Skip to comments.Researchers Decode Dog Genome
Posted on 12/07/2005 5:14:45 PM PST by neverdem
Researchers have decoded the dog genome to a high degree of accuracy, allowing deep insights into the evolutionary history not only of Canis familiaris but also of its devoted companion species, Homo sapiens.
The dog whose genome has been sequenced is Tasha, a female boxer whose owners wish to remain anonymous, said Kerstin Lindblad-Toh, a biologist at the Broad Institute in Cambridge who led a large group of colleagues in the DNA sequencing effort. Their findings are being reported in Thursday's issue of the journal Nature.
The world's dog population numbers some 400 million, divided into about 400 breeds. The researchers chose to sequence Tasha's genome because boxers are quite inbred, easing the decoding task, and because since she is a female, they did not have to bother with a Y chromosome, whose long palindromic regions make it particularly hard slogging.
One insight that has emerged from having a fairly complete dog genome, in addition to those for humans and mice, is that researchers can begin to see the essence of what makes a mammal. The same 5 percent of DNA is conserved in all three species, and this presumably is evolution's basic toolkit for constructing a generic mammal.
Of this conserved tool kit, some 2 percent consists of known genes and the rest of something else, presumably the regulatory elements of DNA that control the operation of the protein-encoding genes, Dr. Lindblad-Toh said.
The conserved genes probably include those deployed during development to construct the organism, But many regulatory elements also seem to be needed, so as to orchestrate an elaborate succession of genes being switched off and on as new tissues and organs are generated.
Another finding that has emerged from a three-way comparison of dog, mouse and human is that genes for brain function seem to have...
(Excerpt) Read more at nytimes.com ...
The fact that these sequences are the same in all three animals indicates they could be crucial switches that control the activity of genes, the authors say. The discovery of such 'non-coding' regions, and the quest to find out what they do, is one of the most intriguing questions facing genomicists.
More the better.
" a female boxer whose owners wish to remain anonymous"
Like it matters.
Amazing what modern science does.
Genomes are tiny! Decoding them is hard! =P
Because he can IS the real answer!
I thought the Senators name was Barbra not Tasha.
And who among us hasn't sometimes wished he was a......uh......oh, never mind. *chuckle*
There are more than 400 million dogs in the world.
Why? "Because he can't make a fist".
I'm glad my butt-sniffing gene is turned off. I know in some humans it is replaced by the butt-kissing gene.
Finally, someone understands me.
BWAH-HAHAHAHAHAHAHAHA.....never thought of that one. :-)
The cost for all of this is hideous, and the odds of a pregnancy resulting are notably less than with the "old fashioned" method. But a nice (and apparently prosperous) lady from Warsaw is paying for it. So I won't complain; I'll just be somewhat bemused.
Female boxer. Is her name Barbera ?
So when do you think the mutations began?
Evelyn, a modified dog Viewed the quivering fringe of a special doily Draped across the piano, with some surprise In the darkened room Where the chairs dismayed And the horrible curtains Muffled the rain She could hardly believe her eyes A curious breeze A garlic breath Which sounded like a snore Somewhere near the Steinway (or even from within) Had caused the doily fringe to waft & tremble in the gloom Evelyn, a dog, having undergone Further modification Pondered the significance of short-person behavior In pedal-depressed panchromatic resonance And other highly ambient domains... Arf she said
Stick around. You'll learn a lot. ;-)
Hair, pinging you FYI. The thread has an interesting article about the dog genome, and the usual funny postings by FReepers.
Sorry dear, but I've NEVER wished to be that limber!
Yeah, probably even harder than algebra! 8-O
This ain't Photoshopped.
I'm a Lab person, but I can appreciate a handsome hunting dog of any breed. My girl is a no-go for show (despite her AKC Ch dad . . . because of her field-trial mom) but she's a versatile, hard-working dog!
LOL! I just LOVE that pic!
That thing is really disquieting ;~D
I've done chilled semen breedings on my (insert real word for female dogs here--and after a few of the jokes on this thread I cannot believe that word would be all that offensive!) twice. No luck either time. And it WAS expensive, and a real pain.
But, I'm excited about this research. I've submitted DNA to UC Davis for some genetic research they were doing (my spinoni, not me myself, I'm sure my DNA is of no interest). There are at least a few genetic diseases (CA in spinoni for instance) that could probably be eradicated with a test for a marker. I love science!
Oh, and I almost forgot to add. Those are lovely puppies! Are they weims?
