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Chillies turn up the heat on (prostate) tumours
newscientist ^ | 15 March 2006 | Roxanne Khamsi

Posted on 03/16/2006 3:38:16 AM PST by S0122017

Chillies turn up the heat on tumours 13:22 15 March 2006 NewScientist.com news service Roxanne Khamsi

Related Articles Oranges, bananas and turmeric prevent leukaemia Chilli receptors detect heart attack pain

The same component of jalapeño peppers that makes them burn the tongue also appears to kill prostate cancer cells. Prostate tumours in mice treated with the compound, called capsaicin, shrank to one-fifth the size of those in non-treated mice, found a new study.

To explore capsaicin’s effect, Phillip Koeffler of the Cedars-Sinai Medical Center in Los Angeles, US, and colleagues exposed human prostate cancer cells in a laboratory dish to the natural compound. They found that capsaicin dramatically slowed the proliferation of the cells in the dish.

And this effect increased as the dose of the chilli compound was raised. Three per cent of prostate cancer cells committed “suicide” – programmed cell death – at low concentrations, rising to up to 75% of tumour cells dying at a higher dose.

Koeffler says this is the first experimental evidence supporting the notion that capsaicin stops the growth of prostate cancer cells.

Human cancer He believes that capsaicin jump starts a pathway that triggers cell death. Molecular tests suggest that it achieves this by causing a cascade of events inside the cell that lead to the release of a protein complex called NF-kappa Beta, which subsequently causes the cell to self-destruct. This is crucial since cancer is characterised by the uncontrolled growth of cells.

The team also found that capsaicin suppressed the growth of human prostate cancer cells by about 80%. These cells were grafted into mice with suppressed immune systems.

But Koeffler says that men concerned about prostate cancer should not interpret these findings as a reason to up their consumption of hot peppers. He stresses that the compound has not been shown to prevent prostate cancer but instead simply slows its growth. And he adds that he hopes to see human trials in the next two years assessing capsaicin’s effect on prostate cancer.

Take a chilli pill After prostate cancer is surgically removed, it tends to reappear in about a quarter of patients, the researchers note. For this reason, they say that capsaicin may be most effective in slowing cancer’s return instead of stopping it from first developing.

He adds that one also must take dosages into consideration. A 200-pound (90-kilogram) person would have to eat about 10 fresh habañera peppers – one of the hottest chillies around – per week to consume an amount of capsaicin equivalent to the levels received by Koeffler’s mice.

A habañera typically contains 300,000 Scoville units – a scale used to measure the hotness of chillis – making them positively scorching to the mouth in comparison with the more popular jalapeños, which contain roughly 2500 to 5000 Scoville units. For this reason, he says it is unreasonable to imagine anyone eating fresh peppers to prevent the return of prostate cancer: “You would have to take it in pill form.”

Journal reference: Cancer Research (DOI: 10.1158/0008-5472.CAN-05-0087)


TOPICS: Culture/Society; Miscellaneous
KEYWORDS: cancer; capsaicin; itburnsitburns; peppers; prostrate; typos
dont forget to check out related research: Oranges, bananas and turmeric prevent leukaemia http://www.newscientist.com/article.ns?id=dn6384 Chilli receptors detect heart attack pain http://www.newscientist.com/article.ns?id=dn4127
1 posted on 03/16/2006 3:38:20 AM PST by S0122017
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To: AntiGuv

human health ping


2 posted on 03/16/2006 3:38:47 AM PST by S0122017
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To: S0122017

Is it OK if I just continue to eat Datil peppers, or do I need to sit on a bunch of them?


3 posted on 03/16/2006 3:50:25 AM PST by SWAMPSNIPER
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To: S0122017; SWAMPSNIPER
But Koeffler says that men concerned about prostate cancer should not interpret these findings as a reason to up their consumption of hot peppers. He stresses that the compound has not been shown to prevent prostate cancer but instead simply slows its growth. ----

***

SO WHY NOT eat them any way??

I eat those things at least twice a day. I swear that they are good for many things.

****

SWAMPSNIPER ....... that might be a little uncomfortable.

;-)

4 posted on 03/16/2006 3:54:16 AM PST by beyond the sea (The definition of a 'Targeted Tax Cut' is ........................ you ain't gettin' it)
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To: S0122017

Why is it I just can't get the picture of a Habanero suppository out of my mind? Ai chihuahua!!


5 posted on 03/16/2006 3:57:40 AM PST by WideGlide (That light at the end of the tunnel might be a muzzle flash.)
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To: beyond the sea

I was chopping some to make relish, had a hole in one of my rubber gloves, took the gloves off to use the bathroom, should have washed my hands FIRST!
After 60 years of Datils, nothing else will do, however, a hybrid of a Datil and a Bell pepper is about perfect for a salad.


6 posted on 03/16/2006 4:00:06 AM PST by SWAMPSNIPER
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To: SWAMPSNIPER
I just eat the jalapenos....... but when I get them on my eyelids or (other tender places) it really gets your attention.

;-)

7 posted on 03/16/2006 4:09:18 AM PST by beyond the sea (The definition of a 'Targeted Tax Cut' is ........................ you ain't gettin' it)
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To: S0122017

and besides, it will keep the septic tank thawed


8 posted on 03/16/2006 4:10:45 AM PST by sure_fine (*not one to over kill the thought process*)
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To: S0122017

It's 'prostate', not 'prostrate' (for future reference).


9 posted on 03/16/2006 4:12:02 AM PST by snarks_when_bored
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To: WideGlide
Why is it I just can't get the picture of a Habanero suppository out of my mind? Ai chihuahua!!

