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Researchers Decode Dog Genome
NY Times ^ | December 7, 2005 | NICHOLAS WADE

Posted on 12/07/2005 5:14:45 PM PST by neverdem

Researchers have decoded the dog genome to a high degree of accuracy, allowing deep insights into the evolutionary history not only of Canis familiaris but also of its devoted companion species, Homo sapiens.

The dog whose genome has been sequenced is Tasha, a female boxer whose owners wish to remain anonymous, said Kerstin Lindblad-Toh, a biologist at the Broad Institute in Cambridge who led a large group of colleagues in the DNA sequencing effort. Their findings are being reported in Thursday's issue of the journal Nature.

The world's dog population numbers some 400 million, divided into about 400 breeds. The researchers chose to sequence Tasha's genome because boxers are quite inbred, easing the decoding task, and because since she is a female, they did not have to bother with a Y chromosome, whose long palindromic regions make it particularly hard slogging.

One insight that has emerged from having a fairly complete dog genome, in addition to those for humans and mice, is that researchers can begin to see the essence of what makes a mammal. The same 5 percent of DNA is conserved in all three species, and this presumably is evolution's basic toolkit for constructing a generic mammal.

Of this conserved tool kit, some 2 percent consists of known genes and the rest of something else, presumably the regulatory elements of DNA that control the operation of the protein-encoding genes, Dr. Lindblad-Toh said.

The conserved genes probably include those deployed during development to construct the organism, But many regulatory elements also seem to be needed, so as to orchestrate an elaborate succession of genes being switched off and on as new tissues and organs are generated.

Another finding that has emerged from a three-way comparison of dog, mouse and human is that genes for brain function seem to have...

(Excerpt) Read more at nytimes.com ...


TOPICS: Culture/Society; Extended News; News/Current Events; US: Massachusetts
KEYWORDS: crevolist; doggieping; genes; genetics; godsgravesglyphs
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news@nature.com has free registration. Boxer bares all Complete dog DNA sequence gives paws for thought.

The fact that these sequences are the same in all three animals indicates they could be crucial switches that control the activity of genes, the authors say. The discovery of such 'non-coding' regions, and the quest to find out what they do, is one of the most intriguing questions facing genomicists.

1 posted on 12/07/2005 5:14:46 PM PST by neverdem
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To: neverdem

More the better.


2 posted on 12/07/2005 5:16:22 PM PST by tallhappy (Juntos Podemos!)
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To: neverdem

" a female boxer whose owners wish to remain anonymous"

Like it matters.


3 posted on 12/07/2005 5:17:51 PM PST by gcruse (http://gcruse.typepad.com)
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To: neverdem

Placemarker


4 posted on 12/07/2005 5:17:51 PM PST by Antonello
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To: neverdem
boxers are quite inbred, easing the decoding task


5 posted on 12/07/2005 5:17:52 PM PST by Izzy Dunne (Hello, I'm a TAGLINE virus. Please help me spread by copying me into YOUR tag line.)
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To: Izzy Dunne

ROTFL!!! HAHAHAHAHAHA


6 posted on 12/07/2005 5:20:51 PM PST by eartotheground
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To: Izzy Dunne

7 posted on 12/07/2005 5:22:27 PM PST by Solamente
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To: neverdem

Amazing what modern science does.

Genomes are tiny! Decoding them is hard! =P


8 posted on 12/07/2005 5:25:49 PM PST by Termite_Commander (Warning: Cynical Right-winger Ahead)
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To: neverdem
Does this mean that science will finally give us an answer to the question 'Why does a dog lick his doodads?' other than 'Because he can!'?


9 posted on 12/07/2005 5:29:09 PM PST by Viking2002 (Allah FUBAR!)
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To: Viking2002
Does this mean that science will finally give us an answer to the question 'Why does a dog lick his doodads?' other than 'Because he can!'?

Because he can IS the real answer!

