Skip to comments.Hangover Helpers: Beyond Sheep Eyes
Posted on 12/31/2005 8:10:49 PM PST by neverdem
click here to read article
The paucity of randomised controlled trials is in stark contrast to the plethora of "hangover cures" marketed on the internet. This confirms the unreliability of the internet in healthcare matters.33 Our findings show that no compelling evidence exists to suggest that any conventional or complementary intervention is effective for preventing or treating alcohol hangover. Encouraging findings for their main outcome measures exist for linolenic acid from B officinalis, a yeast based combination preparation, and tolfenamic acid. However, only single randomised controlled trials for each of the tested interventions were available, most were of small sample size, and all used unvalidated symptom scores. Independent replications of these studies are therefore necessary. The lack of a sensitive standard outcome measure to assess the physiological and subjective effects of alcohol hangover may be one of the reasons for the small body of evidence. The development and initial validation of the hangover symptoms scale will hopefully encourage further systematic research and will aid the integration of trial data.34
Future studies should also investigate the biological changes that occur during alcohol hangover. The trial of O ficus-indica reported that the extract had some effects on individual symptoms, which received some media attention.27 35 The authors suggested that O ficus-indica exerts its action by acting on prostaglandin synthesis and cytokines that are deregulated during alcohol hangover.36 This view is supported by the improvement reported for tolfenamic acid,31 a potent inhibitor of prostaglandin synthesis. However, other data also reported beneficial effects for pyritinol, a nootropic agent that seems to enhance cognitive performance, and Liv.52, an Ayurvedic herbal preparation containing eight extracts with possible effects on alcohol metabolism.18 19 These agents seem not to act directly on the prostaglandin system. Future studies should disentangle the pathology of alcohol hangover to enable the development of effective hangover interventions.
Ethical concerns may relate to research in this area. It is conceivable that positive trials might lead to considerable media interest and industry marketing, which ultimately might lead to an increase in alcohol consumption. However, little evidence exists to show that alleviation of hangover symptoms results in increased alcohol consumption.1 Conversely, no conclusive evidence shows that hangover effectively deters alcohol consumption.
Limitations of our review pertain to the potential incompleteness of the reviewed evidence. We aimed to identify all randomised controlled trials on the topic. The distorting effects on systematic reviews arising from publication bias and location bias are well documented.37-40 For this study we searched databases with a focus on the American and European literature and those that specialise in complementary medicine, and we included hand searches. We imposed no restrictions on language of publication, and the two reviewers independently appraised the clinical evidence. We are therefore confident that our search strategy located the published trials on the subject. However, whether we identified all unpublished trials has to remain uncertain.
What is already known on this topic The alcohol hangover has substantial economic and health consequences
Compliance with moderation to prevent alcohol hangover is poor
What this study adds
Eight randomised controlled trials assessing eight different medical interventions for preventing or treating the symptoms of alcohol hangover were reviewed
No compelling evidence exists to suggest that any conventional or complementary intervention is effective for preventing or treating alcohol hangover
Conclusions Our findings show that no compelling evidence exists to suggest that any complementary or conventional intervention is effective for treating or preventing the alcohol hangover. Future studies should investigate the biological changes that occur during alcohol hangover. Until the pathology of alcohol hangover is understood in more detail, an effective intervention is likely to remain elusive. The most effective way to avoid the symptoms of alcohol induced hangover is thus to practise abstinence or moderation.
oh good...now I have some ideas for tomorrow.
The best pill ever made for a hangover.
Stop drinking = no hangover.
The best thing is to drink pedialyte, the night you drank. You can buy it at any drugstore. Its for dehydrated infants and replenishes electrolytes. Great stuff!!!
Oh heck no! Tylenol (aceti whatever) makes your kidneys and liver work overtime, which is what the booze does anyway. Tylenol is the WORST thing for a hangover. Causes more damage that (if you're a big drinker) you can ill afford.
"Tylenol #3 The best pill ever made for a hangover."
Tylenol with alcohol is toxic to the liver. It can kill you.
And I'm *not* kidding.
"Outer Mongolians are said to have feasted on pickled sheep eyeballs in tomato juice."
They must mean in modern times. Tomatoes are indigenous to the New World.
The last one I took for a hangover was back in '82, and it was wonderful.
I don't drink anymore and didn't know of the health risk. Thanks for the info.
" Until the pathology of alcohol hangover is understood in more detail, an effective intervention is likely to remain elusive."
Advil and tankards of hot tea aren't usually elusive but I guess a sledgehammer headache might make them seem so.
Time heals all wounds.
Actually as all business men know it's
Time wounds all deals!
Happy New Year.
I've still got a half an hour as the world turns.
I don't indulge much but when I do I make sure to do nothing the day after.
I hadn't heard that. What about ibuprofen... isn't that what Advil is?
They're SHEEPHERDERS, not Cowboys!!
Oops, sorry. Wrong thread.
Good Lord, if I never hear about these, ahem, guys again, I'll be happy.
You drink too much, you pay for it. Simple as that. Drink good booze and you won't hang so bad.
simply the best ...
