Free Republic
Browse · Search
News/Activism
Topics · Post Article

Skip to comments.

Officials Stockpile Vaccine, Drugs Against Avian Flu
American Forces Press Service | 06 OCT 05 | Jim Garamone

Posted on 10/07/2005 3:39:56 AM PDT by fifthvirginia

Health officials estimate the Spanish Flu epidemic of 1918 killed 50 million people worldwide -- more than died in World War I. Now President Bush is concerned that a strain of avian flu that has killed millions of birds in Asia could mutate and cross over to humans. "I am concerned about what an avian flu outbreak could mean for the United States and the world," Bush said during an Oct. 4 news conference. "I have thought through the scenarios of what an avian flu outbreak could mean."

The Department of Defense is preparing in case the worst happens. DoD is stockpiling vaccine to combat the so-called avian flu and amassing antiviral drugs.


TOPICS: Front Page News; Government; News/Current Events
KEYWORDS: alqueida; avianflu; biologicalweapons; bioterrorism; biowarfare; birdflu; flu; healthcare; terrorism; wmd; wot
Navigation: use the links below to view more comments.
first 1-5051-79 next last

1 posted on 10/07/2005 3:39:57 AM PDT by fifthvirginia
[ Post Reply | Private Reply | View Replies]

To: fifthvirginia

But do they WORK?


2 posted on 10/07/2005 3:43:09 AM PDT by RandallFlagg (Roll your own cigarettes! You'll save $$$ and smoke less!(Magnetic bumper stickers-click my name)
[ Post Reply | Private Reply | To 1 | View Replies]

To: RandallFlagg
But do they WORK?

Gee, coming from "The Walkin' Dude" himself, that's scary!

Seriously, since our Chinese "friends" are loading fowl with anti-virals ( thus breeding strains of flu that are resistant ) and some reports indicate some of the anti-viral medicines aren't effective. it's cause to worry. See tagline...

3 posted on 10/07/2005 3:55:36 AM PDT by backhoe (Anyone remember "The Stand...?")
[ Post Reply | Private Reply | To 2 | View Replies]

To: RandallFlagg

Tamiflu will work FYI. It can be ordered online. Protect yourself, if you have the means.


4 posted on 10/07/2005 3:59:11 AM PDT by BureaucratusMaximus (Hard-core, politically angry, hyperconservative loaded with vitriol about everything liberal.)
[ Post Reply | Private Reply | To 2 | View Replies]

To: backhoe
I dunno. Remember THIS show?

5 posted on 10/07/2005 4:06:19 AM PDT by RandallFlagg (Roll your own cigarettes! You'll save $$$ and smoke less!(Magnetic bumper stickers-click my name)
[ Post Reply | Private Reply | To 3 | View Replies]

To: BureaucratusMaximus

I just recently read a report that Tamiflu probably would NOT be effective for this new (expected) flu outbreak.
Who knows?!?


6 posted on 10/07/2005 4:10:10 AM PDT by MrLee
[ Post Reply | Private Reply | To 4 | View Replies]

To: backhoe
Seriously, since our Chinese "friends" are loading fowl with anti-virals ( thus breeding strains of flu that are resistant )

I haven't heard this. If true...thats not good. I'd liken it to an indirect form of bio-terrorism towards the West.

7 posted on 10/07/2005 4:10:28 AM PDT by BureaucratusMaximus (Hard-core, politically angry, hyperconservative loaded with vitriol about everything liberal.)
[ Post Reply | Private Reply | To 3 | View Replies]

To: RandallFlagg

I thought it was already reported that Tamiflu was ineffective, so far, when tested against the current strains of H51N?

As as far as a vaccine, I know I read that until it mutates to a person/person strain, there's no point in making a vaccine.


8 posted on 10/07/2005 4:12:52 AM PDT by dawn53
[ Post Reply | Private Reply | To 2 | View Replies]

To: RandallFlagg
Remember THIS show?

Good God- I missed that one entirely- what year was it on?

9 posted on 10/07/2005 4:18:07 AM PDT by backhoe (Anyone remember "The Stand...?")
[ Post Reply | Private Reply | To 5 | View Replies]

To: backhoe

Is there a better way to combat this thing?


10 posted on 10/07/2005 4:18:16 AM PDT by bobjam (E rISE OF tHEORODRE)
[ Post Reply | Private Reply | To 3 | View Replies]

To: bobjam
Is there a better way to combat this thing?

Probably not- it's like the best defense against an atom bomb- "don't be there when it goes off."

11 posted on 10/07/2005 4:22:27 AM PDT by backhoe (Anyone remember "The Stand...?")
[ Post Reply | Private Reply | To 10 | View Replies]

To: bobjam
Is there a better way to combat this thing?