10 posted on 12/07/2005 5:34:26 PM PST by WIladyconservative (Save us from future Freepathons - set up a monthly donation!)
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To: neverdem

I thought the Senators name was Barbra not Tasha.


11 posted on 12/07/2005 5:39:00 PM PST by 359Henrie
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To: WIladyconservative
Because he can IS the real answer!

And who among us hasn't sometimes wished he was a......uh......oh, never mind. *chuckle*


12 posted on 12/07/2005 5:44:13 PM PST by Viking2002 (Allah FUBAR!)
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To: neverdem

There are more than 400 million dogs in the world.


13 posted on 12/07/2005 5:49:24 PM PST by Malesherbes
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To: Viking2002

Why? "Because he can't make a fist".


14 posted on 12/07/2005 6:19:39 PM PST by DuncanWaring (The Lord uses the good ones; the bad ones use the Lord.)
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To: neverdem

I'm glad my butt-sniffing gene is turned off. I know in some humans it is replaced by the butt-kissing gene.


15 posted on 12/07/2005 6:26:30 PM PST by JustAnotherOkie
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To: neverdem

Finally, someone understands me.

16 posted on 12/07/2005 7:13:13 PM PST by aimhigh
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To: DuncanWaring
Why? "Because he can't make a fist".

BWAH-HAHAHAHAHAHAHAHA.....never thought of that one. :-)


17 posted on 12/07/2005 7:26:38 PM PST by Viking2002 (Allah FUBAR!)
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To: neverdem
Coincidentally enough, I was involved this very day in a somewhat related matter. A month ago, my dog, Atlas, because of the show success of the litter he sired a year and a half ago (three of the ten, as 4 week old pups, are pictured below), received a stud inquiry from Poland. So, this morning, I took him to a vet who specializes in this type of thing, where he was, ahhh, "collected," and his output analyzed and then frozen, for later shipment in a liquid nitrogen capsule, to Slovokia, where the female dog (I will refrain here from using the correct name for "female dog" here, lest I offend anyone) from Poland will journey, to be artificially inseminated.

The cost for all of this is hideous, and the odds of a pregnancy resulting are notably less than with the "old fashioned" method. But a nice (and apparently prosperous) lady from Warsaw is paying for it. So I won't complain; I'll just be somewhat bemused.


18 posted on 12/07/2005 7:28:13 PM PST by southernnorthcarolina (I've upped my standards! Up yours!)
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To: All
BOXERS!


19 posted on 12/07/2005 7:31:47 PM PST by uca99
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To: gcruse

Female boxer. Is her name Barbera ?


20 posted on 12/07/2005 7:34:47 PM PST by F.J. Mitchell (Okay, bring our troops home. But don't feign suprise when the terrorists tag along.)
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To: aimhigh

So when do you think the mutations began?

Al

21 posted on 12/07/2005 7:37:36 PM PST by UpToHere
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To: neverdem
Evelyn, a modified dog 
Viewed the quivering fringe of a special doily 
Draped across the piano, with some surprise 
In the darkened room 
Where the chairs dismayed 
And the horrible curtains 
Muffled the rain 
She could hardly believe her eyes 
A curious breeze 
A garlic breath 
Which sounded like a snore 
Somewhere near the Steinway (or even from within) 
Had caused the doily fringe to waft & tremble in the gloom 
Evelyn, a dog, having undergone 
Further modification 
Pondered the significance of short-person behavior 
In pedal-depressed panchromatic resonance 
And other highly ambient domains... 
Arf she said 

22 posted on 12/07/2005 7:37:46 PM PST by megatherium (Hecho in China)
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To: Viking2002

Stick around. You'll learn a lot. ;-)


23 posted on 12/07/2005 7:46:47 PM PST by DuncanWaring (The Lord uses the good ones; the bad ones use the Lord.)
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To: HairOfTheDog

Hair, pinging you FYI. The thread has an interesting article about the dog genome, and the usual funny postings by FReepers.


