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Hangover Helpers: Beyond Sheep Eyes
NY Times ^ | January 1, 2006 | ALEX WILLIAMS

Posted on 12/31/2005 8:10:49 PM PST by neverdem

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Happy New Year! BMJ FReebie! Interventions for preventing or treating alcohol hangover: systematic review of randomised controlled trials Discussion

The paucity of randomised controlled trials is in stark contrast to the plethora of "hangover cures" marketed on the internet. This confirms the unreliability of the internet in healthcare matters.33 Our findings show that no compelling evidence exists to suggest that any conventional or complementary intervention is effective for preventing or treating alcohol hangover. Encouraging findings for their main outcome measures exist for linolenic acid from B officinalis, a yeast based combination preparation, and tolfenamic acid. However, only single randomised controlled trials for each of the tested interventions were available, most were of small sample size, and all used unvalidated symptom scores. Independent replications of these studies are therefore necessary. The lack of a sensitive standard outcome measure to assess the physiological and subjective effects of alcohol hangover may be one of the reasons for the small body of evidence. The development and initial validation of the hangover symptoms scale will hopefully encourage further systematic research and will aid the integration of trial data.34

Future studies should also investigate the biological changes that occur during alcohol hangover. The trial of O ficus-indica reported that the extract had some effects on individual symptoms, which received some media attention.27 35 The authors suggested that O ficus-indica exerts its action by acting on prostaglandin synthesis and cytokines that are deregulated during alcohol hangover.36 This view is supported by the improvement reported for tolfenamic acid,31 a potent inhibitor of prostaglandin synthesis. However, other data also reported beneficial effects for pyritinol, a nootropic agent that seems to enhance cognitive performance, and Liv.52, an Ayurvedic herbal preparation containing eight extracts with possible effects on alcohol metabolism.18 19 These agents seem not to act directly on the prostaglandin system. Future studies should disentangle the pathology of alcohol hangover to enable the development of effective hangover interventions.

Ethical concerns may relate to research in this area. It is conceivable that positive trials might lead to considerable media interest and industry marketing, which ultimately might lead to an increase in alcohol consumption. However, little evidence exists to show that alleviation of hangover symptoms results in increased alcohol consumption.1 Conversely, no conclusive evidence shows that hangover effectively deters alcohol consumption.

Limitations of our review pertain to the potential incompleteness of the reviewed evidence. We aimed to identify all randomised controlled trials on the topic. The distorting effects on systematic reviews arising from publication bias and location bias are well documented.37-40 For this study we searched databases with a focus on the American and European literature and those that specialise in complementary medicine, and we included hand searches. We imposed no restrictions on language of publication, and the two reviewers independently appraised the clinical evidence. We are therefore confident that our search strategy located the published trials on the subject. However, whether we identified all unpublished trials has to remain uncertain.

What is already known on this topic The alcohol hangover has substantial economic and health consequences

Compliance with moderation to prevent alcohol hangover is poor

What this study adds

Eight randomised controlled trials assessing eight different medical interventions for preventing or treating the symptoms of alcohol hangover were reviewed

No compelling evidence exists to suggest that any conventional or complementary intervention is effective for preventing or treating alcohol hangover

Conclusions Our findings show that no compelling evidence exists to suggest that any complementary or conventional intervention is effective for treating or preventing the alcohol hangover. Future studies should investigate the biological changes that occur during alcohol hangover. Until the pathology of alcohol hangover is understood in more detail, an effective intervention is likely to remain elusive. The most effective way to avoid the symptoms of alcohol induced hangover is thus to practise abstinence or moderation.

1 posted on 12/31/2005 8:10:50 PM PST by neverdem
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To: neverdem

oh good...now I have some ideas for tomorrow.


2 posted on 12/31/2005 8:13:11 PM PST by tongue-tied
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To: tongue-tied

Tylenol #3

The best pill ever made for a hangover.


3 posted on 12/31/2005 8:14:08 PM PST by Loud Mime (Build the Border Wall - Enforce the Law)
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To: neverdem

Stop drinking = no hangover.
Simple.


4 posted on 12/31/2005 8:14:17 PM PST by tet68 ( " We would not die in that man's company, that fears his fellowship to die with us...." Henry V.)
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To: neverdem

The best thing is to drink pedialyte, the night you drank. You can buy it at any drugstore. Its for dehydrated infants and replenishes electrolytes. Great stuff!!!


5 posted on 12/31/2005 8:16:55 PM PST by Luigi Vasellini (60% of Saudis, 58%of Iraqis, 55%of Kuwaitis,50% of Jordanians married 1st or 2nd cousins. LOL!!!)
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To: neverdem
"no compelling evidence exists to suggest that any conventional or complementary intervention is effective..."