12 posted on 10/07/2005 4:23:30 AM PDT by OXENinFLA
[ Post Reply | Private Reply | To 10 | View Replies]

To: RandallFlagg; backhoe; BureaucratusMaximus


HONG KONG, Sept 30 (Reuters) - A strain of the H5N1 bird flu virus that may unleash the next global flu pandemic is showing resistance to Tamiflu, the antiviral drug that countries around the world are now stockpiling to fend off the looming threat.

Experts in Hong Kong said on Friday that the human H5N1 strain which surfaced in northern Vietnam this year had proved to be resistant to Tamiflu, a powerful antiviral drug which goes by the generic name, oseltamivir.

They urged drug manufacturers to make more effective versions of Relenza, another antiviral that is also known to be effective in battling the much feared H5N1. Relenza is inhaled.

"There are now resistant H5N1 strains appearing, and we can't totally rely on one drug (Tamiflu)," William Chui, honorary associate professor with the department of pharmacology at the Queen Mary Hospital in Hong Kong, told Reuters.

Chui was referring to the Tamiflu-resistant strain of H5N1 in Vietnam. Chui also said general viral resistance to Tamiflu was growing in Japan, where doctors habitually prescribe the drug to fight the common influenza.

"Manufacturers should think about producing an injectable form of Relenza because resistance to Tamiflu has been seen in Japan and Vietnam. Also with injections, high doses can be given where necessary and onset time is a lot faster," Chui said.

Drugs that are administered intravenously can be better absorbed in patients who have stomach and acidity problems, another expert said.

"We don't have to worry about absorption, injections take drugs right in. But if the patient takes them orally, maybe some amounts won't be absorbed or some may be destroyed by stomach acids," said pharmacist Raymond Mak at Queen Mary Hospital.

Intravenous Relenza would also ensure faster onset, which would be critical in patients who are seriously ill.

"Orally taken drugs take three to four hours to reach maximum blood concentration and three to four hours is very critical in severe cases. But injectable Relenza takes only 30 minutes to reach maximum blood concentration, this is a huge difference," Chui said.

With an intravenous antiviral, doctors can also vary the doses.
While the H5N1 virus is now mostly passed directly from bird to human, health experts have warned that it is just a matter of time before it mutates into a form that is easily transmissible between people. When that happens, it may result in as many as 150 million human deaths.

Two reports in The Lancet medical journal this month said that resistance to anti-flu drugs was growing worldwide.

In places such as China, drug resistance exceeded 70 percent, suggesting that drugs like amantadine and rimantadine will probably no longer be effective for treatment or as a preventive in a pandemic outbreak of flu, the reports said.


13 posted on 10/07/2005 4:40:18 AM PDT by Mother Abigail
[ Post Reply | Private Reply | To 2 | View Replies]

To: All


A few notes:

1. We now know that the 1918 virus was a pure bird flu. It didn't need to mix with pigs or humans to become deadly.

So we can stop worrying about some hapless Chinese pig or Vietnamese farmer providing the fatal improvement; the virus may be able to mutate right in some duck or chicken and then jump straight to us.

Our concern is that the H5 type [such as the new avian flu strains] might be going down a similar path [of adapting to humans] as the 1918 virus did.

Practically any of the bird viruses that we can find with some of these changes tend to be the highly pathogenic avian viruses, like those in Asia.

This suggests to us that these viruses are acquiring mutations that make them more human-adapted.
So far it's a lucky thing. These viruses can get into a person, and they can kill. But they can't yet spread from person to person. The race is on now to figure out what changes are crucial to allowing the virus to be transmissible from one person to another.

Everyone is correct to be concerned [about a possible new epidemic]. The 1918 studies only increase the concern. We need to try to catch this thing before it gets out of the box.

2. CIDRAP offers a new update on laboratory-confirmed human cases of H5N1 avian influenza.

As always, it includes both official and unofficial tallies:
Officially, 116 cases and 60 deaths (51.7% mortality).

Unofficially, 124 cases and 65 deaths (52.4% mortality).

While the cases are still comparatively few, it seems strange that mortality should remain so high.

The consensus seems to be that H5N1 will trade off its lethality as it learns how to infect humans directly. Otherwise, we're in really big trouble.


MA


14 posted on 10/07/2005 5:01:31 AM PDT by Mother Abigail
[ Post Reply | Private Reply | To 13 | View Replies]

To: fifthvirginia
Just returned, after 26 days, from the EU. It is on TV everyday and they seem to have a vaccination for the Bird Flu or that is what I got from the TV. They are really worried and we should be also as the wind (that seem to carry, and spread the flu virus) from the far east gets here before it gets to the EU.
15 posted on 10/07/2005 5:07:53 AM PDT by YOUGOTIT
[ Post Reply | Private Reply | To 1 | View Replies]

To: YOUGOTIT

It is easy to make vaccines for the bird flu.