24 posted on 12/07/2005 7:55:06 PM PST by Wolfstar ("In war, there are usually only two exit strategies: victory or defeat." Mark Steyn)
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To: DuncanWaring
Ha - I've got two here asleep on my bed that teach me more about canine behavior in one week than I'd learn here in 30 years. And I've had dogs off and on for the last 40. LOL God, I love my dogs..................:-)


25 posted on 12/07/2005 8:13:50 PM PST by Viking2002 (Allah FUBAR!)
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To: Viking2002
And who among us hasn't sometimes wished he was a......uh......oh, never mind. *chuckle*

Sorry dear, but I've NEVER wished to be that limber!

26 posted on 12/07/2005 8:24:05 PM PST by WIladyconservative (Save us from future Freepathons - set up a monthly donation!)
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To: WIladyconservative
It's a guy thing. LOL :-)


27 posted on 12/08/2005 2:49:54 AM PST by Viking2002 (Allah FUBAR!)
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To: neverdem; Flyer; technochick99; sinkspur; annyokie; Scott from the Left Coast; 88keys; ...
Ping!


Other articles with keyword "DOGGIEPING" since 12/29/04

28 posted on 12/08/2005 6:06:15 AM PST by HairOfTheDog (Join the Hobbit Hole Troop Support - http://freeper.the-hobbit-hole.net/ 1,000 knives and counting!)
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To: Termite_Commander

Yeah, probably even harder than algebra! 8-O

susie


29 posted on 12/08/2005 6:09:24 AM PST by brytlea (I'm not a conspiracy theorist....really.)
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To: neverdem; HairOfTheDog
My theory?

This ain't Photoshopped.

30 posted on 12/08/2005 6:10:58 AM PST by martin_fierro (< |:)~)
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To: southernnorthcarolina
Oh, those Weims are cuties!

I'm a Lab person, but I can appreciate a handsome hunting dog of any breed. My girl is a no-go for show (despite her AKC Ch dad . . . because of her field-trial mom) but she's a versatile, hard-working dog!


31 posted on 12/08/2005 6:13:32 AM PST by AnAmericanMother (. . . Ministrix of ye Chace (recess appointment), TTGC Ladies' Auxiliary . . .)
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To: UpToHere

LOL! I just LOVE that pic!


32 posted on 12/08/2005 6:13:55 AM PST by AnAmericanMother (. . . Ministrix of ye Chace (recess appointment), TTGC Ladies' Auxiliary . . .)
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To: martin_fierro

That thing is really disquieting ;~D


33 posted on 12/08/2005 6:14:12 AM PST by HairOfTheDog (Join the Hobbit Hole Troop Support - http://freeper.the-hobbit-hole.net/ 1,000 knives and counting!)
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To: southernnorthcarolina

I've done chilled semen breedings on my (insert real word for female dogs here--and after a few of the jokes on this thread I cannot believe that word would be all that offensive!) twice. No luck either time. And it WAS expensive, and a real pain.
But, I'm excited about this research. I've submitted DNA to UC Davis for some genetic research they were doing (my spinoni, not me myself, I'm sure my DNA is of no interest). There are at least a few genetic diseases (CA in spinoni for instance) that could probably be eradicated with a test for a marker. I love science!
Oh, and I almost forgot to add. Those are lovely puppies! Are they weims?
susie


34 posted on 12/08/2005 6:17:23 AM PST by brytlea (I'm not a conspiracy theorist....really.)
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To: martin_fierro

Some of these pictures are really kinda disturbing! :)
susie


35 posted on 12/08/2005 6:19:22 AM PST by brytlea (I'm not a conspiracy theorist....really.)
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To: AnAmericanMother

Agility is so much more fun than conformation (at least my dogs seem to think so). I have swamp collies. One of my current ones is dumb as a stump the other is too smart for me! And they're half sisters. Go figure. I wonder if they'll find the gene(s) for some of the abilities. That would be interesting, but I wonder what it would do to the *art* of dog breeding?
susie


36 posted on 12/08/2005 6:22:09 AM PST by brytlea (I'm not a conspiracy theorist....really.)
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To: brytlea
"I've done chilled semen breedings...twice..."

