Posted on 08/29/2005 12:37:10 AM PDT by LibWhacker
WASHINGTON (Reuters) - Starving -- officially known as caloric restriction -- may make worms and mice live up to 50 percent longer but it will not help humans live super-long lives, two biologists argued on Sunday.
They said their mathematical model showed that a lifetime of low-calorie dieting would only extend human life span by about 7 percent, unlike smaller animals, whose life spans are affected more by the effects of starvation.
This is because restricting calories only indirectly affects life span, said John Phelan of the University of California Los Angeles and Michael Rose of the University of California Irvine.
Researchers at various universities and the National Institutes of Health are testing the theories but there are groups already cutting calories by up to a third in the hope they can live to be 120 or 125, while staying healthy.
"Our message is that suffering years of misery to remain super-skinny is not going to have a big payoff in terms of a longer life," said Phelan, an evolutionary biologist, in a statement.
The idea of caloric restriction has been gaining credence as scientists test it in more and more animals. It is easy to show that creatures that have short life spans such as mice, fish and spiders live longer if they eat less.
All things being equal, then, cutting calories by about a third should also help people to dramatically live longer and proponents of the idea are actively dieting.
"All things, however, are not equal," Phelan and Rose wrote in their report, published in the journal Ageing Research Reviews. "Longevity is not a trait that exists in isolation; it evolves as part of a complex life history, with a wide range of underpinning physiological mechanisms involving, among other things, chronic disease processes."
For instance, in mice, starvation reduces fertility, which in turn lengthens life span as the animal is not stressed by repeated matings and pregnancies and the associated production of hormones, they said.
COMPUTER MODEL OF LIFE SPAN
They came up with a mathematical model based on the known effects of calorie intake and life span.
"In Japanese populations, for example, the normal male diet is approximately 2,300 kilocalories (calories) per day," they wrote -- and the average life span for a Japanese male is 76.7 years.
"Sumo wrestlers, however, consume an average of approximately 5,500 calories per day and have a life expectancy of 56 years," they added.
People living on the Japanese island of Okinawa eat somewhat less than the average Japanese. They also live slightly longer. This could give a basis for calculating the benefits of eating less.
Calculations based on the Okinawa and sumo wrestler data suggest that if Japanese people ate just 1,500 calories a day, the longest average life span attainable would be just under 82 years, Phelan and Rose wrote.
Researchers are trying to find out if perhaps some genetic elements of eating less may explain the effects on mice -- and someday might be translated into people.
In the current issue of the journal Science, Hiroshi Kurosu of the University of Texas Southwestern in Dallas and colleagues found that mutant mice who produced too much of a gene called Klotho lived longer.
It affected a process called the insulin-like growth factor-1 signalling pathway, they reported.
"Klotho protein may function as an anti-aging hormone in mammals," Kurosu and colleagues wrote.
Starving- officially known as a way to die. Well documented by human beings, long before the current rat studies.
(Denny Crane: "Sometimes you can only look for answers from God and failing that... and Fox News".)
"Starving will not make people live longer, research says."
Think this was a slow news day? Low and behold, people, your tax dollars at work thanks to the old, reliable government.
Maybe it just SEEMS longer.
(Denny Crane: "Sometimes you can only look for answers from God and failing that... and Fox News".)
Starving won't make people live longer-researchers
Second sentence:
They said their mathematical model showed that a lifetime of low-calorie dieting would only extend human life span by about 7 percent
That's 5 years on a 70 year life-span.
(Denny Crane: "Sometimes you can only look for answers from God and failing that... and Fox News".)
(Denny Crane: "Sometimes you can only look for answers from God and failing that... and Fox News".)
Vice versa.
This reminds me of a study done a while back of people who spend an inordinate amount of time working out. It seems that when the life span gained is subtracted from the time spent exercising, it is a net loss.
(Denny Crane: "Sometimes you can only look for answers from God and failing that... and Fox News".)
I have thought about death for the first time lately-lesion on my lung. It doesn't look like cancer, but the scare got me thinking.
(Denny Crane: "Sometimes you can only look for answers from God and failing that... and Fox News".)
Hadn't heard of this... Best wishes to you, Jeff. I hope it's nothing and that you live to see your children turn 100!
LOL!!!
You don’t bring nothing with you here
And you can’t take nothing back
I ain’t never seen a hearse, with a luggage rack
from You'll Be There, a George Strait song
I've sent up a prayer.
I don't think we were meant to die either. But He gave us free will and just look what we've done with it. Joyfully, He loves us enough to have sent His Son so that we could go Home for the immortal part of our life.
As to living on a low-calorie diet and potentially increasing one's lifespan by 7%, I would think that only works for those with good health who die of old age.
Actually, it was an honest attempt to show that reducing food intake would not substantally increase your lifespan.
This has been a field of study by independent researchers for quite some time.
This seems to be the first attempt to produce serious data about observations of increased longevity in certain animals when caloric intake is restricted.
If you feel that way you made a mistake.
After 43 years with the same woman I wish I could make another 43.Try being a friend to your wife, it works.
Calorie restriction has extended the life span of every species in every experiment. However, to obtain maximum benefits the restriction must be life long. Starting CR in middle age will result in modest benefits. There are downsides, e.g., fragile immune system. BTW, a recent experiment showed that metformin, a cheap generic diabetes med, caused the same gene expression as CR. Further experiments are underway to see if metformin can produce the same healthy life extension benefits as CR. See details on lef.org
That's a disapointment, here I thought my Strep throat was helping me out.
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