can still interpret the article to mean that an abortion clinic could be a donor (in my opinion).

Sorry. Maybe I should learn English at 3AM...

20 posted on 05/03/2005 4:31:11 AM PDT by topher (John 5:58 + Exodus 21:22 +Jer 1:5 + Gen 9:6 +John 14:6 + Rev 12:1-17)
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To: Finalapproach29er
These are ADULT stem cells. Are you against that, too?

No. I interpreted the word donor to mean an abortion clinic could be a donor of sorts -- maybe that is skewing things. The article was unclear where exactly they got the stem cells. You can take the stem cells of an aborted baby with cornea developed -- because they did not state that the donors were adults.

I also was trying to interpret this at 3AM.

I wish they would have explicitly stated these are not embryonic stem cells and they do use aborted babies as donors.

21 posted on 05/03/2005 4:35:53 AM PDT by topher (John 5:58 + Exodus 21:22 +Jer 1:5 + Gen 9:6 +John 14:6 + Rev 12:1-17)
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To: topher
Boy, you missed the point here. These were not embryonic stem cells. They were stem cells from the same person. This is exciting because it is another nail in the need for embryonic stem cell use.
22 posted on 05/03/2005 4:39:58 AM PDT by Founding Father (A proud "vigilante." My money goes to support Minutemen, not Republicans.)
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To: topher

Stem cells from the patient or a donor are used to redevelop the cornea...
----
No baby needed


23 posted on 05/03/2005 5:11:59 AM PDT by Finalapproach29er (America is gradually becoming the Godless,out-of-control golden-calf scene,in "The Ten Commandments")
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To: Grn_Lantern

"Notice they're "from the donor" and not a dead baby."

Notice the source of the stem cells is virtually buried in the story.

They didn't want to say "ADULT STEM CELL". The MSM wants to blur the source in these stories so as to push acceptence of killing of the unborn.

Watch this story be edited and altered to serve the embryonic goals that the evil one's have.


24 posted on 05/03/2005 5:40:23 AM PDT by George from New England
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To: Founding Father

>Stem cells from the patient or a donor<

Notice:
NOT EMBRYONIC STEM CELLS!!


25 posted on 05/03/2005 5:42:41 AM PDT by G Larry (Aggressively promote conservative judges!)
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To: topher

While liberal media outlets might well weasel on the source of stem cells by using 'donor' to include murdered, unwilling 'donors', the fact that the article explicitly says 'from the patient' shows that the procedure works with adult stem cells (like all the successful stem cell procedures to date). Autodonation (patient as source) also has the virtue of no chance of tissue rejection and no need for anti-rejection drugs (a point which should be made loudly to everyone who through stupidity or wickedness equates 'stem cells' with 'embryonic stem cells'.)


26 posted on 05/03/2005 5:59:26 AM PDT by The_Reader_David (Christ is Risen! Christos Anesti! Khristos Voskrese! Al-Masih Qam! Hristos a Inviat!)
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To: Founding Father; topher; Coleus

These are ethical adult stem cells - or they should be, since the patient is the most accessible source.


1: Ophthalmology. 2005 Mar;112(3):470-7.

Outcomes and DNA analysis of ex vivo expanded stem cell allograft for ocular surface reconstruction.

Daya SM, Watson A, Sharpe JR, Giledi O, Rowe A, Martin R, James SE.

Corneo-Plastic Unit, Queen Victoria Hospital, East Grinstead, West Sussex, United Kingdom. sdaya@centreforsight.com

PURPOSE: To investigate the outcome of a new technique of ex vivo expanded stem cell allograft for limbal stem cell deficiency (LSCD), and to characterize the ocular surface genotype after surgery.

DESIGN: Retrospective noncomparative case series.

PARTICIPANTS: Ten eyes of 10 patients with profound LSCD arising from ectodermal dysplasia (3 eyes), Stevens-Johnson syndrome (3 eyes), chemical injury (2 eyes), thermal injury (1 eye), and rosacea blepharoconjunctivitis (1 eye).

INTERVENTION: Allogeneic corneal limbal stem cells were cultured on plastic and transplanted to the recipient eye after removal of conjunctival pannus. Amniotic membrane was applied in a bandage capacity. The procedure was combined with other reconstructive surgery in 2 cases. Nine patients received systemic cyclosporin A immunosuppression, and the DNA genotype was investigated with surface impression cytology.

MAIN OUTCOME MEASURES: Parameters of LSCD,
including vascularization, conjunctivalization, inflammation, epithelial defect, photophobia, and pain.

RESULTS: The mean follow-up period was 28 months (range,
12-50). Seven of 10 eyes (70%) had improved parameters of LSCD at final follow-up and were considered successes. Four (40%) had improved visual acuity, including 3 having had further procedures for visual rehabilitation. Three
patients failed to improve-1 with a thermal burn and lid deformity, 1 with Stevens-Johnson syndrome and severe dry eye, and 1 with ectodermal dysplasia who developed an epithelial defect at 26 months. DNA analysis of the first 7 cases showed no ex vivo donor stem cell DNA present beyond 9 months.
CONCLUSIONS: Ex vivo expanded stem cell allograft is a useful technique for restoring the ocular surface in profound LSCD. The absence of donor DNA beyond 9 months suggests that ongoing immunosuppression may be unnecessary and raises questions regarding the origin of the host corneal epithelium.