That is what I have found as well. Time heals all wounds.
6 posted on 12/31/2005 8:18:58 PM PST by Ninian Dryhope ("Bush lied, people dyed. Their fingers." The inestimable Mark Steyn)
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To: Loud Mime

Oh heck no! Tylenol (aceti whatever) makes your kidneys and liver work overtime, which is what the booze does anyway. Tylenol is the WORST thing for a hangover. Causes more damage that (if you're a big drinker) you can ill afford.


7 posted on 12/31/2005 8:23:31 PM PST by tongue-tied
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To: Loud Mime

"Tylenol #3 The best pill ever made for a hangover."

Tylenol with alcohol is toxic to the liver. It can kill you.

And I'm *not* kidding.


8 posted on 12/31/2005 8:23:53 PM PST by dsc (Islamic sexual violence against women should be treated as the repressive epidemic it is.)
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To: neverdem

"Outer Mongolians are said to have feasted on pickled sheep eyeballs in tomato juice."

They must mean in modern times. Tomatoes are indigenous to the New World.


9 posted on 12/31/2005 8:25:16 PM PST by dsc (Islamic sexual violence against women should be treated as the repressive epidemic it is.)
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To: tongue-tied

The last one I took for a hangover was back in '82, and it was wonderful.

I don't drink anymore and didn't know of the health risk. Thanks for the info.


10 posted on 12/31/2005 8:26:11 PM PST by Loud Mime (Build the Border Wall - Enforce the Law)
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To: neverdem

" Until the pathology of alcohol hangover is understood in more detail, an effective intervention is likely to remain elusive."

Advil and tankards of hot tea aren't usually elusive but I guess a sledgehammer headache might make them seem so.


11 posted on 12/31/2005 8:26:43 PM PST by Domestic Church (AMDG...as it is I'm sticking with hot tea to ring in the New Year anyhow)
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To: neverdem

Watermelon!


12 posted on 12/31/2005 8:26:49 PM PST by Jet Jaguar
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To: Ninian Dryhope

Time heals all wounds.



Actually as all business men know it's

Time wounds all deals!

Happy New Year.
I've still got a half an hour as the world turns.


13 posted on 12/31/2005 8:29:07 PM PST by tet68 ( " We would not die in that man's company, that fears his fellowship to die with us...." Henry V.)
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To: Ninian Dryhope
Write off the next day. Laze around in your PJs on the couch. Put a big X on the calender. Do nothing productive and do not expect anything from yourself. Make no plans. Be a sloth.

I don't indulge much but when I do I make sure to do nothing the day after.

14 posted on 12/31/2005 8:29:23 PM PST by SoCar (Rudy in 2008)
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To: tongue-tied; dsc

I hadn't heard that. What about ibuprofen... isn't that what Advil is?


15 posted on 12/31/2005 8:30:22 PM PST by Ramius (Buy blades for war fighters: freeper.the-hobbit-hole.net --> 1000 knives and counting!)
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To: neverdem
""Something about near-raw fish really breathes life back into you."
16 posted on 12/31/2005 8:30:43 PM PST by Redbob
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To: neverdem

They're SHEEPHERDERS, not Cowboys!!

Oops, sorry. Wrong thread.


17 posted on 12/31/2005 8:31:01 PM PST by Tall_Texan (Santa Claus is an illegal alien.)
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To: Tall_Texan

lol!


18 posted on 12/31/2005 8:32:00 PM PST by Jet Jaguar
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To: Tall_Texan

Good Lord, if I never hear about these, ahem, guys again, I'll be happy.


19 posted on 12/31/2005 8:33:58 PM PST by Sociopathocracy (Ad majorem Dei gloriam)
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To: neverdem

You drink too much, you pay for it. Simple as that. Drink good booze and you won't hang so bad.


20 posted on 12/31/2005 8:34:12 PM PST by satchmodog9 (Most people stand on the tracks and never even hear the train coming)
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To: neverdem

bump


21 posted on 12/31/2005 8:34:20 PM PST by jra
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To: neverdem

simply the best ...

Vivaxl ... http://www.nutraceutics.com/


22 posted on 12/31/2005 8:36:06 PM PST by Bobibutu
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To: Ramius

Disclaimer: I am not a doctor.

However, I was a Hep C patient, and studied a lot about such things.

Ibuprofin doesn't seem to have the acute toxicity of Tylenol with alcohol. However, it does burden the liver.

If your liver is healthy, that shouldn't be a problem at doctor-recommended doses.

When I was doing chemotherapy, back in 2000-2001, most Hep C patients took ibuprofin to alleviate the side effects of the interferon and ribavirin, because it seemed to be the least bad of the bad choices available.


23 posted on 12/31/2005 8:38:48 PM PST by dsc (Islamic sexual violence against women should be treated as the repressive epidemic it is.)
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To: Ramius
Not sure, but ibuprofen is also processed by the kidneys, so maybe not. I rely on plain old aspirin when I need it.