They don't just burn on the way in...

10 posted on 03/16/2006 4:19:40 AM PST by glorgau
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To: S0122017

Chile is a pepper.

Chili is a food made with, among other things, chile.

"Chillies" sound like refrigerated underwear for men with low sperm counts. :D


11 posted on 03/16/2006 4:21:18 AM PST by hellinahandcart
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To: hellinahandcart

It ain't my title. I just copy-pasted.

Science reporters always use the stupidest titles, like "kha-nyou smell a rat" when they discover a rodent named kha-nyou, or "saved by 'sand' poured into the wounds" when discussing a new bloodclotter that is sand-like in appearance. They seem to think they are funny, but it is just detrimental to true science.


12 posted on 03/16/2006 4:39:11 AM PST by S0122017
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To: beyond the sea

Datils are a local strain of Habenero, same fire, different taste. Try cross pollinating Bell to Habenero, I'll bet it is good.


13 posted on 03/16/2006 4:40:47 AM PST by SWAMPSNIPER
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To: S0122017

I already know you didn't do it; I checked the article at the website.

It's "chilli" everywhere you look.



14 posted on 03/16/2006 4:46:57 AM PST by hellinahandcart
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To: SteelTrap

fyi


15 posted on 03/16/2006 4:48:19 AM PST by mathluv (Bushbot, Snowflake, Dittohead ---- Bring it on!!!)
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To: S0122017
Image hosting by Photobucket

For all that ails you.

16 posted on 03/16/2006 4:58:48 AM PST by randita
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To: S0122017

I eat peppers everyday! I'm Cured!.........


17 posted on 03/16/2006 5:20:23 AM PST by Red Badger (And he will be a wild man; his hand will be against every man, and every man's hand against him...)
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To: hellinahandcart
Chile is a pepper.

Chile is a country........and more than one (Chiles) was our former (late) governor and Senator...........

18 posted on 03/16/2006 5:22:06 AM PST by Red Badger (And he will be a wild man; his hand will be against every man, and every man's hand against him...)
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To: SWAMPSNIPER

Hand out free condoms with capsaicin extract!
Aint that a laugh?


19 posted on 03/16/2006 5:22:06 AM PST by S0122017
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To: WideGlide
Why is it I just can't get the picture of a Habanero suppository out of my mind?

Hard boiled eggs and pickled habaneros shortly before a flight will keep that liberal next to you on the plane off of the arm rest and leaning away. It is a toxic defense cloud... ; ^)

20 posted on 03/16/2006 5:34:59 AM PST by Sir Francis Dashwood (LET'S ROLL!)
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To: S0122017
The team also found that capsaicin suppressed the growth of human prostate cancer cells by about 80%

I'm not sure I agree with their findings.

If I eat too many chilis, my prostate feels like its on fire and that it's gonna explode!

21 posted on 03/16/2006 5:40:55 AM PST by Bear_Slayer (When liberty is outlawed only outlaws will have liberty)
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To: S0122017

I guess "prostrate" tumors lie down a lot??


22 posted on 03/16/2006 5:41:53 AM PST by linda_22003
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To: S0122017

A hot chile a day will keep the ass doctor away.


23 posted on 03/16/2006 5:46:47 AM PST by wolfcreek
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To: wolfcreek
A hot chile a day will keep the ass doctor away.

Not if you suffer from hemorrhoids! LOL!

24 posted on 03/16/2006 5:51:28 AM PST by Night Hides Not (Closing in on 3000 posts, of which maybe 50 were worthwhile!)
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To: Red Badger

I ate and still eat peppers all my life too. It didn't help.


25 posted on 03/16/2006 6:49:35 AM PST by MAWG (In the shadows, on permanent ambush duty.)
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To: Red Badger
Chile is a country

You mean, also a country. :D


26 posted on 03/16/2006 7:52:19 AM PST by hellinahandcart
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To: hellinahandcart

Yeah, that, too....er also..........whatever.........


27 posted on 03/16/2006 7:53:19 AM PST by Red Badger (And he will be a wild man; his hand will be against every man, and every man's hand against him...)
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To: Red Badger

Well, come on, the peppers were around before the country was...


28 posted on 03/16/2006 7:55:09 AM PST by hellinahandcart
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To: S0122017
This might explain why my dad had the inherent need to stage hot chili pepper contests with this navy buddies and his male children. :)
29 posted on 03/16/2006 10:03:48 AM PST by Galveston Grl (Getting angry and abandoning power to the Democrats is not a choice.)
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To: beyond the sea

We eat Mexican food all the time. My freezer is full of green sauce, red sauce, whole chiles and chopped chiles.


30 posted on 03/17/2006 6:15:28 AM PST by tiki
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To: tiki
My freezer is full of green sauce, red sauce, whole chiles and chopped chiles.

You'll live longer than all the Dems. who are afraid of hot peppers!

31 posted on 03/17/2006 10:15:40 AM PST by beyond the sea (The definition of a 'Targeted Tax Cut' is ........................ you ain't gettin' it)
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To: hellinahandcart

We grow for the company that cans that Hatch brand and quite a few others.


32 posted on 03/17/2006 12:53:51 PM PST by tiki
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To: tiki

I lived in New York for a long time, and had a teeny, useless little freezer, so my parents in New Mexico used to dry roasted green chiles and ship them to me every year.

By the time those babies were dried, they could pack a bushel into a shoebox.:D


33 posted on 03/17/2006 1:56:14 PM PST by hellinahandcart
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