The problem is we don't know what particular strain of flu will make the jump. The strain that makes the jump isn't around right now, so the one that does will certainly be different than today's strain.

The vaccine you develop today may not work at all on the virus which eventually comes out.

There is little sense stockpiling 200 million doses if you don't know it will work.

But then, it just might. So you should have some vaccines ready to go just in case but don't spend $10 billion doing it.


16 posted on 10/07/2005 5:19:53 AM PDT by JustDoItAlways
[ Post Reply | Private Reply | To 15 | View Replies]

To: Mother Abigail
We now know that the 1918 virus was a pure bird flu. It didn't need to mix with pigs or humans to become deadly.

Not according to Recombinomics.

http://www.recombinomics.com/News/10050503/1918_Recombination_Confirmed.html

However, the 1918 pandemic strain was not an avian strain. It was a recombinant between a swine virus, like the H1N1 classical swine virus from Iowa in 1930, and an H1N1 human virus, like the WSN/33 virus from a human in London in 1933. This observation had been made previously, based on the published sequences of five of the eight 1918 genes.

The same relationship is seen in the three newly published genes, PB2, PB2, and PA. In each case the sequences from H1N1 classical swine and H1N1 human isolates in the early 1930's form complimentary polymorphisms, much like the 2001 H5N1 co-circulating sequences in Hong Kong.

The evolution by recombination is the mechanism of rapid change employed by most if not all viruses. H5N1 efficiently evolves via recombination, and the latest sequences of the three polymerase genes from 1918 show that the same mechanism was used for all eight of the 1918 genes.

17 posted on 10/07/2005 5:19:58 AM PDT by ordinaryguy
[ Post Reply | Private Reply | To 14 | View Replies]

To: backhoe

Are the RATS now going to blame Bush because:

a) He hasn't reacted quick enough
b) There isn't enough vaccines to go around
c) Using the military just proves that Bush is a fascist
d) all of the above


18 posted on 10/07/2005 5:22:44 AM PDT by EQAndyBuzz (Liberal Talking Point - Bush = Hitler ... Republican Talking Point - Let the Liberals Talk)
[ Post Reply | Private Reply | To 3 | View Replies]

To: fifthvirginia

This may sound trite, but WASH YOUR HANDS.


19 posted on 10/07/2005 5:32:41 AM PDT by Misschuck
[ Post Reply | Private Reply | To 1 | View Replies]

To: BureaucratusMaximus

They are giving their chickens Amantadine, an anti-viral.


20 posted on 10/07/2005 5:39:38 AM PDT by texpat72 (<><)
[ Post Reply | Private Reply | To 7 | View Replies]

To: EQAndyBuzz
You named it:

(d) all of the above

21 posted on 10/07/2005 5:42:17 AM PDT by backhoe
[ Post Reply | Private Reply | To 18 | View Replies]

To: ordinaryguy


As a rule, I normally defer to the brilliant Dr. Niman, but the new work by Dr. Taubenberg seems to be definitive.


http://www.businessweek.com/technology/content/oct2005/tc2005106_4568_tc057.htm


Scientist Jeffery Taubenberger says studies of the virus behind a deadly 1918 epidemic boost concerns about the danger of today's avian strains

In 1918, a devastating flu epidemic swept the world, killing more than 50 million people, including an estimated 675,000 in the U.S. The disease was deadlier than previous flu outbreaks, killing more than 2% of those infected. Some people died within hours, and many families lost at least one member.

Why was the virus so dangerous? Could such a pandemic happen again? Could the strains of avian flu now destroying poultry in Asia and spreading from Russia toward Europe turn into deadly human viruses?

CUTTING-EDGE METHODS.  The urgency of those questions inspired scientists to embark on a several-year quest to unearth lung tissue from victims of the 1918 flu and to analyze the viruses' genes. The task has been challenging. Some samples came from tissue saved from long-ago autopsies. Others came from people buried in Alaska and frozen by the permafrost.

In both types of samples, however, the amounts of virus were tiny -- usually just a single copy of DNA fragments. As a result, researchers had to use cutting-edge molecular biology methods to read the genetic codes.

Now they have succeeded. In an Oct. 6 paper in Nature, scientists, led by Jeffery K. Taubenberger of the Armed Forces Institute of Pathology, report that they have read the full genetic sequence of the 1918 virus, along with the codes of scores of other influenza strains, including the avian flu.

