That would be Wickard v. Filburn, which IMHO marked the death knell of the Tenth Amendment and the end of limitations to federal powers. I had some hope that the current Court was working to roll it back, with rulings like Printz and Morrisson, but Gonzales v. Raich put an end to that. I'm terribly disappointed in Justice Scalia. Justice Thomas is the last true hero on the Court.
Agreed. I'll be pleasantly shocked if anyone as conservative as Justice Thomas sits on the SCOTUS ever again.