I guess if we come down with H5N1 the proper procedure would be to drink a whole case of Pinot Noir, or swallow a whole bottle of supplement, just to get a microgram or two of resveratrol into the bloodstream. (don't try this at home).
I am especially skeptical of health websites that start out with a Flash presentation and ones where the president of the company writes the research reports.
Having said that, I guess the oxidation and liver metabolism issues are something to keep in mind.
There are enough other cytokine storm inhibitors on 2ndreconmarine's list, available for lower cost, to keep me busy taking pills ;).
In any case, I wouldn't wait until I had the avian flu (H5N1) before taking these remedies. They seem to take days, if not weeks, to build up affect in some cases, and H5N1 can take you down in hours, by the worse case scenarios.
Here's where we have a -big- advantage over previous pandemics. Something like FreeRepublic.com can provide us better early warning, so we can start to take measures before it likely gets to us personally.
posted on 11/28/2005 6:26:39 PM PST
(To err is human; to moo is bovine.)
Infectious Disease 2005 May 15;191(10):1719-29. Epub 2005 Apr 13.
Palamara AT, Nencioni L, Aquilano K, De Chiara G, Hernandez L, Cozzolino F, Ciriolo MR, Garaci E.
Institute of Microbiology, University of Rome La Sapienza, Rome, Italy. email@example.com
We have previously shown that the life cycles of several viruses are influenced by host-cell redox states. Reports of the antioxidant activities of the plant polyphenol resveratrol (RV) prompted us to investigate its effects on influenza virus replication in vitro and in vivo. We found that RV strongly inhibited the replication of influenza virus in MDCK cells but that this activity was not directly related to glutathione-mediated antioxidant activity. Rather, it involved the blockade of the nuclear-cytoplasmic translocation of viral ribonucleoproteins and reduced expression of late viral proteins seemingly related to the inhibition of protein kinase C activity and its dependent pathways. RV also significantly improved survival and decreased pulmonary viral titers in influenza virus-infected mice. No toxic effects were observed in vitro or in vivo. That RV acts by inhibiting a cellular, rather than a viral, function suggests that it could be a particularly valuable anti-influenza drug.
Why would they note in vivo if it was essentially impossible to get free resveratrol into the bloodstream?
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