DEADLY QUALITIES.  Simultaneously, a team at the Centers for Disease Control & Prevention wrote in a paper in the Oct. 7 issue of Science that they used the genetic information to recreate the deadly 1918 strain. They proved how virulent the virus was by giving it to mice. The mice quickly died.

The work of these two teams is more than just a scientific tour-de-force. It also opens the door to understanding why some flu strains are deadlier than others -- and to figuring out how a virus that originally infects only birds is able to evolve to target humans.

Soon it should be possible to use this information to learn if today's flu strains are mutating in ways that could bring another pandemic.

...........(snip)

That seems to raise a key point, since one huge question is whether epidemics are likely to be caused by a bird flu virus that suddenly mutates so that it can infect humans, or whether a bird virus and a human flu virus get together and mix genes, creating an even more dangerous strain. What is the story for the 1918 virus?

This is the biggest surprise, we think. The data support the conclusion that this was an entirely avian virus that adapted for humans. It was not an assortment or mix of bird and human virus, as in the last two pandemics [in 1957 and 1968].


MA


22 posted on 10/07/2005 5:45:56 AM PDT by Mother Abigail
[ Post Reply | Private Reply | To 17 | View Replies]

To: ordinaryguy
Jeffrey Taubenberger, of the US Armed Forces Institute of Pathology, who contributed to both studies, said:

The research also indicates that the Spanish flu jumped species directly from birds to humans. The less serious pandemics of 1957 and 1968 began when an avian virus first mingled its genes with those of a flu strain that could already infect people, either in a human or in animals such as pigs that can harbour both varieties.

If a direct jump has occurred once, it could occur again, providing a fresh route by which modern avian flu could evolve. “For H5N1, it could go either way,” Dr Taubenberger said. “There is still a risk that H5N1 could become pandemic through reassortment with a contemporary human flu strain, but it’s also possible that it could completely adapt to humans like the virus did in 1918.”

http://www.freerepublic.com/focus/f-news/1399613/posts?page=1617#1617

23 posted on 10/07/2005 5:49:02 AM PDT by EBH (Never give-up, Never give-in, and Never Forget)
[ Post Reply | Private Reply | To 17 | View Replies]

To: Mother Abigail; bitt; Judith Anne
The local county board has been telling businesses to plan for a lot of people to be unable to make it to work because of the flu. Also, quarantine laws that were taken off the books in the 50's have been quietly reactivated.

Keep an eye out for any reports of sick geese or other migratory birds. I think that will be the first sign.
24 posted on 10/07/2005 5:51:00 AM PDT by redgolum ("God is dead" -- Nietzsche. "Nietzsche is dead" -- God.)
[ Post Reply | Private Reply | To 22 | View Replies]

To: fifthvirginia
DoD is stockpiling vaccine to combat the so-called avian flu

What vaccine is that?

25 posted on 10/07/2005 5:52:59 AM PDT by Jim Noble (In a time of universal deceit telling the truth is a revolutionary act - Orwell)
[ Post Reply | Private Reply | To 1 | View Replies]

To: dawn53

From the CDC web site:

Antiviral Agents for Influenza
Four different influenza antiviral drugs (amantadine, rimantadine, oseltamivir, and zanamivir) are approved by the U.S. Food and Drug Administration (FDA) for the treatment and/or prophylaxis of influenza. All four have activity against influenza A viruses. However, sometimes influenza strains can become resistant to these drugs, and therefore the drugs may not always be effective. For example, analyses of some of the 2004 H5N1 viruses isolated from poultry and humans in Asia have shown that the viruses are resistant to two of the medications (amantadine and rimantadine). Monitoring of avian viruses for resistance to influenza antiviral medications is ongoing.

According to this Tamiflu and Relenzea both seem to work against this strain.


26 posted on 10/07/2005 5:54:41 AM PDT by Kozak (Anti Shahada: " There is no God named Allah, and Muhammed is his False Prophet")
[ Post Reply | Private Reply | To 8 | View Replies]

To: redgolum; Judith Anne; 2ndreconmarine; Fitzcarraldo; Covenantor; rejoicing; Rushmore Rocks; ...

thanks for the ping - might as well ping everyone.....


27 posted on 10/07/2005 5:59:39 AM PDT by bitt (THE PRESIDENT: "Ask the pollsters. My job is to lead and to solve problems. ")
[ Post Reply | Private Reply | To 24 | View Replies]

To: fifthvirginia

bttt


28 posted on 10/07/2005 6:01:07 AM PDT by Guenevere (God bless our military!...and God bless the President of the United States!)
[ Post Reply | Private Reply | To 1 | View Replies]

To: Kozak

I found the article that says it's resistant to Tamiflu.