PMID: 15745776 [PubMed - indexed for MEDLINE]


You can do Medline searches at
http://www.ncemi.org/

Go to the left side bar "Medbot searches." It's often easiest to put in the researcher's last name and then first initial, no punctuation. Do a search for relevant pubished articles.

More information on amniotic membrane bandage
"The amniotic membranes used to make the AMCL's come from human placentas obtained immediately following elective cesarean sections at the end of a normal gestation period.""
http://www.wangvisioninstitute.com/Nashville%20Business%20Journal_9_30_02.htm


27 posted on 05/03/2005 7:14:11 AM PDT by hocndoc (Choice is the # 1 killer in the US)
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To: hocndoc
First, thanks for your posting. Below is just some of my concerns because the just used the word donor...

They might do some research using late term abortions -- which is my biggest concern.

I just wish they would have said adult donors in the article.

But in China, they have been known to kill condemned prisoners in such a way as to exploit the organs for donation (and for a price).

So the term Adult Living Donor would have been nice to clarify things...

It was unclear from the article.

In the past, organizations such as the March of Dimes have funded research to have fetuses born alive for research purposes.

28 posted on 05/03/2005 9:26:10 AM PDT by topher (John 5:58 + Exodus 21:22 +Jer 1:5 + Gen 9:6 +John 14:6 + Rev 12:1-17)
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To: topher

Meant in the kindest way, although blunt: Slow down and think it out next time. "Might" is not right. Everything and anything can be perverted in this fallen world, I agree. But this article and this line of research supports life.

(someone might suggest that you are a candidate for the therapy, if you're not careful!)


29 posted on 05/03/2005 9:31:33 AM PDT by hocndoc (Choice is the # 1 killer in the US)
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To: airborne; El Gato; JudyB1938; Ernest_at_the_Beach; Robert A. Cook, PE; lepton; LadyDoc; jb6; ...

FReepmail me if you want on or off my health and science ping list.

N.B. In comment# 27, "Nine patients received systemic cyclosporin A immunosuppression", i.e. an anti-rejection drug because of a foreign body transplant.


30 posted on 05/03/2005 10:43:50 AM PDT by neverdem (May you be in heaven a half hour before the devil knows that you're dead.)
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To: neverdem

But look at the conclusion - there is no foreign DNA in some after 9 months, and it appears that the new cells are autologous.

MMMMM-could it be that the native stem cells are activated/recruited?


31 posted on 05/03/2005 10:50:33 AM PDT by hocndoc (Choice is the # 1 killer in the US)
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To: hocndoc
Thanks for the links, in particular http://www.ncemi.org/. "EKG of the Week" is dynamite! Added to "favorites".
32 posted on 05/03/2005 10:50:50 AM PDT by neverdem (May you be in heaven a half hour before the devil knows that you're dead.)
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To: cpforlife.org; Peach; Mr. Silverback

Interesting stem cell ping, if you didn't read it already.


33 posted on 05/03/2005 10:57:18 AM PDT by neverdem (May you be in heaven a half hour before the devil knows that you're dead.)
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To: hocndoc
But look at the conclusion - there is no foreign DNA in some after 9 months, and it appears that the new cells are autologous.

It's quite an interesting conclusion. I was only trying to emphasize the fact that an anti-rejection drug was used because it was thought to be necessary for a foreign body transplant, i.e. allografts.

34 posted on 05/03/2005 11:06:28 AM PDT by neverdem (May you be in heaven a half hour before the devil knows that you're dead.)
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To: Founding Father

bttt


35 posted on 05/03/2005 2:13:44 PM PDT by firewalk
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To: hocndoc
I am having trouble with arthritis -- maybe the pain is fouling up my thoughts.

Sorry. I really should slow down and use the brain for thinking, and not just rant.

36 posted on 05/03/2005 4:08:46 PM PDT by topher (John 5:58 + Exodus 21:22 +Jer 1:5 + Gen 9:6 +John 14:6 + Rev 12:1-17)
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To: Hillary's Lovely Legs

Sorry for my awful posting here. I hope you will accept my apology -- good luck with your eyesight.


37 posted on 05/03/2005 4:10:22 PM PDT by topher (John 5:58 + Exodus 21:22 +Jer 1:5 + Gen 9:6 +John 14:6 + Rev 12:1-17)
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To: Founding Father
I am sorry about my reckless rant. I did not understand that this is not anything to do with fetal or with embryonic stem cells.

I hope you will accept my apology.

38 posted on 05/03/2005 4:11:41 PM PDT by topher (John 5:58 + Exodus 21:22 +Jer 1:5 + Gen 9:6 +John 14:6 + Rev 12:1-17)
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To: Finalapproach29er
Sorry for what I posted earlier -- maybe I need to get my eyes examined and my head.