Some of these pictures are really kinda disturbing! :)
Agility is so much more fun than conformation (at least my dogs seem to think so). I have swamp collies. One of my current ones is dumb as a stump the other is too smart for me! And they're half sisters. Go figure. I wonder if they'll find the gene(s) for some of the abilities. That would be interesting, but I wonder what it would do to the *art* of dog breeding?
I've only tried once, but I couldn't get my shepherd to keep his balls in the ice cube tray.
Wish I knew then what I knew now, she's a natural born mother, perfect temperament, perfect health, immensely talented in agility and also a good bird dog (that's despite the ignorance of her handler). But we might run into some surprises because she's the product of a profound out-cross. Her parents being from different branches of the Lab tree have ZERO common ancestors back as far as we can trace. When I bred Siamese cats, that kind of breeding always resulted in tremendous variation within the litter that persisted for a generation or two. It was certainly the case with Shelley's litter - they ran the gamut from couch-potato show Lab to my wild girl, and everything in between, and in size and appearance there's just as much variation. I met one of Shelley's full brothers (different litter) at a hunt club training day, and he looks EXACTLY like a show Lab - he's like a double cube, 2 inches taller than the Shell and probably 30 pounds heavier, with a head like a concrete block.
You're right about the "art" of breeding for abilities or looks - lots of times you don't know why you know what you know . . . I don't think there's any money in carrying this research that far though.
Actually, I try to keep my COAs low, as I think that even tho you get less consistancy in litters, you might get fewer immune system problems (don't know if that's as big a problem in labs as in goldens). I like to do outcrosses to fairly linebred dogs myself. And, my first show golden was from multi-titled parents (obed, conf, field and tracking). But....I held her back because I was a terrible trainer (and had 3 small boys and a husband who also thought they needed soem attention!)She only got one conformation point, one JH leg, a WC and was one leg away from a CDX when I retired her (we played at agility, but she developed uveitis and I don't think she felt confident on the dog walk etc because of her vision, but maybe I'm making excuses).
If you would like to see some pictures, pm me. She was a sweetie (and an outcross) and lived to almost 13. I am pretty sure (in hindsight) that she died of erlichia, altho we never got a definitive diagnosis. I would love to have her again (but she was a terrible producer--however, I think alot of that was bad choices in sires on my part--that darned *art* of breeding!)
Ya gotta know what yer doin'.... ;)
I don't think the situation with the immune system in the Labs is QUITE as bad as in Goldens, the major problems seem to be with hips and eyes and oddball cancers.
I subscribe to the Golden Retriever News because there's just no equivalent magazine for Labs, I mean with good solid medical and training advice (Just Labs is just a photo mag for doting owners).
My girl was originally training in obedience and was probably ready for CD, but my trainer said she thought she would be happier in agility. She was . . . but now that she's settled down a bit we might go back and try for it. If we can get the running down, she might be able to do CDX now. I think JH is achievable (she already has her UKC Started Retriever title) but there's no way this sweet girl is EVER going to get even a single conformation point. A cousin of mine is an AKC judge, we were at a family reunion and I asked her as a favor to watch my dog trot out and back. When she stopped laughing, she told me all the things that are "wrong" with Shelley - she's got sort of a conformation front end but a field trial hind end (feet set down too close together in back - although of course that's great for the dog walk) and a very fieldy head. And of course she's TOO SKINNY!
You can see what we're dealing with here -
That's asking a lot. My dogs are considered the brains of the operation. I just pay the vet bills and drive.
She has a lovely face, and she looks wonderful for twelve.
Had a shepherd growing up. She was a GREAT dog, but she was a sucker for skunks and porcupines. She always *thought* she would win. Evidence suggests she never did!
She actually died at about 12 yrs and 7 months. She was only sick for 6 weeks. She came from some really long lived lines. I wish all of my dogs could be as healthy into old age as she was. In fact, I hope I am as healthy into old age as she was!
You're lab looks great to me, but I happen to not care as much for the conformation body type on labs. Your dog looks like she could work!
The last time we were out retriever training, we set up a 75 yard mark across a draw or gully from the line - the draw was deep, a little damp, and overgrown with grass, probably 18" high. When I gave the word Shelley took off from the line like an arrow, went sailing down into the draw, and she must have stepped in a hole because she tumbled end over end TWICE. She didn't miss a beat or swerve an inch from her line, kept right on going and grabbed that duck . . . her legs were still churning as she went pinwheeling through the air. And she pulled up completely sound - just a tough little girl.
When she leaves the line, you kind of expect a sonic boom . . . the first time she ever saw a duck fall down, she knew that was what she was born to do.
Her first mark on her first hunt test.
We keep her on the skinny side to save her joints, on account of all the jumping impact in agility.
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