Here's the link, dated Sept. 30, 2005.

http://www.cnn.com/2005/WORLD/asiapcf/09/30/birdflu.drugs.reut/


29 posted on 10/07/2005 6:02:51 AM PDT by dawn53
[ Post Reply | Private Reply | To 26 | View Replies]

To: lucyblue

FYI...


30 posted on 10/07/2005 6:14:53 AM PDT by Purdue Pete
[ Post Reply | Private Reply | To 1 | View Replies]

To: fifthvirginia

My question is why the HHS is only willing to stockpile 100,000 doses of anti-radiation countermeasures? This just came out on Friday and nobody is worried about this? I for one am. If a nuke gets detonated in any major city, there won't be enough to protect anyone.


31 posted on 10/07/2005 6:20:44 AM PDT by cmiller623 (Mayor Antonio Villa....or never mind. Los Angeles is doomed!)
[ Post Reply | Private Reply | To 1 | View Replies]

To: Jim Noble
Last I read the 'vaccine' is the recent experimental one. It would take either a very large single dose shot or has been indicated two shots several weeks apart. Hence the reason that the Whitehouse is looking to lift liability claims against vaccine manufacturers in the event of a pandemic.

There is a long evolving thread located here: http://www.freerepublic.com/focus/f-news/1399613/posts?q=1&&page=1 the thread was started back in May 2005 and has been cataloging the events of the Avian Flu for sometime.
32 posted on 10/07/2005 6:27:53 AM PDT by EBH (Never give-up, Never give-in, and Never Forget)
[ Post Reply | Private Reply | To 25 | View Replies]

To: bitt


Would you mind adding my ping list to yours?

From time to time I am out of the electronic loop, and these good people are wonderful posters.


Marie;cherry;united1000;Keri;Maestro;riri;Black Agnes;vetvetdoug;Cathy Ryan;per loin;gas_dr;oberon;CholeraJoe;TaxRelief;null and void;seamole;Endeavor;Cathy
Ryan;ksen;JudithAnne;theFIRMBSS;frontdeboeuf;Domestic Church;twntaipan;freeperfromnj;flutters;nov 3;tigerlikesrooster;inshanghai;lucyT;spetznaz; dougherty; Billthedrill; Caipirabob; martin_fierro; rmlew; neverdem;backhoe; neverdem; Judith Anne; Dog Gone; Marie; cherry; united1000; keri; maestro; riri;muawiyah;The Electrician;Elisha_Ben_Abuya; Dog Gone;;null and void; dsc;;vetvetdoug;;CzarNicky;neverdem;I_dmc;OXENinFLA;7.62 x 51mm;randog;Serb5150;wizardoz;agere_contra;Tax-chick;The Great RJ ;phil1750;FormerACLUmember;yooling;The_Reader_David;stevio;Sicon; doc30; Don
Simmons;Wolfie;katana;HMFIC;theFIRMbss;todd1;NautiNurse;thombo;WL-law;thombo;HMFIC;Nov3;wrathof59;;Bon mots;future snake
eater;marvlus;muawiyah;RadioAstronomer;exnavychick;gabz;Atchafalaya;Doctor Stochastic;NRA2BFree;rebelBanker;Aracelis;FrogMom;kanawa;petronski; proud American in Canada;eyespysomething;KJC1;scott7278;Paul_Denton ;Semper911;eternalhope;Jedidah;little
jeremiah;2ndreconmarine;oorang;eternalhope;ordinaryguy;redgolum;myprecious;Iowa granny


33 posted on 10/07/2005 6:29:35 AM PDT by Mother Abigail
[ Post Reply | Private Reply | To 27 | View Replies]

To: dawn53

Yeah this is somewhat disturbing. He goes on about an injectable form of Relenza, but it doesn't exist at this point, and I don't see it as a possbility in time for this flu season. Could be very interesting times.


34 posted on 10/07/2005 6:46:20 AM PDT by Kozak (Anti Shahada: " There is no God named Allah, and Muhammed is his False Prophet")
[ Post Reply | Private Reply | To 29 | View Replies]

To: bitt; Mother Abigail; Judith Anne
Del. on front lines of avian flu fight

SNIP

An avian flu outbreak on a Delaware farm disrupted industry operations in 2004, triggering a regional quarantine, bird restrictions and the forced slaughter of hundreds of thousands of birds. Investigators detected the disease on an independent farm that was producing and ferrying birds to live-sale markets in New York.

Delaware officials said the 2004 virus was stamped out by quick government action and a decision to compost dead birds inside sealed-up poultry houses, limiting opportunities for exposure beyond individual farms.

Scuse said he was scheduled to be interviewed Thursday by a BBC film crew preparing a report on avian flu that included 2004 government actions.