I've only tried once, but I couldn't get my shepherd to keep his balls in the ice cube tray.


37 posted on 12/08/2005 6:34:31 AM PST by Joe 6-pack (Que me amat, amet et canem meum.)
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To: brytlea
We have some very cute swamp collies in the Hunting Retriever Club (UKC). They're the little red field variety, a lot more driven than your average show dog. One of them is currently an all-@$$-and-elbows 9 month old puppy . . . he and my little Shelley love to play together, it's like porpoises frolicking in the sea, they leap over each others' backs and run until their tongues hang out. My girl will be 5 in March, but she still is very puppyish in demeanor and just ADORES the little ones (unless they gnaw on her ears, then she gets snappish.) I'm very sorry that I had her spayed, but I promised myself that I would not breed my first dog since I didn't know what I was doing.

Wish I knew then what I knew now, she's a natural born mother, perfect temperament, perfect health, immensely talented in agility and also a good bird dog (that's despite the ignorance of her handler). But we might run into some surprises because she's the product of a profound out-cross. Her parents being from different branches of the Lab tree have ZERO common ancestors back as far as we can trace. When I bred Siamese cats, that kind of breeding always resulted in tremendous variation within the litter that persisted for a generation or two. It was certainly the case with Shelley's litter - they ran the gamut from couch-potato show Lab to my wild girl, and everything in between, and in size and appearance there's just as much variation. I met one of Shelley's full brothers (different litter) at a hunt club training day, and he looks EXACTLY like a show Lab - he's like a double cube, 2 inches taller than the Shell and probably 30 pounds heavier, with a head like a concrete block.

You're right about the "art" of breeding for abilities or looks - lots of times you don't know why you know what you know . . . I don't think there's any money in carrying this research that far though.

38 posted on 12/08/2005 6:35:52 AM PST by AnAmericanMother (. . . Ministrix of ye Chace (recess appointment), TTGC Ladies' Auxiliary . . .)
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To: AnAmericanMother

Actually, I try to keep my COAs low, as I think that even tho you get less consistancy in litters, you might get fewer immune system problems (don't know if that's as big a problem in labs as in goldens). I like to do outcrosses to fairly linebred dogs myself. And, my first show golden was from multi-titled parents (obed, conf, field and tracking). But....I held her back because I was a terrible trainer (and had 3 small boys and a husband who also thought they needed soem attention!)She only got one conformation point, one JH leg, a WC and was one leg away from a CDX when I retired her (we played at agility, but she developed uveitis and I don't think she felt confident on the dog walk etc because of her vision, but maybe I'm making excuses).
If you would like to see some pictures, pm me. She was a sweetie (and an outcross) and lived to almost 13. I am pretty sure (in hindsight) that she died of erlichia, altho we never got a definitive diagnosis. I would love to have her again (but she was a terrible producer--however, I think alot of that was bad choices in sires on my part--that darned *art* of breeding!)

susie


39 posted on 12/08/2005 6:44:57 AM PST by brytlea (I'm not a conspiracy theorist....really.)
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To: Joe 6-pack

Ya gotta know what yer doin'.... ;)

susie


40 posted on 12/08/2005 6:45:38 AM PST by brytlea (I'm not a conspiracy theorist....really.)
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To: brytlea
By all means send pics! I love to look at dog pics, and I have a soft spot for Goldens. I almost got one, but couldn't stick the hair . . . but many of Shelley's good doggie friends are Goldens and she seems to especially enjoy their company.

I don't think the situation with the immune system in the Labs is QUITE as bad as in Goldens, the major problems seem to be with hips and eyes and oddball cancers.

I subscribe to the Golden Retriever News because there's just no equivalent magazine for Labs, I mean with good solid medical and training advice (Just Labs is just a photo mag for doting owners).