Oh, and really spicy food seems to help me the "day after", but whatever food makes you feel better is best.

It just scares me when folks want to take Tylenol for a hangover. "Read and follow directions" really means something. (Not a dig on you personally by the way).
24 posted on 12/31/2005 8:41:19 PM PST by tongue-tied
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To: dsc

Found a couple of articles on webMD, and it seems there's still some dispute about the toxicity of acetomenophen especially is regular doses. In high doses (like ten+ caps) there's no argument that it does deliver toxins to the liver and do damage.

No similar threat noted from ibuprofen.

Huh. Learn sumpthin new every day.


25 posted on 12/31/2005 8:44:54 PM PST by Ramius (Buy blades for war fighters: freeper.the-hobbit-hole.net --> 1000 knives and counting!)
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To: Jet Jaguar

Injected with vodka!

Happy New Year!


26 posted on 12/31/2005 8:45:33 PM PST by ChefKeith (Flies,fleas,ants,ticks,cockroaches,lawyers & politicians All the same. Useless!!!)
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To: neverdem

BTTT


27 posted on 12/31/2005 8:47:29 PM PST by Fiddlstix (Tagline Repair Service. Let us fix those broken Taglines. Inquire within(Presented by TagLines R US))
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To: tongue-tied
For me, hangover prevention seems to work pretty well. If you pace yourself the night before, the next morning isn't all that bad.
28 posted on 12/31/2005 8:53:38 PM PST by capt. norm (Headline: "Energizer bunny arrested, charged with battery")
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To: capt. norm
Oh that is always a good idea. However, on "amateur night" it is best to post preventive medicine like this.

No one really thinks about toxicity of simple over the counter drugs normally, but it does matter.

The best plan is to NOT drink, but have massive amounts of sex so that there is no chance to drink to cause a hangover.
29 posted on 12/31/2005 9:01:05 PM PST by tongue-tied
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To: Ramius; dsc

My understanding is that each alone can burden the liver, but when combined is when they're dangerous. Apparently it has to do with the fact that the liver is already under stress from dealing with the alcohol and it doesn't take much acetomenphen to do the damage. It happened to a girl in the town we used to live in; it was all over the news there. She didn't die but sustained liver damage.


30 posted on 12/31/2005 9:03:40 PM PST by metmom (Welfare was never meant to be a career choice.)
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To: tongue-tied
I am reminded of a (adjusted) saying:

"Before you go out and drink all that beer, remember that you have a wife and kidneys."

31 posted on 12/31/2005 9:07:11 PM PST by capt. norm (Headline: "Energizer bunny arrested, charged with battery")
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To: capt. norm

LOL...how true. I wish someone would post the picture of Homer saying "Liver, do your duty!" because I haven't the capability.


32 posted on 12/31/2005 9:11:30 PM PST by tongue-tied
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To: Luigi Vasellini
The best thing is to drink pedialyte, the night you drank.

Hydration makes sense, and getting something to eat before going to sleep.

When I was younger I somehow managed to go jogging after those nights thinking I'd sweat the juice out. I still didn't feel all that great afterward, but seem to recall regaining equilibrium sooner.

Did you read "The Right Stuff?" Woolfe describes the test pilots going to work huffing pure o2 from a tank to burn off the residual alcohol from their previous night's carousing. Does anyone know if there is any sense in this?

33 posted on 12/31/2005 9:30:27 PM PST by tsomer
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To: tsomer
Woolfe describes the test pilots going to work huffing pure o2 from a tank to burn off the residual alcohol from their previous night's carousing. Does anyone know if there is any sense in this?

Back in the days when I was indulging in ethyl alcohol imbued consumables (in other words, back when I was a drunk) I used to huff O2 from my Dad's Oxy-Acetylene setup.. I always thought I felt better afterwards... (Two observations on this tactic... First, make sure you run the O2 long enough to clear out any acetylene that may be in the pipe and second, it took a long time using that method..so maybe it was the coffee kicking in!)

34 posted on 12/31/2005 9:52:08 PM PST by NoCmpromiz (Sober since Mar 15, 1982)
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To: Loud Mime

Tylenol used with any alcohol will destroy your liver. Check a thread from about 2 weeks ago, and you may change your mind!


35 posted on 12/31/2005 9:54:01 PM PST by Fierce Allegiance (I miss my dad.)
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To: NoCmpromiz

LMAO, all my piledriver crew would do that. Drove me nuts. I could just see one sucking a huge hit of acetylene and dying. I did not allow that on my jobs.


36 posted on 12/31/2005 9:55:27 PM PST by Fierce Allegiance (I miss my dad.)
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To: neverdem

Hair of the dog.