Since the 2004 outbreak, Delmarva Poultry Industry and health agencies developed a plan including education for poultry workers, protective clothing and decontamination equipment, monitoring worker health and using human flu vaccines to minimize risks that human and avian viruses will combine in dangerous ways.

SNIP

State Division of Public Health officials meanwhile reported making "extensive" preparations for combating a human epidemic in the event the most-dangerous strain of bird flu jumps from birds to humans.

Health managers were taking some cues from a little-noticed avian influenza control plan developed earlier this year by a joint poultry industry and government task force.

The task force plan focuses heavily on prevention and treatment of flu among workers in the Delmarva Peninsula's $1.7 billion-a-year broiler industry. Farms on the peninsula produced more than 561 million broilers, roasters and cornish hens last year, making chicken the region's largest and most important agricultural industry.

Delaware Department of Natural Resources and Environmental Control Secretary John A. Hughes said he worked closely with Scuse during the 2004 outbreak, and said that environmental restrictions on dead bird disposal might have to be relaxed in the event of another virus episode.

"As long as it's in a state where it's transmissible from poultry to human beings, then you have a huge problem in containing it and keeping it from spreading," Hughes said. "It will probably necessitate extermination of the entire population, which is a substantial environmental problem."

this stuff is taken very seriously in this region.....

35 posted on 10/07/2005 7:17:11 AM PDT by Gabz
[ Post Reply | Private Reply | To 27 | View Replies]

To: RandallFlagg

It is guess work every year. No it probably will not work. They have said on the news thaat there is no vaccine for the avian flue. Which is why there is such a panic.


36 posted on 10/07/2005 7:18:50 AM PDT by television is just wrong (http://hehttp://print.google.com/print/doc?articleidisblogs.blogspot.com/ (visit blogs, visit ads).)
[ Post Reply | Private Reply | To 2 | View Replies]

To: fifthvirginia
>The Department of Defense is preparing in case the worst happens

If the DoD
sent, say, the National Guard
to your door and said

their medic must give
you a shot, would you take it?!
Which would worry you

more, threat of the "flu,"
or threat of what somebody
might put in the shot?

37 posted on 10/07/2005 7:22:10 AM PDT by theFIRMbss
[ Post Reply | Private Reply | To 1 | View Replies]

To: redgolum
"Keep an eye out for any reports of sick geese or other migratory birds. I think that will be the first sign."

I was just admiring a large flock of geese out in the field. None look sick.

38 posted on 10/07/2005 7:25:48 AM PDT by blam
[ Post Reply | Private Reply | To 24 | View Replies]

To: fifthvirginia; All
A cargo plane carrying small amounts of flu virus crashed on railway tracks near Winnipeg's city center Thursday, killing the pilot but missing buildings and vehicles, authorities said. The research samples of frozen influenza and herpes viruses were destroyed in the crash and ensuing fire ...
39 posted on 10/07/2005 7:33:48 AM PDT by theFIRMbss
[ Post Reply | Private Reply | To 1 | View Replies]

To: bitt

Thank you for the ping bitt, would have missed it otherwise.


40 posted on 10/07/2005 7:45:41 AM PDT by Oorang ( A great deal of talent is lost to the world for want of a little courage. -Goethe)
[ Post Reply | Private Reply | To 27 | View Replies]

To: dawn53; Kozak; texpat72; Mother Abigail; RandallFlagg; backhoe; BureaucratusMaximus; MrLee
The virulence and temerity of this bug is alarmingly evidenced by recent studies performed on 80 mice. It was found that all H5N1 infected mice that received a placebo died within 3 days. 10 Mice that received a 5 day regimen of oseltamivir phosphate (Tamiflu) antiviral drug had mortality rate of 50%. 10 mice receiving 8 days of the drug had a fatality rate of 20%.

Yahoo news (18 Jul 05)

Recominomic news (H5N1 in vivo Tamiflu study)

"Infection in mice does not produce the typical picture seen in human disease," cautioned John Nicholls, a researcher at the University of Hong Kong, in a commentary accompanying the report in the issue of the journal Nature-Medicine that came out the week of 14 Jul 05. However, a breakthrough in the lethality of SARS may provide therapeutic agents to deal with complications of H5N1.

NYT 14 Jul 05 story

Normal regimen of Tamiflu is 75 mg twice daily for 5 days within 48 hours of onset of symptoms. In several double-blind seasonal studies done on the efficacy of Tamiflu in otherwise healthy unvaccinated adults (13 to 65 years old), it was found that 75 mg taken daily for 42 days reduced the incidence of influenza from 4.8% in the placebo group to 1.2%. For geriatric patients living in skilled nursing home the same dosage reduced the 4.4% rate in the placebo group to 0.4% Moreover, postexposure prophylaxis of household contacts w/in 48 hours of onset of symptoms of index cases, reduced the laboratory confirmed infection rate from 12% in the placebo group, to 1%.