My girl was originally training in obedience and was probably ready for CD, but my trainer said she thought she would be happier in agility. She was . . . but now that she's settled down a bit we might go back and try for it. If we can get the running down, she might be able to do CDX now. I think JH is achievable (she already has her UKC Started Retriever title) but there's no way this sweet girl is EVER going to get even a single conformation point. A cousin of mine is an AKC judge, we were at a family reunion and I asked her as a favor to watch my dog trot out and back. When she stopped laughing, she told me all the things that are "wrong" with Shelley - she's got sort of a conformation front end but a field trial hind end (feet set down too close together in back - although of course that's great for the dog walk) and a very fieldy head. And of course she's TOO SKINNY!

You can see what we're dealing with here -


41 posted on 12/08/2005 7:04:39 AM PST by AnAmericanMother (. . . Ministrix of ye Chace (recess appointment), TTGC Ladies' Auxiliary . . .)
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To: brytlea
"Ya gotta know what yer doin'.... ;)"

That's asking a lot. My dogs are considered the brains of the operation. I just pay the vet bills and drive.

42 posted on 12/08/2005 7:04:44 AM PST by Joe 6-pack (Que me amat, amet et canem meum.)
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To: Joe 6-pack
Image hosted by TinyPic.com
43 posted on 12/08/2005 7:11:11 AM PST by apackof2 (You can stand me up at the gates of hell, I'll stand my ground and I won’t back down)
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To: neverdem
MY Baby Hannah - RIP
44 posted on 12/08/2005 7:22:45 AM PST by SengirV
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To: apackof2; brytlea


45 posted on 12/08/2005 8:01:36 AM PST by Joe 6-pack (Que me amat, amet et canem meum.)
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To: AnAmericanMother
I hope I'm doing this right:
This was my old girl when she was probably about 12 yrs.
Image hosted by Photobucket.com

46 posted on 12/08/2005 8:11:30 AM PST by brytlea (I'm not a conspiracy theorist....really.)
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To: brytlea
What a sweetie! "Here, gimme five!"

She has a lovely face, and she looks wonderful for twelve.

47 posted on 12/08/2005 8:12:31 AM PST by AnAmericanMother (. . . Ministrix of ye Chace (recess appointment), TTGC Ladies' Auxiliary . . .)
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To: Joe 6-pack

Had a shepherd growing up. She was a GREAT dog, but she was a sucker for skunks and porcupines. She always *thought* she would win. Evidence suggests she never did!

susie


48 posted on 12/08/2005 8:12:48 AM PST by brytlea (I'm not a conspiracy theorist....really.)
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To: AnAmericanMother

She actually died at about 12 yrs and 7 months. She was only sick for 6 weeks. She came from some really long lived lines. I wish all of my dogs could be as healthy into old age as she was. In fact, I hope I am as healthy into old age as she was!

You're lab looks great to me, but I happen to not care as much for the conformation body type on labs. Your dog looks like she could work!
susie


49 posted on 12/08/2005 8:15:18 AM PST by brytlea (I'm not a conspiracy theorist....really.)
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To: brytlea
My dog is a workin' fool. She's simply full of energy and determination.

The last time we were out retriever training, we set up a 75 yard mark across a draw or gully from the line - the draw was deep, a little damp, and overgrown with grass, probably 18" high. When I gave the word Shelley took off from the line like an arrow, went sailing down into the draw, and she must have stepped in a hole because she tumbled end over end TWICE. She didn't miss a beat or swerve an inch from her line, kept right on going and grabbed that duck . . . her legs were still churning as she went pinwheeling through the air. And she pulled up completely sound - just a tough little girl.

When she leaves the line, you kind of expect a sonic boom . . . the first time she ever saw a duck fall down, she knew that was what she was born to do.


Her first mark on her first hunt test.

We keep her on the skinny side to save her joints, on account of all the jumping impact in agility.

50 posted on 12/08/2005 8:23:42 AM PST by AnAmericanMother (. . . Ministrix of ye Chace (recess appointment), TTGC Ladies' Auxiliary . . .)
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