Vivaxl ... http://www.nutraceutics.com/
Disclaimer: I am not a doctor.
However, I was a Hep C patient, and studied a lot about such things.
Ibuprofin doesn't seem to have the acute toxicity of Tylenol with alcohol. However, it does burden the liver.
If your liver is healthy, that shouldn't be a problem at doctor-recommended doses.
When I was doing chemotherapy, back in 2000-2001, most Hep C patients took ibuprofin to alleviate the side effects of the interferon and ribavirin, because it seemed to be the least bad of the bad choices available.
Found a couple of articles on webMD, and it seems there's still some dispute about the toxicity of acetomenophen especially is regular doses. In high doses (like ten+ caps) there's no argument that it does deliver toxins to the liver and do damage.
No similar threat noted from ibuprofen.
Huh. Learn sumpthin new every day.
Injected with vodka!
Happy New Year!
My understanding is that each alone can burden the liver, but when combined is when they're dangerous. Apparently it has to do with the fact that the liver is already under stress from dealing with the alcohol and it doesn't take much acetomenphen to do the damage. It happened to a girl in the town we used to live in; it was all over the news there. She didn't die but sustained liver damage.
"Before you go out and drink all that beer, remember that you have a wife and kidneys."
LOL...how true. I wish someone would post the picture of Homer saying "Liver, do your duty!" because I haven't the capability.
Hydration makes sense, and getting something to eat before going to sleep.
When I was younger I somehow managed to go jogging after those nights thinking I'd sweat the juice out. I still didn't feel all that great afterward, but seem to recall regaining equilibrium sooner.
Did you read "The Right Stuff?" Woolfe describes the test pilots going to work huffing pure o2 from a tank to burn off the residual alcohol from their previous night's carousing. Does anyone know if there is any sense in this?
Back in the days when I was indulging in ethyl alcohol imbued consumables (in other words, back when I was a drunk) I used to huff O2 from my Dad's Oxy-Acetylene setup.. I always thought I felt better afterwards... (Two observations on this tactic... First, make sure you run the O2 long enough to clear out any acetylene that may be in the pipe and second, it took a long time using that method..so maybe it was the coffee kicking in!)
Tylenol used with any alcohol will destroy your liver. Check a thread from about 2 weeks ago, and you may change your mind!
LMAO, all my piledriver crew would do that. Drove me nuts. I could just see one sucking a huge hit of acetylene and dying. I did not allow that on my jobs.
Hair of the dog.
Getting a hit of acetylene was almost enough to make me swear off drinking. The stuff positively reeks (especially with a hangover!)
The original Thai version of "Red Bull." Not carbonated or watered down, full of B Vitamins to replenish what you deplete. Even with it's sweetness, it doesn't ruin a beer.
Cheers everyone, and Happy New Year!
Yup. Try soldering flux mixed with it, or welding fumes in a ships hold. Puking into your welding sheild is nasty. I will make you swear off drinking for the rest of the shift.
You said it!! Never have a hangover......because I have never taken a drink in my life...........and I sure feel the better for it. Try Martinelli's grape /cider. SUPER STUFF!!!!!CHEERS to you all...
"My understanding is that each alone can burden the liver, but when combined is when they're dangerous. Apparently it has to do with the fact that the liver is already under stress from dealing with the alcohol and it doesn't take much acetomenphen to do the damage."
That's what I was trying to get said, but you were clearer.
"Found a couple of articles on webMD, and it seems there's still some dispute about the toxicity of acetomenophen especially is regular doses. In high doses (like ten+ caps) there's no argument that it does deliver toxins to the liver and do damage."
That's Tylenol alone. Mixed with alcohol, the picture is entirely different.
"Back in the days when I was indulging in ethyl alcohol imbued consumables (in other words, back when I was a drunk) I used to huff O2 from my Dad's Oxy-Acetylene setup."
Guess I'm the duty doom-sayer on this thread.
You should never, never, never inhale any gasses from any source not cleared for human consumption. Even tiny amounts of contaminants can kill you.
Beer, Football and greasy food.
I am pretty sure welding O2 and medical O2 are dispensed from the same bulk tanks...
But possibly not under the same conditions, and there is no reason to be meticulous about preventing contamination of welding tanks.
Yep. The 'Stews' used to used the O2 on planes after a bad night. . .
Excerpt from link: Ibuprofen (Motrin) has been reported to cause severe liver injury in people with hepatitis C.
After three maximum discomfort hangovers, I learned my tipping point and have stayed on this side of it ever since.
"Ibuprofen (Motrin) has been reported to cause severe liver injury in people with hepatitis C."
There certainly is a lot of contradictory information out there on Hep C.
The man I trust is here:
There's more good information there than anywhere else, I think.
This man has made helping veterans with service-connected Hep C a personal crusade, to his financial detriment. And saved my life along the way (not to in anyway diminish God's role, or that of Our Lady).
It would be a good thing if anybody wanted to go here:
and sign the petition to protest the VA's treatment of the only doctor who's acting like he cares about vets.