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First Link Found Between Obesity, Inflammation And Vascular Disease
ScienceDaily ^ | 2005-09-17

Posted on 09/18/2005 7:02:26 PM PDT by sourcery

HOUSTON (Sept. 16, 2005) - Researchers at The University of Texas M. D. Anderson Cancer Center and The University of Texas Health Science Center at Houston have found that human fat cells produce a protein that is linked to both inflammation and an increased risk of heart disease and stroke.

They say the discovery, reported in Journal of the American College of Cardiology, goes a long way to explain why people who are overweight generally have higher levels of the molecule, known as C-reactive protein (CRP), which is now used diagnostically to predict future cardiovascular events.

And they also report some good news: the researchers found that aspirin and statin drugs, now commonly used to treat heart diseases, effectively damp down production of CRP from fat cells.

"This study is the first to show how body fat participates in the inflammatory process that leads to cardiovascular disease, but also demonstrates that this process can be blocked by drugs now on the market," said study leader Edward T. H. Yeh, M.D., who is both chairman of the Department of Cardiology at M. D. Anderson and director of the Research Center for Cardiovascular Disease at the Brown Foundation Institute of Molecular Medicine for the Prevention of Human Diseases at the UT Health Science Center at Houston.

UT Health Science Center at Houston President James T. Willerson, M.D., is a co-author of the study.

Adipose tissue (body fat) has been lately regarded as a separate body organ which can produce a number of different biologically active molecules - such as cytokine proteins that are associated with inflammation, and the hormone resistin, which is linked to insulin resistance and the development of type two diabetes.

Even if they are healthy, people with more adipose tissue also tend to have higher levels of CRP. Previous research, however, had only found CRP to be produced in liver tissue, although Yeh, Willerson and Paolo Calabro, M.D., discovered in 2003 that the protein also is manufactured in the walls of blood vessels.

"But that didn't explain obesity's connection to high levels of CRP and it also was not clear why CRP is higher in patients who have metabolic disorders," Yeh said.

So the research team decided to see whether fat cells themselves can be stimulated by inflammatory cytokines or resistin to produce CRP. To help find out, plastic surgery patients at M. D. Anderson donated adipose tissue that would have been discarded, and the research team then isolated fat cells, cultured them and stimulated them under a number of different conditions. They found the cells produced cytokines that resulted in inflammation and that this process triggered production of high levels of C-reactive proteins.

The researchers also discovered that resistin, the hormone associated with diabetes and insulin resistance, can stimulate production of CRP proteins. "And this is interesting because it is known that resistin is itself produced by fat cells," Yeh said.

"We know that patients with metabolic syndromes have higher levels of CRPs, as well as a higher risk of developing heart disease and stroke, but no one understands why that is," Yeh said. "If fat cells by themselves produce inflammatory signals that trigger cells to produce CRPs, and if CRPs also produce biological effects on vascular walls, that could explain the higher risk of cardiovascular disease."

The investigators then solved the other part of the puzzle -- why it is that aspirin, statin drugs and an agent known as troglitazone, used to treat diabetes, can reduce CRP levels. They exposed the cultured fat cells that were producing high levels of CRPs to these drugs, and found production of the proteins declined. "We knew from studying patients that these drugs can reduce C-reactive proteins, but now we have direct proof of their benefit."

Even as the CRP picture becomes clearer, there is still much that is not known, say the researchers, including the reason why fat tissue produces an inflammatory response, and just precisely how CRP participates in that process.

"Inflammation is a very complicated phenomenon, but at least we now have a few more clues as to what it does and how the damage it produces can be prevented," Yeh noted.


TOPICS: Culture/Society; News/Current Events
KEYWORDS: chd; creactiveprotein; crp; fatpeople; health; heart; heartdisease; inflamation; inflammation; medicine; obesity; stroke; tuboflard

1 posted on 09/18/2005 7:02:27 PM PDT by sourcery
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To: neverdem; SunkenCiv; Ernest_at_the_Beach; AntiGuv

Ping


2 posted on 09/18/2005 7:03:09 PM PDT by sourcery (Givernment: The way the average voter spells "government.")
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To: sourcery

ok


3 posted on 09/18/2005 7:06:04 PM PDT by tbird5
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To: sourcery

Is this true, or just a load of CRP?


4 posted on 09/18/2005 7:07:46 PM PDT by Jeff Chandler (Peace Begins in the Womb)
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This from the Medical Journal, Duh!