37 posted on 12/31/2005 9:57:26 PM PST by Cboldt
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To: Fierce Allegiance
sucking a huge hit of acetylene

Getting a hit of acetylene was almost enough to make me swear off drinking. The stuff positively reeks (especially with a hangover!)

38 posted on 12/31/2005 10:00:47 PM PST by NoCmpromiz (Sober since Mar 15, 1982)
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To: neverdem
I swear by this stuff:

The original Thai version of "Red Bull." Not carbonated or watered down, full of B Vitamins to replenish what you deplete. Even with it's sweetness, it doesn't ruin a beer.

Cheers everyone, and Happy New Year!

39 posted on 12/31/2005 10:03:58 PM PST by kstewskis ("Go to your room!"....Dan Rowan to Dick Martin)
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To: NoCmpromiz

Yup. Try soldering flux mixed with it, or welding fumes in a ships hold. Puking into your welding sheild is nasty. I will make you swear off drinking for the rest of the shift.


40 posted on 12/31/2005 10:09:26 PM PST by Fierce Allegiance (I miss my dad.)
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To: tet68
Stop drinking = no hangover.

You said it!! Never have a hangover......because I have never taken a drink in my life...........and I sure feel the better for it. Try Martinelli's grape /cider. SUPER STUFF!!!!!CHEERS to you all...

41 posted on 12/31/2005 10:11:46 PM PST by pollywog (Psalm 121;1 I Lift my eyes to the hills from whence cometh my help.)
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To: metmom

"My understanding is that each alone can burden the liver, but when combined is when they're dangerous. Apparently it has to do with the fact that the liver is already under stress from dealing with the alcohol and it doesn't take much acetomenphen to do the damage."

That's what I was trying to get said, but you were clearer.


42 posted on 01/01/2006 12:02:21 AM PST by dsc (Islamic sexual violence against women should be treated as the repressive epidemic it is.)
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To: Ramius

"Found a couple of articles on webMD, and it seems there's still some dispute about the toxicity of acetomenophen especially is regular doses. In high doses (like ten+ caps) there's no argument that it does deliver toxins to the liver and do damage."

That's Tylenol alone. Mixed with alcohol, the picture is entirely different.


43 posted on 01/01/2006 12:03:24 AM PST by dsc (Islamic sexual violence against women should be treated as the repressive epidemic it is.)
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To: NoCmpromiz

"Back in the days when I was indulging in ethyl alcohol imbued consumables (in other words, back when I was a drunk) I used to huff O2 from my Dad's Oxy-Acetylene setup."

Guess I'm the duty doom-sayer on this thread.

You should never, never, never inhale any gasses from any source not cleared for human consumption. Even tiny amounts of contaminants can kill you.


44 posted on 01/01/2006 12:07:27 AM PST by dsc (Islamic sexual violence against women should be treated as the repressive epidemic it is.)
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To: neverdem

Beer, Football and greasy food.


45 posted on 01/01/2006 12:14:50 AM PST by demsux
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To: dsc

I am pretty sure welding O2 and medical O2 are dispensed from the same bulk tanks...


46 posted on 01/01/2006 4:11:27 AM PST by joesnuffy (A camel once bit our sister.. but we knew what to do.. we gathered rocks and squashed her!)
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To: joesnuffy

But possibly not under the same conditions, and there is no reason to be meticulous about preventing contamination of welding tanks.


47 posted on 01/01/2006 4:13:31 AM PST by dsc (Islamic sexual violence against women should be treated as the repressive epidemic it is.)
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To: tsomer

Yep. The 'Stews' used to used the O2 on planes after a bad night. . .


48 posted on 01/01/2006 5:31:04 AM PST by doberville
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To: Ramius; dsc; Loud Mime
FYI: Painkillers and Liver Disease/Hepatitis

Excerpt from link: Ibuprofen (Motrin) has been reported to cause severe liver injury in people with hepatitis C.

After three maximum discomfort hangovers, I learned my tipping point and have stayed on this side of it ever since.

49 posted on 01/01/2006 7:13:52 AM PST by pa_dweller (levy = a tax <__> levee = an embankment for protection from floods)
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To: pa_dweller

"Ibuprofen (Motrin) has been reported to cause severe liver injury in people with hepatitis C."

There certainly is a lot of contradictory information out there on Hep C.

The man I trust is here:

http://www.hepatitisdoctor.com

There's more good information there than anywhere else, I think.

This man has made helping veterans with service-connected Hep C a personal crusade, to his financial detriment. And saved my life along the way (not to in anyway diminish God's role, or that of Our Lady).

It would be a good thing if anybody wanted to go here:

http://hcvets.com/

and sign the petition to protest the VA's treatment of the only doctor who's acting like he cares about vets.


50 posted on 01/01/2006 8:15:42 AM PST by dsc (Islamic sexual violence against women should be treated as the repressive epidemic it is.)
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