FDA Tamiflu lable PDF

One thing to keep in mind here is that the Tamiflu tablets cost $5 ea. Moreover, it seems likely that post exposure prophelaxis regimin needs to be either doubled, or the dosage increased (according to the mouse study) for expected efficacy. It should be stressed, that preventative prophylaxis regimin absolutely should NOT be initiated until a local epidemic manifests itself. And finally, with respect to efficacy of the current vaccine, a normal flu vaccine contains 15 mcg of innoculant. It has been clinically ascertained that at least TWO (and speculatively as many as three) injections of as much as 90 mcg per injection are required so as to garner an efficatious immuno-response. Present vaccine manufacturing capabilities are woefully inadequate to fullfil the demands for the vaccine at present (we can't even manufacture sufficient quantities of normal flu vaccine).

In any case, I ran some numbers a while back, figuring that there are about 295 million U.S. residents. I figured that there were about 65% in the 13-65 year range. If H5N1 becomes readily transmitable human-to-human, I assumed the standard 4.8% influenza infection rate. From those index cases, I included an additional 2.5 people per index case (assumption based on average family size statistics) with a 12% risk for each 2.5 family members, and then assumed a 55% mortality rate on the total number of speculative cases. I ballparked about 10 to 15 million deaths in the U.S. alone. I know there are a whole lot of assumptions there, but those fatalities would manifest themselves in 3 to 6 months (the first time around), and in 1918 the Spanish flu went around the world three times in 18 months, and I would alos expect several waves of a pandemic avian flu.

FYI, there is good evidence that efficatious homeopathic prophylaxis is available: N-Acetyl cystein influenza symptomology attenuation (automatic PDF download) Moreover, one should familiarize themseves with homeopathic phrophalactic properties of Elderberry.

Glycoscience home page

And something definitely to file away in the back of the brain (you never know if this may become useful information):

Haldol attenuation of cytokine storms

To underscore the critical paragraph:

"Haloperidol has anti-inflammatory effects on cytokines," Dr. Milbrandt noted. "Given these effects, treatment with haloperidol may have reduced the cytokine storm associated with critical illness, thereby reducing multi-organ dysfunction and improving survival." If you need this stuff, you are in a VERY bad way, and that would be your last hope.

The primary number one thing you can do as a preventative measure: WASH YOUR HANDS WITH SOAP AND WATER FREQUENTLY. Keep sanitary wipes in your car. When you enter from a public place, wipe your hands with one immediately. Also, remember not to accumulate used snot rags in the garbage can, but flush them down the toilette immediately. When they dry out, the virus particles they contain can be quite readily aerosolized when the garbage is discarded. Disinfect your teethbrushes in a mild solution of bleach (1 tsp in 16 oz water). Rinse well before using.

41 posted on 10/07/2005 7:52:18 AM PDT by raygun
[ Post Reply | Private Reply | To 29 | View Replies]

To: RandallFlagg

"This is who we are".


42 posted on 10/07/2005 7:54:33 AM PDT by Wolfie
[ Post Reply | Private Reply | To 5 | View Replies]

To: All
To go the Tamiflu route, you'd be lookin' at a 65 tablet prescription (@ $5/tab) per family member. This would allow an entire family to initiate a 42 day prophylactic regimin (upon onset of local epidemic), and initiate a 10 day post-exposure prophylaxis (index case within family).
43 posted on 10/07/2005 8:00:15 AM PDT by raygun
[ Post Reply | Private Reply | To 41 | View Replies]

To: cmiller623
My question is why the HHS is only willing to stockpile 100,000 doses of anti-radiation countermeasures? This just came out on Friday and nobody is worried about this? I for one am. If a nuke gets detonated in any major city, there won't be enough to protect anyone.

My medicine cabinet has a bottle of potassium iodide tablets for each member of family and the pets. If the Indians and Pakistanis turn loose on each other, the wind patterns will blown the fallout into the northwest of the United States. It's cheap insurance and keeps forever. It's not a panacea, just one more measure of preparation.

44 posted on 10/07/2005 9:54:55 AM PDT by Myrddin
[ Post Reply | Private Reply | To 31 | View Replies]

To: raygun

I get mine for $30/regime, last year I took 2 of them...so $60...if need be I'll whip out the AMEX and not worry about it, if I live I can pay off the AMEX, if we die, good luck collecting on it AMEX...

Any other antivirals work, I have a load of Acyclovir for cold sores...(no I don't have the type that are below the belt!)