I misread what this was about.

Once again my sincere apology.

39 posted on 05/03/2005 4:12:45 PM PDT by topher (John 5:58 + Exodus 21:22 +Jer 1:5 + Gen 9:6 +John 14:6 + Rev 12:1-17)
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To: The_Reader_David
My apology for what I posted here. Sorry I fouled up such a wonderful thread.

Maybe there is a positive side that people will read it, and see that adult stem cells or patient stem cells are the way to go, and stop harming itty bitty babies.

Once again, a sincere apology.

40 posted on 05/03/2005 4:15:57 PM PDT by topher (John 5:58 + Exodus 21:22 +Jer 1:5 + Gen 9:6 +John 14:6 + Rev 12:1-17)
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To: topher

It's cool, with all the talk of embryonic stem cells I can see how you can make the mistake.

And thanks, I can see now with glasses.


41 posted on 05/03/2005 4:28:15 PM PDT by Hillary's Lovely Legs (If God wanted us to bend over he'd put diamonds on the floor.)
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To: Hillary's Lovely Legs
As someone who lost their eyesight and was looking at cornea transplants only a year ago, this is very exciting news.

Wow, HLL, I had no idea about your story!. I'm so glad that, with technology, your voice has been so enjoyed on FR! I agree that this new scientific breakthrough is very exciting, especially since it doesn't involve killing babies. Regards...
42 posted on 05/03/2005 4:35:22 PM PDT by demkicker (Support DeLay, the Hammer, and the filibuster ban on judicial nominations!)
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To: topher

Apology accepted. I fear I may you an apology as well: it was the wicked and fools who advocate the murder of innocents to produces 'cures' that I was referring to, but I realized too late you might have mistaken my intent as suggestion your confusion was due to either.

Autodonation is ideal (unless one is trying to treat a gentic defect) for the reasons I elucidated, and this should be pointed out whenever the culture of death tries to justify the dismemberment of unborn children in the public's mind by tying it to the will-o'-the-wisp of hypothetical miracle cures.

(Incidentally your reference to the Antichrist is quite a propos: there is a prophecy known in the Orthodox Church (I forget which saint it is due to) that 'in the days of the Antichrist, all the miracles of Christ will be reproduced, except that the dead will not be raised'. Note the subtlety of the wording--the reproduction of the miracles is not by the Antichrist, but a sign of the end-times.)


43 posted on 05/03/2005 5:31:34 PM PDT by The_Reader_David (Christ is Risen! Christos Anesti! Khristos Voskrese! Al-Masih Qam! Hristos a Inviat!)
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To: topher

Absolutely accepted and glad to know another fervent believer against abortion. FF


44 posted on 05/03/2005 6:12:40 PM PDT by Founding Father (A proud "vigilante." My money goes to support Minutemen, not Republicans.)
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To: neverdem

excellent.


45 posted on 05/03/2005 6:47:04 PM PDT by bitt ("There are troubling signs Bush doesn't care about winning a third term." (JH2))
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To: George from New England
Notice the source of the stem cells is virtually buried in the story.

I am convinced that most people don't understand this issue at all. Here is the gist of a radio commercial I heard earlier today. A newsperson says, "Some people are against stem cell research....are they still against it when the stem cells used are your own?"

Well, of friggin course not!! IF the people writing the commercial understood the issue AT ALL, then they would KNOW that this isn't an issue. It was ridiculous.

46 posted on 05/03/2005 9:58:44 PM PDT by Dianna
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To: Founding Father
Stem cells from the patient or a donor are used to redevelop the cornea, the transparent film at the front of the eye which lets in light.

They couldn't bring themselves to say ADULT stem cells.

47 posted on 05/03/2005 10:10:06 PM PDT by <1/1,000,000th%
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To: Kelly_2000

Would it be possible for doctors at a parents request to extract foetal stem cells from a developing foetus in utero and then preserve and store them for the unborn childs own use later in life if necessary...a 'bank your own stem cells' approach?

While this wouldnt be of help to older generations could it not be helpful to the newborn through their lifetimes to have their own foetal stem cells being available to them WITHOUT any recourse to ethically problematic sources like abortion?


48 posted on 05/04/2005 6:16:53 AM PDT by FYREDEUS (FYREDEUS)
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To: Dianna

"IF the people writing the commercial understood the issue AT ALL, then they would KNOW that this isn't an issue"

The people writing the commercial DO UNDERSTAND the issue. The people writing...want to confuse and brainwash the mass to thinking their way. Their way and satan's is one in the same.


49 posted on 05/04/2005 6:44:58 AM PDT by George from New England
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To: FYREDEUS
Hi Fyre

Yes it is possible, and I do not agree with this practice. As I mentioned synthesis techniques are being researched I am in favour of this approach.

50 posted on 05/04/2005 8:09:57 AM PDT by Kelly_2000
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