Infectious Disease 2005 May 15;191(10):1719-29. Epub 2005 Apr 13.
Palamara AT, Nencioni L, Aquilano K, De Chiara G, Hernandez L, Cozzolino F, Ciriolo MR, Garaci E.
Institute of Microbiology, University of Rome La Sapienza, Rome, Italy. firstname.lastname@example.org
We have previously shown that the life cycles of several viruses are influenced by host-cell redox states. Reports of the antioxidant activities of the plant polyphenol resveratrol (RV) prompted us to investigate its effects on influenza virus replication in vitro and in vivo. We found that RV strongly inhibited the replication of influenza virus in MDCK cells but that this activity was not directly related to glutathione-mediated antioxidant activity. Rather, it involved the blockade of the nuclear-cytoplasmic translocation of viral ribonucleoproteins and reduced expression of late viral proteins seemingly related to the inhibition of protein kinase C activity and its dependent pathways. RV also significantly improved survival and decreased pulmonary viral titers in influenza virus-infected mice. No toxic effects were observed in vitro or in vivo. That RV acts by inhibiting a cellular, rather than a viral, function suggests that it could be a particularly valuable anti-influenza drug.
Why would they note in vivo if it was essentially impossible to get free resveratrol into the bloodstream?
No one, not even Longevintex, claims it is essentially impossible to get resveratrol into the blood. It was just a question of how hard it was to do this. Did you need intravenous injections of laboratory pure nitrogen packed resveratrol, or are some old pills bought for lowest cost a year ago and just rediscovered on the back of your medicine cabinet shelf just fine?
posted on 11/28/2005 7:17:38 PM PST
(To err is human; to moo is bovine.)
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