"Acyclovir inhibits the replication of viral DNA needed to reproduce itself. Virally infected cells absorb more acyclovir than normal cells and convert more of it to an active form which prolongs its antiviral activity where it is most needed."


45 posted on 10/07/2005 10:05:06 AM PDT by MD_Willington_1976
[ Post Reply | Private Reply | To 43 | View Replies]

To: raygun
"Haloperidol has anti-inflammatory effects on cytokines,"

The problem with this and other orally administered drugs, as JA and others have pointed out, is that administration would be impossible if the patient is that sick. Of course, if you are trained in IM procedures and have the supplies, you're way ahead of most of us. Thanks for the nice summary info.

46 posted on 10/07/2005 11:29:18 AM PDT by steve86 (@)
[ Post Reply | Private Reply | To 41 | View Replies]

To: Myrddin

Thank you for your post. I wasn't aware of what potassium iodide is or what it does, but after reading your reply and doing some additional reading on the subject I'll be getting some for my medicine cabinet as well.


47 posted on 10/07/2005 3:08:08 PM PDT by Serb5150
[ Post Reply | Private Reply | To 44 | View Replies]

To: BearWash
Do you know what Haldol is? Its not Tylenol w/Codeine. Haldol is a schedule 9 drug similiar to that of morphine. Its probably more related to Thorazine than any opiate though (but I'm not a pharmacist so what do I know?).

Haldol in this case would be by injection. I mention the Haldol, becuase the bug in and of itself isn't so bad its the cytokine storm that kills. Believe me, from what I understand about this bug, it is very plausible that w/in 48 hours of onset of symptoms the thought may fleet across one's mind about making funeral arrangements. When the doc is throwing their hands up in surrender, just remember Haldol. It will be useful when they're beginning to talk respirator. And let me tell you something about "repirator", its a futile effort at best. Can you say hemoraghic pnuemonia? I'm sure you can say "drowning in your own blood" (instead of very bad chest congestion from a normally wicked flu). That's pretty much the last thing you can throw at this thing. Again, its not the bug that's so lethal, your immune system becomes your worst enemy.

48 posted on 10/07/2005 3:16:02 PM PDT by raygun
[ Post Reply | Private Reply | To 46 | View Replies]

To: BearWash
Do you know what Haldol is? Its not Tylenol w/Codeine. Haldol is a schedule 9 drug similiar to that of morphine. Its probably more related to Thorazine than any opiate though (but I'm not a pharmacist so what do I know?).

Haldol in this case would be by injection. I mention the Haldol, becuase the bug in and of itself isn't so bad its the cytokine storm that kills. Believe me, from what I understand about this bug, it is very plausible that w/in 48 hours of onset of symptoms the thought may fleet across one's mind about making funeral arrangements. When the doc is throwing their hands up in surrender, just remember Haldol. It will be useful when they're beginning to talk respirator. And let me tell you something about "repirator", its a futile effort at best. Can you say hemoraghic pnuemonia? I'm sure you can say "drowning in your own blood" (instead of very bad chest congestion from a normally wicked flu). That's pretty much the last thing you can throw at this thing. Again, its not the bug that's so lethal, your immune system becomes your worst enemy.

49 posted on 10/07/2005 3:22:18 PM PDT by raygun
[ Post Reply | Private Reply | To 46 | View Replies]

To: Serb5150
Thank you for your post. I wasn't aware of what potassium iodide is or what it does, but after reading your reply and doing some additional reading on the subject I'll be getting some for my medicine cabinet as well.

The potassium iodide (or iodate) provides iodine to saturate your thyroid. After a nuclear exchange, there may be a fair amount of radioactive iodine in the fallout for up to 81 days. Saturating your thyroid with non-radioactive iodine prevents uptake of the radioactive variety that could lead to destruction of the thryoid.

Having a good supply of calcium citrate is valuable to ward off uptake of radioactive compounds that chemically resemble calcium. While the iodine is an emergency action to protect against a short term event, a daily intake of calcium is a good idea to avoid osteoporosis and muscle cramps.

50 posted on 10/07/2005 3:35:20 PM PDT by Myrddin
[ Post Reply | Private Reply | To 47 | View Replies]


Navigation: use the links below to view more comments.
first 1-5051-79 next last

Disclaimer: Opinions posted on Free Republic are those of the individual posters and do not necessarily represent the opinion of Free Republic or its management. All materials posted herein are protected by copyright law and the exemption for fair use of copyrighted works.

Free Republic
Browse · Search
News/Activism
Topics · Post Article

FreeRepublic, LLC, PO BOX 9771, FRESNO, CA 93794
FreeRepublic.com is powered by software copyright 2000-2008 John Robinson