5 posted on 09/18/2005 7:08:46 PM PDT by JimDingle (Give Dingle a Jingle)
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To: Jeff Chandler
Is this true, or just a load of CRP?

That's an inflammatory question :-)

6 posted on 09/18/2005 7:09:11 PM PDT by sourcery (Givernment: The way the average voter spells "government.")
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To: JimDingle
This from the Medical Journal, Duh!

The point is that the key piece of evidence that convinced the medical establishment that "cholesterol clogs your arteries" was the fact that the statin drugs lowered the risk of heart attacks. However, the evidence that the mechanism by which the statin drugs work is by reducing inflammation strongly calls the "cholesterol is the culprit" theory into question.

Reference: The Cholesterol Myths.

7 posted on 09/18/2005 7:13:25 PM PDT by sourcery (Givernment: The way the average voter spells "government.")
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To: Jeff Chandler

just a load of CRP!


8 posted on 09/18/2005 7:15:21 PM PDT by SweetCaroline (Experience is what you get when you didn't get what you wanted!!)
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To: sourcery

fat bloated bump


9 posted on 09/18/2005 7:37:00 PM PDT by satchmodog9 (Murder and weather are our only news)
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To: sourcery
Cholesterol is a personal problem ~ statins don't work with some people (because of a so-called "rare" cellular metabolic difference) ~ and with some men, unless they get a regular input of "new fat" in their diet, their cholesterol production increases!

Best bet is a diet high in walnuts, walnut products, and salmon.

10 posted on 09/18/2005 7:45:50 PM PDT by muawiyah (/ hey coach do I gotta' put in that "/sarcasm " thing again?)
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To: satchmodog9
More CR*P from the idiots that gave you statins and introduced the idiotic notion that you have "good" cholesterol and "bad" cholesterol. C-reactive-protein is released in response to inflammation, it does not cause it. Blocking it's production with a medication will do nothing to reduce whatever caused the cellular injury thats calling in the troops, but it will sell lots of pills, because doctor will be happy with the numbers they see on a chart.
11 posted on 09/18/2005 7:58:01 PM PDT by tryingtomakesenseofthis
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To: sourcery
Thanks for the ping. I linked to your thread on Trauma unit is Iraq's version of MASH .
12 posted on 09/18/2005 9:12:41 PM PDT by neverdem (May you be in heaven a half hour before the devil knows that you're dead.)
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To: sourcery
The Life Extension Foundation has been preaching this gospel for years.

The facts related to this study have been known for over a decade via data from international studies.

It's amazing how many deaths could be avoided if the FDA and doctors just opened their eyes.

13 posted on 09/19/2005 12:01:32 AM PDT by zarf (It's swollen, yes.)
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To: muawiyah


I'm saved--I just put walnuts in the chocolate chip cookies I made today! ;)








14 posted on 09/19/2005 12:13:43 AM PDT by RichRepublican (Some days you're the windshield--some days you're the bug.)
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To: RichRepublican

Now, chop off a small filet from that salmon you just baked in your oven, and make a walnut/chocolate chip cookie salmon sandwich!


15 posted on 09/19/2005 10:57:24 AM PDT by muawiyah (/ hey coach do I gotta' put in that "/sarcasm " thing again?)
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To: Coleus
Ping!
16 posted on 09/19/2005 7:46:44 PM PDT by SunkenCiv (Down with Dhimmicrats! I last updated by FR profile on Sunday, August 14, 2005.)
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To: SunkenCiv

thanks, very interesting, explains a lot.


17 posted on 09/19/2005 8:23:41 PM PDT by Coleus (Roe v. Wade and Endangered Species Act both passed in 1973, Murder Babies/save trees, birds, algae)
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To: sourcery

The nanny liberals are off cigarettes and on to food! Run for your lives. (not for exercise!)


18 posted on 09/19/2005 8:25:21 PM PDT by ladyinred (It is all my fault okay?)
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To: Jeff Chandler

Just you wait, next they will be warning us about "second hand fat" !!!:-)


19 posted on 09/19/2005 8:29:23 PM PDT by ladyinred (It is all my fault okay?)
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To: sourcery

ok


20 posted on 09/19/2005 8:32:11 PM PDT by dalebert
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Inflammatory, versus Flaming...
Richard Simmons

21 posted on 09/19/2005 8:40:21 PM PDT by SunkenCiv (Down with Dhimmicrats! I last updated by FR profile on Sunday, August 14, 2005.)
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